Ribonucleic acid (RNA) folds into complex structures which allow it to interact specifically with other molecules in the cell. In HIV-1, minute differences in RNA folding can be crucial in determining whether viral RNA...
Infections with Clostridioides difficile (for short: C. difficile) are often recurrent, because dormant stages of the bacterium persist in the intestine. Thus far, there was no drug that can effectively combat the...
On the World Day for Laboratory Animals April 24, 2023, special attention is paid to the use of animals for research and development of products for humans. In drug research, among other areas, extensive animal testing...
Dr Yannic Bartsch's TWINCORE junior research group "Antiviral Antibody Omics" is being funded as a Helmholtz Young Investigator Group (HYIG). Over the next five years, the immunologist will receive a total of 1.5...
The COVID-19 pandemic has dramatically demonstrated that the development of effective agents against viral pathogens is of great importance for global health. Although effective vaccines are available for many viral...
Infection with SARS-CoV-2 leads to severe disease in some people, whereas others do not get ill or only experience mild disease. What causes these differences is not fully understood. It is already known that an...
In the ImageTox project, the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and the CISPA Helmholtz Center for Information Security are pooling their expertise in the fields of drug discovery and...
Systematically attenuating DNA targeting activity can achieve CRISPR-driven editing in bacteria, greatly boosting colony counts and even increasing the frequency of precise genome editing. This was shown in a study of...
