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At first glance, mucus sounds more unpleasant than essential. In fact, it forms an important protective layer on our mucous membranes: It transports dirt, bacteria, and viruses out of the body and makes it difficult for pathogens to penetrate our cells in the first place. Prof. Christian Sieben, head of the research group “Nano Infection Biology” at the Helmholtz Centre for Infection Research (HZI), is studying this crucial moment in an infection in great detail. Using state-of-the-art microscopy, he observes individual virus particles and investigates how they interact with our cells. In this episode of InFact, he explains how respiratory viruses overcome our natural barriers and why influenza viruses in particular have significant pandemic potential.

23.07.2026

HZI Campus

A view inside a laboratory; two hands wearing blue gloves working with a pipette

News

Bacteria have spent decades evolving resistance to virtually every antibiotic we have thrown at them. To stay ahead, new drugs must hit targets that existing antibiotics have never touched. A research team at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) has now developed a series of synthetic drug candidates that do exactly that: By blocking an essential molecular supply system, these molecules cut off the bacteria's essential vitamins supply and starve them to death. The team published its findings in two studies back to back in the Journal of Medicinal Chemistry.

21.07.2026

HIPS

Macrophages under an electron microscope

News

Macrophages are considered the “scavenger cells” of the immune system, but some pathogens exploit these very cells as hiding places. Researchers from the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg and Philipps-Universität Marburg have now discovered a mechanism that helps immune cells to balance their response to infection: a long non-coding ribonucleic acid called SAILR, which acts as an apoptosis regulator. The findings were published recently in the journal PNAS.

20.07.2026

HIRI

News

Prof. Hortense Slevogt, research group leader at the Helmholtz Centre for Infection Research (HZI) and lead senior physician at Hannover Medical School (MHH), has been appointed to the Commission on Anti-Infectives, Resistance and Therapy (ART) at the Robert Koch Institute (RKI). The ART Commission is an independent expert panel at the RKI that develops recommendations on the rational use of anti-infectives based on current scientific evidence. Its goal is to ensure the effective use of anti-infectives while limiting the emergence and spread of resistant pathogens.

15.07.2026

HZI Campus

Photo of Leonard Knegendorf at an office workstation

News

Premature babies in the intensive care unit are particularly at risk of becoming infected with potentially pathogenic bacteria. A team of doctors in Hanover has now investigated which external factors play a role in this. They concluded that climatic conditions have an influence. The study was led and designed by Dr Leonard Knegendorf, a clinician-scientist at TWINCORE, the Centre for Experimental and Clinical Infection Research. The findings were published in the scientific journal "Antimicrobial Resistance & Infection Control". TWINCORE is a joint institution of the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH).

13.07.2026

TWINCORE

Collage of portraits of Alexander Titz and Christian Sieben

News

New broad-spectrum antiviral agents are considered an important contribution to pandemic preparedness. A project led by Alexander Titz, Professor of Organic and Pharmaceutical Chemistry at Saarland University (UdS), and Prof. Christian Sieben, research group leader at the Helmholtz Centre for Infection Research (HZI), aims to develop such active compounds to fill a gap in pandemic prevention. To achieve this, the two researchers intend to block a step that occurs at the very beginning of viral infection: the binding of viruses to sugar molecules on the cell surface. The Volkswagen Foundation is now funding the development of such inhibitors with almost one million euros.

06.07.2026

HZI Campus

HIPS

HZI in the media

a drug candidate. HIPS is a site of the Helmholtz Center for Infection Research (HZI) in collaboration with Saarland University.

Balancing

21.07.2026

Phys.org

Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, a site of the Braunschweig Helmholtz Center for

20.07.2026

Medical Xpress

Forschende des Helmholtz-Instituts für RNA-basierte Infektionsforschung (HIRI) in Würzburg, einem Standort des Braunschweiger Helmholtz- ...

20.07.2026

DeutschesGesundheitsPortal

... das HIPS übernimmt die chemische Synthese und Optimierung der Kandidaten, während die smartbax GmbH exklusive ...

19.07.2026

healthcare-in-europe.com

Berit Lange, Leiterin der Abteilung Epidemiologie, Helmholtz-Zentrum für Infektionsforschung (HZI) in Braunschweig , ergänzt: „Eine ...

17.07.2026

Biermann Medizin

Prof. Dr. Berit Lange gegenüber dem SMC . Sie ist Leiterin der Abteilung Epidemiologie am Helmholtz-Zentrum ...

15.07.2026

Apotheken Umschau

In den Laboren wachsen Stammzellen zu komplexen Geweben heran. Gezüchtet in Brutschränken, gepflegt von Robotern ...

13.07.2026

Deutschlandfunk

und leitet das Zoologische Institut. Am Helmholtz-Zentrum für Infektionsforschung verantwortet er die Forschungsgruppe „Neuroinflammation

10.07.2026

Zwischengas

... von DZIF-Wissenschaftler Prof. Mark Brönstrup am Helmholtz-Zentrum für Infektionsforschung (HZI) geleitete Projekt für die Entwicklung ...

09.07.2026

Bionity.COM

... Artificial Intelligence Methods Das Projekt am Helmholtz-Zentrum für Infektionsforschung unter Leitung von Dr. Alina Bazarova ...

08.07.2026

Niedersächsisches Landesjustizportal

... ), und Prof. Christian Sieben , Forschungsgruppenleiter am Helmholtz-Zentrum für Infektionsforschung (HZI), hat zum Ziel, mit der ...

06.07.2026

Biermann Medizin

Am Exponat des Helmholtz-Institut für Pharmazeutische Forschung Saarland können Besuchende nach wertvollen Bodenbakterien suchen. ...

29.06.2026

WerbePost - Rheinische Anzeigenblätter

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