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New, resistance-breaking drugs are urgently needed to effectively treat infections with antibiotic-resistant germs in the future. Researchers from Saarbrücken and Vienna have now found a possible starting point for the development of such drugs in the natural product Saarvienin A. This novel molecule is capable of killing bacteria even if they are already resistant to clinically used antibiotics. The researchers published their findings in the journal Angewandte Chemie International Edition.

28.05.2025

HIPS

HZI podcast "InFact" with Theresa Graalmann on the topic autoimmune diseases

News

When our immune system chooses the wrong enemy and turns against our own body, autoimmune diseases can result. Dr. Dr. Theresa Graalmann is a physician and clinician scientist who heads the junior research group “Translational Immunology” at TWINCORE – Center for Experimental and Clinical Infection Research. In this episode of the HZI podcast InFact, she explains how rheumatism, lupus, and vascular inflammation develop and how doctors and scientists work together to incorporate patient data and state-of-the-art cell analyses directly into the development of new therapeutic approaches.

27.05.2025

TWINCORE

Study authors Maureen Obara and Dr Matthias Bruhn

News

Monoclonal antibodies against SARS-CoV-2 were considered a promising approach for the prevention and therapy of corona virus infections. However, the ongoing evolution of the virus regularly produces new variants that are no longer neutralized by the antibodies. Researchers from TWINCORE, together with partners from Hanover and Bern, have now been able to clarify the underlying mechanism in more detail. The TWINCORE is a joint institution of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and Hannover Medical School (MHH). Instead of using a single antibody, they propose the combination of several antibodies for treatment. They have published their findings in the scientific journal eBioMedicine.

26.05.2025

TWINCORE

News

Decisions have been made on future Clusters of Excellence in the second round of competition under the Excellence Strategy – the joint initiative of the federal and state governments to further strengthen top-level research at universities in Germany. The Helmholtz Centre for Infection Research (HZI) is part of two of the funded Clusters of Excellence together with university partners: RESIST and NUCLEATE. RESIST at Hannover Medical School (MHH) will receive funding for another seven years. In this cluster, scientists are investigating how people who are susceptible to infection can be better protected. In the newly approved NUCLEATE cluster at the Julius-Maximilians-Universität Würzburg (JMU) with the Technical University of Munich and the Ludwig-Maximilians-Universität München, group leaders from the Helmholtz Institute for RNA-based Infection Research (HIRI), a site of the HZI in cooperation with the JMU, are conducting research into nucleic acid-based therapies. A total of 70 Clusters of Excellence were selected for funding.

26.05.2025

HZI Campus

TWINCORE

CiiM

HIRI

News

Bats are known as natural hosts for highly pathogenic viruses such as MERS- and SARS-related coronaviruses, as well as the Marburg and Nipah viruses. In contrast to the severe and often fatal disease outcomes these viruses cause in humans, bats generally do not show obvious signs of viral illness following infection. An international research team led by Dr. Max Kellner and Prof. Josef Penninger, Scientific Director of the Helmholtz Centre for Infection Research (HZI), has developed an innovative organoid research platform that allowed them to closely investigate the cellular antiviral defense mechanisms of mucosal epithelial tissues of bats. The results have now been published in Nature Immunology and could pave the way for the development of new therapies against viral diseases.

21.05.2025

HZI Campus

News

Yesterday, the biomedical project forge of the state of Lower Saxony reviewed the most promising ideas from across the region and selected the winners: At the fourth portfolio conference of the Institute for Biomedical Translation (IBT) Lower Saxony, a high-caliber jury selected projects from the Helmholtz Centre for Infection Research (HZI) in Braunschweig, the University Medical Center Göttingen (UMG) and TWINCORE - Centre for Experimental and Clinical Infection Research, which will receive funding of almost 3 million euros. TWINCORE is a joint institution of the HZI and Hannover Medical School (MHH). A total of 25 million euros will be available to the IBT Lower Saxony until 2028 to accelerate the transfer of cutting-edge research in the life sciences in Lower Saxony and bring it to the world in the form of start-ups and entrepreneurial ideas.

14.05.2025

HZI Campus

TWINCORE

CiiM

HZI in the media

Erlangen-Nürnberg (FAU) und des Helmholtz-Instituts für Pharmazeutische Forschung Saarland (HIPS) haben DataSAIL entwickelt – ein ...

06.06.2025

BigData-Insider

Forscher der Saar-Universität und es Helmholtz-Instituts für pharmazeutische Forschung haben in einem internationalen Forschungsprojekt ...

02.06.2025

Die Rheinpfalz

mimic the function of real organs. Researchers at the Helmholtz Center for Infection Research (HZI) in Braunschweig, Germany, led by Dr. Max

01.06.2025

ARCHYDE

Max Kellner und Prof. Josef Penninger – wissenschaftlicher Geschäftsführer des Helmholtz-Zentrums für Infektionsforschung (HZI) – haben ...

01.06.2025

Regional Heute

de Viena (da Áustria ) e o Instituto Helmholtz para Pesquisa Farmacêutica de Saarland (da Alemanha ) encontraram um novo antibiótico

31.05.2025

Galileu

Forscher der Universität des Saarlands, dem Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS) und Arbeitsgruppen ...

28.05.2025

Focus Online

NMR) identifizierte dann ein Team am Helmholtz-Institut für Pharmazeutische Forschung Saarland ein völlig neues Molekül: Saarvienin A.

28.05.2025

MedMedia

Ein weiterer Meilenstein ist der Neubau des Helmholtz-Instituts für RNA-basierte Infektionsforschung (HIRI), das 2017 ...

27.05.2025

kma - Das Gesundheitswirtschaftsmagazin

Philipps-Universität Marburg Helmholtz Munich Helmholtz-Zentrum für Infektionsforschung LMU Klinikum München Stiftung Tierärztliche

27.05.2025

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