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The Science4Life Startup Competition supports teams of founders from the life sciences, chemistry, and energy sectors in transforming their excellent scientific ideas into marketable innovations. In the latest concept phase, the team behind the “PROTON” project from the Helmholtz Centre for Infection Research (HZI) was named the winner. PROTON is developing a novel active substance for the treatment of infections caused by the bacterium Staphylococcus aureus. Of the 91 applications for the concept phase of the Science4Life Venture Cup, the organizers invited ten teams to present their concepts. Ultimately, they selected five winning teams from the fields of life sciences and chemistry, as well as one team from the field of energy research.

Two researchers from the Helmholtz Centre for Infection Research (HZI) serve as advisors to a European consortium working to combat antimicrobial resistance. Prof. Rolf Müller, Scientific Director of the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and Head of the Research Unit “Novel Antibiotics” at the German Center for Infection Research (DZIF), and Prof. Katharina Schaufler, Head of the Department “Epidemiology and ecology of antimicrobial resistance” at the Helmholtz Institute for One Health, have been appointed to the Scientific Advisory Board of the European Partnership on One Health Antimicrobial Resistance (EUP OHAMR). HIPS and HIOH are sites of the HZI in collaboration with Saarland University and partner institutions in Greifswald, respectively.

Maternal health during pregnancy plays a critical role in shaping the long-term health of her child. Researchers at the Helmholtz Centre for Infection Research (HZI), together with partners at the Hebrew University of Jerusalem, are investigating how maternal inflammatory conditions influence immune development in newborns. The project focuses on immune cells in the oral and intestinal mucosa, key tissues that form the body’s first line of defense against pathogens. The researchers aim to understand how these immune compartments are shaped early in life and how this may influence the child’s susceptibility to infections, inflammatory diseases, and vaccine responses later in life.

When viruses infect the respiratory tract, they first come into contact with a viscous gel called mucus. Only viruses that can overcome this layer on the cells of the mucous membranes are able to infect a host. In the joint project ONEMUC, which is funded by the German Federal Ministry of Research, Technology and Space (BMFTR) with 4.3 million euros, researchers at the Helmholtz Centre for Infection Research (HZI) and cooperation partners are investigating the role of mucus as a barrier in the transmission of zoonotic influenza A viruses. At the HZI, group leaders Prof. Christian Sieben and Dr Julia Port are investigating how mucus and environmental factors influence virus transmission. The five-year project started on March 1, 2026.

Most bacteria, including many bacterial pathogens, are surrounded by an outer protective layer of sugar molecules, known as a capsule. This primarily protects the bacteria from environmental influences, but also serves as a kind of cloak of invisibility, enabling them to evade the phagocytes of our immune system. Structural biologists at the Helmholtz Centre for Infection Research (HZI) have now used cryo-electron microscopy to visualize the central Wza-Wzc protein complex, with which sugar molecules pass from the interior of the bacterial cell to the outside, in three dimensions at the atomic level for the first time. Their investigations also show how the channel is formed and which molecular players are involved in the active transport of sugar molecules through the channel. The researchers hope that their study will help identify target structures for potential drugs that could inhibit or completely prevent the formation of the bacterial capsule in the future. This would also make such bacterial pathogens vulnerable to attack by the immune system. The study was conducted in collaboration with researchers from the Centre for Structural Systems Biology (CSSB) in Hamburg and has now been published in the journal Nature Communications.

Researchers at the Helmholtz Institute for One Health (HIOH), a site of the Helmholtz Centre for Infection Research (HZI), together with an interdisciplinary team of partners, have identified the fire-footed rope squirrel (Funisciurus pyrropus) as a likely natural reservoir of the monkeypox virus (MPXV). Their study was published today in the renowned scientific journal Nature. The discovery was based on the detailed investigation of an mpox outbreak among wild sooty mangabeys (Cercocebus atys) in Taï National Park, Côte d’Ivoire. Scientists combined ecological, behavioral and molecular evidence to document, for the first time, the interspecies transmission of MPXV in the wild, from fire-footed rope squirrels to sooty mangabeys.