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Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters
ACS Pharm.Transl.Sci.
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Büssing R., Bublitz A., Karge B., Brönstrup M., Strowig T., Ott I.
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An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile
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Esarev I.V., Karge B., Zeng H., Lippmann P., Jones P.G., Schrey H., ... , Brönstrup M., Ott I.
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Silver Organometallics that are Highly Potent Thioredoxin and Glutathione Reductase Inhibitors: Exploring the Correlations of Solution Chemistry with the Strong Antibacterial Effects
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Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis
Int.J.Antimicrob.Agents
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Jerye K., Lüken H., Steffen A., Schlawis C., Jänsch L., ... , Schulz S., Brönstrup M.
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Activity-Based Protein Profiling Identifies Protein Disulfide-Isomerases as Target Proteins of the Volatile Salinilactones
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microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data
Nature microbiology,
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Pfütze S., Charria-Giron E., Schulzke E., Toshe R., Khonsanit A., Franke R., Surup F., ... , Brönstrup M., Stadler M.
(2024)
Depicting the Chemical Diversity of Bioactive Meroterpenoids Produced by the Largest Organism on Earth
Angew.Chem.Int.Ed Engl.
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Haid S., Matthaei A., Winkler M., Sake S.M., Gunesch A.P., Milke V., Köhler N.M., Rückert J., Vieyres G., Kühl D., Nguyen T.-T., Göhl M., Lasswitz L., Zapatero-Belinchon F.J., Brogden G., Gerold G., Wiegmann B., Bilitewski U., Brown R.J.P., Brönstrup M., ... , Schulz T.F., Pietschmann T.
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Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets
Antimicrob.Agents Chemother.
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Eggert A., Schuppe K.T., Fuchs H.L.S., Brönstrup M., Kalesse M.
(2023)
Total Synthesis of Acanthodoral Using a Rearrangement Strategy
Organic Letters
Author count: 9
Mahdavi S.M., Bockfeld D., Büssing R., Karge B., Bannenberg T., Frank R., Brönstrup M., ... , Ott I., Tamm M.
(2024)
Synthesis of N-heterocyclic carbene gold(i) complexes from the marine betaine 1,3-dimethylimidazolium-4-carboxylate
Dalton Transactions
Author count: 18
Rox K., Jansen R., Lukezic T., Greweling-Pils M., Herrmann J., Miethke M., Hüttel S., Hennessen F., Abou Fayad A., Holzhausen C., Lundberg C.V., Teague J., Sudarman E., Bülter L., Hesterkamp T., Stadler M., ... , Brönstrup M., Müller R.
(2024)
Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models
Microbiol.Spectr.,
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Author count: 8
Charria-Giron E., Marin-Felix Y., Beutling U., Franke R., Brönstrup M., Vasco-Palacios A.M., ... , Caicedo N.H., Surup F.
(2023)
Metabolomics insights into the polyketide-lactones produced by Diaporthe caliensis sp. nov., an endophyte of the medicinal plant Otoba gracilipes
Microbiol.Spectr.
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Schwitalla J.W., Le N.T.H., Um S., Schalk F., Brönstrup M., ... , Baunach M., Beemelmanns C.
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Heterologous expression of the cryptic mdk gene cluster and structural revision of maduralactomycin A
RSC Adv.,
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Schneider I., Fetz V., Prochnow H.P., Brönstrup M.
(2023)
Artificial Siderophores with a Trihydroxamate-DOTAM Scaffold Deliver Iron and Antibiotic Cargo into the Bacterial Pathogen Escherichia coli
Isr.J.Chem.,
63
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Author count: 9
Jian L., Zscherp R., Beutling U., Shen X., Xu S., Zhang X., Brönstrup M., ... , Klahn P., Sun Q.
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Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors
J.Med.Chem.
Author count: 8
Wu Y., Zoller B.G.E., Kamal M.A.M., Hotop S.K., Lehr C.M., Brönstrup M., ... , Dersch P., Empting M.
(2023)
Establishment of an In Bacterio assay for the Assessment of Carbon Storage Regulator A (CsrA) inhibitors
Chembiochem.
Author count: 14
Allartz P., Hotop S.K., Muntau B., Schlaphof A., Thome-Bolduan C., Gabriel M., Petersen N., Lintzel M., Behrens C., Eggert P., Pörtner K., Steiner J., ... , Brönstrup M., Tappe D.
(2023)
Detection of bornavirus-reactive antibodies and BoDV-1 RNA only in encephalitis patients from virus endemic areas: a comparative serological and molecular sensitivity, specificity, predictive value, and disease duration correlation study
Infection
Author count: 5
Friederich J., Xu C., Raunft P., Fuchs H.L.S., Brönstrup M.
(2023)
Tetrazine-induced activation of a trimethyl lock as a click-to-release system for protected doxorubicin
Chem.Commun.,
59
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Author count: 7
Peukert C., Vetter A.C., Fuchs H.L.S., Harmrolfs K., Karge B., ... , Stadler M., Brönstrup M.
(2023)
Siderophore conjugation with cleavable linkers boosts the potency of RNA polymerase inhibitors against multidrug-resistant E. coli
Chem.Sci.,
14
Author count: 8
Cedeno-Sanchez M., Charria-Giron E., Lambert C., Luangsa-ard J.J., Decock C., Franke R., ... , Brönstrup M., Stadler M.
(2023)
Segregation of the genus Parahypoxylon (Hypoxylaceae, Xylariales) from Hypoxylon by a polyphasic taxonomic approach
MycoKeys,
95
Author count: 6
Zapol'skii V.A., Kaul S., Karge B., Brönstrup M., Gjikaj M., Kaufmann D.E.
(2023)
A New Way to 2,3,4-Trisubstituted Benzo[h]quinolines: Synthesis, Consecutive Reactions and Cellular Activities â
Molecules.,
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Author count: 14
Maingot M., Bourotte M., Vetter A.C., Schellhorn B., Antraygues K., Scherer H., Gitzinger M., Kemmer C., Dale G.E., Defert O., Lociuro S., Brönstrup M., ... , Willand N., Trebosc V.
(2023)
Structure-activity relationships of actively FhuE transported rifabutin derivatives with potent activity against Acinetobacter baumannii
Eur.J.Med.Chem.,
252
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Lai Y.H., Franke R., Pinkert L., Overwin H., Brönstrup M.
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Molecular Signatures of the Eagle Effect Induced by the Artificial Siderophore Conjugate LP-600 in E. coli
ACS Infect.Dis.,
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Author count: 5
Peukert C., Rox K., Karge B., Hotop S.K., Brönstrup M.
(2023)
Synthesis and Characterization of DOTAM-Based Sideromycins for Bacterial Imaging and Antimicrobial Therapy
ACS Infect.Dis.,
9
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Author count: 17
Wimmer S., Hoff K., Martin B., Grewer M., Denni L., Lascorz Massanet R., Raimondi M.V., Bülbül E.F., Melesina J., Hotop S.K., Haupenthal J., Rohde H., Heisig P., Hirsch A.K.H., Brönstrup M., ... , Sippl W., Holl R.
(2022)
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors
Bioorg.Chem.,
131
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Borgert S.R., Henke S., Witzgall F., Schmelz S., Zur Lage S., Hotop S.K., Stephen S., Lübken D., Krüger J., Gomez N.O., Van Ham M., Jänsch L., Kalesse M., Pich A., Brönstrup M., ... , Häußler S., Blankenfeldt W.
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Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa
Nat.Commun.,
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Author count: 8
Peukert C., Gasser V., Orth T., Fritsch S., Normant V., Cunrath O., ... , Schalk I.J., Brönstrup M.
(2022)
Trojan Horse Siderophore Conjugates Induce Pseudomonas aeruginosa Suicide and Qualify the TonB Protein as a Novel Antibiotic Target
J.Med.Chem.,
66
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Author count: 11
Kruck D., Bode H., Krusche J., Beck C., Ohlsen K., Sander J., Römling U., Burrichter A., Varo J.G., ... , Charoenpattarapreeda J., Brönstrup M.
(2022)
Journal Club : [u.a.] Gesteuerter Abbau von Proteinen in Bakterien durch BacPROTAC-Wirkstoffe [etc.]
Biospektrum,
28
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Author count: 6
Fiorini F., Bajerski F., Jeske O., Lepleux C., Overmann J., Brönstrup M.
(2022)
A Metabolomics-Based Toolbox to Assess and Compare the Metabolic Potential of Unexplored, Difficult-to-Grow Bacteria
Mar Drugs,
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Author count: 18
Cooper M.S., Zhang L., Ibrahim M., Zhang K., Sun X., Röske J., Göhl M., Brönstrup M., Cowell J.K., Sauerhering L., Becker S., Vangeel L., Jochmans D., Neyts J., Rox K., Marsh G.P., ... , Maple H.J., Hilgenfeld R.
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Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease
J.Med.Chem.,
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Author count: 11
Suo H., Hochnadel I., Petriv N., Franke R., Schmidt J., Limanska N., Tugai A., Jedicke N., Brönstrup M., ... , Manns M.P., Yevsa T.
(2022)
Elucidating the mechanism behind and investigating the efficacy of Traditional Chinese Medicine and Traditional Tibetan Medicine in combination with standard therapeutics in hepatocellular carcinoma and cholangiocarcinoma in vitro
Front Pharmacol.,
13
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Testolin G., Richter J., Ritter A., Prochnow H., Köhnke J., Brönstrup M.
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Optical Modulation of Antibiotic Resistance by Photoswitchable Cystobactamids
Chem.Eur.J.
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Göhl M., Zhang L., El Kilani H., Sun X., Zhang K., ... , Brönstrup M., Hilgenfeld R.
(2022)
From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease G
Molecules,
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Author count: 12
Suerbaum S., Coombs N., Patel L., Pscheniza D., Rox K., Falk C., Gruber A.D., Kershaw O., Chhatwal P., Brönstrup M., ... , Bilitewski U., Josenhans C.
(2022)
Correction for Suerbaum et al., "Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model"
MBio.
Author count: 16
Arshad H., Siokis A., Franke R., Habib A., Alfonso J.C.L., Poliakova Y., Lücke E., Michaelis K., Brönstrup M., Meyer-Hermann M., Bilitewski U., Vila J., Abel L., Illig T., ... , Schreiber J., Pessler F.
(2022)
Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease
Cells,
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Author count: 14
Brauer M., Hotop S.K., Wurster M., Herrmann J., Miethke M., Schlüter R., Dittmann S., Zühlke D., Brönstrup M., Lalk M., Müller R., Sievers S., ... , Bernhardt J., Riedel K.
(2022)
Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress
mSphere
Author count: 15
Ballmann R., Hotop S.K., Bertoglio F., Steinke S., Heine P.A., Chaudhry M.Z., Jahn D., Pucker B., Baldanti F., Piralla A., Schubert M., Cícín-Saín L., Brönstrup M., ... , Hust M., Dübel S.
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ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein
Viruses.,
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Author count: 9
Fritsch S., Gasser V., Peukert C., Pinkert L., Kuhn L., Perraud Q., Normant V., ... , Brönstrup M., Schalk I.J.
(2022)
Uptake Mechanisms and Regulatory Resfponses to MECAM- and DOTAM-Based Artificial Siderophores and Their Antibiotic Conjugates in Pseudomonas aeruginosa
ACS Infect.Dis.,
8
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Author count: 8
Peukert C., Popat Gholap S., Green O., Pinkert L., van den Heuvel J., Van Ham M., ... , Shabat D., Brönstrup M.
(2022)
Enzyme-Activated, Chemiluminescent Siderophore-Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial Pathogens
Angew.Chem.Int.Ed Engl.
Author count: 12
Suerbaum S., Coombs N., Patel L., Pscheniza D., Rox K., Falk C., Gruber A.D., Kershaw O., Chhatwal P., Brönstrup M., ... , Bilitewski U., Josenhans C.
(2022)
Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model
MBio.,
13
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Author count: 16
Hotop S.K., Reimering S., Shekhar A., Asgari E., Beutling U., Dahlke C., Fathi A., Khan F., Lütgehetmann M., Ballmann R., Gerstner A., Tegge W., Cicin-Sain L., Bilitewski U., ... , McHardy A.C., Brönstrup M.
(2022)
Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2
Emerg.Microbes Infect,
11
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Author count: 19
Arisetti N., Fuchs H.L.S., Coetzer J., Orozco M., Ruppelt D., Bauer A., Heimann D., Kuhnert E., Bhamidimarri S.P., Bafna J.A., Hinkelmann B., Eckel K., Sieber S.A., Müller P.P., Herrmann J., Müller R., Winterhalter M., ... , Steinem C., Brönstrup M.
(2021)
Total synthesis and mechanism of action of the antibiotic armeniaspirol A
Chem.Sci.,
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Author count: 6
Ahsendorf H.P., Diesterbeck U.S., Hotop S.K., Winkler M., Brönstrup M., Czerny C.P.
(2022)
Characterisation of an Anti-Vaccinia Virus F13 Single Chain Fragment Variable from a Human Anti-Vaccinia Virus-Specific Recombinant Immunoglobulin Library
Viruses,
14
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Author count: 10
Hotop S.K., Abd El Wahed A., Beutling U., Czerny F., Sievers C., Diederichsen U., Frank R., Stahl-Hennig C., ... , Brönstrup M., Fritz H.J.
(2019)
Serological Analysis of Herpes B Virus at Individual Epitope Resolution: From Two-Dimensional Peptide Arrays to Multiplex Bead Flow Assays
Anal.Chem.,
91
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Author count: 8
Roche B., Garcia-Rivera M.A., Normant V., Kuhn L., Hammann P., Brönstrup M., ... , Mislin G.L.A., Schalk I.J.
(2021)
A role for PchHI as the ABC transporter in iron acquisition by the siderophore pyochelin in Pseudomonas aeruginosa
Environmental Microbiology
Author count: 6
Jimidar C.C., Grunenberg J., Karge B., Fuchs H.L.S., Brönstrup M., Klahn P.
(2021)
Masked Amino Trimethyl Lock (H2N-TML) Systems: New Molecular Entities for the Development of Turn-On Fluorophores and Their Application in Hydrogen Sulfide (H2S) Imaging in Human Cells
Chemistry - A European Journal
Author count: 23
Becker K., Cao S., Nilsson A., Erlandsson M., Hotop S.K., Kuka J., Hansen J., Haldimann K., Grinberga S., Berruga-Fernández T., Huseby D.L., Shariatgorji R., Lindmark E., Platzack B., Böttger E.C., Crich D., Friberg L.E., Vingsbo Lundberg C., Hughes D., Brönstrup M., Andrén P.E., ... , Liepinsh E., Hobbie S.N.
(2021)
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis
EBioMedicine,
73
(November 2021)
Author count: 8
Pinkert L., Lai Y.H., Peukert C., Hotop S.K., Karge B., Schulze L.M., ... , Grunenberg J., Brönstrup M.
(2021)
Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens
J.Med.Chem.
Author count: 12
Rox K., Heyner M., Krull J., Harmrolfs K., Rinne V., Hokkanen J., Perez Vilaro G., Díez J., Müller R., Kröger A., ... , Sugiyama Y., Brönstrup M.
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Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A
ACS Pharm.Transl.Sci.,
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Author count: 12
Rath S., Rox K., Kleine Bardenhorst S., Schminke U., Dörr M., Mayerle J., Frost F., Lerch M.M., Karch A., Brönstrup M., ... , Pieper D.H., Vital M.
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Higher Trimethylamine-N-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria
mSystems.
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Miethke M., Pieroni M., Weber T., Brönstrup M., Hammann P., Halby L., Arimondo P.B., Glaser P., Aigle B., Bode H.B., Moreira R., Li Y., Luzhetskyy A., Medema M.H., Pernodet J.L., Stadler M., Tormo J.R., Genilloud O., Truman A.W., Weissman K.J., Takano E., Sabatini S., Stegmann E., Brötz-Oesterhelt H., Wohlleben W., Seemann M., Empting M., Hirsch A.K.H., Loretz B., Lehr C.M., Titz A., Herrmann J., Jaeger T., Alt S., Hesterkamp T., Winterhalter M., Schiefer A., Pfarr K., Hoerauf A., Graz H., Graz M., Lindvall M., Ramurthy S., Karlen A., van Dongen M., Petkovic H., Keller A., Peyrane F., Donadio S., Fraisse L., Piddock L.J.V., Gilbert I.H., ... , Moser H.E., Müller R.
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Towards the sustainable discovery and development of new antibiotics
Nat.Rev.Chem.
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Peukert C., Langer L.N.B., Wegener S.M., Tutov A., Bankstahl J.P., Karge B., Bengel F.M., ... , Ross T.L., Brönstrup M.
(2021)
Optimization of Artificial Siderophores as (68)Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections
J.Med.Chem.,
64
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Büssing R., Karge B., Lippmann P., Jones P.G., Brönstrup M., Ott Ingo
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Gold(I) and Gold(III) N-Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase
ChemMedChem.
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Rox K., Rath S., Pieper D.H., Vital M., Brönstrup M.
(2021)
A simplified LC-MS/MS method for the quantification of the cardiovascular disease biomarker trimethylamine-N-oxide and its precursors
J.Pharmaceut.Analy.
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Franke R., Overwin H., Häussler S., Brönstrup M.
(2021)
Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa
mSystems.
Author count: 11
Tegge W., Guerra G., Höltke A., Schiller L., Beutling U., Harmrolfs K., Gröbe L., Wullenkord H., Xu C., ... , Weich H., Brönstrup M.
(2021)
Selective bacterial targeting and infection-triggered release of antibiotic colistin conjugates
Angew.Chem.Int.Ed Engl.,
60
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Author count: 9
de Oliveira L.M.F., Steindorff M., Darisipudi M.N., Mrochen D.M., Trübe P., Bröker B.M., Brönstrup M., ... , Tegge W., Holtfreter S.
(2021)
Discovery of staphylococcus aureus adhesion inhibitors by automated imaging and their characterization in a mouse model of persistent nasal colonization
Microorg.,
9
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Author count: 9
Villanova V., Galasso C., Fiorini F., Lima S., Brönstrup M., Sansone C., Brunet C., ... , Brucato A., Scargiali F.
(2021)
Biological and chemical characterization of new isolated halophilic microorganisms from saltern ponds of Trapani, Sicily
Algal Res.,
54
(April 2021)
Author count: 8
Dreger A., Hoff K., Agoglitta O., Hotop S.K., Brönstrup M., Heisig P., ... , Kirchmair J., Holl R.
(2021)
Antibacterial activity of xylose-derived LpxC inhibitors - Synthesis, biological evaluation and molecular docking studies
Bioorg.Chem.,
107
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Author count: 10
Lettl C., Schindele F., Testolin G., Bär A., Rehm T., Brönstrup M., Schobert R., Bilitewski U., ... , Haas R., Fischer W.
(2020)
Inhibition of Type IV Secretion Activity and Growth of Helicobacter pylori by Cisplatin and Other Platinum Complexes
Front Cell Infect.Microbiol.,
10
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Richter R., Kamal M.A.M., Garcia-Rivera M.A., Kaspar J., Junk M., Elgaher W.A.M., Srikakulam S.K., Gress A., Beckmann A., Grißmer A., Meier C., Vielhaber M., Kalinina O., Hirsch A.K.H., Hartmann R.W., Brönstrup M., ... , Schneider-Daum N., Lehr C.M.
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A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria
Mater.Today Bio,
8
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Testolin G., Cirnski K., Rox K., Prochnow H., Fetz V., Grandclaudon C., Mollner T., Baiyoumy A., Ritter A., Leitner C., Krull J., van den Heuvel J., Vassort A., Sordello S., Hamed M.M., Elgaher W.A.M., Herrmann J., Hartmann R.W., ... , Müller R., Brönstrup M.
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Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high: In vivo efficacy
Chem.Sci.,
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Wosniok P.R., Knopf C., Dreisigacker S., Orozco-Rodriguez J.M., Hinkelmann B., Müller P.P., ... , Brönstrup M., Menche D.
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SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs
Chem.Eur.J.,
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Depke T., Häußler S., Brönstrup M.
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The peptide chain release factor methyltransferase prmc influences the pseudomonas aeruginosa pa14 endo-and exometabolome
Metabolites,
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Felgner S., Preusse M., Beutling U., Stahnke S., Pawar V., Rohde M., Brönstrup M., ... , Stradal T., Häußler S.
(2020)
Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake
Elife.,
9
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Author count: 14
Tegtmeyer N., Neddermann M., Lind J., Pachathundikandi S.K., Sharafutdinov I., Gutiérrez-Escobar A.J., Brönstrup M., Tegge W., Hong M., Rohde M., Delahay R.M., Vieth M., ... , Sticht H., Backert S.
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Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori
Cell Rep.,
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Untargeted LC-MS metabolomics differentiates between virulent and avirulent clinical strains of Pseudomonas aeruginosa
Biomolecules,
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A Metabolomics Exploration of the Sexual Phase in the Marine Diatom Pseudo-nitzschia multistriata
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Filovirus antiviral activity of cationic amphiphilic drugs is associated with lipophilicity and ability to induce phospholipidosis
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Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection
Mucosal Immunol.,
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Elucidation of the life cycle of the endophytic genus Muscodor and its transfer to Induratia in Induratiaceae fam. nov., based on a polyphasic taxonomic approach
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Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry
Antiviral Res.,
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New Frontiers in Drug Discovery: Academia Meets Industry at the International Helmholtz Drug Discovery Conference (HDDC)
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Cystobactamid 507: Concise Synthesis, Mode of Action and Optimization toward More Potent Antibiotics
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Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics
Eur.J.Med.Chem.,
188
Author count: 14
Pachathundikandi S.K., Tegtmeyer N., Arnold I.C., Lind J., Neddermann M., Falkeis-Veits C., Chattopadhyay S., Brönstrup M., Tegge W., Hong M., Sticht H., Vieth M., ... , Müller A., Backert S.
(2019)
T4SS-dependent TLR5 activation by Helicobacter pylori infection
Nat.Commun.,
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Arshad H., Alfonso J.C.L., Franke R., Michaelis K., Araujo L., Habib A., Zboromyrska Y., Lucke E., Strungaru E., Akmatov M.K., Hatzikirou H., Meyer-Hermann M., Petersmann A., Nauck M., Brönstrup M., Bilitewski U., Abel L., Sievers J., Vila J., Illig T., ... , Schreiber J., Pessler F.
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Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia
J.Transl.Med.,
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(2020)
Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis
J.Virol.,
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Author count: 13
Sommer R., Rox K., Wagner S., Hauck D., Henrikus S.S., Newsad S., Arnold T., Ryckmans T., Brönstrup M., Imberty A., Varrot A., ... , Hartmann R.W., Titz A.
(2019)
Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure-Activity Relationship Study of C-Glycosidic LecB Inhibitors
J.Med.Chem.,
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Author count: 5
Stein A., Compera D., Karge B., Brönstrup M., Franke J.
(2019)
Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L
Beilstein.J.Org.Chem.,
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Author count: 13
Smith D., Buddie A.G., Goss R.J.M., Overmann J., Lepleux C., Brönstrup M., Kloareg B., Meiners T., Brennecke P., Ianora A., Bouget F.Y., ... , Gribbon P., Pina M.
(2019)
Discovery pipelines for marine resources: an ocean of opportunity for biotechnology?
World J.Microbiol.Biotechnol.,
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Author count: 11
Ahsendorf H.P., Gan L.L., Eltom K.H., Abd El Wahed A., Hotop S.K., Roper R.L., Beutling U., Brönstrup M., Stahl-Hennig C., ... , Hoelzle L.E., Czerny C.P.
(2019)
Species-Specific Conservation of Linear Antigenic Sites on Vaccinia Virus A27 Protein Homologs of Orthopoxviruses
Viruses.,
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Klahn P., Fetz V., Ritter A., Collisi W., Hinkelmann B., Arnold T., Tegge W., Rox K., Hüttel S., Mohr K.I., Wink J., Stadler M., Wissing J., ... , Jänsch L., Brönstrup M.
(2019)
The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates
Chem.Sci.,
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Koch S., Damas M., Freise A., Hage E., Dhingra A., Ruckert J., Gallo A., Kremmer E., Tegge W., Brönstrup M., ... , Brune W., Schulz T.F.
(2019)
Kaposi's sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression
PLoS.Pathog.,
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Naini A., Sasse F., Brönstrup M.
(2019)
The intriguing chemistry and biology of soraphens
Nat.Prod.Rep.,
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In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics
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Diagnosing Zika virus infection against a background of other flaviviruses: Studies in high resolution serological analysis
Sci.Rep.,
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(2019)
Identification and quantification of (t)RNA modifications in Pseudomonas aeruginosa by liquid chromatography-tandem mass spectrometry
Chembiochem.,
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Franke R., Hinkelmann B., Fetz V., Stradal T., Sasse F., ... , Klawonn F., Brönstrup M.
(2019)
xCELLanalyzer: A Framework for the Analysis of Cellular Impedance Measurements for Mode of Action Discovery
SLAS.Discov.
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(2019)
CluMSID: an R package for similarity-based clustering of tandem mass spectra to aid feature annotation in metabolomics
Bioinformatics.,
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Metabolome and transcriptome-wide effects of the carbon storage regulator A in enteropathogenic Escherichia coli
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A metabolome-wide characterization of the diabetic phenotype in ZDF rats and its reversal by pioglitazone
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Discovery and Total Synthesis of Natural Cystobactamid Derivatives with Superior Activity against Gram-Negative Pathogens
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Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria
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Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa
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(2017)
Treatment of Vinca minor Leaves with Methyl Jasmonate Extensively Alters the Pattern and Composition of Indole Alkaloids
J.Nat.Prod.,
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Wildermuth R., Speck K., Haut F.L., Mayer P., Karge B., ... , Brönstrup M., Magauer T.
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A modular synthesis of tetracyclic meroterpenoid antibiotics
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Lukat P., Katsuyama Y., Wenzel S., Binz T., Konig C., Blankenfeldt W., ... , Brönstrup M., Müller R.
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Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity
Chem.Sci.,
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Miller A.K., Brönstrup M.
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Drug Innovation in Academia: A Helmholtz Drug Research Initiative Conference
ChemMedChem.,
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(2017)
Oxidation of the Meroterpenoid (-)-Terreumol C from the Mushroom Tricholoma terreum: Discovery of Cytotoxic Analogues
J.Nat.Prod.,
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Biscarbene gold(i) complexes: Structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability
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Appendino G., Brönstrup M., Kubanek J.M.
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Olfaction, taste and chemoreception: Scientific evidence replaces "Essays in biopoetry"
Nat.Prod.Rep.,
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Editorial: Are natural products the solution to antimicrobial resistance?
Nat.Prod.Rep.,
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Gilardi A., Bhamidimarri S.P., Brönstrup M., Bilitewski U., Marreddy R.K.R., Pos K.M., Benier L., Gribbon P., ... , Winterhalter M., Windshugel B.
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Biophysical characterization of E. coli TolC interaction with the known blocker hexaamminecobalt
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van Duuren J.B.J.H., Müsken M., Karge B., Tomasch J., Wittmann C., ... , Häußler S., Brönstrup M.
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Use of Single-Frequency Impedance Spectroscopy to Characterize the Growth Dynamics of Biofilm Formation in Pseudomonas aeruginosa
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Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats
Mol.Microbiol.
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Ferreira K., Hu H.Y., Fetz V., Prochnow H., Rais B., ... , Muller P.P., Brönstrup M.
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Multivalent Siderophore-DOTAM Conjugates as Theranostics for Imaging and Treatment of Bacterial Infections
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Clustering of MS2 spectra using unsupervised methods to aid the identification of secondary metabolites from Pseudomonas aeruginosa
J.Chromatogr.B Analyt.Technol.Biomed.Life Sci.,
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Bifunctional antimicrobial conjugates and hybrid antimicrobials
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The myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition
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Krasavin M., Parchinsky V., Kantin G., Manicheva O., Dogonadze M., Vinogradova T., ... , Karge B., Brönstrup M.
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New nitrofurans amenable by isocyanide multicomponent chemistry are active against multidrug-resistant and poly-resistant Mycobacterium tuberculosis
Bioorg.Med.Chem.,
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Zapolskii V.A., Namyslo J.C., Sergeev G., Brönstrup M., Gjikaj M., Kaufmann D.E.
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Reinvestigation of the nitration of trichloroethene - Subsequent reactions of the products and evaluation of their antimicrobial and antifungal activity
Eur.J.Org.Chem.,
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Schmidt C., Karge B., Misgeld R., Prokop A., Franke R., ... , Brönstrup M., Ott I.
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Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram-Positive Directed Antibacterial Effects
Chem.Eur.J.,
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Klahn P., Brönstrup M.
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New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development
Curr Top.Microbiol.Immunol.,
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Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa)
Sci Rep.,
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Synthesis of GPR40 targeting H- and F-probes towards selective beta cell imaging
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Synthesis and Biological Investigation of Delta-Prostaglandin J (Delta-PGJ) Analogues and Related Compounds
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Synthesis and Characterization of a Promising Novel FFAR1/GPR40 Targeting Fluorescent Probe for b[beta]-Cell Imaging
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Industrial natural product chemistry for drug discovery and development
Nat.Prod.Rep.,
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Angew.Chem Int.Ed Engl.,
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Targeting DnaN for tuberculosis therapy using novel griselimycins
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