Prof. Dr. Thomas Pietschmann

Prof. Dr. Thomas Pietschmann
Forschungsgruppenleiter

Der gebürtige Würzburger Thomas Pietschmann studierte Biologie an der Justus-Maximilian-Universität Würzburg und der Duke University, Durham USA. Im Jahr 2000 promovierte er am Institut für Virologie der Universität Würzburg über Mechanismen der Virusmorphogenese bei Retroviren und schloss sich als Postdoc der Gruppe von Professor Ralf Bartenschlager am Institut für Virologie in Mainz an. 2002 wechselte er gemeinsam mit Bartenschlager an die Abteilung für Molekulare Virologie der Universität Heidelberg. Dort etablierte Thomas Pietschmann eine Emmy Noether-Nachwuchsgruppe, die sich mit der Morphogenese und dem Eintrittsmechanismus des Hepatitis-C-Virus beschäftigte. Im Frühjahr 2007 wurde er mit seiner Arbeitsgruppe an das TWINCORE berufen und leitet dort seit 2012 das Institut für Experimentelle Virologie.  Seit 2021 ist er Sprecher des Helmholtz Forschungsprogramms „Infektionsforschung" am HZI und ist seit 2023 Vorstandsmitglied des Deutschen Zentrums für Infektionsforschung (DZIF) und Prokurist für die Wissenschaftliche Geschäftsführung des HZI.

Publikationen
Garcia R., Popoff A., Bader C.D., Löhr J., Walesch S., Walt C., Boldt J., Bunk B., Haeckl F.P.J., Gunesch A.P., Birkelbach J., Nübel U., Pietschmann T., ... , Bach T., Müller R. (2024)
Discovery of the Pendulisporaceae: An extremotolerant myxobacterial family with distinct sporulation behavior and prolific specialized metabolism
Chem, 10

Lauber C., Zhang X., Vaas J., Klingler F., Mutz P., Dubin A., Pietschmann T., Roth O., Neuman B.W., Gorbalenya A.E., ... , Bartenschlager R., Seitz S. (2024)
Deep mining of the Sequence Read Archive reveals major genetic innovations in coronaviruses and other nidoviruses of aquatic vertebrates
PLoS Pathogens, 20 (4/ April)

Frericks N., Brown R.J.P., Reinecke B.M., Herrmann M., Brüggemann Y., Todt D., Miskey C., Vondran F.W.R., Steinmann E., ... , Pietschmann T., Sheldon J. (2024)
Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes
J.Virol., 98 (3)

Sake S.M., Zhang X., Rajak M.K., Urbanek-Quaing M., Carpentier A., Gunesch A.P., Grethe C., Matthaei A., R++ckert J., Galloux M., Larcher T., Le Goffic R., Hontonnou F., Chatterjee A.K., Johnson K., Morwood K., Rox K., Elgaher W.A.M., Huang J., Wetzke M., Hansen G., Fischer N., El+®ou+½t J.F., Rameix-Welti M.A., Hirsch A.K.H., Herold E., Empting M., Lauber C., Schulz T.F., Krey T., ... , Haid S., Pietschmann T. (2024)
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor
Nature Communications, 15 (1)

Haid S., Matthaei A., Winkler M., Sake S.M., Gunesch A.P., Milke V., Köhler N.M., Rückert J., Vieyres G., Kühl D., Nguyen T.-T., Göhl M., Lasswitz L., Zapatero-Belinchon F.J., Brogden G., Gerold G., Wiegmann B., Bilitewski U., Brown R.J.P., Brönstrup M., ... , Schulz T.F., Pietschmann T. (2024)
Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets
Antimicrob.Agents Chemother.

Matthaei A., Joecks S., Frauenstein A., Bruening J., Bankwitz D., Friesland M., Gerold G., Vieyres G., Kaderali L., ... , Meissner F., Pietschmann T. (2024)
Landscape of protein-protein interactions during hepatitis C virus assembly and release
Microbiol.Spectr., 12 (2)

Pink I., Hennigs J.K., Ruhl L., Sauer A., Boblitz L., Huwe M., Fuge J., Falk C.S., Pietschmann T., de Zwaan M., Prasse A., Kluge S., Klose H., ... , Hoeper M.M., Welte T. (2023)
Blood T cell phenotypes correlate with fatigue severity in post-acute sequelae of COVID-19
Infection

Meister T.L., Friesland M., Frericks N., Wetzke M., Haid S., Steinmann J., Todt D., ... , Pietschmann T., Steinmann E. (2023)
Virucidal activity of oral, hand, and surface disinfectants against respiratory syncytial virus
J.Hosp.Infect., 141 (Nov 2023)

Liang T.J., Law J.L.M., Pietschmann T., Ray S.C., Bukh J., Bull R., Chung R.T., Tyrrell D.L., ... , Houghton M., Rice C.M. (2023)
Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model
Clin.Infect.Dis., 77

Stahl Y., Kabar I., Heinzow H., Maasoumy B., Bremer B., Wedemeyer H., Schmidt H.H.-J., Pietschmann T., ... , Schlevogt B., Behrendt P. (2023)
Enhanced monitoring and detection of recent genotype 3 hepatitis E virus infection through urine antigen testing
Emerg.Microbes Infect., 12 (2)

Zhang Y., Kinast V., Sheldon J., Frericks N., Todt D., Zimmer M., Caliskan N., Brown R.J.P., ... , Steinmann E., Pietschmann T. (2023)
Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses
Microbiol.Spectr.

Lange F., Garn J., Anagho H.A., Vondran F.W.R., von Hahn T., ... , Pietschmann T., Carpentier A. (2023)
Hepatitis D virus infection, innate immune response and antiviral treatments in stem cell-derived hepatocytes
Liver Int.

Vieyres G., Pietschmann T. (2023)
The role of human lipoproteins for hepatitis C virus persistence
Current Opinion in Virology, 60

Sake S.M., Kosch C., Blockus S., Haid S., Gunesch A.P., Zhang X., Friesland M., Trummer S.B., Grethe C., Kühnel A., Rückert J., Duprex W.P., Huang J., Rameix-Welti M.A., Empting M., Fischer N., Hirsch A.K.H., ... , Schulz T.F., Pietschmann T. (2022)
Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages
Antimicrob.Agents Chemother.

Keller L., Oueis E., Kaur A., Safaei N., Kirsch S.H., Gunesch A.P., Haid S., Rand U., Cicin-Sain L., Fu C., Wink J., ... , Pietschmann T., Müller R. (2022)
Persicamidines - Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses
Angew.Chem.Int.Ed Engl.

Haack P.A., Harmrolfs K., Bader C.D., Garcia R., Gunesch A.P., Haid S., Popoff A., Voltz A., Kim H., Bartenschlager R., ... , Pietschmann T., Müller R. (2022)
Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors
Angew.Chem.Int.Ed Engl.

Baier C., Huang J., Reumann K., Indenbirken D., Thol F., Koenecke C., Ebadi E., Heim A., Bange F.C., Haid S., ... , Pietschmann T., Fischer N. (2022)
Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients
Antimicrob.Resist.Infect.Control, 11 (1)

Reinecke B., Frericks N., Lauber C., Dinkelborg K., Matthaei A., Vondran F.W.R., Behrendt P., Haid S., ... , Brown R.J.P., Pietschmann T. (2022)
The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection
J Virol.

Gömer A., Brown R.J.P., Pfaender S., Deterding K., Reuter G., Orton R., Seitz S., Bock C.T., Cavalleri J.M.V., Pietschmann T., Wedemeyer H., ... , Steinmann E., Todt D. (2022)
Intra-host analysis of hepaciviral glycoprotein evolution reveals signatures associated with viral persistence and clearance
Virus Evol., 8 (1)

Wetzke M., Funken D., Lange M., Bejo L., Haid S., Monteiro J.G.T., Schütz K., Happle C., Schulz T.F., Seidenberg J., ... , Pietschmann T., Hansen G. (2022)
IRIS: Infection with RespIratory Syncytial Virus in infants-a prospective observational cohort study
BMC Pulm Med, 22 (1)

Schuhenn J., Meister T.L., Todt D., Bracht T., Schork K., Billaud J.N., Elsner C., Heinen N., Karakoese Z., Haid S., Kumar S., Brunotte L., Eisenacher M., Di Y., Lew J., Falzarano D., Chen J., Yuan Z., Pietschmann T., Wiegmann B., Uebner H., Taube C., Le-Trilling V.T.K., Trilling M., Krawczyk A., Ludwig S., Sitek B., Steinmann E., Dittmer U., Lavender K.J., ... , Sutter K., Pfaender S. (2022)
Differential interferon- a
Proc.Natl.Acad.Sci.U.S.A., 119 (8)

Paulsen M., Zychlinsky Scharff A., de Cassan K., Sugianto R.I., Blume C., Blume H., Christmann M., Hauß C., Illig T., Jonczyk R., Klopp N., Kopfnagel V., Lichtinghagen R., Lucas H., Luhr A., Mutschler F., Pietschmann T., Pott P.C., Prokein J., Schaefer P., Stahl F., Stanislawski N., von der Born J., Schmidt B.M.W., Heiden S., Stiesch M., ... , Memaran N., Melk A. (2021)
Children and Adolescents' Behavioral Patterns in Response to Escalating COVID-19 Restriction Reveal Sex and Age Differences
J.Adolesc.Health

Weber T., Potthoff J., Bizu S., Labuhn M., Dold L., Schoofs T., Horning M., Ercanoglu M.S., Kreer C., Gieselmann L., Vanshylla K., Langhans B., Janicki H., Ströh L.J., Knops E., Nierhoff D., Spengler U., Kaiser R., Bjorkman P.J., Krey T., Bankwitz D., Pfeifer N., Pietschmann T., ... , Flyak A.I., Klein F. (2021)
Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization
Immunity., 55 (2)

Bader C.D., Panter F., Garcia R., Tchesnokov E.P., Haid S., Walt C., Spröer C., Kiefer A.F., Götte M., Overmann J., ... , Pietschmann T., Müller R. (2022)
Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium
Chemistry.

Bankwitz D., Krey T., Pietschmann T. (2022)
[Development approaches for vaccines against hepatitis C virus infections] / Entwicklungsansätze für Impfstoffe gegen Hepatitis-C-Virus-Infektionen
Bundesgesundheitsblatt.Gesundheitsforschung.Gesundheitsschutz. (Jan)

Zapatero-Belinchón F.J., Moeller R., Lasswitz L., Van Ham M., Becker M., Brogden G., Rosendal E., Bi W., Carriquí-Madronal B., Islam K., Lenman A., Gunesch A.P., Kirui J., Pietschmann T., Överby A.K., ... , Jänsch L., Gerold G. (2021)
Fluvastatin mitigates SARS-CoV-2 infection in human lung cells
iScience, 24 (12)

Nicolay W., Moeller R., Kahl S., Vondran F.W.R., Pietschmann T., ... , Kunz S., Gerold G. (2021)
Characterization of rna sensing pathways in hepatoma cell lines and primary human hepatocytes
Cells, 10 (11)

Ricke-Hoch M., Stelling E., Lasswitz L., Gunesch A.P., Kasten M., Zapatero-Belinchon F.J., Brogden G., Gerold G., Pietschmann T., Montiel V., Balligand J.L., Facciotti F., Hirsch E., Gausepohl T., Elbahesh H., Rimmelzwaan G.F., Höfer A., Kühnel M.P., Jonigk D., Eigendorf J., Tegtbur U., Mink L., Scherr M., Illig T., Schambach A., Pfeffer T.J., Hilfiker A., ... , Haverich A., Hilfiker-Kleiner D. (2021)
Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease
PLoS ONE, 16 (8)

Risso-Ballester J., Galloux M., Cao J., Le Goffic R., Hontonnou F., Jobart-Malfait A., Desquesnes A., Sake S.M., Haid S., Du M., Zhang X., Zhang H., Wang Z., Rincheval V., Zhang Y., Pietschmann T., Eléouet J.F., ... , Rameix-Welti M.A., Altmeyer R. (2021)
A condensate-hardening drug blocks RSV replication in vivo
Nature, 595 (7868)

Martin-Benlloch X., Lanfranchi D.A., Haid S., Pietschmann T., Davioud-Charvet E., Elhabiri M. (2021)
Magnesium Complexes of Ladanein: A Beneficial Strategy for Stabilizing Polyphenolic Antivirals
European Journal of Inorganic Chemistry

Jo W.K., Schadenhofer A., Habierski A., Kaiser F.K., Saletti G., Ganzenmueller T., Hage E., Haid S., Pietschmann T., Hansen G., Schulz T.F., Rimmelzwaan G.F., ... , Osterhaus A.D.M.E., Ludlow M. (2021)
Reverse genetics systems for contemporary isolates of respiratory syncytial virus enable rapid evaluation of antibody escape mutants
Proc.Natl.Acad.Sci.U.S.A., 118 (14)

Zapatero-Belinchón F.J., Dietzel E., Dolnik O., Döhner K., Costa R., Hertel B., Veselkova B., Kirui J., Klintworth A., Manns M.P., P÷hlmann S., Pietschmann T., Krey T., Ciesek S., Gerold G., Sodeik B., ... , Becker S., von Hahn T. (2019)
Characterization of the filovirus-resistant cell line SH-SY5Y reveals redundant role of cell surface entry factors
Viruses, 11 (3)

Tegtmeyer B., Vieyres G., Todt D., Lauber C., Ginkel C., Engelmann M., Herrmann M., Pfaller C.K., Vondran F.W.R., Broering R., Vafadarnejad E., Saliba A.E., Puff C., Baumgärtner W., Miskey C., Ivics Z., Steinmann E., ... , Pietschmann T., Brown R.J.P. (2021)
Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements
J.Virol., 95 (10)

Bankwitz D., Bahai A., Labuhn M., Doepke M., Ginkel C., Khera T., Todt D., Ströh L.J., Dold L., Klein F., Klawonn F., Krey T., Behrendt P., Cornberg M., ... , McHardy A.C., Pietschmann T. (2021)
Hepatitis C reference viruses highlight potent antibody responses and diverse viral functional interactions with neutralising antibodies
GUT

Brown R.J.P., Tegtmeyer B., Sheldon J., Khera T., Anggakusuma, Todt D., Vieyres G., Weller R., Joecks S., Zhang Y., Sake S., Bankwitz D., Welsch K., Ginkel C., Engelmann M., Gerold G., Steinmann E., Yuan Q., Ott M., Vondran F.W.R., Krey T., Ströh L.J., Miskey C., Ivics Z., Herder V., Baumgärtner W., Lauber C., Seifert M., Tarr A.W., Mcclure C.P., Randall G., Baktash Y., Ploss A., Thi V.L.D., Michailidis E., Saeed M., Verhoye L., Meuleman P., Goedecke N., Wirth D., ... , Rice C.M., Pietschmann T. (2020)
Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice
Sci Adv, 6 (45)

Tran H.T.L., Morikawa K., Anggakusuma, Zibi R., Thi V.L.D., Penin F., Heim M.H., Quadroni M., Pietschmann T., ... , Gouttenoire J., Moradpour D. (2020)
OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease
PLoS ONE, 15 (7)

Wahlicht T., Vieyres G., Bruns S.A., Meumann N., Büning H., Hauser H., Schmitz I., ... , Pietschmann T., Wirth D. (2020)
Controlled Functional Zonation of Hepatocytes in Vitro by Engineering of Wnt Signaling
ACS Synth.Biol., 9 (7)

Haid S., Grethe C., Bankwitz D., Grunwald T., Pietschmann T. (2020)
Erratum: Correction for Haid et al., "Identification of a Human Respiratory Syncytial Virus Cell Entry Inhibitor by Using a Novel Lentiviral Pseudotype System" (Journal of virology (2015) 90 6 (3065-3073) PII: e01690-19)
J.Virol., 94 (14)

Vieyres G., Reichert I., Carpentier A., Vondran F.W.R., Pietschmann T. (2020)
The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly
PLoS.Pathog., 16 (6)

Gunesch A.P., Zapatero-Belinchon F.J., Pinkert L., Steinmann E., Manns M.P., Schneider G., Pietschmann T., ... , Brönstrup M., von Hahn T. (2020)
Filovirus antiviral activity of cationic amphiphilic drugs is associated with lipophilicity and ability to induce phospholipidosis
Antimicrob.Agents Chemother., 64 (8)

Alberione M.P., Moeller R., Kirui J., Ginkel C., Doepke M., Ströh L.J., Machtens J.P., ... , Pietschmann T., Gerold G. (2020)
Single-nucleotide variants in human CD81 influence hepatitis C virus infection of hepatoma cells
Med.Microbiol.Immunol., 209 (4)

Kinast V., Plociennikowska A., Anggakusuma, Bracht T., Todt D., Brown R.J., Boldanova T., Zhang Y., Brueggemann Y., Friesland M., Engelmann M., Vieyres G., Broering R., Vondran F.W.R., Heim M.H., Sitek B., Bartenschlager R., ... , Pietschmann T., Steinmann E. (2020)
C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle
J.Hepatol., 73 (3)

Köllmann C., Sake S.M., Jones P.G., Pietschmann T., Werz D.B. (2020)
Protecting-Group-Mediated Diastereoselective Synthesis of C4-Methylated Uridine Analogs and Their Activity against the Human Respiratory Syncytial Virus
J.Org.Chem., 85 (6)

Blockus S., Sake S.M., Wetzke M., Grethe C., Graalmann T., Pils M., Le Goffic R., Galloux M., Prochnow H., Rox K., Huttel S., Rupcic Z., Wiegmann B., Dijkman R., Rameix-Welti M.A., Eleouet J.F., Duprex W.P., Thiel V., Hansen G., Brönstrup M., ... , Haid S., Pietschmann T. (2020)
Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry
Antiviral Res., 177 (May)

Carpentier A., Sheldon J., Vondran F.W.R., Brown R.J.P., Pietschmann T. (2020)
Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus
GUT, 69 (9)

Prochnow H., Rox K., Birudukota N.V.S., Weichert L., Hotop S.K., Klahn P., Mohr K., Franz S., Banda D.H., Blockus S., Schreiber J., Haid S., Oeyen M., Martinez J.P., Süssmuth R.D., Wink J., Meyerhans A., Goffinet C., Messerle M., Schulz T.F., Kröger A., Schols D., ... , Pietschmann T., Brönstrup M. (2020)
Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis
J.Virol., 94 (2)

Köllmann C., Wiechert S.M., Jones P.G., Pietschmann T., Werz D.B. (2019)
Synthesis of 4'/5'-Spirocyclopropanated Uridine and d-Xylouridine Derivatives and Their Activity against the Human Respiratory Syncytial Virus
Org.Lett., 21 (17)

Gerold G., Moeller R., Pietschmann T. (2020)
Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion
Cold Spring Harb.Perspect.Med., 10 (2)

Gottschick C., Raupach-Rosin H., Langer S., Hassan L., Horn J., Dorendorf E., Caputo M., Bittner M., Beier L., Rübsamen N., Schlinkmann K., Zoch B., Guzmán C.A., Hansen G., Heselich V., Holzapfel E., Hübner J., Pietschmann T., Pieper D.H., Pletz M., Riese P., Schmidt-Pokrzywniak A., Hartwig S., Von Kaisenberg C., Aydogdu M., Buhles M., Dressler F., Eberl W., Haase R., von Koch F.E., Feidicker S., Frambach T., Franz H.G.B., Guthmann F., Koch H.G., Seeger S., Oberhoff C., Pauker W., Petry K.U., Schild R.L., Tchirikov M., Röhrig E., ... , Karch A., Mikolajczyk R. (2019)
Erratum: Cohort profile: The LoewenKIDS Study - Life-course perspective on infections, the microbiome and the development of the immune system in early childhood (International Journal of Epidemiology (2019) DOI: 10.1093/ije/dyz001)
Int.J.Epidemiol., 48 (4)

Kinast V., Leber S.L., Brown R.J.P., Vieyres G., Behrendt P., Essbach C., Strnad P., Vondran F.W.R., Cornberg M., Wex C., Pietschmann T., Haybaeck J., ... , Todt D., Steinmann E. (2019)
Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver
Cells, 8 (6)

Martin-Benlloch X., Haid S., Novodomska A., Rominger F., Pietschmann T., ... , Davioud-Charvet E., Elhabiri M. (2019)
Physicochemical Properties Govern the Activity of Potent Antiviral Flavones
ACS Omega, 4 (3)

Vieyres G., Pietschmann T. (2019)
HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit
Cells, 8 (3)

Pietschmann T., Brown R.J.P. (2019)
Hepatitis C Virus
Trends in Microbiology, 27 (4)

Gottschick C., Raupach-Rosin H., Langer S., Hassan L., Horn J., Dorendorf E., Caputo M., Bittner M., Beier L., Rübsamen N., Schlinkmann K., Zoch B., Guzmán C.A., Hansen G., Heselich V., Holzapfel E., Hübner J., Pietschmann T., Pieper D.H., Pletz M., Riese P., Schmidt-Pokrzywniak A., Hartwig S., von Kaisenberg C., Aydogdu M., Buhles M., Dressler F., Eberl W., Haase R., Edler von Koch F., Feidicker S., Frambach T., Franz H.G.B., Guthmann F., Koch H.G., Seeger S., Oberhoff C., Pauker W., Petry K.U., Schild R.L., Tchirikov M., ... , Röhrig E., Mikolajczyk R. (2019)
Cohort profile: The LoewenKIDS Study - life-course perspective on infections, the microbiome and the development of the immune system in early childhood
Int.J.Epidemiol., 48 (4)

Banda D.H., Perin P.M., Brown R.J.P., Todt D., Solodenko W., Hoffmeyer P., Sahu K.K., Houghton M., Meuleman P., Müller R., ... , Kirschning A., Pietschmann T. (2019)
A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors
J.Hepatol., 70 (6)

Khera T., Behrendt P., Bankwitz D., Brown R.J.P., Todt D., Doepke M., Khan A.G., Schulze K., Law J., Logan M., Hockman D., Wong J.A.J.-X., Dold L., Gonzalez-Motos V., Spengler U., Viejo-Borbolla A., Ströh L., Krey T., Tarr A.W., Steinmann E., Manns M.P., Klein F., Guzmán C.A., Marcotrigiano J., ... , Houghton M., Pietschmann T. (2019)
Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants
J.Hepatol., 70 (4)

Garcia-Nicolas O., V'kovski P., Vielle N.J., Ebert N., Züst R., Portmann J., Stalder H., Gaschen V., Vieyres G., Stoffel M., Schweizer M., Summerfield A., Engler O., Pietschmann T., Todt D., Alves M.P., ... , Thiel V., Pfaender S. (2018)
The small compound inhibitor K22 displays broad antiviral activity against different members of the family Flaviviridae and offers potential as pan-viral inhibitor
Antimicrob.Agents Chemother., 62 (11)

Bruening J., Lasswitz L., Banse P., Kahl S., Marinach C., Vondran F.W., Kaderali L., Silvie O., Pietschmann T., ... , Meissner F., Gerold G. (2018)
Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB
PLoS Pathog., 14 (7)

Banse P., Moeller R., Bruening J., Lasswitz L., Kahl S., Khan A.G., Marcotrigiano J., ... , Pietschmann T., Gerold G. (2018)
CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells
Viruses., 10 (4)

Bartenschlager R., Baumert T.F., Bukh J., Houghton M., Lemon S.M., Lindenbach B.D., Lohmann V., Moradpour D., Pietschmann T., Rice C.M., ... , Thimme R., Wakita T. (2018)
Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: considerations for scientists and funding agencies
Virus Res., 248 (March)

Baier C., Haid S., Beilken A., Behnert A., Wetzke M., Brown R.J.P., Schmitt C., Ebadi E., Hansen G., Schulz T.F., ... , Pietschmann T., Bange F.C. (2018)
Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease
Antimicrob.Resist.Infect.Control, 7 (1)

Knegendorf L., Drave S.A., Dao Thi V, Debing Y., Brown R.J.P., Vondran F.W.R., Resner K., Friesland M., Khera T., Engelmann M., Bremer B., Wedemeyer H., Behrendt P., Neyts J., Pietschmann T., ... , Todt D., Steinmann E. (2018)
Hepatitis E virus replication and interferon responses in human placental cells
Hepatol.Commun., 2 (2)

Riber C.F., Andersen A.H.F., Gajda P., Lovschall K.B., Dagnaes-Hansen F., Banda D.H., ... , Pietschmann T., Tolstrup M. (2017)
Synthetic Polymer with a Structure-Driven Hepatic Deposition and Curative Pharmacological Activity in Hepatic Cells
ACS Macro Lett., 6 (9)

Behrendt P., Perin P., Menzel N., Banda D., Pfaender S., Alves M.P., Thiel V., Meulemann P., Colpitts C.C., Schang L.M., Vondran F.W.R., Anggakusuma, Manns M.P., ... , Steinmann E., Pietschmann T. (2017)
Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry
Antiviral Res., 147 (November)

Weller R., Hueging K., Brown R.J.P., Todt D., Joecks S., ... , Vondran F.W.R., Pietschmann T. (2017)
Hepatitis C virus strain-dependent usage of apolipoprotein E modulates assembly efficiency and specific infectivity of secreted virions
J.Virol., 91 (18)

Bartenschlager R., Cornberg M., Pietschmann T. (2017)
[Personalized treatment of viral hepatitis of the present and the future : Hepatitis B, C, delta, and E]
Internist (Berl), 58 (7)

Vasiliauskaite I., Owsianka A., England P., Khan A.G., Cole S., Bankwitz D., Foung S.K.H., Pietschmann T., Marcotrigiano J., Rey F.A., ... , Patel A.H., Krey T. (2017)
Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2
MBio., 8 (3)

Anggakusuma, Romero-Brey I., Berger C., Colpitts C.C., Boldanova T., Engelmann M., Todt D., Perin P.M., Behrendt P., Vondran F.W.R., Xu S., Goffinet C., Schang L.M., Heim M.H., Bartenschlager R., ... , Pietschmann T., Steinmann E. (2015)
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation
Hepatology, 62 (3)

Bankwitz D., Doepke M., Hueging K., Weller R., Bruening J., Behrendt P., Lee J.Y., Vondran F.W.R., Manns M.P., ... , Bartenschlager R., Pietschmann T. (2017)
Maturation of secreted HCV particles by incorporation of secreted apoE protects from antibodies by enhancing infectivity
J.Hepatol., 67 (3)

Pfaender S., Walter S., Grabski E., Todt D., Bruening J., Romero-Brey I., Gather T., Brown R.J., Hahn K., Puff C., Pfankuche V.M., Hansmann F., Postel A., Becher P., Thiel V., Kalinke U., Wagner B., Bartenschlager R., Baumgartner W., Feige K., Pietschmann T., ... , Cavalleri J.M., Steinmann E. (2017)
Immune protection against reinfection with nonprimate hepacivirus
Proc.Natl.Acad.Sci U.S A, 114 (12)

Siddharta A., Pfaender S., Vielle N.J., Dijkman R., Friesland M., Becker B., Yang J., Engelmann M., Todt D., Windisch M.P., Brill F.H., Steinmann J., Steinmann J., Becker S., Alves M.P., Pietschmann T., Eickmann M., ... , Thiel V., Steinmann E. (2017)
Virucidal activity of WHO-recommended formulations against enveloped viruses including Zika, Ebola and emerging Coronaviruses
J Infect.Dis., 215 (6)

Gerold G., Bruening J., Pietschmann T. (2016)
Decoding protein networks during virus entry by quantitative proteomics
Virus Res., 218

Pietschmann T. (2017)
Clinically approved ion channel inhibitors close gates for hepatitis C virus and open doors for drug repurposing in infectious viral diseases
J.Virol., 91 (2)

Khera T., Todt D., Steinmann E., Pietschmann T., Brown R.J.P., Vercauteren K., Verhoye L., Farhoudi A., Meuleman P., Mcclure C.P., Bhuju S., Geffers R., Baumert T.F., Baumert T.F., ... , Baumert T.F., Pietschmann T. (2017)
Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy
Antiviral Res., 139

Gerold G., Bruening J., Weigel B., Pietschmann T. (2017)
Protein interactions during the flavivirus and hepacivirus life cycle
Mol.Cell Proteomics, 16 (4)

Anggakusuma, Brown R.J.P., Banda D.H., Todt D., Vieyres G., ... , Steinmann E., Pietschmann T. (2016)
Hepacivirus NS3/4A proteases interfere with MAVS signaling in both their cognate animal hosts and humans: Implications for zoonotic transmission
J.Virol., 90 (23)

von Schaewen M., Dorner M., Hueging K., Foquet L., Gerges S., Hrebikova G., Heller B., Bitzegeio J., Doerrbecker J., Horwitz J.A., Gerold G., Suerbaum S., Rice C.M., Meuleman P., ... , Pietschmann T., Ploss A. (2016)
Expanding the Host Range of Hepatitis C Virus through Viral Adaptation
MBio., 7 (6)

Xu S., Ducroux A., Ponnurangam A., Vieyres G., Franz S., Musken M., Zillinger T., Malassa A., Ewald E., Hornung V., Barchet W., Häußler S., ... , Pietschmann T., Goffinet C. (2016)
cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites
Cell Host.Microbe, 20 (4)

Bankwitz D., Pietschmann T. (2016)
Hepatitis C virus plays hide and seek with neutralizing antibodies
Hepatology, 64 (6)

Weller R., Todt D., Engelmann M., Friesland M., Wedemeyer H., ... , Pietschmann T., Steinmann E. (2016)
Apolipoprotein E polymorphisms and their protective effect on Hepatitis E virus replication
Hepatology, 64 (6)

Pfaender S., Grabski E., Detje C.N., Riebesehl N., Lienenklaus S., Steinmann E., ... , Kalinke U., Pietschmann T. (2016)
Hepatitis C Virus Stimulates Murine CD8a[alpha]-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner
PLoS Pathog., 12 (7)

Vieyres G., Welsch K., Gerold G., Gentzsch J., Kahl S., Vondran F.W., ... , Kaderali L., Pietschmann T. (2016)
ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production
PLoS Pathog., 12 (4)

Walter S., Bollenbach A., Doerrbecker J., Pfaender S., Brown R.J., Vieyres G., Scott C., Foster R., Kumar A., Zitzmann N., Griffin S., Penin F., ... , Pietschmann T., Steinmann E. (2016)
Ion-channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7
J Virol., 90 (10)

Todt D., Francois C., Anggakusuma, Behrendt P., Engelmann M., Knegendorf L., Vieyres G., Wedemeyer H., Hartmann R., Pietschmann T., ... , Duverlie G., Steinmann E. (2016)
Antiviral activity of different interferon (sub-) types against hepatitis E virus replication
Antimicrob.Agents Chemother., 60 (4)

Haid S., Grethe C., Bankwitz D., Grunwald T., Pietschmann T. (2015)
Identification of a human respiratory syncytial virus (hRSV) cell entry inhibitor by using a novel lentiviral pseudotype (hRSVpp) system
J Virol., 90 (6)

Walker A., Skibbe K., Steinmann E., Pfaender S., Kuntzen T., Megger D.A., Groten S., Sitek B., Lauer G.M., Kim A.Y., Pietschmann T., ... , Allen T.M., Timm J. (2015)
Distinct escape pathway by HCV genotype 1a from a dominant CD8+ T cell response by selection of altered epitope processing
J Virol., 90

Vercauteren K., Brown R.J., Mesalam A.A., Doerrbecker J., Bhuju S., Geffers R., Van Den Eede N., Mcclure C.P., Troise F., Verhoye L., Baumert T., Farhoudi A., Cortese R., Ball J.K., Leroux-Roels G., Pietschmann T., ... , Nicosia A., Meuleman P. (2015)
Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice
GUT, 65

Gerold G., Meissner F., Bruening J., Welsch K., Perin P.M., Baumert T.F., Vondran F.W., Kaderali L., Marcotrigiano J., Khan A.G., Mann M., ... , Rice C.M., Pietschmann T. (2015)
Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry
Cell Rep., 12 (5)

Hueging K., Weller R., Doepke M., Vieyres G., Todt D., Wolk B., Vondran F.W., Geffers R., Lauber C., Kaderali L., ... , Penin F., Pietschmann T. (2015)
Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses
PLoS ONE, 10 (7)

Perin P.M., Haid S., Brown R.J., Doerrbecker J., Schulze K., Zeilinger C., von Schaewen M., Heller B., Vercauteren K., Luxenburger E., Baktash Y.M., Vondran F.W., Speerstra S., Awadh A., Mukhtarov F., Schang L.M., Kirschning A., Müller R., Guzmán C.A., Kaderali L., Randall G., Meuleman P., ... , Ploss A., Pietschmann T. (2016)
Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1
Hepatology, 63

Lump E., Castellano L.M., Meier C., Seeliger J., Erwin N., Sperlich B., Sturzel C.M., Usmani S., Hammond R.M., von Einem J., Gerold G., Kreppel F., Bravo-Rodriguez K., Pietschmann T., Holmes V.M., Palesch D., Zirafi O., Weissman D., Sowislok A., Wettig B., Heid C., Kirchhoff F., Weil T., Klarner F.G., Schrader T., Bitan G., Sanchez-Garcia E., Winter R., ... , Shorter J., Munch J. (2015)
A molecular tweezer antagonizes seminal amyloids and HIV infection
Elife., 4

Tarr A.W., Khera T., Hueging K., Sheldon J., Steinmann E., ... , Pietschmann T., Brown R.J. (2015)
Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design
Viruses., 7 (7)

Lauber C., Vieyres G., Terczynska-Dyla E., Anggakusuma, Dijkman R., Gad H.H., Akhtar H., Geffers R., Vondran F.W., Thiel V., Kaderali L., ... , Pietschmann T., Hartmann R. (2015)
Transcriptome analysis reveals a classical interferon signature induced by IFNlambda4 in human primary cells
Genes Immun., 16 (6)

Koutsoudakis G., Romero-Brey I., Berger C., Perez-Vilaro G., Perin P.M., Vondran F.W., Kalesse M., Harmrolfs K., Müller R., Martinez J.P., Pietschmann T., Bartenschlager R., Bronstrup M., ... , Meyerhans A., Diez J. (2015)
Soraphen A: a broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity
J Hepatol., 63 (4)

Pfaender S., Walter S., Todt D., Behrendt P., Doerrbecker J., Woelk B., Engelmann M., Gravemann U., Seltsam A., Steinmann J., Burbelo P.D., Klawonn F., Feige K., Pietschmann T., ... , Cavalleri J.M., Steinmann E. (2015)
Assessment of cross-species transmission of hepatitis C-related non-primate hepacivirus in a population of humans at high risk of exposure
J Gen.Virol., 96 (9)

Anggakusuma, Frentzen A., Gürlevik E., Yuan Q., Steinmann E., Ott M., Staeheli P., Schmid-Burgk J., Schmidt T., Hornung V., ... , Kuehnel F., Pietschmann T. (2015)
Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons
J.Virol., 89 (7)

Vercauteren K., Van Den Eede N., Mesalam A.A., Belouzard S., Catanese M.T., Bankwitz D., Wong-Staal F., Cortese R., Dubuisson J., Rice C.M., Pietschmann T., Leroux-Roels G., ... , Nicosia A., Meuleman P. (2014)
Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents
Hepatology, 60 (5)

Pfaender S., Brinkmann J., Todt D., Riebesehl N., Steinmann J., Steinmann J., ... , Pietschmann T., Steinmann E. (2015)
Mechanisms of methods for hepatitis C virus inactivation
Appl.Environ.Microbiol., 81 (5)

Hedenstierna M., Weiland O., Brass A., Bankwitz D., Behrendt P., Uhnoo I., Aleman S., Cardell K., Fryden A., Norkrans G., Eilard A., Glaumann H., Pietschmann T., ... , Sällberg M., Brenndörfer E.D. (2015)
Long-term follow-up of successful hepatitis C virus therapy: Waning immune responses and disappearance of liver disease are consistent with cure
Aliment.Pharmacol.Ther., 41 (6)

Grabski E., Wappler I., Pfaender S., Steinmann E., Haid S., Dzionek A., ... , Pietschmann T., Kalinke U. (2014)
Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus induced interferon-alpha responses of plasmacytoid dendritic cells
Journal of Virology, 89

Pfaender S., Cavalleri J.M., Walter S., Doerrbecker J., Campana B., Brown R.J., Burbelo P.D., Postel A., Hahn K., Kusuma A., Riebesehl N., Baumgartner W., Becher P., Heim M.H., Pietschmann T., ... , Feige K., Steinmann E. (2014)
Clinical course of infection and viral tissue tropism of hepatitis C virus-like non-primate hepaciviruses in horses
Hepatology, 61 (2)

Bankwitz D., Vieyres G., Hueging K., Bitzegeio J., Doepke M., Chhatwal P., Haid S., Catanese M.T., Zeisel M.B., Nicosia A., Baumert T.F., ... , Kaderali L., Pietschmann Thomas (2014)
Role of the hypervariable region 1 (HVR1) for the interplay of hepatitis C virus with entry factors and lipoproteins
Journal of Virologie, 88

Pietschmann Thomas (2014)
In sero veritas: What serum markers teach us about HCV infection of primary human hepatocytes
GUT, 63 (9)

Irving W.L., Rupp D., Mcclure C.P., Than L.M., Titman A., Ball J.K., Steinmann Eike, Bartenschlager R., ... , Pietschmann Thomas, Brown Richard J.P. (2014)
Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region
Antiviral Research, 110 (1)

Gerold Gisa, Pietschmann Thomas (2014)
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
Digestive Diseases, 32 (5)

Lange M., Fiedler M., Bankwitz D., Osburn W., Viazov S., Brovko O., Zekri A.R., Khudyakov Y., Nassal M., Pumpens P., Pietschmann Thomas, Timm J., ... , Roggendorf M., Walker A. (2014)
Hepatitis C virus hypervariable region 1 variants presented on hepatitis B virus capsid-like particles induce cross-neutralizing antibodies
PLoS ONE, 9 (7)

Doerrbecker J., Friesland M., Riebesehl N., Ginkel C., Behrendt P., Brown R.J., Ciesek S., Wedemeyer H., Sarrazin C., Kaderali L., ... , Pietschmann T., Steinmann E. (2014)
Incorporation of primary patient-derived glycoproteins into authentic infectious hepatitis C virus particles
Hepatology, 60

Pfaender S., Brown R.J., Pietschmann T., Steinmann E. (2014)
Natural reservoirs for homologs of hepatitis C virus
Emerging Microbes and Infections, 3

Vieyres G., Dubuisson J., Pietschmann Thomas (2014)
Incorporation of hepatitis C virus e1 and e2 glycoproteins: the keystones on a peculiar virion
Viruses, 6 (3)

Brown R.J.P., Koutsoudakisu G., Urbanowicz R.A., Mirza D., Ginkel C., Riebesehl N., Calland N., Albecka A., Price L., Hudson N., Descamps V., Backx M., Patrick McClure C., Duverlie G., Pecheur E.I., Dubuisson J., Perez-Del-Pulgar S., Forns X., Steinmann Eike, Tarr A.W., ... , Pietschmann Thomas, Ball J.K. (2014)
Analysis of serine codon conservation reveals diverse phenotypic constraints on hepatitis C virus glycoprotein evolution
Journal of Virology, 88 (1)

Steinmann Eike, Pietschmann Thomas (2013)
Cell culture systems for hepatitis C virus
Current Topics in Microbiology and Immunology, 369

Gerold G., Pietschmann Thomas (2013)
A circuit of paracrine signals between liver sinusoid endothelial cells and hepatocytes regulates hepatitis C virus replication
Hepatology, 59

Gerold Gisa, Pietschmann Thomas (2013)
Hepatitis C virus NS5B polymerase primes innate immune signaling
Hepatology, 57 (3)

Steinmann J., Buer J., Pietschmann Thomas, Steinmann Eike (2013)
Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea
British Journal of Pharmacology, 168 (5)

Hamming O.J., Terczynska-Dyla E., Vieyres G., Dijkman R., Jorgensen S.E., Akhtar H., Siupka P., Pietschmann T., ... , Thiel V., Hartmann R. (2013)
Interferon lambda 4 signals via the IFNambda receptor to regulate antiviral activity against HCV and coronaviruses
Embo Journal, 32 (23)

Hüging K., Döpke M., Vieyres G., Bankwitz D., Frentzen A., Dörrbecker J., Gumz F., Haid S., Wölk B., ... , Kaderali L., Pietschmann T. (2013)
Apolipoprotein E co-determines tissue-tropism of hepatitis C virus and it is crucial for viral cell-to-cell transmission by contributing to a post-envelopment step of assembly
Journal of Virology, 88 (3)

Pfaender S., Heyden J., Friesland M., Ciesek S., Ejaz A., Steinmann J., Steinmann J., Malarski A., Stoiber H., Tsiavaliaris G., Bader W., Jahreis G., ... , Pietschmann T., Steinmann E. (2013)
Inactivation of Hepatitis C Virus Infectivity by Human Breast Milk
Journal of Infectious Diseases, 208 (12)

Steinmann Eike, Doerrbecker Juliane, Friesland Martina, Riebesehl Nina, Ginkel Corinne, Hillung Julia, Gentzsch Juliane, Lauber C., Brown Richard, ... , Frentzen Anne, Pietschmann Tim (2013)
Characterization of hepatitis C virus intra- and inter-genotypic chimeras reveals a role of the glycoproteins in virus envelopment
Journal of Virology, 52

Behrendt P., Doerrbecker J., Riebesehl N., Wilhelm C., Ciesek S., Erichsen T.J., Steinmann J., Ott M., Manns M.P., ... , Pietschmann T., Steinmann E. (2013)
Stability and transmission of hepatitis C virus in different anesthetic agents
American Journal of Infection Control, 41 (10)

Zahid M.N., Turek M., Xiao F., Dao Thi V, Guerin M., Fofana I., Bachellier P., Thompson J., Delang L., Neyts J., Bankwitz D., Pietschmann Thomas*, Dreux M., Cosset F.L., Grunert F., ... , Baumert T.F., Zeisel M.B. (2013)
The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C virus infection and viral dissemination
Hepatology, 57 (2)

Steinmann E., Gravemann U., Friesland M., Doerrbecker J., Muller T.H., ... , Pietschmann Thomas*, Seltsam A. (2013)
Two pathogen reduction technologies-methylene blue plus light and shortwave ultraviolet light-effectively inactivate hepatitis C virus in blood products
Transfusion, 53 (5)

Nandakumar R., Finsterbusch K., Lipps C., Neumann B., Grashoff M., Nair S., Hochnadel I., Lienenklaus S., Wappler I., Steinmann E., Hauser H., ... , Pietschmann T., Kröger A. (2013)
Hepatitis C Virus Replication in Mouse Cells is Restricted by IFN-Dependent and -Independent Mechanisms
Gastroenterology, 145 (6)

Anggakusuma, Colpitts C.C., Schang L.M., Rachmawati H., Frentzen A., Pfaender S., Behrendt P., Brown R.J., Bankwitz D., Steinmann J., Ott M., Meuleman P., Rice C.M., Ploss A., ... , Pietschmann T., Steinmann E. (2013)
Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells
GUT, 63

Frentzen Anne, Kusuma Angga, Guerlevik E., Hueging Kathrin, Knocke S., Ginkel Corinne, Brown Richard J.P., Heim M., Dill M.T., Kröger Andrea, Kalinke Ulrich, Kaderali L., ... , Kuehnel F., Pietschmann Thomas (2013)
Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells
Hepatology

Haid S., Grethe C., Dill M.T., Heim M., Kaderali L., Pietschmann T. (2013)
Isolate-dependent use of Claudins for cell entry by hepatitis C virus
Hepatology, 59 (1)

Doerrbecker J., Meuleman P., Kang J., Riebesehl N., Wilhelm C., Friesland M., Pfaender S., Steinmann J., ... , Pietschmann T., Steinmann E. (2013)
Thermostability of seven hepatitis C virus genotypes in vitro and in vivo
Journal of Viral Hepatitis, 20 (7)

Gentzsch J., Brohm C., Steinmann Eike, Friesland M., Menzel N., Vieyres G., Perin P.M., Frentzen Anne, ... , Kaderali L., Pietschmann Thomas (2013)
Hepatitis C Virus p7 is Critical for Capsid Assembly and Envelopment
PLoS Pathogens, 9 (5)

Westhaus S., Bankwitz D., Ernst S., Rohrmann K., Wappler I., Agne C., Luchtefeld M., Schieffer B., Sarrazin C., Manns M.P., Pietschmann T., ... , Ciesek S., von Hahn T. (2013)
Characterization of the inhibition of hepatitis C virus entry by In vitro-generated and patient-derived oxidized low-density lipoprotein
Hepatology, 57 (5)

Vieyres G., Pietschmann Thomas (2013)
Entry and replication of recombinant hepatitis C viruses in cell culture
Methods, 59 (2)

Fofana I., Fafi-Kremer S., Carolla P., Fauvelle C., Zahid M.N., Turek M., Heydmann L., Cury K., Hayer J., Combet C., Cosset F.L., Pietschmann Thomas*, Hiet M.S., Bartenschlager R., Habersetzer F., Doffoel M., Keck Z.Y., Foung S.K., Zeisel M.B., ... , Stoll-Keller F., Baumert T.F. (2012)
Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies1
Gastroenterology, 143 (1)

Doerrbecker J., Behrendt P., Mateu-Gelabert P., Ciesek S., Riebesehl N., Wilhelm C., Steinmann J.*, ... , Pietschmann Thomas*, Steinmann E.* (2013)
Transmission of hepatitis C virus among people who inject drugs: viral stability and association with drug preparation equipment
Journal of Infectious Diseases, 207 (2)

Vieyres G., Brohm C., Friesland M., Gentzsch J., Wolk B., Roingeard P., ... , Steinmann E., Pietschmann Thomas* (2013)
Subcellular Localization and Function of an Epitope-Tagged p7 Viroporin in Hepatitis C Virus-Producing Cells
Journal of Virology, 87 (3)

Kugler J., Schmelz S., Gentzsch J., Haid S., Pollmann E., van den Heuvel Joop, Franke R., Pietschmann Thomas, ... , Heinz Dirk W., Collins J. (2012)
High Affinity Peptide Inhibitors of the Hepatitis C Virus NS3-4A Protease Refractory to Common Resistant Mutants
Journal of Biological Chemistry, 287 (46)

Frentzen A., Hueging K., Bitzegeio J., Pietschmann Thomas*, Steinmann E. (2012)
Two methods of heterokaryon formation to discover HCV restriction factors2
Journal of Visualized Experiments (65)

Ejaz A., Steinmann E., Bánki Z., Anggakusuma, Khalid S., Lengauer S., Wilhelm C., Zoller H., Schloegl A., Steinmann J., Grabski E., Kleines M., ... , Pietschmann Thomas*, Stoiber H. (2012)
Specific Acquisition of Functional CD59 but Not CD46 or CD55 by Hepatitis C Virus
PLoS ONE, 7 (9)

Menzel N., Fischl W., Hueging K., Bankwitz D., Frentzen A., Haid S., Gentzsch J., Kaderali L., ... , Bartenschlager R., Pietschmann Thomas* (2012)
MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles1
PLoS Pathogens, 8 (7)

Sandmann L., Wilson M., Back D., Wedemeyer H., Manns M.P., Steinmann E., Pietschmann Thomas*, ... , von Hahn T., Ciesek S. (2012)
Antiretroviral drugs do not facilitate hepatitis C virus (HCV) infection in vitro
Antiviral Research, 96 (1)

Barbier J., Wegner J., Benson S., Gentzsch J., Pietschmann Thomas*, Kirschning A. (2012)
Total synthesis of a noricumazole a library and evaluation of HCV inhibition1
Chemistry, 18 (29)

von Hahn T., Schiene-Fischer C., Van N.D., Pfaender S., Karavul B., Steinmann E., Potthoff A., Strassburg C., Hamdi N., Abdelaziz A.I., Sarrazin C., Muller T., Berg T., Trepo E., Wedemeyer H., Manns M.P., ... , Pietschmann Thomas*, Ciesek S. (2012)
Hepatocytes that express variants of cyclophilin a are resistant to HCV infection and replication1
Gastroenterology, 143 (2)

Stegmann K.A., Bjorkstrom N.K., Ciesek S., Lunemann S., Jaroszewicz J., Wiegand J., Malinski P., Dustin L.B., Rice C.M., Manns M.P., Pietschmann T., Cornberg M., ... , Ljunggren H.G., Wedemeyer H. (2012)
Interferon a[alpha]-stimulated natural killer cells from patients with acute hepatitis C virus (HCV) infection recognize HCV-infected and uninfected hepatoma cells via DNAX accessory molecule-11
Journal of Infectious Diseases, 205 (9)

Steinmann E., Ciesek S., Friesland M., Erichsen T.J., Pietschmann Thomas* (2011)
Prolonged survival of hepatitis C virus in the anesthetic propofol2
Clinical Infectious Diseases, 53 (9)

Haybaeck J., Zeller N., Wolf M.J., Weber A., Wagner U., Kurrer M.O., Bremer J., Iezzi G., Graf R., Clavien P.A., Thimme R., Blum H., Nedospasov S.A., Zatloukal K., Ramzan M., Ciesek S., Pietschmann Thomas*, Marche P.N., Karin M., Kopf M., Browning J.L., ... , Aguzzi A., Heikenwalder M. (2009)
Erratum: A lymphotoxin-driven pathway to hepatocellular carcinoma3
Cancer Cell, 16 (5)

Chhatwal P., Bankwitz D., Grentzsch J., Frenzen A., Schult Ph., ... , Lohmann V., Pietschmann Thomas* (2012)
Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication
PLoS ONE, 7 (4)

Haid S., Novodomska A., Gentzsch J., Grethe C., Geuenich S., Bankwitz D., Chhatwal P., Jannack B., Hennebelle T., Bailleul F., Keppler O.T., Ponisch M., Bartenschlager R., Hernandez C., Lemasson M., Rosenberg A., Wong-Staal F., ... , vioud-Charvet E., Pietschmann Thomas* (2012)
A Plant-Derived Flavonoid Inhibits Entry of All HCV Genotypes into Human Hepatocytes
Gastroenterology, 143 (1)

Ruhl M., Chhatwal P., Strathmann H., Kuntzen T., Bankwitz D., Skibbe K., Walker A., Heinemann F.M., Horn P.A., Allen T.M., Hoffmann D., ... , Pietschmann Thomas*, Timm J. (2012)
Escape from a dominant HLA-B*15-restricted CD8+ T cell response against hepatitis C virus requires compensatory mutations outside the epitope1
Journal of Virology, 86 (2)

Ciesek S., von Hahn T., Colpitts C.C., Schang L.M., Friesland M., Steinmann J., Manns M.P., Ott M., Wedemeyer H., Meuleman P., ... , Pietschmann Thomas*, Steinmann E. (2011)
The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry
Hepatology, 54 (6)

Doerrbecker J., Friesland M., Ciesek S., Erichsen T.J., Mateu-Gelabert P., Steinmann J., Steinmann J., ... , Pietschmann Thomas*, Steinmann E. (2011)
Inactivation and survival of hepatitis C virus on inanimate surfaces
Journal of Infectious Diseases, 204 (12)

von Hahn T., Schulze A., Wust I.C., Heidrich B., Becker T., Steinmann E., Helfritz F.A., Rohrmann K., Urban S., Manns M.P., ... , Pietschmann Thomas*, Ciesek S. (2011)
The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitits B or C virus
PLoS ONE, 6 (9)

Steinmann E., Pietschmann Thomas* (2010)
Hepatitis C virus P7 - a viroporin crucial for virus assembly and an emerging target for antiviral therapy
Viruses, 285 (41)

Ciesek S., Westhaus S., Wicht M., Wappler I., Henschen S., Sarrazin C., Hamdi N., Abdelaziz A.I., Strassburg C.P., Wedemeyer H., Manns M.P., ... , Pietschmann Thomas*, von Hahn T. (2011)
Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles
Journal of Virology, 85 (15)

Frentzen A., Huging K., Bitzegeio J., Friesland M., Haid S., Gentzsch J., Hoffmann M., Lindemann D., Zimmer G., Zielecki F., Weber F., ... , Steinmann E., Pietschmann Thomas* (2011)
Completion of hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines
PLoS Pathogens, 7 (4)

Lupberger J., Zeisel M.B., Xiao F., Thumann C., Fofana I., Zona L., Davis C., Mee C.J., Turek M., Gorke S., Royer C., Fischer B., Zahid M.N., Lavillette D., Fresquet J., Cosset F.L., Rothenberg S.M., Pietschmann Thomas*, Patel A.H., Pessaux P., Doffoel M., Raffelsberger W., Poch O., McKeating J.A., ... , Brino L., Baumert T.F. (2011)
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy
Nature medicine, 17 (5)

Gentzsch J., Hinkelmann B., Kaderali L., Irschik Herbert*, Jansen Rolf*, Sasse Florenz*, ... , Frank Ronald*, Pietschmann Thomas* (2011)
Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity
Antiviral Research, 89 (2)

Burgel B., Friesland M., Koch A., Manns M.P., Wedemeyer H., Weissenborn K., Schulz-Schaeffer W.J., Pietschmann Thomas*, ... , Steinmann E., Ciesek S. (2011)
Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration
Journal of Viral Hepatitis, 18 (8)

Bitzegeio J., Bankwitz D., Hueging K., Haid S., Brohm C., Zeisel M.B., Herrmann E., Iken M., Ott M., ... , Baumert T.F., Pietschmann Thomas* (2010)
Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors
PLoS Pathogens, 6

Montserret R., Saint N., Vanbelle C., Salvay A.G., Simorre J.P., Ebel C., Sapay N., Renisio J.G., Bockmann A., Steinmann E., Pietschmann Thomas*, Dubuisson J., ... , Chipot C., Penin F. (2010)
NMR structure and ion channel activity of the p7 protein from hepatitis C virus
Journal of Biological Chemistry, 285 (41)

von Hahn T., Steinmann E., Ciesek S., Pietschmann Thomas* (2010)
Know your enemy: translating insights about the molecular biology of hepatitis C virus into novel therapeutic approaches
Expert Review of Gastroenterology and Hepatology, 4 (1)

Lemon S.M., McKeating J.A., Pietschmann Thomas*, Frick D.N., Glenn J.S., Tellinghuisen T.L., ... , Symons J., Furman P.A. (2010)
Development of novel therapies for hepatitis C
Antiviral Research, 86 (1)

Ciesek S., Steinmann E., Iken M., Ott M., Helfritz F.A., Wappler I., Manns M.P., ... , Wedemeyer H., Pietschmann Thomas* (2010)
Glucocorticosteroids increase cell entry by hepatitis C virus
Gastroenterology, 138 (5)

Bankwitz D., Steinmann E., Bitzegeio J., Ciesek S., Friesland M., Herrmann E., Zeisel M.B., Baumert T.F., Keck Z.Y., Foung S.K., ... , Pecheur E.I., Pietschmann Thomas* (2010)
Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes
Journal of Virology, 84 (11)

Ciesek S., Friesland M., Steinmann J., Becker B., Wedemeyer H., Manns M.P., Steinmann J., ... , Pietschmann Thomas*, Steinmann E. (2010)
How stable is the hepatitis C virus (HCV)? Environmental stability of HCV and its susceptibility to chemical biocides
Journal of Infectious Diseases, 201 (12)

Stegmann K.A., Björkström N.K., Liermann H., Ciesek S., Riese P., Wiegand J., Hadem J., Suneetha P.V., Jaroszewicz J., Wang C., Schlaphoff V., Fytili P., Cornberg M., Manns M.P., Geffers R., Pietschmann T., Guzmán C.A., ... , Ljunggren H.-G., Wedemeyer H. (2010)
Interf alpha-induced TRAIL on human NK cells is associated with control of hepatitis C virus infection
Gastroenterology, 138 (5)

Brohm C., Steinmann E., Friesland M., Lorenz I.C., Patel A., Penin F., ... , Bartenschlager R., Pietschmann Thomas* (2009)
Characterization of determinants important for hepatitis C virus p7 function in morphogenesis by using trans-complementation
Journal of Virology, 83 (22)

Haid S., Windisch M.P., Bartenschlager R., Pietschmann Thomas* (2010)
Mouse-specific residues of claudin-1 limit hepatitis C virus genotype 2a infection in a human hepatocyte cell line
Journal of Virology, 84 (2)

Steinmann J., Becker B., Bischoff B., Paulmann D., Friesland M., Pietschmann Thomas*, ... , Steinmann J., Steinmann E. (2009)
Virucidal activity of 2 alcohol-based formulations proposed as hand rubs by the World Health Organization
American Journal of Infection Control, 38 (1)

Ciesek S., Steinmann E., Wedemeyer H., Manns M.P., Neyts J., Tautz N., Madan V., Bartenschlager R., ... , von Hahn T., Pietschmann Thomas* (2009)
Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A
Hepatology, 50 (5)

Haybaeck J., Zeller N., Wolf M.J., Weber A., Wagner U., Kurrer M.O., Bremer J., Iezzi G., Graf R., Clavien P.A., Thimme R., Blum H., Nedospasov S.A., Zatloukal K., Ramzan M., Ciesek S., Pietschmann Thomas*, Marche P.N., Karin M., Kopf M., Browning J.L., ... , Aguzzi A., Heikenwalder M. (2009)
A lymphotoxin-driven pathway to hepatocellular carcinoma
Cancer Cell, 16 (4)

Schaller T., Appel N., Koutsoudakis G., Kallis S., Lohmann V., ... , Pietschmann Thomas*, Bartenschlager R. (2007)
Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes
Journal of Virology, 81 (9)

Steinmann E., Whitfield T., Kallis S., Dwek R.A., Zitzmann N., ... , Pietschmann Thomas*, Bartenschlager R. (2007)
Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus
Hepatology, 46 (2)

Pietschmann Thomas* (2009)
Full-length infectious HCV chimeras
Methods in Molecular Biology, 510

Witteveldt J., Evans M.J., Bitzegeio J., Koutsoudakis G., Owsianka A.M., Angus A.G., Keck Z.Y., Foung S.K., Pietschmann Thomas*, ... , Rice C.M., Patel A.H. (2009)
CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells
Journal of General Virology, 90 (Pt 1)

Pietschmann Thomas*, Zayas M., Meuleman P., Long G., Appel N., Koutsoudakis G., Kallis S., Leroux-Roels G., ... , Lohmann V., Bartenschlager R. (2009)
Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations
PLoS Pathogens, 5 (6)

Haid S., Pietschmann Thomas*., Pecheur E.I. (2009)
Low pH-dependent Hepatitis C Virus Membrane Fusion Depends on E2 Integrity, Target Lipid Composition, and Density of Virus Particles
Journal of Biological Chemistry, 284 (26)

Pietschmann Thomas* (2009)
Virology: Final entry key for hepatitis C
Nature, 457 (7231)

Pietschmann Thomas* (2008)
Regulation of hepatitis C virus replication by microRNAs
Journal of Hepatology, 50 (3)

Jirasko V., Montserret R., Appel N., Janvier A., Eustachi L., Brohm C., Steinmann E., Pietschmann Thomas*, ... , Penin F., Bartenschlager R. (2008)
Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly
Journal of Biological Chemistry, 283 (42)

Steinmann E., Brohm C., Kallis S., Bartenschlager R., Pietschmann Thomas* (2008)
Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles
Journal of Virology, 82 (14)

Pietschmann Thomas*, Steinmann E., Ciesek S. (2008)
[Hepatitis C virus cell culture models--new perspectives for research and clinic]
Deutsche Medizinische Wochenschrift, 133 (30)

Ciesek S., Steinmann E., Manns M.P., Wedemeyer H., Pietschmann Thomas* (2008)
The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase
Journal of Infectious Diseases, 198 (7)

Steinmann E., Penin F., Kallis S., Patel A.H., Bartenschlager R., Pietschmann Thomas* (2007)
Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions
PLoS Pathogens, 3 (7)

Zeisel M.B., Koutsoudakis G., Schnober E.K., Haberstroh A., Blum H.E., Cosset F.L., Wakita T., Jaeck D., Doffoel M., Royer C., Soulier E., Schvoerer E., Schuster C., Stoll-Keller F., Bartenschlager R., Pietschmann Thomas*, ... , Barth H., Baumert T.F. (2007)
Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81
Hepatology, 46 (6)