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Annual flu vaccines protect against severe infection, but they vary in efficacy and may not match the most virulent strains of the season. The reality of a universal flu vaccine, which would protect people from all strains, and ideally longer than a single season, remains elusive. This major roadblock is addressed by the INCENTIVE consortium, which is funded by the European Commission and coordinated at the Helmholtz Centre for Infection Research (HZI) by Prof. Carlos A. Guzman. Findings published in the Journal of Virology suggest that universal flu vaccines are coming closer.

Yesterday, the lighthouse project of the state of Lower Saxony reached its latest milestone: At the second portfolio conference of the Institute for Biomedical Translation (IBT) Lower Saxony, a high-caliber jury selected projects from the Helmholtz Centre for Infection Research and the Hannover Medical School that will receive funding of over 1.6 million euros. A total of 25 million euros are available to the IBT Lower Saxony until 2028 to accelerate the transfer of cutting-edge research in the life sciences in Lower Saxony and to bring it out into the world in the form of startups and entrepreneurial ideas.

Fascinating insights into the world of infection research - the Helmholtz Center invites you to its Open Day on September 21. Interested visitors can look forward to the presentation of selected research projects, speeches and discussions with leading experts from the HZI. Between 11 a.m. and 4 p.m., it is possible to get to experience research to fight pathogens at first hand.

Certain changes in the genetic material of pathogens can alter their ability to infect human cells or protect them better from defense by the immune system. Researchers were able to observe this effect particularly impressive in the SARS-CoV-2 virus. During the coronavirus pandemic, an interdisciplinary team at TWINCORE, Centre for Experimental and Clinical Infection Research in Hanover, investigated the interaction between pairs of mutations that might have triggered several of these changes in infectivity and immune escape. They have now published their findings in the journal Genome Biology. The TWINCORE is a joint institution of the Helmholtz Centre for Infection Research (HZI) in Braunschweig and Hannover Medical School (MHH).

The protective effect of established COVID-19 vaccines is initially very robust, but wanes relatively quickly. This limitation imposes a need for periodic booster shots, which drives vaccine hesitation. In contrast, an innovative vector vaccine developed at the Helmholtz Centre for Infection Research (HZI) presents a compelling alternative. It elicits prolonged immune response in animal models, and maintains its efficacy over extended time. The concept employs an animal cytomegalovirus (MCMV; murine cytomegalovirus) as the vector that expresses and delivers the coronavirus spike protein information. Crucially, this vector poses no threat to humans, enhancing the vaccine's safety profile.

Modern cutting-edge research generates enormous amounts of data, presenting scientists with the challenge of visualizing and analyzing it. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg and the Technical University of Applied Sciences Würzburg-Schweinfurt (THWS) have developed a tool for visualizing large data sets. The sCIRCLE tool allows users to explore single-cell analysis data in an interactive and user-friendly way. Their results have been published in the journal NAR Genomics and Bioinformatics.