Prof. Dr. Mark Brönstrup

Prof. Dr. Mark Brönstrup
Forschungsgruppenleiter

Mark Brönstrup studierte Chemie an der Philipps-Universität Marburg und am Imperial College in London. 1999 promovierte er an der TU Berlin in organischer Chemie. Nach der Promotion arbeitete er von 2000 bis 2004 zunächst als Laborleiter für Massenspektrometrie beim Pharmakonzern Aventis, unterbrochen von einem Forschungs-Sabbatical 2003 an der Harvard Medical School.

Von 2005 bis 2010 leitete er bei Sanofi-Aventis die Naturstoff-Forschung in Frankfurt mit dem Ziel, Leitstrukturen aus natürlichen Quellen zu entdecken und diese über Strukturveränderungen zu klinischen Kandidaten zu optimieren.

Von 2010 bis 2013 beschäftigte er sich mit Translationsforschung als Leiter der Sektion Biomarker & Diagnostics in der Diabetes Division sowie als Domain Head für Biomarker, Bioimaging und Biological Assays bei Sanofi.

Seit Dezember 2013 leitet er die Abteilung für Chemische Biologie am Helmholtz-Zentrum für Infektionsforschung. Zudem hält er eine Professur (W3) an der Leibniz-Universität Hannover inne. 

Publikationen
Rox K., Kühne A., Herrmann J., Jansen R., Hüttel S., Bernecker S., Hagos Y., Brönstrup M., Stadler M., ... , Hesterkamp T., Müller R. (2024)
Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters
ACS Pharm.Transl.Sci.

Büssing R., Bublitz A., Karge B., Brönstrup M., Strowig T., Ott I. (2024)
An organometallic hybrid antibiotic of metronidazole with a Gold(I) N-Heterocyclic Carbene overcomes metronidazole resistance in Clostridioides difficile
J.Biol.Inorg.Chem.

Esarev I.V., Karge B., Zeng H., Lippmann P., Jones P.G., Schrey H., ... , Brönstrup M., Ott I. (2024)
Silver Organometallics that are Highly Potent Thioredoxin and Glutathione Reductase Inhibitors: Exploring the Correlations of Solution Chemistry with the Strong Antibacterial Effects
ACS infectious diseases, 10 (5)

Li Q., Jansen H., Hansen G., Nurjadi D., Herrmann J., Stadler M., Brönstrup M., Müller R., He C., Graspeuntner S., ... , Rupp J., Shima K. (2024)
Inhibitory effect of sorangicin A against mutant DNA-dependent RNA polymerase in the obligate intracellular bacterium Chlamydia trachomatis
Int.J.Antimicrob.Agents

Jerye K., Lüken H., Steffen A., Schlawis C., Jänsch L., ... , Schulz S., Brönstrup M. (2024)
Activity-Based Protein Profiling Identifies Protein Disulfide-Isomerases as Target Proteins of the Volatile Salinilactones
Adv.Sci.

Zuffa S., Schmid R., Bauermeister A., Gomes P., Caraballo-Rodriguez A.M., El Abiead Y., Aron A.T., Gentry E.C., Zemlin J., Meehan M.J., Avalon N.E., Cichewicz R.H., Buzun E., Terrazas M.C., Hsu C.Y., Oles R., Ayala A.V., Zhao J., Chu H., Kuijpers M.C.M., Jackrel S.L., Tugizimana F., Nephali L.P., Dubery I.A., Madala N.E., Moreira E.A., Costa-Lotufo L.V., Lopes N.P., Rezende-Teixeira P., Jimenez P.C., Rimal B., Patterson A.D., Traxler M.F., Pessotti R.D.C., Alvarado-Villalobos D., Tamayo-Castillo G., Chaverri P., Escudero-Leyva E., Quiros-Guerrero L.M., Bory A.J., Joubert J., Rutz A., Wolfender J.L., Allard P.M., Sichert A., Pontrelli S., Pullman B.S., Bandeira N., Gerwick W.H., Gindro K., Massana-Codina J., Wagner B.C., Forchhammer K., Petras D., Aiosa N., Garg N., Liebeke M., Bourceau P., Kang K.B., Gadhavi H., Carvalho L.P.S., Silva dos Santos M., Perez-Lorente A.I., Molina-Santiago C., Romero D., Franke R., Brönstrup M., Vera-Ponce de Leon A., Pope P.B., La Rosa S.L., La Barbera G., Roager H.M., Laursen M.F., Hammerle F., Siewert B., Peintner U., Licona-Cassani C., Rodriguez-Orduna L., Rampler E., Hildebrand F., Koellensperger G., Schoeny H., Hohenwallner K., Panzenboeck L., Gregor R., O'Neill E.C., Roxborough E.T., Odoi J., Bale N.J., Ding S., Sinninghe Damste J.S., Guan X.L., Cui J.J., Ju K.S., Silva D.B., Silva F.M.R., da Silva G.F., Koolen H.H.F., Grundmann C., Clement J.A., Mohimani H., Broders K., McPhail K.L., Ober-Singleton S.E., Rath C.M., McDonald D., Knight R., ... , Wang M., Dorrestein P.C. (2024)
microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data
Nature microbiology, 9 (2)

Pfütze S., Charria-Giron E., Schulzke E., Toshe R., Khonsanit A., Franke R., Surup F., ... , Brönstrup M., Stadler M. (2024)
Depicting the Chemical Diversity of Bioactive Meroterpenoids Produced by the Largest Organism on Earth
Angew.Chem.Int.Ed Engl.

Haid S., Matthaei A., Winkler M., Sake S.M., Gunesch A.P., Milke V., Köhler N.M., Rückert J., Vieyres G., Kühl D., Nguyen T.-T., Göhl M., Lasswitz L., Zapatero-Belinchon F.J., Brogden G., Gerold G., Wiegmann B., Bilitewski U., Brown R.J.P., Brönstrup M., ... , Schulz T.F., Pietschmann T. (2024)
Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets
Antimicrob.Agents Chemother.

Eggert A., Schuppe K.T., Fuchs H.L.S., Brönstrup M., Kalesse M. (2023)
Total Synthesis of Acanthodoral Using a Rearrangement Strategy
Organic Letters

Mahdavi S.M., Bockfeld D., Büssing R., Karge B., Bannenberg T., Frank R., Brönstrup M., ... , Ott I., Tamm M. (2024)
Synthesis of N-heterocyclic carbene gold(i) complexes from the marine betaine 1,3-dimethylimidazolium-4-carboxylate
Dalton Transactions

Rox K., Jansen R., Lukezic T., Greweling-Pils M., Herrmann J., Miethke M., Hüttel S., Hennessen F., Abou Fayad A., Holzhausen C., Lundberg C.V., Teague J., Sudarman E., Bülter L., Hesterkamp T., Stadler M., ... , Brönstrup M., Müller R. (2024)
Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models
Microbiol.Spectr., 12 (1)

Charria-Giron E., Marin-Felix Y., Beutling U., Franke R., Brönstrup M., Vasco-Palacios A.M., ... , Caicedo N.H., Surup F. (2023)
Metabolomics insights into the polyketide-lactones produced by Diaporthe caliensis sp. nov., an endophyte of the medicinal plant Otoba gracilipes
Microbiol.Spectr.

Schwitalla J.W., Le N.T.H., Um S., Schalk F., Brönstrup M., ... , Baunach M., Beemelmanns C. (2023)
Heterologous expression of the cryptic mdk gene cluster and structural revision of maduralactomycin A
RSC Adv., 13 (48)

Schneider I., Fetz V., Prochnow H.P., Brönstrup M. (2023)
Artificial Siderophores with a Trihydroxamate-DOTAM Scaffold Deliver Iron and Antibiotic Cargo into the Bacterial Pathogen Escherichia coli
Isr.J.Chem., 63 (7-8)

Jian L., Zscherp R., Beutling U., Shen X., Xu S., Zhang X., Brönstrup M., ... , Klahn P., Sun Q. (2023)
Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors
J.Med.Chem.

Wu Y., Zoller B.G.E., Kamal M.A.M., Hotop S.K., Lehr C.M., Brönstrup M., ... , Dersch P., Empting M. (2023)
Establishment of an In Bacterio assay for the Assessment of Carbon Storage Regulator A (CsrA) inhibitors
Chembiochem.

Allartz P., Hotop S.K., Muntau B., Schlaphof A., Thome-Bolduan C., Gabriel M., Petersen N., Lintzel M., Behrens C., Eggert P., Pörtner K., Steiner J., ... , Brönstrup M., Tappe D. (2023)
Detection of bornavirus-reactive antibodies and BoDV-1 RNA only in encephalitis patients from virus endemic areas: a comparative serological and molecular sensitivity, specificity, predictive value, and disease duration correlation study
Infection

Friederich J., Xu C., Raunft P., Fuchs H.L.S., Brönstrup M. (2023)
Tetrazine-induced activation of a trimethyl lock as a click-to-release system for protected doxorubicin
Chem.Commun., 59 (48)

Peukert C., Vetter A.C., Fuchs H.L.S., Harmrolfs K., Karge B., ... , Stadler M., Brönstrup M. (2023)
Siderophore conjugation with cleavable linkers boosts the potency of RNA polymerase inhibitors against multidrug-resistant E. coli
Chem.Sci., 14

Cedeno-Sanchez M., Charria-Giron E., Lambert C., Luangsa-ard J.J., Decock C., Franke R., ... , Brönstrup M., Stadler M. (2023)
Segregation of the genus Parahypoxylon (Hypoxylaceae, Xylariales) from Hypoxylon by a polyphasic taxonomic approach
MycoKeys, 95

Zapol'skii V.A., Kaul S., Karge B., Brönstrup M., Gjikaj M., Kaufmann D.E. (2023)
A New Way to 2,3,4-Trisubstituted Benzo[h]quinolines: Synthesis, Consecutive Reactions and Cellular Activities â 
Molecules., 28 (6)

Maingot M., Bourotte M., Vetter A.C., Schellhorn B., Antraygues K., Scherer H., Gitzinger M., Kemmer C., Dale G.E., Defert O., Lociuro S., Brönstrup M., ... , Willand N., Trebosc V. (2023)
Structure-activity relationships of actively FhuE transported rifabutin derivatives with potent activity against Acinetobacter baumannii
Eur.J.Med.Chem., 252

Lai Y.H., Franke R., Pinkert L., Overwin H., Brönstrup M. (2023)
Molecular Signatures of the Eagle Effect Induced by the Artificial Siderophore Conjugate LP-600 in E. coli
ACS Infect.Dis., 9 (3)

Peukert C., Rox K., Karge B., Hotop S.K., Brönstrup M. (2023)
Synthesis and Characterization of DOTAM-Based Sideromycins for Bacterial Imaging and Antimicrobial Therapy
ACS Infect.Dis., 9 (2)

Wimmer S., Hoff K., Martin B., Grewer M., Denni L., Lascorz Massanet R., Raimondi M.V., Bülbül E.F., Melesina J., Hotop S.K., Haupenthal J., Rohde H., Heisig P., Hirsch A.K.H., Brönstrup M., ... , Sippl W., Holl R. (2022)
Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors
Bioorg.Chem., 131

Borgert S.R., Henke S., Witzgall F., Schmelz S., Zur Lage S., Hotop S.K., Stephen S., Lübken D., Krüger J., Gomez N.O., Van Ham M., Jänsch L., Kalesse M., Pich A., Brönstrup M., ... , Häußler S., Blankenfeldt W. (2022)
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa
Nat.Commun., 13 (1)

Peukert C., Gasser V., Orth T., Fritsch S., Normant V., Cunrath O., ... , Schalk I.J., Brönstrup M. (2022)
Trojan Horse Siderophore Conjugates Induce Pseudomonas aeruginosa Suicide and Qualify the TonB Protein as a Novel Antibiotic Target
J.Med.Chem., 66 (1)

Kruck D., Bode H., Krusche J., Beck C., Ohlsen K., Sander J., Römling U., Burrichter A., Varo J.G., ... , Charoenpattarapreeda J., Brönstrup M. (2022)
Journal Club : [u.a.] Gesteuerter Abbau von Proteinen in Bakterien durch BacPROTAC-Wirkstoffe [etc.]
Biospektrum, 28 (7)

Fiorini F., Bajerski F., Jeske O., Lepleux C., Overmann J., Brönstrup M. (2022)
A Metabolomics-Based Toolbox to Assess and Compare the Metabolic Potential of Unexplored, Difficult-to-Grow Bacteria
Mar Drugs, 20 (11)

Cooper M.S., Zhang L., Ibrahim M., Zhang K., Sun X., Röske J., Göhl M., Brönstrup M., Cowell J.K., Sauerhering L., Becker S., Vangeel L., Jochmans D., Neyts J., Rox K., Marsh G.P., ... , Maple H.J., Hilgenfeld R. (2022)
Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease
J.Med.Chem., 65 (19)

Suo H., Hochnadel I., Petriv N., Franke R., Schmidt J., Limanska N., Tugai A., Jedicke N., Brönstrup M., ... , Manns M.P., Yevsa T. (2022)
Elucidating the mechanism behind and investigating the efficacy of Traditional Chinese Medicine and Traditional Tibetan Medicine in combination with standard therapeutics in hepatocellular carcinoma and cholangiocarcinoma in vitro
Front Pharmacol., 13

Testolin G., Richter J., Ritter A., Prochnow H., Köhnke J., Brönstrup M. (2022)
Optical Modulation of Antibiotic Resistance by Photoswitchable Cystobactamids
Chem.Eur.J.

Göhl M., Zhang L., El Kilani H., Sun X., Zhang K., ... , Brönstrup M., Hilgenfeld R. (2022)
From Repurposing to Redesign: Optimization of Boceprevir to Highly Potent Inhibitors of the SARS-CoV-2 Main Protease G
Molecules, 27 (13)

Suerbaum S., Coombs N., Patel L., Pscheniza D., Rox K., Falk C., Gruber A.D., Kershaw O., Chhatwal P., Brönstrup M., ... , Bilitewski U., Josenhans C. (2022)
Correction for Suerbaum et al., "Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model"
MBio.

Arshad H., Siokis A., Franke R., Habib A., Alfonso J.C.L., Poliakova Y., Lücke E., Michaelis K., Brönstrup M., Meyer-Hermann M., Bilitewski U., Vila J., Abel L., Illig T., ... , Schreiber J., Pessler F. (2022)
Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease
Cells, 11 (15)

Brauer M., Hotop S.K., Wurster M., Herrmann J., Miethke M., Schlüter R., Dittmann S., Zühlke D., Brönstrup M., Lalk M., Müller R., Sievers S., ... , Bernhardt J., Riedel K. (2022)
Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress
mSphere

Ballmann R., Hotop S.K., Bertoglio F., Steinke S., Heine P.A., Chaudhry M.Z., Jahn D., Pucker B., Baldanti F., Piralla A., Schubert M., Cícín-Saín L., Brönstrup M., ... , Hust M., Dübel S. (2022)
ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein
Viruses., 14 (6)

Fritsch S., Gasser V., Peukert C., Pinkert L., Kuhn L., Perraud Q., Normant V., ... , Brönstrup M., Schalk I.J. (2022)
Uptake Mechanisms and Regulatory Resfponses to MECAM- and DOTAM-Based Artificial Siderophores and Their Antibiotic Conjugates in Pseudomonas aeruginosa
ACS Infect.Dis., 8 (6)

Peukert C., Popat Gholap S., Green O., Pinkert L., van den Heuvel J., Van Ham M., ... , Shabat D., Brönstrup M. (2022)
Enzyme-Activated, Chemiluminescent Siderophore-Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial Pathogens
Angew.Chem.Int.Ed Engl.

Suerbaum S., Coombs N., Patel L., Pscheniza D., Rox K., Falk C., Gruber A.D., Kershaw O., Chhatwal P., Brönstrup M., ... , Bilitewski U., Josenhans C. (2022)
Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model
MBio., 13 (2)

Hotop S.K., Reimering S., Shekhar A., Asgari E., Beutling U., Dahlke C., Fathi A., Khan F., Lütgehetmann M., Ballmann R., Gerstner A., Tegge W., Cicin-Sain L., Bilitewski U., ... , McHardy A.C., Brönstrup M. (2022)
Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2
Emerg.Microbes Infect, 11 (1)

Arisetti N., Fuchs H.L.S., Coetzer J., Orozco M., Ruppelt D., Bauer A., Heimann D., Kuhnert E., Bhamidimarri S.P., Bafna J.A., Hinkelmann B., Eckel K., Sieber S.A., Müller P.P., Herrmann J., Müller R., Winterhalter M., ... , Steinem C., Brönstrup M. (2021)
Total synthesis and mechanism of action of the antibiotic armeniaspirol A
Chem.Sci., 12 (48)

Ahsendorf H.P., Diesterbeck U.S., Hotop S.K., Winkler M., Brönstrup M., Czerny C.P. (2022)
Characterisation of an Anti-Vaccinia Virus F13 Single Chain Fragment Variable from a Human Anti-Vaccinia Virus-Specific Recombinant Immunoglobulin Library
Viruses, 14 (2)

Hotop S.K., Abd El Wahed A., Beutling U., Czerny F., Sievers C., Diederichsen U., Frank R., Stahl-Hennig C., ... , Brönstrup M., Fritz H.J. (2019)
Serological Analysis of Herpes B Virus at Individual Epitope Resolution: From Two-Dimensional Peptide Arrays to Multiplex Bead Flow Assays
Anal.Chem., 91 (17)

Roche B., Garcia-Rivera M.A., Normant V., Kuhn L., Hammann P., Brönstrup M., ... , Mislin G.L.A., Schalk I.J. (2021)
A role for PchHI as the ABC transporter in iron acquisition by the siderophore pyochelin in Pseudomonas aeruginosa
Environmental Microbiology

Jimidar C.C., Grunenberg J., Karge B., Fuchs H.L.S., Brönstrup M., Klahn P. (2021)
Masked Amino Trimethyl Lock (H2N-TML) Systems: New Molecular Entities for the Development of Turn-On Fluorophores and Their Application in Hydrogen Sulfide (H2S) Imaging in Human Cells
Chemistry - A European Journal

Becker K., Cao S., Nilsson A., Erlandsson M., Hotop S.K., Kuka J., Hansen J., Haldimann K., Grinberga S., Berruga-Fernández T., Huseby D.L., Shariatgorji R., Lindmark E., Platzack B., Böttger E.C., Crich D., Friberg L.E., Vingsbo Lundberg C., Hughes D., Brönstrup M., Andrén P.E., ... , Liepinsh E., Hobbie S.N. (2021)
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis
EBioMedicine, 73 (November 2021)

Pinkert L., Lai Y.H., Peukert C., Hotop S.K., Karge B., Schulze L.M., ... , Grunenberg J., Brönstrup M. (2021)
Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens
J.Med.Chem.

Rox K., Heyner M., Krull J., Harmrolfs K., Rinne V., Hokkanen J., Perez Vilaro G., Díez J., Müller R., Kröger A., ... , Sugiyama Y., Brönstrup M. (2021)
Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A
ACS Pharm.Transl.Sci., 4 (5)

Rath S., Rox K., Kleine Bardenhorst S., Schminke U., Dörr M., Mayerle J., Frost F., Lerch M.M., Karch A., Brönstrup M., ... , Pieper D.H., Vital M. (2021)
Higher Trimethylamine-N-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria
mSystems.

Miethke M., Pieroni M., Weber T., Brönstrup M., Hammann P., Halby L., Arimondo P.B., Glaser P., Aigle B., Bode H.B., Moreira R., Li Y., Luzhetskyy A., Medema M.H., Pernodet J.L., Stadler M., Tormo J.R., Genilloud O., Truman A.W., Weissman K.J., Takano E., Sabatini S., Stegmann E., Brötz-Oesterhelt H., Wohlleben W., Seemann M., Empting M., Hirsch A.K.H., Loretz B., Lehr C.M., Titz A., Herrmann J., Jaeger T., Alt S., Hesterkamp T., Winterhalter M., Schiefer A., Pfarr K., Hoerauf A., Graz H., Graz M., Lindvall M., Ramurthy S., Karlen A., van Dongen M., Petkovic H., Keller A., Peyrane F., Donadio S., Fraisse L., Piddock L.J.V., Gilbert I.H., ... , Moser H.E., Müller R. (2021)
Towards the sustainable discovery and development of new antibiotics
Nat.Rev.Chem.

Peukert C., Langer L.N.B., Wegener S.M., Tutov A., Bankstahl J.P., Karge B., Bengel F.M., ... , Ross T.L., Brönstrup M. (2021)
Optimization of Artificial Siderophores as (68)Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections
J.Med.Chem., 64 (16)

Büssing R., Karge B., Lippmann P., Jones P.G., Brönstrup M., Ott Ingo (2021)
Gold(I) and Gold(III) N-Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase
ChemMedChem.

Rox K., Rath S., Pieper D.H., Vital M., Brönstrup M. (2021)
A simplified LC-MS/MS method for the quantification of the cardiovascular disease biomarker trimethylamine-N-oxide and its precursors
J.Pharmaceut.Analy.

Franke R., Overwin H., Häussler S., Brönstrup M. (2021)
Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa
mSystems.

Tegge W., Guerra G., Höltke A., Schiller L., Beutling U., Harmrolfs K., Gröbe L., Wullenkord H., Xu C., ... , Weich H., Brönstrup M. (2021)
Selective bacterial targeting and infection-triggered release of antibiotic colistin conjugates
Angew.Chem.Int.Ed Engl., 60 (33)

de Oliveira L.M.F., Steindorff M., Darisipudi M.N., Mrochen D.M., Trübe P., Bröker B.M., Brönstrup M., ... , Tegge W., Holtfreter S. (2021)
Discovery of staphylococcus aureus adhesion inhibitors by automated imaging and their characterization in a mouse model of persistent nasal colonization
Microorg., 9 (3)

Villanova V., Galasso C., Fiorini F., Lima S., Brönstrup M., Sansone C., Brunet C., ... , Brucato A., Scargiali F. (2021)
Biological and chemical characterization of new isolated halophilic microorganisms from saltern ponds of Trapani, Sicily
Algal Res., 54 (April 2021)

Dreger A., Hoff K., Agoglitta O., Hotop S.K., Brönstrup M., Heisig P., ... , Kirchmair J., Holl R. (2021)
Antibacterial activity of xylose-derived LpxC inhibitors - Synthesis, biological evaluation and molecular docking studies
Bioorg.Chem., 107 (Febr. 2021)

Lettl C., Schindele F., Testolin G., Bär A., Rehm T., Brönstrup M., Schobert R., Bilitewski U., ... , Haas R., Fischer W. (2020)
Inhibition of Type IV Secretion Activity and Growth of Helicobacter pylori by Cisplatin and Other Platinum Complexes
Front Cell Infect.Microbiol., 10 (December 2020)

Richter R., Kamal M.A.M., Garcia-Rivera M.A., Kaspar J., Junk M., Elgaher W.A.M., Srikakulam S.K., Gress A., Beckmann A., Grißmer A., Meier C., Vielhaber M., Kalinina O., Hirsch A.K.H., Hartmann R.W., Brönstrup M., ... , Schneider-Daum N., Lehr C.M. (2020)
A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria
Mater.Today Bio, 8

Testolin G., Cirnski K., Rox K., Prochnow H., Fetz V., Grandclaudon C., Mollner T., Baiyoumy A., Ritter A., Leitner C., Krull J., van den Heuvel J., Vassort A., Sordello S., Hamed M.M., Elgaher W.A.M., Herrmann J., Hartmann R.W., ... , Müller R., Brönstrup M. (2020)
Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high: In vivo efficacy
Chem.Sci., 11 (5)

Wosniok P.R., Knopf C., Dreisigacker S., Orozco-Rodriguez J.M., Hinkelmann B., Müller P.P., ... , Brönstrup M., Menche D. (2020)
SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs
Chem.Eur.J., 26 (66)

Depke T., Häußler S., Brönstrup M. (2020)
The peptide chain release factor methyltransferase prmc influences the pseudomonas aeruginosa pa14 endo-and exometabolome
Metabolites, 10 (10)

Felgner S., Preusse M., Beutling U., Stahnke S., Pawar V., Rohde M., Brönstrup M., ... , Stradal T., Häußler S. (2020)
Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake
Elife., 9 (September)

Tegtmeyer N., Neddermann M., Lind J., Pachathundikandi S.K., Sharafutdinov I., Gutiérrez-Escobar A.J., Brönstrup M., Tegge W., Hong M., Rohde M., Delahay R.M., Vieth M., ... , Sticht H., Backert S. (2020)
Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori
Cell Rep., 32 (11)

Depke T., Thöming J.G., Kordes A., Häussler S., Brönstrup M. (2020)
Untargeted LC-MS metabolomics differentiates between virulent and avirulent clinical strains of Pseudomonas aeruginosa
Biomolecules, 10 (7)

Fiorini F., Borgonuovo C., Ferrante M.I., Brönstrup M. (2020)
A Metabolomics Exploration of the Sexual Phase in the Marine Diatom Pseudo-nitzschia multistriata
Mar Drugs, 18 (6)

Gunesch A.P., Zapatero-Belinchon F.J., Pinkert L., Steinmann E., Manns M.P., Schneider G., Pietschmann T., ... , Brönstrup M., von Hahn T. (2020)
Filovirus antiviral activity of cationic amphiphilic drugs is associated with lipophilicity and ability to induce phospholipidosis
Antimicrob.Agents Chemother., 64 (8)

Brönstrup M., Sasse F. (2020)
Natural products targeting the elongation phase of eukaryotic protein biosynthesis
Nat.Prod.Rep., 37 (6)

Mamareli P., Kruse F., Lu C.W., Guderian M., Floess S., Rox K., Allan D.S.J., Carlyle J.R., Brönstrup M., Müller R., Berod L., ... , Sparwasser T., Lochner M. (2020)
Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection
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Pachathundikandi S.K., Tegtmeyer N., Arnold I.C., Lind J., Neddermann M., Falkeis-Veits C., Chattopadhyay S., Brönstrup M., Tegge W., Hong M., Sticht H., Vieth M., ... , Müller A., Backert S. (2019)
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Sikandar A., Cirnski K., Testolin G., Volz C., Brönstrup M., Kalinina O.V., ... , Müller R., Koehnke J. (2018)
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Discovery and Total Synthesis of Natural Cystobactamid Derivatives with Superior Activity against Gram-Negative Pathogens
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Abouzeid S., Beutling U., Surup F., Abdel Bar F.M., Amer M.M., Badria F.A., Yahyazadeh M., ... , Brönstrup M., Selmar D. (2017)
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Miller A.K., Brönstrup M. (2017)
Drug Innovation in Academia: A Helmholtz Drug Research Initiative Conference
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Appendino G., Brönstrup M., Kubanek J.M. (2017)
Olfaction, taste and chemoreception: Scientific evidence replaces "Essays in biopoetry"
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Moore B.S., Carter G.T., Brönstrup M. (2017)
Editorial: Are natural products the solution to antimicrobial resistance?
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Gilardi A., Bhamidimarri S.P., Brönstrup M., Bilitewski U., Marreddy R.K.R., Pos K.M., Benier L., Gribbon P., ... , Winterhalter M., Windshugel B. (2017)
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Kanwal S., Jensch I., Palm G.J., Brönstrup M., Rohde M., Kohler T.P., Somplatzki D., Tegge W., ... , Jenkinson H.F., Hammerschmidt S. (2017)
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Krasavin M., Parchinsky V., Kantin G., Manicheva O., Dogonadze M., Vinogradova T., ... , Karge B., Brönstrup M. (2017)
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