Hepatitis D virus (HDV) infects the liver and causes severe inflammation. According to WHO estimates, 12 million people worldwide are infected with HDV. Currently, there are only a few treatment options. A team of researchers from TWINCORE, the Centre for Experimental and Clinical Infection Research in Hannover, has developed a stem cell-based infection model for HDV and has used it to discover a possible target for an attack on the virus. They are now publishing their results in the scientific journal JHEP Reports. The TWINCORE is a joint institution of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and Hannover Medical School (MHH).

Scientists at the Helmholtz Centre for Infection Research (HZI) are studying important mechanisms for the development of infectious diseases and how they can be treated or prevented. Some of the research questions can only be answered with the help of animal experiments. Dr. Julia Port, head of the junior research group “Laboratory of Transmission Immunology”, and Dr. Marina Greweling-Pils, head of the research group “Core Facility of Comparative Medicine” and Animal Welfare Officer at the HZI, explain in an interview to mark the World Day for Laboratory Animals 2025 why not all animal experiments can be replaced and why choosing the right animal model is crucial for reliable scientific results.

Organoids are a pioneering tool in biomedical research. These tiny, organ-like cell structures are grown from stem cells and open up completely new possibilities for studying infectious diseases in human tissue. In this episode of the HZI podcast InFact, Dr Kristin Metzdorf, Deputy Head of the Department “Innovative Organoid Research” at the Helmholtz Centre for Infection Research (HZI), explains why these “mini-organs” are ideal for studying the interplay of the host with viruses or bacteria.