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Hepatitis D is by far the most severe form of chronic viral hepatitis frequently leading to liver failure, hepatocellular carcinoma and death. However, there is very limited knowledge on disease pathophysiology and host-virus interactions explaining the large interindividual variability in the course of hepatitis D. Hannover Medical School (MHH) with its Department of Gastroenterology, Hepatology and Endocrinology and its Centre for Individualised Infection Medicine (CiiM), a joint institution of MHH and the Helmholtz Centre for Infection Research (HZI) in Braunschweig, coordinates an international project for an unbiased screening of a large multicenter cohort of well-defined HDV-infected patients to better understand individual factors determining the outcome of infection and to identify subjects benefitting from currently available treatments. In a highly competitive call for proposals, the D-SOLVE consortium (“Understanding the individual host response against Hepatitis D Virus to develop a personalized approach for the management of hepatitis D”) has received four-year funding of 6.75 million euros from the Horizon 2020 EU Horizon Call „Personalised medicine and infectious diseases: understanding the individual host response to viruses (e.g. SARS-CoV-2)“ of the European Union. In addition to the MHH as project partner and coordinator, institutions from Germany, France, Italy, Sweden and Romania are involved in the project.

22.06.2022

CiiM

News

The coronavirus SARS-CoV-2 can infect various body tissues. While the detection of the virus in the nasopharynx is established as a diagnostic method, the amount of virus found there does not allow a prognosis of the course of the disease. In a recent study, a research team from the Helmholtz Centre for Infection Research (HZI) in cooperation with the University of Rijeka, Croatia, investigated the correlation between the viral load in different tissues and the mortality of patients with a severe course of COVID-19. The researchers show for the first time that viral load can contribute to clinical prognosis, as a higher viral load in the lungs at the time of ventilation correlates with an increased risk of death. In this interview, first author Henrike Maaß and study leader Prof Luka Cicin-Sain, head of the department “Viral Immunology” at HZI, talk about the research results that were published in the journal Viruses MDPI.

20.06.2022

HZI Campus

News

The development of new active substances against pathogenic bacteria, parasites, fungi and viruses is gaining importance, as established antiinfectives are becoming increasingly ineffective due to the development of resistance. At the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), a team led by Prof Rolf Müller has optimized an antimicrobial natural product that is active against infections with both, the hospital acquired MRSA pathogen and the malaria causing parasite, for preclinical research and future potential application in humans. The researchers have published their results in the journal Angewandte Chemie International Edition.

16.06.2022

HZI Campus

HIPS

News

The State of Lower Saxony bundles top biomedical research in the new "Institute for Biomedical Translation" The COVID-19 pandemic has impressively underlined the enormous importance of a rapid transfer of biomedical innovations into application. The Hannover-Braunschweig-Göttingen-Wolfsburg metropolitan region is one of Germany's leading locations for biomedical research. Despite Lower Saxony's internationally recognised research strength in the three clinically highly relevant areas of infectious medicine, organ repair or replacement and neuroscience, the knowledge gained still finds its way into medical application too rarely or too slowly. For this reason, the state of Lower Saxony is now bundling top biomedical research in the "Institute for Biomedical Translation" (IBT).

15.06.2022

HZI Campus

TWINCORE

News

On 11 June 2022, virologist Prof Melanie Brinkmann was awarded the ScienceHero Prize. With this award, the Konferenz Biologischer Fachbereiche (Conference of Biology Departments) recognises people and organisations that stand for good teaching and creative research. The prize was awarded at the plenary session of the Mathematisch-Naturwissenschaftliche Fakultätentag (Mathematics and Natural Sciences Faculty Association), which took place in Braunschweig this time.

14.06.2022

HZI Campus

News

Friend or foe? Immune systems constantly face this question. They must recognize and clear foreign invaders without eliciting autoimmunity. Prokaryotic CRISPR-Cas systems recognize invaders based on genetic sequence. But what happens if the host genome shares the same sequences? A research team of the Helmholtz Institute in Würzburg in cooperation with the North Carolina State University (USA) has now discovered a control mechanism exhibited by CRISPR-Cas systems that use Cas13 nucleases: These systems only trigger an extensive immune response if the concentration of the target RNA exceeds a certain threshold. This discovery opens new opportunities for the use of CRISPR-Cas13 in the treatment of hereditary and infectious diseases. The scientists now published their findings in the journal “Cell Host & Microbe”.

13.06.2022

HIRI

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HZI in the media

... ” Seit Mai 2025 im Humanprogramm des Helmholtz-Zentrums für Infektionsforschung (HZI), Dr. Max Kellner-Leiter der jungen ...

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Die heutigen Nachrichten

” (Vico) within the Human program at the Helmholtz Centre for Infection Research (HZI).the‌ Vico group continues to investigate resilience

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purposes.

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... der TU Braunschweig, dem Braunschweig Integrated Centre of Systems Biology (BRICS) und dem Helmholtz-Zentrum für ...

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n-tv

Direktor des Helmholtz-Instituts für RNA-basierte Infektionsforschung (HIRI) in Würzburg, einem Standort des Braunschweiger Helmholtz- ...

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MTA Dialog

Studie und Hersteller des Prüfpräparats. Das Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS) war bei ...

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Kölner News Journal

at the Helmholtz Institute for RNA-based Infection Research (HIRI) and the Institute of Molecular Infection Biology (IMIB) in Würzburg has

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Phys.org

Leiter der Abteilung Chemische Biologie am Helmholtz-Zentrum für Infektionsforschung in Braunschweig www.helmholtz-hzi.de ...

10.09.2025

BR Bayerischer Rundfunk

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