Comparative Pathology
Our service
Customized histo- pathology work for your research:
- Blinded and randomized histo-pathological evaluation (scores) specifically designed for your research question inclusive the interpretation and illustration of your data (approx. 50 projects per year)
- More than 100 antigen specific staining methods for bright field and fluorescence microscopy as single or double staining
- We establish staining methods upon your demand.
- Animal and human tissues as well as cytological samples and even cell cultures can be processed.
Overview of our technical services:
- Fixation using Formaldehyde, Ethanol-Carnoy, HOPE
- Tissue embedding and sectioning in Paraffin, cryo and plastic
- Automated hematoxylin-eosin (HE)- staining
- Histo-chemical staining (i.e. PAS, Masson-Trichrom, Ziehl-Neeslen, Gram staining, …)
- Immun-histo-chemical staining (i.e. CD4, FoxP3, CD11c, Influenza A, MCMV, …)
- Every antibody staining is possible in fluorescence as well
- Double staining (i.e. CD4/Caspase3, CD3/FoxP3), fluorescence and histo-chemical
Our service
Customized histo- pathology work for your research:
- Blinded and randomized histo-pathological evaluation (scores) specifically designed for your research question inclusive the interpretation and illustration of your data (approx. 50 projects per year)
- More than 100 antigen specific staining methods for bright field and fluorescence microscopy as single or double staining
- We establish staining methods upon your demand.
- Animal and human tissues as well as cytological samples and even cell cultures can be processed.
Overview of our technical services:
- Fixation using Formaldehyde, Ethanol-Carnoy, HOPE
- Tissue embedding and sectioning in Paraffin, cryo and plastic
- Automated hematoxylin-eosin (HE)- staining
- Histo-chemical staining (i.e. PAS, Masson-Trichrom, Ziehl-Neeslen, Gram staining, …)
- Immun-histo-chemical staining (i.e. CD4, FoxP3, CD11c, Influenza A, MCMV, …)
- Every antibody staining is possible in fluorescence as well
- Double staining (i.e. CD4/Caspase3, CD3/FoxP3), fluorescence and histo-chemical
Alina Katharina Loriani Fard
Comparative pathology supports infectious disease research by integrating histological, molecular, and pathological analyses while taking species-specific differences into account.
Alina Loriani Fard studied veterinary medicine at the University of Veterinary Medicine Hannover and graduated in 2017. She subsequently worked for two years as a research associate at Hannover Medical School in the fields of neuroanatomy and cell biology, where she investigated the function of dopaminergic neurons. She completed her doctoral research at the Institute of Veterinary Pathology at Freie Universität Berlin, focusing on molecular pathological aspects of immuno-oncology. In parallel, she completed a five-year specialist training program in veterinary pathology and worked in interdisciplinary research groups, where she performed and interpreted histopathological analyses, including as part of the Sonderforschungsbereich “Innate Immunity of the Lung” and the Einstein Center 3R. In 2024, she joined the HZI, where she initially worked as a research associate and animal welfare officer in the Service Platforms of Comparative Medicine and Comparative Pathology. Since 2026, she is head of the Comparative Pathology Platform.
Team
Selected Publications
Osbelt, L., Almási, É. D. H., Wende, M., Kienesberger, S., Voltz, A., Lesker, T. R., Muthukumarasamy, U., Knischewski, N., Nordmann, E., Bielecka, A. A., Giralt-Zúñiga, M., Kaganovitch, E., Kühne, C., Baier, C., Pietsch, M., Müsken, M., Greweling-Pils, M. C., Breinbauer, R., Flieger, A., Schlüter, D., … Strowig, T. (2024). Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms. Nature Microbiology, 9(7), 1792–1811. DOI: 10.1038/s41564-024-01710-0
Rox, K., Jansen, R., Lukežič, T., Greweling-Pils, M., Herrmann, J., Miethke, M., Hüttel, S., Hennessen, F., Abou Fayad, A., Holzhausen, C., Lundberg, C. V., Teague, J., Sudarman, E., Bülter, L., Hesterkamp, T., Stadler, M., Brönstrup, M., & Müller, R. (2024). Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models. Microbiology spectrum, 12(1), e0128923. DOI: 10.1128/spectrum.01289-23
Abassi, L., Bertoglio, F., Mačak Šafranko, Ž., Schirrmann, T., Greweling-Pils, M., Seifert, O., Khan, F., Katzmarzyk, M., Jacobsen, H., Gödecke, N., Heine, P. A., Frenzel, A., Nowack, H., Dübel, S., Kurolt, I. C., Kontermann, R. E., Markotić, A., Schubert, M., Hust, M., & Čičin-Šain, L. (2023). Evaluation of the Neutralizing Antibody STE90-C11 against SARS-CoV-2 Delta Infection and Its Recognition of Other Variants of Concerns. Viruses, 15(11), 2153. DOI: 10.3390/v15112153
Metzdorf, K., Jacobsen, H., Greweling-Pils, M. C., Hoffmann, M., Lüddecke, T., Miller, F., Melcher, L., Kempf, A. M., Nehlmeier, I., Bruder, D., Widera, M., Ciesek, S., Pöhlmann, S., & Čičin-Šain, L. (2023). TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection. Viruses, 15(2), 271. DOI: 10.3390/v15020271
Herppich, S., Hoenicke, L., Kern, F., Kruse, F., Smout, J., Greweling-Pils, M. C., Geffers, R., Burton, O. T., Liston, A., Keller, A., Floess, S., & Huehn, J. (2023). Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell differentiation. European journal of immunology, 53(10), e2250270. DOI: 10.1002/eji.202250270
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