Cellular Metabolism in Infection

Our Research

The Cordes laboratory focuses on understanding the critical role of metabolism in cellular functions and its contribution to metabolic diseases associated with inflammation. We aim to characterize metabolic heterogeneity and interconnectivity of cells and pathogens by using metabolic flux, mass spectrometry, and engineering approaches. By understanding how metabolism drives cell function, we can identify metabolic vulnerabilities in inflammatory diseases.

We are specifically interested in applying metabolic systems biology approaches to uncover how metabolic pathways are reprogrammed in response to genetic perturbation, environmental stress, nutrient availability, or inflammatory signaling. We also aim to understand host-pathogen interactions and study inter- and intracellular transport mechanisms involved in metabolic and functional processes. Ultimately, our goal is to identify metabolic targets that can be targeted by therapeutically improving the lives of those affected by inflammatory diseases.