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Phages to the rescue: in situ editing of the gut microbiota
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Ten Years of the Synthetic Biology Summer Course at Cold Spring Harbor Laboratory
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TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases
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A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria
Mol Cell
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Yu Y., Gawlitt S., de Andrade e Sousa , Merdivan E., Piraud M., ... , Beisel C.L., Barquist L.
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SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9
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Shortened CRISPR-Cas9 arrays enable multiplexed gene targeting in bacteria from a smaller DNA footprint
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Mol.Cell,
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Cetin R., Wegner M., Luwisch L., Saud S., Achmedov T., Süsser S., Vera-Guapi A., Müller K., Matthess Y., Quandt E., Schaubeck S., ... , Beisel C.L., Kaulich M.
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Sabeti Azad M., Cardoso Batista A., Faulon J.L., Beisel C.L., Bonnet J., Kushwaha M.
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Vialetto E., Yu Y., Collins S.P., Wandera K.G., Barquist L., Beisel C.L.
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A target expression threshold dictates invader defense and prevents autoimmunity by CRISPR-Cas13
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Beneficial commensal bacteria promote Drosophila growth by downregulating the expression of peptidoglycan recognition proteins
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Genome Editing with Cas9 in Lactobacilli
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A TXTL-Based Assay to Rapidly Identify PAMs for CRISPR-Cas Systems with Multi-Protein Effector Complexes
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A Hyperthermoactive-Cas9 Editing Tool Reveals the Role of a Unique Arsenite Methyltransferase in the Arsenic Resistance System of Thermus thermophilus HB27
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Illuminating the path to DNA repair
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Advances in CRISPR Technologies for Microbial Strain Engineering
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CRISPR technologies and the search for the PAM-free nuclease
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Rapid Testing of CRISPR Nucleases and Guide RNAs in an E.coli Cell-Free Transcription-Translation System
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Collias D., Leenay R.T., Slotkowski R.A., Zuo Z., Collins S.P., McGirr B.A., ... , Liu J., Beisel C.L.
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A positive, growth-based PAM screen identifies noncanonical motifs recognized by the S. pyogenes Cas9
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Your Base Editor Might Be Flirting with Single (Stranded) DNA: Faithful On-Target CRISPR Base Editing without Promiscuous Deamination
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Jacobsen T., Ttofali F., Liao C., Manchalu S., Gray B.N., Beisel C.L.
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Characterization of Cas12a nucleases reveals diverse PAM profiles between closely-related orthologs
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CRISPR-Cas Systems and the Paradox of Self-Targeting Spacers
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An educational module to explore CRISPR technologies with a cell-free transcription-translation system
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Competitive exclusion is a major bioprotective mechanism of lactobacilli against fungal spoilage in fermented milk products
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CRATES: A one-step assembly method for Class 2 CRISPR arrays
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Pickar-Oliver A., Black J.B., Lewis M.M., Mutchnick K.J., Klann T.S., Gilcrest K.A., Sitton M.J., Nelson C.E., Barrera A., Bartelt L.C., Reddy T.E., Beisel C.L., ... , Barrangou R., Gersbach C.A.
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Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells
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Modular one-pot assembly of CRISPR arrays enables library generation and reveals factors influencing crRNA biogenesis
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Wandera K.G., Collins S.P., Wimmer F., Marshall R., Noireaux V., Beisel C.L.
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An enhanced assay to characterize anti-CRISPR proteins using a cell-free transcription-translation system
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The Acidaminococcus sp. Cas12a nuclease recognizes GTTV and GCTV as non-canonical PAMs
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Characterization of the all-E. coli transcription-translation system myTXTL by mass spectrometry
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Genome Editing with CRISPR-Cas9 in Lactobacillus plantarum Revealed That Editing Outcomes Can Vary Across Strains and Between Methods
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Distinct timescales of RNA regulators enable the construction of a genetic pulse generator
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The Francisella novicida Cas 12a is sensitive to the structure downstream of the terminal repeat in CRISPR arrays
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Bacterial Adaptation to the Host's Diet Is a Key Evolutionary Force Shaping Drosophila-Lactobacillus Symbiosis
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Mathematical Modeling of RNA-Based Architectures for Closed Loop Control of Gene Expression
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Dugar G., Leenay R.T., Eisenbart S.K., Bischler T., Aul B.U., ... , Beisel C.L., Sharma C.M.
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CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9
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A detailed cell-free transcription-translation-based assay to decipher CRISPR protospacer-adjacent motifs
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