Microorganisms produce a wide variety of natural products that can be used as active ingredients to treat diseases such as infections or cancer. The blueprints for these molecules can be found in the microbes' genes, but often remain inactive under laboratory conditions. A team of researchers at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) has now developed a groundbreaking genetic method that leverages a natural bacterial mechanism for the transfer of genetic material and uses it for the production of new active ingredients. The team published its results in the journal Science.

In April 2024, the Helmholtz Centre for Infection Research (HZI) completely revamped its website together with the digital agency +Pluswerk. The aim of this relaunch was to present the HZI and its scientific work to the public in an appealing, contemporary design. The new HZI website has now won the TYPO3 Award in the “Health” category. The award was presented at the TYPO3 Conference 2024 in Düsseldorf.

When women are pregnant and nurse their babies, their bodies change and various organs, such as the breasts or the immune system, are adapted to ensure the health of both mother and child. This happens throughout evolution in all mammals. An international research team led by Josef Penninger, Scientific Director of the Helmholtz Centre for Infection Research (HZI), and Masahiro Onji from the Medical University of Vienna now reports the surprising finding that the intestine also changes completely in pregnant and nursing females, resulting in a doubling of the intestinal surface area and a striking structural reorganisation. The researchers also provide the first genetic and mechanistic evidence of how this intestinal epithelial expansion occurs in mothers, with direct implications for the transgenerational health of the babies. The study has now been published in the journal Nature.