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A virus lurking in the connective tissue
Study by the HZI shows how a herpesvirus on the one hand rests inactive in connective tissue cells and on the other hand can replicate in the same cells when needed
NEWS
Novel candidate drug against persistent intestinal pathogen
New HZI study shows efficacy of the natural product chlorotonil A against dormant stages of the Clostridioides difficile bacterium
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Bacterial weapons against viral diseases
Discovery of two novel classes of natural products with activity against RNA viruses
NEWS
Sugar-based inhibitors disarm the pathogen Pseudomonas aeruginosa
HIPS researchers develop promising active ingredient to combat multi-resistant bacteria

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World Day for Laboratory Animals and Alternative Models on April 24

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Overview of vaccination and the vaccine research at HZI

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The topics of our research groups and background information on the strategy of the HZI

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Selected Publications

A list of all publications can be found in our publication database.

All Publications

Thandapani, P. Kloetgen, A. Witkowski, M.T. Glytsou, C. Lee, A.K. Wang, E. Wang, J. LeBoeuf, S.E. Avrampou, K. Papagiannakopoulos, T. Tsirigos, A. Aifantis, I.

Valine tRNA levels and availability regulate complex I assembly in leukaemia
Nature, 00280836 (ISSN) (2022)
Georg, P. Astaburuaga-García, R. Bonaguro, L. Brumhard, S. Michalick, L. Lippert, L.J. Kostevc, T. Gäbel, C. Schneider, M. Streitz, M. Demichev, V. Gemünd, I. Barone, M. Tober-Lau, P. Helbig, E.T. Hillus, D. Petrov, L. Stein, J. Dey, H.P. Paclik, D. [...]

Complement activation induces excessive T cell cytotoxicity in severe COVID-19
Cell, 00928674 (ISSN) (2022)
Sandmann, L. Cornberg, M.

HCC and HBV reactivation-A preventable condition not to be missed
Hepatology, 0270-9139 (Linking) (2022)
Hezaveh, K. Shinde, R.S. Klötgen, A. Halaby, M.J. Lamorte, S. Ciudad, M.T. Quevedo, R. Neufeld, L. Liu, Z.Q. Jin, R. Grünewald, B.T. Foerster, E.G. Chaharlangi, D. Guo, M. Makhijani, P. Zhang, X. Pugh, T.J. Pinto, D.M. Co, I.L. McGuigan, A.P. Jang, G. [...]

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity
Immunity, 10747613 (ISSN) (2022)
Dietz, C.A. Cornberg, M.

Lonafarnib
Hepatology, 02709139 (ISSN) (2022)
Ludwig, L.S. Lareau, C.A. Bao, E.L. Liu, N. Utsugisawa, T. Tseng, A.M. Myers, S.A. Verboon, J.M. Ulirsch, J.C. Luo, W. Muus, C. Fiorini, C. Olive, M.E. Vockley, C.M. Munschauer, M. Hunter, A. Ogura, H. Yamamoto, T. Inada, H. Nakagawa, S. Ohzono, S. S [...]

Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1
Blood, 0006-4971 (2022)
Dähling, S. Mansilla, A.M. Knöpper, K. Grafen, A. Utzschneider, D.T. Ugur, M. Whitney, P.G. Bachem, A. Arampatzi, P. Imdahl, F. Kaisho, T. Zehn, D. Klauschen, F. Garbi, N. Kallies, A. Saliba, A.E. Gasteiger, G. Bedoui, S. Kastenmüller, W.

Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches
Immunity, 10747613 (2022)
Tsay, H.C. Yuan, Q. Balakrishnan, A. Kaiser, M. Möbus, S. Kozdrowska, E. Farid, M. Tegtmeyer, P.K. Borst, K. Vondran, F.W.R. Kalinke, U. Kispert, A. Manns, M.P. Ott, M. Sharma, A.D.

Corrigendum to: Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis [J Hepatol (2019) 722-734] (Journal of Hepatology (2019) 722-734, (S0168827818326357), (10.1016/j.jhep.2018.12.016))
Journal of Hepatology, 01688278 (2022)
Nusser, A. Sagar Swann, J.B. Krauth, B. Diekhoff, D. Calderon, L. Happe, C. Grün, D Boehm, T.

Developmental dynamics of two bipotent thymic epithelial progenitor types
Nature, 0028-0836 (Linking) (2022)
Iram, T. Kern, F. Kaur, A. Myneni, S. Morningstar, A.R. Shin, H. Garcia, M.A. Yerra, L. Palovics, R. Yang, A.C. Hahn, O. Lu, N. Shuken, S.R. Haney, M.S. Lehallier, B. Iyer, M. Luo, J. Zetterberg, H. Keller, A. Zuchero, J.B. Wyss-Coray, T.

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
Nature, 00280836 (ISSN) (2022)

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Selected Publications

Valine tRNA levels and availability regulate complex I assembly in leukaemia

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

HCC and HBV reactivation-A preventable condition not to be missed

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

Lonafarnib

Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1

Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches

Corrigendum to: Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis [J Hepatol (2019) 722-734] (Journal of Hepatology (2019) 722-734, (S0168827818326357), (10.1016/j.jhep.2018.12.016))

Developmental dynamics of two bipotent thymic epithelial progenitor types

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17