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Regulatorische T-Zelle (blau) in Interaktion mit Bakterienzellen.

News

The intestines can do more than just digest and absorb food. It has been known for a while that the intestines harbour a large part of the immune system and that intestinal bacteria are critically involved in the development and function of the intestinal immune system. The so-called gut-associated immune system ensures that we stay healthy and that our immune defence works properly. Researchers from the Helmholtz Centre for Infection Research (HZI) and its location in Würzburg, the Helmholtz Institute for RNA-based Infection Research (HIRI), have now demonstrated how the initial microbial colonisation of the intestine immediately after birth determines the unique properties of gut-draining lymph nodes. Using single-cell technology, the scientists demonstrated on the transcriptome level that the scaffold cells of these lymph nodes are stably imprinted by the intestinal microbes during the first days after birth. Furthermore, they can memorize these properties for the lifetime of the host and continuously pass this information on to migrating immune cells. The scientists published their results in Nature Communications.

04.10.2018

HZI Campus

HIRI

Immunologische Abwehr: Eine T-Zelle wird für den Kampf gegen Krankheitserreger von einer dendritischen Zelle fit gemacht.

News

The initiative “Immunology & Inflammation” unifies efforts in immunological research within the Helmholtz Association. 23 working groups from five Helmholtz Centres are joining forces to address some of the most complex problems in today's immunology in ways that can only be explored in collaboration.

13.08.2018

HZI Campus

3D-Modellierung des Proteinkomplexes PqsBC mit dem Fettsäurebindekanal (blau). Die Ausschnittvergrößerung zeigt, dass der Kanal eine optimale Länge für die Bindung einer Fettsäurekette aus acht Kohlenstoffatomen besitzt.

News

The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals. Pseudomonas manages time and again to survive attacks of the immune system and antibiotic therapies. One key to the success of this persistent pathogen is its complex communication system as the bacteria use various signalling substances to communicate with each other and to control infection processes. Scientists from the Helmholtz Centre for Infection Research (HZI) in Braunschweig and the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) in Saarbrücken recently discovered how these bacteria produce a large part of the variety of signalling molecules: The ability of a single protein complex to change its shape allows the bacteria to process molecules of different sizes into signalling substances. If it is possible to develop an inhibitor for this complex, one could “freeze” its motion and interrupt the communication of the bacteria. The scientists published their results in ChemBioChem.

05.07.2018

HZI Campus

Streptococcus pyogenes löst am häufigsten nekrotisierende Fasziitis aus.

News

Necrotising fasciitis (NF) is the most severe form of tissue death caused by bacteria. The bacterium Streptococcus pyogenes is one of the main causes of this disease. The infections take a rapid course and are associated with devastating consequences for the afflicted individuals ranging from severe necrosis to toxic shock. The disease is often fatal. However, if detected at an early stage, it can be cured by treatment with medication and removal of the afflicted tissue. Scientists from the Helmholtz Centre for Infection Research (HZI) recently discovered the crucial role and protective effect of pathogen-specific antibodies in the first stage of the Streptococcus infection. Accordingly, early clinical application of a cocktail of human immunoglobulin G containing such specific antibodies might prevent the manifestation of tissue necrosis and the progress of the disease. The study was completed in cooperation with clinicians from the University hospitals in Bergen (Norway), Gothenburg and Stockholm (Sweden) and Copenhagen (Denmark) and was recently published in the Journal of Infectious Diseases.

27.06.2018

HZI Campus

News

Infections continue to be amongst the main causes of death throughout the world. Individually customised prevention and therapies promise to open up new options for curing diseases. But what is the current status of the research throughout the world and what are the most urgent questions – from an ethical, social and economic point of view? Experts will discuss these issues from 21 to 23 June in Hannover.

05.06.2018

CiiM

HZI-Forscherin Susanne Häußler mit Bundesministerin Anja Karliczek und Minister Björn Thümler.

News

High-ranking visitors at the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH): Federal Minister of Research Anja Karliczek and Lower Saxony's Minister for Science and Culture Björn Thümler used their personal visit on 31 May 2018 to catch up on the state of modern infection research in Lower Saxony. They visited the study centre of the NAKO health study in Hannover, which is being coordinated by the HZI, and the TWINCORE, Centre for Experimental and Clinical Infection Research, an institution that is run jointly by the Helmholtz Centre for Infection Research in Braunschweig and the Hannover Medical School.

31.05.2018

HZI Campus

TWINCORE

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HZI in the media

could be reintroduced at any time. Epidemiologists at the Helmholtz Center for Infection Research (HZI) have now shown that many people do

23.10.2025

MSN.com

... eingeschleppt werden könnte. Epidemiolog:innen des Helmholtz-Zentrums für Infektionsforschung (HZI) haben nun gezeigt, dass ...

23.10.2025

innovations report

this development, a research team at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), in collaboration with the Swiss

22.10.2025

Phys.org

Malaria-Medikamentes ermöglichen könnte. Das HIPS ist ein Standort des Helmholtz-Zentrums für Infektionsforschung in Zusammenarbeit mit ...

22.10.2025

Verband Deutscher Biologen e.V.

(Bild: DOI: 10.1021/jacs.5c08354 / Hips / CC BY 4.0) Wissenschaftler am Hips entwickelten eine Plattform zur Produktion von Furanoliden, die effektiv gegen Bakterien und Krebszellen wirken können und vielversprechende Wirkstoffe darstellen.

21.10.2025

PROCESS

at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), in partnership with the Helmholtz Centre for Infection Research (HZI

20.10.2025

Bioengineer.org

their biological activity. HIPS is a site of the Helmholtz Center for Infection Research (HZI) in collaboration with Saarland University.

20.10.2025

Phys.org

... die Abteilung „Experimentelle Immunologie“ am Helmholtz-Zentrum für Infektionsforschung (HZI) in Braunschweig, lehrt als Professor an ...

17.10.2025

Deutsches Ärzteblatt

Einrichtungen als nationale assoziierte Partner: das Helmholtz-Zentrum für Infektionsforschung Braunschweig, die Universität Bayreuth, das

17.10.2025

AlphaGalileo

... diesem Ergebnis kommt ein Forschungsteam des Helmholtz-Zentrums für Infektionsforschung (HZI) in Zusammenarbeit mit der ...

14.10.2025

Deutsches Ärzteblatt

Individualisierte Infektionsmedizin, einer gemeinsamen Einrichtung des Helmholtz-Zentrums für Infektionsforschung und der MHH. Bis zuletzt

13.10.2025

Springer

Ein Grippe-Test könnte in Zukunft womöglich sehr schnell gehen: einfach ein Kaugummi kauen. Ein deutsches ...

09.10.2025

Apotheken Umschau

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