Prof Dr Christian Sieben

Research Group Leader

Christian Sieben studied Biology at the TU Darmstadt with majors in physiology and cell biology. After graduating in plant cell biology, he moved to the Humboldt-Universität zu Berlin to start a PhD in single-cell virology. During this time, he developed microscopy approaches to decipher respiratory virus infection at the level of individual cells. He then moved to EPFL in Switzerland to study super-resolution microscopy techniques, which now allow him to study virus infection at the single protein level. In 2020, Christian started his group Nanoscale Infection Biology (NIBI) at HZI in Braunschweig.

Publications

Schlegel J., Sieben C. (2026)

Organizing the interface-Plasma membrane architecture and receptor dynamics in virus-cell interactions

FEBS Lett.

DOI: 10.1002/1873-3468.70347 HZI-Repositorium PubMed

Er J., Ray S., Xie E., Schusterbauer R., Rosentreter M., Etouki R., Xing N., Wiesner A., Nickl P., Ahmed R., Page T., Hocevar A., Bawadkji O., Herrmann A., Radnik J., Hodoroaba V.D., Sieben C., ... , Paulus B., Donskyi I.S. (2026)

Controlled Triazine-Based Covalent Functionalization of Black Phosphorus for Degradable Hybrid Materials

Small

DOI: 10.1002/smll.73572 HZI-Repositorium PubMed

Camviel N., Gambarotto D., Andre V., Stadelmann R., Sieben C., Gottardo R., ... , Manley S., Arber C. (2026)

CAR-modified marrow infiltrating lymphocytes efficiently target malignant plasma cells with very low antigen density

Mol.Ther.

DOI: 10.1016/j.ymthe.2026.02.004 HZI-Repositorium PubMed

Yuan B., Sieben C., Raj P., Rietschel T., Hennell James R., Gatzemeier A., Jänsch L., ... , Marlovits T.C., Heinz D.W. (2026)

Molecular insights into the capsular polysaccharide transporter Wza-Wzc complex

Nat.Commun., 17 (1)

DOI: 10.1038/s41467-026-69136-2 HZI-Repositorium PubMed

Bej R., Xie E., Ludwig K., Schmidt R.F., Kerkhoff Y., Dalgliesh R., Paul N., Gradzielski M., Herrmann A., ... , Sieben C., Haag R. (2025)

Mucin-Inspired Filamentous Sulfated Copolymers Effectively Inhibit Human Respiratory Syncytial Virus (hRSV) Infectivity

Adv.Sci.

DOI: 10.1002/advs.202515908 HZI-Repositorium PubMed

Lorenz S.M., Wahida A., Bostock M.J., [...], Sieben C., ... , [...], Conrad M (2025)

A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis

Cell, 189 (1/ January 2026)

DOI: 10.1016/j.cell.2025.11.014 HZI-Repositorium PubMed

Broich L., Wullenkord H., Osman M.K., Fu Y., Müsken M., Reuther P., ... , Brönstrup M., Sieben C. (2025)

Single influenza A viruses induce nanoscale cellular reprogramming at the virus-cell interface

Nature Communications, 16 (1)

DOI: 10.1038/s41467-025-58935-8 HZI-Repositorium PubMed

Osman M.K., Robert J., Broich L., Frank D., Grosse R., Schwemmle M., Wrobel A.G., Ciminski K., ... , Sieben C., Reuther P. (2025)

The bat influenza A virus subtype H18N11 induces nanoscale MHCII clustering upon host cell attachment

Nature Communications, 16 (1)

DOI: 10.1038/s41467-025-58834-y HZI-Repositorium PubMed

Broich L., Fu Y., Sieben C. (2025)

Live-Cell Single-Molecule Imaging of Influenza A Virus-Receptor Interaction

(4)

DOI: 10.1007/978-1-0716-4326-6_4 PubMed

Sieben C. (2024)

Regulatory fractal or evolutionary accident? [Regulatorisches Fraktal oder evolutionärer Unfall?]

Biospektrum, 30 (5)

DOI: 10.1007/s12268-024-2277-8 HZI-Repositorium

Gabele L., Bochow I., Rieke N., Sieben C., Michaelsen-Preusse K., ... , Hosseini S., Korte M. (2024)

H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses in vitro

Frontiers in Cellular Neuroscience, 18

DOI: 10.3389/fncel.2024.1444876 HZI-Repositorium PubMed

Dobramysl U., Sieben C., Holcman D. (2024)

Mean time to infection by small diffusing droplets containing SARS-CoV-2 during close social contacts

Networks and Heterogeneous Media, 19 (1)

DOI: 10.3934/nhm.2024017 HZI-Repositorium

Menke L., Sieben C. (2024)

An Improved Workflow for the Quantification of Orthohantavirus Infection Using Automated Imaging and Flow Cytometry

Viruses., 16 (2)

DOI: 10.3390/v16020269 HZI-Repositorium PubMed

Feng J., Nie C., Xie E., Thongrom B., Reiter-Scherer V., Block S., Herrmann A., Quaas E., ... , Sieben C., Haag R. (2023)

Sulfated Polyglycerol-Modified Hydrogels for Binding HSV-1 and RSV

ACS Appl.Mater.Interfaces.

DOI: 10.1021/acsami.3c09553 PubMed

Xie E., Ahmad S., Smyth R.P., Sieben C. (2023)

Advanced fluorescence microscopy in respiratory virus cell biology

(116)

DOI: 10.1016/bs.aivir.2023.05.002 PubMed

Kastner M., Karner A., Zhu R., Huang Q., Geissner A., Sadewasser A., Lesch M., W+Ârmann X., Karlas A., Seeberger P.H., Wolff T., Hinterdorfer P., ... , Herrmann A., Sieben C. (2023)

Relevance of Host Cell Surface Glycan Structure for Cell Specificity of Influenza A Viruses

Viruses, 15 (7)

DOI: 10.3390/v15071507 HZI-Repositorium PubMed

Degen M., Santos J.C., Pluhackova K., Cebrero G., Ramos S., Jankevicius G., Hartenian E., Guillerm U., Mari S.A., Kohl B., Müller D.J., Schanda P., Maier T., Perez C., Sieben C., ... , Broz P., Hiller S. (2023)

Structural basis of NINJ1-mediated plasma membrane rupture in cell death

Nature

DOI: 10.1038/s41586-023-05991-z HZI-Repositorium PubMed

Menke L., Sperber H.S., Aji A.K., Chiantia S., Schwarzer R., Sieben C. (2023)

Advances in fluorescence microscopy for orthohantavirus research

Microscopy.(Oxf)

DOI: 10.1093/jmicro/dfac075 HZI-Repositorium PubMed

Blundell B., Sieben C., Manley S., Rosten E., Ch'ng Q., Cox S. (2021)

3D Structure From 2D Microscopy Images Using Deep Learning

Front Bioinform., 1

DOI: 10.3389/fbinf.2021.740342 HZI-Repositorium PubMed