The German National Cohort (NAKO) contributes its scientific expertise to the National Decade of Post-Infectious Diseases initiated by the Federal Ministry of Research, Technology and Space (BMFTR). With two central projects, it makes an important contribution to research into the long-term health consequences of infectious diseases such as Long COVID. The aim of the research decade is to better understand the causes and mechanisms of post-infectious diseases and to develop new treatment options. The Helmholtz Centre for Infection Research (HZI) coordinates the Clinical Research Center (CRC) of the NAKO in Hanover.

With funding from the Lower Saxony Ministry of Science and Culture (MWK) and the Volkswagen Foundation, the Helmholtz Centre for Infection Research (HZI) in Braunschweig has launched the large-scale project HUMAN. Interdisciplinary teams are investigating the interactions between humans, bacteria and viruses. Six internationally recruited young researchers are currently setting up new research groups with innovative approaches and bringing cutting-edge research from Stanford, Stockholm and Vienna, among others, to Lower Saxony. The project, led by Prof. Josef Penninger, Scientific Director of the HZI, initially has around 32 million euros available in the program “zukunft.niedersachsen”, with the option of an increase to up to 70 million euros after a successful interim evaluation. Today, the established groups were presented to Lower Saxony's Minister of Science, Falko Mohrs, and the CEO of the Volkswagen Foundation, Dr. Georg Schütte.

How Long COVID develops is still largely unknown. New molecular connections are revealed in a recent study led by the Centre for Individualised Infection Medicine (CiiM). Using their approach of examining different molecular levels within individual cells, the researchers identified a specific condition in immune cells that was directly associated with elevated inflammation markers, fatigue, and respiratory problems in patients with Long COVID. The study was published in the journal Nature Immunology. The CiiM is a joint institution of the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH).