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A built-in “hairpin” prevents rogue CRISPR RNAs
The CRISPR-Cas gene-editing system has long been the focus of research as a promising tool in genome editing. However, the emphasis has been on its underlying mechanisms and nucleases. In contrast, little research has examined how CRISPR-Cas systems have evolved and been optimized. In collaboration with the universities of Leipzig, Freiburg, and Michigan (USA), a research team at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg found an optimization mechanism in CRISPR-Cas13, providing insights into the evolution of these systems. The results were recently published in EMBO Journal.
14.04.2026
HIRI
Section of a mouse dorsal root ganglion with two subtypes of pain receptors marked in cyan and magenta.
News
First “protein map” of neurons that initiate pain
Helmholtz researchers have created the first detailed protein map of specific sensory neurons that trigger pain. The team from the Max Delbrück Center and the Helmholtz Centre for Infection Research (HZI) determined the complete set of proteins in nerve cells and generated a high-resolution map of the cells. Their study, published in “Nature Communications,” will help researchers better understand the molecular mechanisms of chronic inflammatory pain and identify new drug targets.
14.04.2026
HZI Campus
Dot-like colonies of the bacterium Klebsiella pneumoniae (blue) on a round plate
News
When Resistance and Virulence go hand in hand
Antimicrobial resistance is one of the greatest challenges to global health. Using an innovative high-throughput method, researchers from the Department “Epidemiology and Ecology of Antimicrobial Resistance” led by Prof. Katharina Schaufler at the Helmholtz Institute for One Health (HIOH) have now uncovered a previously hidden link between antibiotic resistance and virulence in Klebsiella pneumoniae. Virulence describes the extent to which a pathogen can cause disease. The findings were published in the international journal Clinical Microbiology and Infection. HIOH is a site of the Helmholtz Centre for Infection Research.
13.04.2026
HIOH
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One center - six locations

The HZI locations at a glance

The Sites of the Helmholtz Centre for Infection Research are distributed all over Germany. In addition to the main campus in Braunschweig, there are facilities in five other cities: Hamburg, Hanover, Saarbrücken, Würzburg and Greifswald.

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One center - six locations

The HZI locations at a glance

The Sites of the Helmholtz Centre for Infection Research are distributed all over Germany. In addition to the main campus in Braunschweig, there are facilities in five other cities: Hamburg, Hanover, Saarbrücken, Würzburg and Greifswald.

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Events

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23
April
2026
9.00 am | Braunschweig
Career Guidance
Future Day 2026
Host: HZI Campus
Scientific
28
April
2026
11.00 am | Braunschweig
Workshop
Translating European Expertise to Pandemic Preparedness
Host: HZI Campus
Scientific
05
May
2026
4.00 pm | Hannover
Conference
IBT Pre-Seed Portfolio Conference #6
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07
May
2026
11.00 am | HZI wide
Wissenschaftskommunikation
HIPS exhibit on MS Wissenschaft
Host: HIPS
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Transmission of MPXV from fire-footed rope squirrels to sooty mangabeys

Nature