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With advancing age, a person's immune system often grows weaker. One reason behind this is the gradual decline of the stem cell population that the body draws on in its ongoing effort to replace old worn-out or damaged immune cells. Now, scientists at the University of Ulm, Germany, in collaboration with the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany, have at last identified the mechanism underlying age-related immune function loss. Although it takes place in all cells of the body throughout a person's life, the accumulation of DNA damage in certain blood stem cells activates a gene critical for their differentiation into mature defender cells - a process, which compromises the stem cells' capacity for continuous, lifelong self-renewal, and ultimately responsible for their loss. The researchers' findings are published in the renowned scientific journal Cell and are in fact the current issue's cover story.

02.03.2012

HZI Campus

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29.02.2012

HIPS

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23.02.2012

HZI Campus

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In medieval Europe, the Black Death once decimated large parts of the population. Although in Europe no longer a genuine cause for concern, in Africa, South America, and India the Bubonic plague still to this day poses a viable threat to public health. The culprit behind the pandemic is a bacterium of the genus Yersinia. Each year in Germany, the pathogen's slightly less virulent relative is responsible for causing several thousand cases of diarrheal disease – often times with serious consequences. Scientists at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany, working closely with their colleagues at the Ruhr University in Bochum, Germany, have identified a mechanism that enables these bacteria to turn on their weaponry once inside the host. It turns out that Yersinia possesses a built-in molecular thermometer that jump-starts the bacterial pathogenic program at precisely 37 degrees Celsius, which corresponds to normal human body temperature.

20.02.2012

HZI Campus

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Slime-like and near impenetrable are biofilms built by a number of bacterial cells during the course of an infection. Typically, they are composed of long molecular strands called polymers. Many different species of bacteria, among them dangerous pathogens like Pseudomonas and Staphylococcus, use biofilms to shield themselves against the host's immune system attacks and antibiotics' pharmacological mechanism of action. In Germany alone, 100,000 infections annually are related to bacterial biofilms. A joint research initiative by the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany, and the TWINCORE, Centre for Experimental and Clinical Infection Research, aims to target bacterial biofilms using Nature's own list of active ingredients.

10.02.2012

HZI Campus

TWINCORE

HIPS

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Prof. Dr. Lars Zender has received one of the most distinguished German cancer research awards. The Johann-Georg-Zimmermann Award, endowed with 10 000 Euro, highlights Zender’s findings on chronic liver damage and liver cancer development. Liver cancer (hepatocellular carcinoma) developed in livers after chronic infection with Hepatitis-B and -C virus. Zender is heading a research group at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany, and holds a professorship for experimental gastrointestinal oncology at the Hannover Medical School (MHH). He has pioneered the development of systems to conduct RNA interference screens in vivo. The award ceremony took place on Monday, 16th January, at the MHH.

13.01.2012

HZI Campus

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HZI in the media

... späten 1990ern hob sie der am Saarbrücker Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS) tätige ...

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Biermann Medizin

Mdisk, stock.adobe.com

Braunschweig – Das Helmholtz-Zentrum für Infektionsforschung ( HZI ) in Braunschweig erhält für sein ...

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Josef Penninger, wissenschaftlicher Geschäftsführer des Helmholtz Zentrums für Infektionsforschung in Braunschweig und Professor für

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EUROPE SAYS

... Körperzellen. Damit tragen wir, wie das Helmholtz-Zentrum für Infektionsforschung (HZI) es treffend beschreibt, unseren „ganz ...

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MSN Deutschland

Eine Impfung bringt das Immunsystem in Stellung, bevor der echte Erreger kommt. Erfahren Sie, wie ...

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Apotheken Umschau

Livia V. Patrono, one of the senior authors at the Helmholtz Institute for One Health (HIOH) in Germany, said in a statement .

The research

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IFL Science

says Livia Patrono, a veterinarian and disease ecologist at Helmholtz Institute for One Health in Greifswald, Germany. In 2012, an infected

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Science News

... Dr. rer. nat. Jakob Wirbel vom Helmholtz-Zentrum für Infektionsforschung (Braunschweig). Das Experiment aus Stanford sei ...

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Deutsches Ärzteblatt

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