Respiratory syncytial virus (RSV) can cause severe lower respiratory tract infections, particularly in newborns and the elderly. How the virus manages to evade the immune system and what changes it triggers in infected cells had not yet been fully understood. Researchers from TWINCORE, Centre for Experimental and Clinical Infection Research, have now, together with interdisciplinary colleagues from Würzburg, Regensburg, Braunschweig and Hannover, demonstrated how the virus interferes with the genetic programme of respiratory cells, inhibits the immune response and disrupts cell function. They have published these findings in the journal Science Advances.

Environmental factors such as chemical pollutants, psychosocial stressors, and antibiotics as well as an unhealthy diet affect the human immune system and microbiome. They can contribute to an increased risk of infection, reduced immune resilience, and an altered immune response to vaccination. To date, there has been little research into how these factors affect viral immune responses in pregnant women as well as in children and adolescents. The aim of the EMVIC collaborative project is to close this gap using data from the LiNA mother–child cohort of the Helmholtz Centre for Environmental Research (UFZ). The project is coordinated by the UFZ with participation from the University of Leipzig, Hannover Medical School, and the Helmholtz Centre for Infection Research (HZI), and will start on 1 July.

There is an urgent need for novel drugs in the fight against infectious diseases, and natural compounds derived from soil bacteria are a promising source for their development. Researchers at HIPS, the HZI site in Saarland, are counting on the public’s help: The citizen science project MICROBELIX aims to harness the biodiversity of soil bacteria for drug discovery.