Newsroom

Story

Over the past few years, public awareness of the microbial communities in our gut has grown significantly – partially thanks to Giulia Enders' book "Gut: The Inside Story Of Our Body's Most Under-Rated Organ". Scientific studies on antibiotics and the microbiota have also attracted attention: The use of these products is hypothesised to disrupt the sensitive inhabitants of our intestine and may cause serious damage. So how can we protect our gut flora against this?

04.09.2017

HZI Campus

Biofilm eines klinischen Isolates von Pseudomonas aeruginosa

News

Chronic lung infections caused by the bacterium Pseudomonas aeruginosa require complex and, in most cases, long-term treatment with antibiotics. It is generally not possible to completely heal the infection or even significantly reduce the bacterial load—new medication is badly needed. Scientists at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and the German Center for Infection Research (DZIF) are now improving an anti-infective active ingredient with a new mode of action. The starting point is a substance that can block the pathogenicity of the bacterium and weaken its protective biofilm. The Helmholtz Validation Fund, the DZIF and the Helmholtz Centre for Infection Research (HZI) are contributing a joint investment of 2.7 million euros to improve this class of substance, aiming to achieve a preclinical candidate.

18.08.2017

HZI Campus

HIPS

News

To be able to develop new drugs against infectious diseases researchers need to understand their molecular basis. How does the proliferation of a pathogen proceed, what interactions take place between it and the host cell and how are these processes regulated? For this purpose, protein-RNA complexes are examined. They play an important role at different times in the lifecycle of the pathogen or the host cell and are thus involved in infection processes. Researchers from the Helmholtz Centre for Infection Research (HZI), the Leibniz Universität Hannover, the EMBL Heidelberg and the Bijvoet Center for Biomolecular Research at Utrecht University have now developed an integrated structure analysis platform that is able to very simply and effectively calculate the structure of large protein-RNA complexes on the basis of diverse experimental data. The so-called “M3 Framework” is available free of charge for researchers from academic institutes. The researchers published their results in the scientific journal Nature Methods.

15.08.2017

HZI Campus

News

31.07.2017

News

Stem cells in the bone marrow provide a life-long supply of blood and immune cells. If they display defects – either caused by hereditary diseases or blood cancer – the transplantation of bone marrow cells of a suitable donor is often the only therapeutic option. To avoid rejection of the transplanted stem cells, the patients immune response needs to be dampened. The consequence: Bacteria and viruses have an easy time. Especially infections with the highly prevalent Cytomegalovirus are a leading cause of clinical complications – ranging from graft rejection to life-threatening disease. Scientists of TWINCORE and the German Cancer Research Center have now switched prespective: They investigated the influence of virus infections of bone marrow donors on the success of a transplantation. Their – striking – results were recently published in „Cell Reports“.

14.06.2017

TWINCORE

News

Scientists studying infections used to focus mainly on the direct interaction of the immune system with pathogens, but have since moved on to look more closely at the interactions that go on between microbiota, immune system and pathogen. Using mouse models, researchers from the Helmholtz Centre for Infection Research (HZI) recently elucidated a relationship between gut microbiomes of various compositions and the susceptibility to Salmonella infections. In their study, the scientists from Braunschweig identified several bacterial families that have a protective effect against Salmonella. The researchers also elucidated the immune mechanism in the mucosa of the gut that is regulated by the protective bacterial families. Published in Cell Host & Microbe, the results of the study of the HZI scientists are an important step towards a better understanding of the interactions of the triad of microbiota, immune system and pathogen.

14.06.2017

HZI Campus

Back to the first page
...
83
84
85
86
...
150

HZI in the media

Dr. Rolf Müller, Managing Director of Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), were both named laureates of the

22.12.2025

Research Information

... ein Interview mit Josef Penninger geführt . Er ist wissenschaftlicher Geschäftsführer des Helmholtz-Zentrum für Infektionsforschung in ...

21.12.2025

T3N

Institut für RNA-basierte Infektionsforschung (HIRI), einem Standort des Braunschweiger Helmholtz-Zentrums für Infektionsforschung (HZI) in ...

19.12.2025

healthcare-in-europe.com

Biosyntheseweg aufzuklären. Das HIPS ist ein Standort des Helmholtz-Zentrums für Infektionsforschung (HZI) in Zusammenarbeit mit ...

18.12.2025

Bionity.COM

Finanzierungsmöglichkeiten fehlen.

Josef Penninger, wissenschaftlicher Geschäftsführer des Helmholtz-Zentrums für Infektionsforschung (HZI)

16.12.2025

MedMedia

Korte from the Technical University of Braunschweig and the Helmholtz Centre for Infection Research (HZI).

The research was carried out as

12.12.2025

The Hindu

... des Leibniz Lungenzentrums Borstel, des Helmholtz-Instituts für Pharmazeutische Forschung Saarland sowie weiterer wissenschaftlicher ...

12.12.2025

Bionity.COM

Einrichtungen des regionalen Forschungsökosystems – darunter das Helmholtz-Zentrum für Infektionsforschung (HZI), das Deutsche Zentrum für

12.12.2025

EUROPE SAYS

Korte of the Technical University of Braunschweig and the Helmholtz Centre for Infection Research (HZI). The findings emerged from the

12.12.2025

The New Indian Express

Universität Würzburg. Seit 2018: Postdoc am Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI), Entwicklung Bayes’scher ...

12.12.2025

BIOspektrum

Center Borstel - Leibniz Lung Center, the Helmholtz Institute for Pharmaceutical Research Saarland and other scientific institutions in

11.12.2025

Technology Networks

von Humboldt professor, head of department at the Helmholtz Centre for Infection Research, Braunschweig and full professor at the Hannover

10.12.2025

European Research Council

Register now for the HZI-Newsletter

and stay up to date!

Email address *

We use rapidmail to send our newsletter. I agree that my data entered here will be transmitted to rapidmail. I have taken note of the HZI's privacy policy and have been informed of my rights.