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Medically relevant compounds can often be found in nature. To make them suitable for drugs, they need to be isolated from their natural sources. If sufficient quantities of the agent cannot be isolated in that manner, chemical synthesis comes into play. Without chemical synthesis, many agents were not available for the industrial production of drugs. Phil S. Baran of the Scripps Research Institute in La Jolla, USA, aims to develop the “perfect synthesis”. His methods and reagents are applied in fundamental chemical research and in the production of pharmaceuticals. They are commercially marketed with much success. In honour of his outstanding achievements, he is being awarded the Inhoffen Medal by the “Friends of the HZI”, the sponsors' association of the Helmholtz Centre for Infection Research (HZI).

04.04.2019

HZI Campus

News

An increasing number of bacteria are developing resistance to commonly used antibiotics, making it imperative to advance research into new antibiotics for clinical and medical use. Olga Kalinina, the new endowed professor for substance bioinformatics, is dedicating herself to this task. Since January this year, the scientist has been based at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), a branch site of the Helmholtz Centre for Infection Research (HZI) and the Saarland University, working on developing new antibiotics from biologically active natural substances. Her research will be supported until 2022 by the Klaus Faber Foundation in Saarbrücken, with a total of 1.6 million euros.

29.03.2019

News

The treatment of hepatitis C has been based on specific effective antiviral medications for a number of years. Since future development of resistance cannot be ruled out, alternative treatment options are being researched as well. So-called cell entry inhibitors are considered to be promising candidates. In combined efforts with colleagues from the Leibniz University Hannover, scientists from the Helmholtz Centre for Infection Research (HZI) and the TWINCORE pinpointed the target site on the virus and developed improved drug candidates. Their study has recently been published in the Journal of Hepatology.

25.03.2019

HZI Campus

Mikroskopische Aufnahme einer dendritischen Zelle

News

Dendritic cells act as the guardians of our immune system. They are lurking for foreign invaders, swallow them, break them into pieces and present the fragments on the cell surface. When the dendritic cells and their pathogen fragments come into contact with specialised white blood cells, called T cells, these T cells are activated and they can destroy the infected cells. Researchers from TWINCORE, a joint facility of the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), have now discovered how the uptake of antigens and presentation of antigen fragments on human dendritic cells are regulated in terms of time and space. These findings form the foundation for the development of improved vaccines. The study has just been published in the journal Blood Advances.

21.03.2019

HZI Campus

News

On 20 February 2019, the Helmholtz Centre for Infection Research (HZI) and Evotec AG announced their cooperation, scheduled for three years initially. They aim to develop new antibiotics that overcome resistant bacterial pathogens – a global health threat. The research activities will initially focus on the optimisation of cystobactamids, which are natural anti-bacterial substances that have a novel chemical scaffold and are effective against the most harmful Gram-negative bacteria. The research cooperation with Evotec resulted from an intensive preceding cooperation of the HZI, its Helmholtz Institute for Pharmaceutical Research Saarland, and the Leibniz University Hannover, supported by the German Center for Infection Research (DZIF).

28.02.2019

HZI Campus

HIPS

News

For the characterization of new bioactive metabolites from tropical Basidiomycetes, a division of fungi, Dr Clara Chepkirui of the Helmholtz Centre for Infection Research (HZI) in Brunswick was awarded this year’s DECHEMA-Doktorandenpreis für Naturstoff-Forschung. While doing her doctorate in the HZI department Microbial Drugs, headed by Prof Marc Stadler, Chepkirui discovered the microporenic acids, which proved effective against bacterial biofilms.

25.02.2019

HZI Campus

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HZI in the media

could be reintroduced at any time. Epidemiologists at the Helmholtz Center for Infection Research (HZI) have now shown that many people do

23.10.2025

MSN.com

... eingeschleppt werden könnte. Epidemiolog:innen des Helmholtz-Zentrums für Infektionsforschung (HZI) haben nun gezeigt, dass ...

23.10.2025

innovations report

this development, a research team at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), in collaboration with the Swiss

22.10.2025

Phys.org

Malaria-Medikamentes ermöglichen könnte. Das HIPS ist ein Standort des Helmholtz-Zentrums für Infektionsforschung in Zusammenarbeit mit ...

22.10.2025

Verband Deutscher Biologen e.V.

(Bild: DOI: 10.1021/jacs.5c08354 / Hips / CC BY 4.0) Wissenschaftler am Hips entwickelten eine Plattform zur Produktion von Furanoliden, die effektiv gegen Bakterien und Krebszellen wirken können und vielversprechende Wirkstoffe darstellen.

21.10.2025

PROCESS

at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), in partnership with the Helmholtz Centre for Infection Research (HZI

20.10.2025

Bioengineer.org

their biological activity. HIPS is a site of the Helmholtz Center for Infection Research (HZI) in collaboration with Saarland University.

20.10.2025

Phys.org

... die Abteilung „Experimentelle Immunologie“ am Helmholtz-Zentrum für Infektionsforschung (HZI) in Braunschweig, lehrt als Professor an ...

17.10.2025

Deutsches Ärzteblatt

Einrichtungen als nationale assoziierte Partner: das Helmholtz-Zentrum für Infektionsforschung Braunschweig, die Universität Bayreuth, das

17.10.2025

AlphaGalileo

... diesem Ergebnis kommt ein Forschungsteam des Helmholtz-Zentrums für Infektionsforschung (HZI) in Zusammenarbeit mit der ...

14.10.2025

Deutsches Ärzteblatt

Individualisierte Infektionsmedizin, einer gemeinsamen Einrichtung des Helmholtz-Zentrums für Infektionsforschung und der MHH. Bis zuletzt

13.10.2025

Springer

Ein Grippe-Test könnte in Zukunft womöglich sehr schnell gehen: einfach ein Kaugummi kauen. Ein deutsches ...

09.10.2025

Apotheken Umschau

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