Dr. Frank Surup

Dr. Frank Surup
Wissenschaftler
+49 531 6181-4256

Frank Surup promovierte 2007 bei Prof. Stephanie Grond und Prof. Axel Zeeck in Göttingen. Anschließend forschte er zwei Jahre an der Harvard Medical School (Boston, USA) im Labor von Prof. Jon Clardy.

Seit 2010 arbeitet er am Helmholtz-Zentrum für Infektionsforschung (HZI) in der Abteilung Mikrobielle Wirkstoffe. Dort entdeckte und entwickelte er zahlreiche neuartige Naturstoffe, von denen mehrere als Leitsubstanzen für die Medikamentenentwicklung von zentraler Bedeutung sind.

Seine Forschungsschwerpunkte umfassen die Optimierung von Kultivierungsbedingungen, die Produktion in Fermentern und biotechnologischen Anlagen sowie die Isolierung und Aufreinigung von Naturstoffen. Seine Kernkompetenz ist die Strukturaufklärung der Sekundärmetaboliten mittels spektroskopischer (z. B. NMR) und massenspektrometrischer Methoden.

Insbesondere untersucht er pflanzenassoziierte, filamentöse Pilze, aus denen er bislang über 300 neue Naturstoffe strukturell aufgeklärt hat.

Ihn fasziniert im Besondern, wie Naturstoffe die Interaktionen zwischen Bakterien, Pilzen und Pflanzen vermitteln – etwa als Virulenzfaktoren, Nahrungstoxine oder Abwehrstoffe. 

Publikationen
Fichtner J., Beer Y.Y., Ramm H.G.M., Mühlen S., Surup F., Herrmann J., Meister T.L., Pfaender S., Bilitewski U., Brönstrup M., Müller R., Wirth M., ... , Eskelinen E.L., Schmitz I. (2025)
Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators
FEBS J
DOI: 10.1111/febs.70243 HZI-Repositorium PubMed
Paomephan P., Hassan K., Kirchenwitz M., Pfütze S., Surup F., Cisarova I., ... , Boonchird C., Stadler M. (2025)
The Khamkhains, Neurotrophic Drimane-Type Sesquiterpenoids Derived from a Polyporaceous Basidiomycete Originating from Thailand
J Nat.Prod., 88 (7)
DOI: 10.1021/acs.jnatprod.5c00669 HZI-Repositorium PubMed
Lambert C., Pourmoghaddam M.J., Charria-Giron E., Surup F., Khodaparast S.A., Voglmayr H., ... , Krisai-Greilhuber I., Stadler M. (2025)
Minutellins E-I and daldinone L, new secondary metabolites from different species of the Hypoxylaceae (Xylariales, Ascomycota)
Mycol.
DOI: 10.1080/21501203.2025.2512962 HZI-Repositorium
Schmidt K., Charria-Giron E., Gorelik T.E., Kleeberg C., Muema J.M., Heitkämper S., Verwaaijen B., Kuhnert E., Gerke J., Kalinowski J., Hyde K.D., Stadler M., ... , Cox R., Surup F. (2025)
Lienhwalides: Unique Tropolone-Maleidride Hybrids from Hypoxylon lienhwacheense
Chembiochem.
DOI: 10.1002/cbic.202500037 HZI-Repositorium PubMed
Demir Ö., Schmidt K., Schulz B., Stradal T.E.B., Surup F. (2025)
Cytochalasins from the Ash Endophytic Fungus Nemania diffusa DSM 116299
Molecules, 30 (4)
DOI: 10.3390/molecules30040957 HZI-Repositorium PubMed
Ridley M., Demir Ö., Charria-Giron E., Schulz B., Steinert M., ... , Surup F., Enderle R. (2025)
Priming of ash saplings with a low virulent Hymenoscyphus fraxineus strain as a possible disease control approach for reducing symptoms of ash dieback
Journal of Plant Diseases and Protection, 132 (2)
DOI: 10.1007/s41348-024-01056-z HZI-Repositorium
Wongkanoun S., Charria-Giron E., Cedeno-Sanchez M., Chainuwong B., Somrithipol S., Kuhnert E., Srikitikulchai P., Pornputtapong N., Surup F., ... , Luangsa-ard J., Stadler M. (2025)
Hypoxylon luteogranulatum (Hypoxylaceae, Xylariales), a novel species from Thailand with distinct chemical and ecological traits
Mycol.
DOI: 10.1080/21501203.2024.2435979
Zdouc M.M., Blin K., Louwen N.L.L., Navarro J., Loureiro C., Bader C.D., Bailey C.B., Barra L., Booth T.J., Bozhüyük K.A.J., Cediel-Becerra J.D.D., Charlop-Powers Z., Chevrette M.G., Chooi Y.H., D'Agostino P.M., de Rond T., Del Pup E., Duncan K.R., Gu W., Hanif N., Helfrich E.J.N., Jenner M., Katsuyama Y., Korenskaia A., Krug D., Libis V., Lund G.A., Mantri S., Morgan K.D., Owen C., Phan C.S., Philmus B., Reitz Z.L., Robinson S.L., Singh K.S., Teufel R., Tong Y., Tugizimana F., Ulanova D., Winter J.M., Aguilar C., Akiyama D.Y., Al-Salihi S.A.A., Alanjary M., Alberti F., Aleti G., Alharthi S.A., Rojo M.Y.A., Arishi A.A., Augustijn H.E., Avalon N.E., velar-Rivas J.A., Axt K.K., Barbieri H.B., Barbosa J.C.J., Barboza Segato L.G., Barrett S.E., Baunach M., Beemelmanns C., Beqaj D., Berger T., Bernaldo-Agüero J., Bettenbühl S.M., Bielinski V.A., Biermann F., Borges R.M., Borriss R., Breitenbach M., Bretscher K.M., Brigham M.W., Buedenbender L., Bulcock B.W., Cano-Prieto C., Capela J., Carrion V.J., Carter R.S., Castelo-Branco R., Castro-Falcon G., Chagas F.O., Charria-Giron E., Chaudhri A.A., Chaudhry V., Choi H., Choi Y., Choupannejad R., Chromy J., Donahey M.S.C., Collemare J., Connolly J.A., Creamer K.E., Crüsemann M., Cruz A.A., Cumsille A., Dallery J.F., Damas-Ramos L.C., Damiani T., de Kruijff M., Martin B.D., Sala G.D., Dillen J., Doering D.T., Dommaraju S.R., Durusu S., Egbert S., Ellerhorst M., Faussurier B., Fetter A., Feuermann M., Fewer D.P., Foldi J., Frediansyah A., Garza E.A., Gavriilidou A., Gentile A., Gerke J., Gerstmans H., Gomez-Escribano J.P., Gonzalez-Salazar L.A., Grayson N.E., Greco C., Gomez J.E.G., Guerra S., Flores S.G., Gurevich A., Gutierrez-Garcia K., Hart L., Haslinger K., He B., Hebra T., Hemmann J.L., Hindra H., Höling L., Holland D.C., Holme J.E., Horch T., Hrab P., Hu J., Huynh T.H., Hwang J.Y., Iacovelli R., Iftime D., Iorio M., Jayachandran S., Jeong E., Jing J., Jung J.J., Kakumu Y., Kalkreuter E., Kang K.B., Kang S., Kim W., Kim G.J., Kim H., Kim H.U., Klapper M., Koetsier R.A., Kollten C., Kovacs A., Kriukova Y., Kubach N., Kunjapur A.M., Kushnareva A.K., Kust A., Lamber J., Larralde M., Larsen N.J., Launay A.P., Le N.T., Lebeer S., Lee B.T., Lee K., Lev K.L., Li S.M., Li Y.X., Licona-Cassani C., Lien A., Liu J., Lopez J.A.V., Machushynets N.V., Macias M.I., Mahmud T., Maleckis M., Martinez-Martinez A.M., Mast Y., Maximo M.F., McBride C.M., McLellan R.M., Bhatt K.M., Melkonian C., Merrild A., Metsä-Ketelä M., Mitchell D.A., Müller A.V., Nguyen G.S., Nguyen H.T., Niedermeyer T.H.J., O'Hare J.H., Ossowicki A., Ostash B.O., Otani H., Padva L., Paliyal S., Pan X., Panghal M., Parade D.S., Park J., Parra J., Rubio M.P., Pham H.T., Pidot S.J., Piel J., Pourmohsenin B., Rakhmanov M., Ramesh S., Rasmussen M.H., Rego A., Reher R., Rice A.J., Rigolet A., Romero-Otero A., Rosas-Becerra L.R., Rosiles P.Y., Rutz A., Ryu B., Sahadeo L.A., Saldanha M., Salvi L., Sanchez-Carvajal E., Santos-Medellin C., Sbaraini N., Schoellhorn S.M., Schumm C., Sehnal L., Selem N., Shah A.D., Shishido T.K., Sieber S., Silviani V., Singh G., Singh H., Sokolova N., Sonnenschein E.C., Sosio M., Sowa S.T., Steffen K., Stegmann E., Streiff A.B., Strüder A., Surup F., Svenningsen T., Sweeney D., Szenei J., Tagirdzhanov A., ... , Tan B., Tarnowski M.J. (2025)
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Nucleic Acids Res., 53 (D1)
DOI: 10.1093/nar/gkae1115 HZI-Repositorium PubMed
Hoberg N., Harms K., Surup F., Rühl M. (2024)
Bifunctional Sesquiterpene/Diterpene Synthase Agr2 from Cyclocybe aegerita Gives Rise to the Novel Diterpene Cyclocybene
ACS Chem.Biol.
DOI: 10.1021/acschembio.4c00178 HZI-Repositorium PubMed
Harms K., Charria-Giron E., Stchigel A.M., Marin-Felix Y., Surup F. (2024)
Reaping the Chemical Diversity of Morinagamyces vermicularis Using Feature-Based Molecular Networking
J.Nat.Prod., 87 (9)
DOI: 10.1021/acs.jnatprod.4c00654 HZI-Repositorium PubMed
Charria-Giron E., Zeng H., Gorelik T.E., Pahl A., Truong K.N., Schrey H., ... , Surup F., Marin-Felix Y. (2024)
Arcopilins: A New Family of Staphylococcus aureus Biofilm Disruptors from the Soil Fungus Arcopilus navicularis
J.Med.Chem., 67 (17)
DOI: 10.1021/acs.jmedchem.4c00585 HZI-Repositorium PubMed
Demir Ö., Chen Y., Lambert C., Schüffler A., Surup F., Stadler M. (2024)
Elucidation of the life cycle of a saprotrophic inoperculate discomycete that is associated with pinesap using a polyphasic taxonomic approach
Mycological Progress, 23 (1)
DOI: 10.1007/s11557-024-01978-w HZI-Repositorium
Demir Ö., Schulz B., Rabsch L., Steinert M., Surup F. (2024)
Strong antagonism of an endophyte of Fraxinus excelsior towards the ash dieback pathogen, Hymenoscyphus fraxineus, is mediated by the antifungal secondary metabolite PF1140
Appl.Environ.Microbiol.
DOI: 10.1128/aem.00665-24 HZI-Repositorium PubMed
Surup F. (2024)
Die Auferstehung von Paleomycin, Urvater der Glykopeptid-Antibiotika
Biospektrum, 30 (2)
DOI: 10.1007/s12268-024-2150-9
Hyde K.D., Baldrian P., Chen Y., Thilini Chethana K.W., de Hoog S., Doilom M., de Farias A.R.G., Goncalves M.F.M., Gonkhom D., Gui H., Hilario S., Hu Y., Jayawardena R.S., Khyaju S., Kirk P.M., Kohout P., Luangharn T., Maharachchikumbura S.S.N., Manawasinghe I.S., Mortimer P.E., Niego A.G.T., Phonemany M., Sandargo B., Senanayake I.C., Stadler M., Surup F., Thongklang N., Wanasinghe D.N., ... , Bahkali A.H., Walker A. (2024)
Current trends, limitations and future research in the fungi?
Fungal Diversity
DOI: 10.1007/s13225-023-00532-5
Pfütze S., Charria-Giron E., Schulzke E., Toshe R., Khonsanit A., Franke R., Surup F., ... , Brönstrup M., Stadler M. (2024)
Depicting the Chemical Diversity of Bioactive Meroterpenoids Produced by the Largest Organism on Earth
Angew.Chem.Int.Ed Engl.
DOI: 10.1002/anie.202318505 HZI-Repositorium PubMed
Charria-Giron E., Marin-Felix Y., Beutling U., Franke R., Brönstrup M., Vasco-Palacios A.M., ... , Caicedo N.H., Surup F. (2023)
Metabolomics insights into the polyketide-lactones produced by Diaporthe caliensis sp. nov., an endophyte of the medicinal plant Otoba gracilipes
Microbiol.Spectr.
DOI: 10.1128/spectrum.02743-23 HZI-Repositorium PubMed
Mountessou B.Y.G., Anoumedem E.G.M., Kemkuignou B.M., Marin-Felix Y., Surup F., ... , Stadler M., Kouam S.F. (2023)
Secondary metabolites of Diaporthe cameroonensis, isolated from the Cameroonian medicinal plant Trema guineensis
Beilstein.J.Org.Chem., 19
DOI: 10.3762/bjoc.19.112 HZI-Repositorium PubMed
Harms K., Paomephan P., Boonpratuang T., Choeyklin R., Boonchird C., Surup F. (2023)
ent-Clavilactone J and Its Quinone Derivative, Meroterpenoids from the Fungus Resupinatus sp
J.Nat.Prod., 86 (11)
DOI: 10.1021/acs.jnatprod.3c00174 HZI-Repositorium PubMed
Hennrich O., Weinmann L., Kulik A., Harms K., Klahn P., Youn J.W., ... , Surup F., Mast Y. (2023)
Biotransformation-coupled mutasynthesis for the generation of novel pristinamycin derivatives by engineering the phenylglycine residue
RSC.Chem.Biol., 4 (12)
DOI: 10.1039/d3cb00143a HZI-Repositorium PubMed
Demir Ö., Zeng H., Schulz B., Schrey H., Steinert M., ... , Stadler M., Surup F. (2023)
Bioactive Compounds from an Endophytic Pezicula sp. Showing Antagonistic Effects against the Ash Dieback Pathogen
Biomolecules, 13 (11)
DOI: 10.3390/biom13111632 HZI-Repositorium PubMed
Pfütze S., Nedder D.L., Surup F., Stadler M. (2023)
5'-O-methyl-14-hydroxyarmillane, a new armillane-type sesquiterpene from cultures of Guyanagaster necrorhiza
Mycol.Prog., 22 (10)
DOI: 10.1007/s11557-023-01920-6 HZI-Repositorium
Wetzel C., Jansen-Olliges L., Stadler M., Surup F., Zeilinger C., Roth B. (2023)
Analysis of SARS-CoV-2 spike RBD binding to ACE2 and its inhibition by fungal cohaerin C using surface enhanced Raman spectroscopy
Biomed.Opt.Express, 14 (8)
DOI: 10.1364/BOE.495685 HZI-Repositorium PubMed
Pfütze S., Khamsim A., Surup F., Decock C., Matasyoh J.C., Stadler M. (2023)
Heimionones A-E, New Sesquiterpenoids Produced by Heimiomyces sp., a Basidiomycete Collected in Africa
Molecules, 28 (9)
DOI: 10.3390/molecules28093723 HZI-Repositorium PubMed
Charria-Giron E., Stchigel A.M., Cmoková A., Kolarík M., Surup F., Marin-Felix Y. (2023)
Amesia hispanica sp. nov., Producer of the Antifungal Class of Antibiotics Dactylfungins
J.Fungi.(Basel), 9 (4)
DOI: 10.3390/jof9040463 HZI-Repositorium PubMed
Lambert C., Shao L., Zeng H., Surup F., Saetang P., Aime M.C., Husbands D.R., Rottner K., ... , Stradal T.E.B., Stadler M. (2023)
Cytochalasans produced by Xylaria karyophthora and their biological activities
Mycologia
DOI: 10.1080/00275514.2023.2188868 HZI-Repositorium PubMed
Pfütze S., Khamsim A., Surup F., Decock C., Matasyoh J.C., Stadler M. (2023)
Calamene-Type Sesqui-, Mero-, and Bis-sesquiterpenoids from Cultures of Heimiomyces sp., a Basidiomycete Collected in Africa
J.Nat.Prod.
DOI: 10.1021/acs.jnatprod.2c01015 HZI-Repositorium PubMed
Jansen-Olliges L., Chatterjee S., Jia L., Stahl F., Bär C., Stadler M., ... , Surup F., Zeilinger C. (2022)
Multiformin-Type Azaphilones Prevent SARS-CoV-2 Binding to ACE2 Receptor
Cells, 12 (1)
DOI: 10.3390/cells12010083 HZI-Repositorium PubMed
Feng T., Surup F. (2022)
Secondary Metabolites from Fungi
J.Fungi, 8 (12)
DOI: 10.3390/jof8121271 HZI-Repositorium PubMed
Rezadoost M.H., Kumleh H.H., Farhadpour M., Ghasempour A., Surup F. (2023)
In vitro antiproliferative activity of Parrotia persica exclusive gallotannin
Med.Chem.Res.
DOI: 10.1007/s00044-022-02985-w HZI-Repositorium
Pathompong P., Pfütze S., Surup F., Boonpratuang T., Choeyklin R., Matasyoh J.C., Decock C., ... , Stadler M., Boonchird C. (2022)
Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov
Molecules., 27 (18)
DOI: 10.3390/molecules27185968 HZI-Repositorium PubMed
Mapook A., Hyde K.D., Hassan K., Kemkuignou B.M., Cmoková A., Surup F., Kuhnert E., Paomephan P., Cheng T., de Hoog S., Song Y., Jayawardena R.S., Al-Hatmi A.M.S., Mahmoudi T., Ponts N., Studt-Reinhold L., Richard-Forget F., Chethana K.W.T., Harishchandra D.L., Mortimer P.E., Li H., Lumyong S., Aiduang W., Kumla J., Suwannarach N., Bhunjun C.S., Yu F.M., Zhao Q., ... , Schaefer D., Stadler M. (2022)
Ten decadal advances in fungal biology leading towards human well-being
Fungal Diversity
DOI: 10.1007/s13225-022-00510-3 HZI-Repositorium PubMed
Becker K., Kuhnert E., Cox R.J., Surup F. (2021)
Azaphilone Pigments from Hypoxylon rubiginosum and H. texense: Absolute Configuration, Bioactivity, and Biosynthesis
European Journal of Organic Chemistry, 2021 (36)
DOI: 10.1002/ejoc.202001661 HZI-Repositorium PubMed
Pourmoghaddam M.J., Ekiz G., Lambert C., Surup F., Primahana G., Wittstein K., Khodaparast S.A., Voglmayr H., Krisai-Greilhuber I., ... , Stradal T.E.B., Stadler M. (2022)
Studies on the secondary metabolism of Rosellinia and Dematophora strains (Xylariaceae) from Iran
Mycol.Prog., 21 (8)
DOI: 10.1007/s11557-022-01816-x HZI-Repositorium
Garcia K.Y.M., Quimque M.T.J., Lambert C., Schmidt K., Primahana G., Stradal T.E.B., Ratzenböck A., Dahse H.M., Phukhamsakda C., Stadler M., ... , Surup F., Macabeo A.P.G. (2022)
Antiproliferative and Cytotoxic Cytochalasins from Sparticola triseptata Inhibit Actin Polymerization and Aggregation
J.Fungi.(Basel), 8 (6)
DOI: 10.3390/jof8060560 HZI-Repositorium PubMed
Charria-Girón E., Surup F., Marin-Felix Y. (2022)
Diversity of biologically active secondary metabolites in the ascomycete order Sordariales
Mycological Progress, 21 (4)
DOI: 10.1007/s11557-022-01775-3 HZI-Repositorium
Garcia K.Y.M., Quimque M.T.J., Primahana G., Ratzenböck A., Cano M.J.B., Llaguno J.F.A., Dahse H.M., Phukhamsakda C., Surup F., ... , Stadler M., Macabeo A.P.G. (2021)
COX inhibitory and cytotoxic naphthoketal-bearing polyketides from Sparticola junci
Int.J.Mol.Sci., 22 (22)
DOI: 10.3390/ijms222212379 HZI-Repositorium PubMed
Khodamoradi S., Hahnke R.L., Mast Y., Schumann P., Kämpfer P., Steinert M., Rückert C., Surup F., ... , Rohde M., Wink J. (2021)
Streptomonospora litoralis sp. nov., a halophilic thiopeptides producer isolated from sand collected at Cuxhaven beach
Antonie Van Leeuwenhoek Int.J.Gen.Mol.Microbiol.
DOI: 10.1007/s10482-021-01609-4 HZI-Repositorium PubMed
Sandargo B., Kaysan L., Teponno R.B., Richter C., Thongbai B., ... , Surup F., Stadler M. (2021)
Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp
Beilstein Journal of Organic Chemistry, 17
DOI: 10.3762/bjoc.17.97 HZI-Repositorium PubMed
Nazir M., Saleem M., Tousif M.I., Anwar M.A., Surup F., Ali I., Wang D., Mamadalieva N.Z., Alshammari E., Ashour M.L., Ashour A.M., Ahmed I., Elizbit, ... , Green I.R., Hussain H. (2021)
Meroterpenoids: A comprehensive update insight on structural diversity and biology
Biomolecules, 11 (7)
DOI: 10.3390/biom11070957 HZI-Repositorium PubMed
Primahana G., Narmani A., Surup F., Teponno R.B., Arzanlou M., Stadler M. (2021)
Five tetramic acid derivatives isolated from the iranian fungus colpoma quercinum cctu a372
Biomolecules, 11 (6)
DOI: 10.3390/biom11060783 HZI-Repositorium PubMed
Harms K., Surup F., Stadler M., Stchigel A.M., Marin-Felix Y. (2021)
Morinagadepsin, a depsipeptide from the fungus morinagamyces vermicularis gen. Et comb. nov
Microorg., 9 (6)
DOI: 10.3390/microorganisms9061191 HZI-Repositorium
Primahana G., Risdian C., Mozef T., Wink J., Surup F., Stadler M. (2021)
Amycolatomycins a and b, cyclic hexapeptides isolated from an amycolatopsis sp. 195334cr
Antibiotics, 10 (3)
DOI: 10.3390/antibiotics10030261 HZI-Repositorium PubMed
Harms K., Milic A., Stchigel A.M., Stadler M., Surup F., Marin-Felix Y. (2021)
Three new derivatives of zopfinol from pseudorhypophila mangenotii gen. Et comb. nov
J.Fungi, 7 (3)
DOI: 10.3390/jof7030181 HZI-Repositorium PubMed
Lambert C., Pourmoghaddam M.J., Cedeno-Sanchez M., Surup F., Khodaparast S.A., Krisai-Greilhuber I., Voglmayr H., ... , Stradal T.E.B., Stadler M. (2021)
Resolution of the Hypoxylon fuscum complex (hypoxylaceae, xylariales) and discovery and biological characterization of two of its prominent secondary metabolites
J.Fungi, 7 (2)
DOI: 10.3390/jof7020131 HZI-Repositorium PubMed
Anoumedem E.G.M., Mountessou B.Y.G., Kouam S.F., Narmani A., Surup F. (2020)
Simplicilones A and B Isolated from the Endophytic Fungus Simplicillium subtropicum SPC3
Antibiotics, 9 (11)
DOI: 10.3390/antibiotics9110753 HZI-Repositorium PubMed
Grubbs K.J., Surup F., Biedermann P.H.W., McDonald B.R., Klassen J.L., Carlson C.M., ... , Clardy J., Currie C.R. (2020)
Cycloheximide-Producing Streptomyces Associated With Xyleborinus saxesenii and Xyleborus affinis Fungus-Farming Ambrosia Beetles
Front.Microbiol., 11
DOI: 10.3389/fmicb.2020.562140 HZI-Repositorium PubMed
Shao L., Marin-Felix Y., Surup F., Stchigel A.M., Stadler M. (2020)
Seven New Cytotoxic and Antimicrobial Xanthoquinodins from Jugulospora vestita
J Fungi (Basel), 6 (4)
DOI: 10.3390/jof6040188 HZI-Repositorium PubMed
Feng J., Surup F., Hauser M., Miller A., Wennrich J.P., Stadler M., ... , Cox R.J., Kuhnert E. (2020)
Biosynthesis of oxygenated brasilane terpene glycosides involves a promiscuous N-acetylglucosamine transferase
Chem.Commun.(Camb.), 56 (82)
DOI: 10.1039/d0cc03950k HZI-Repositorium PubMed
Kallscheuer N., Jeske O., Sandargo B., Boedeker C., Wiegand S., Bartling P., Jogler M., Rohde M., Petersen J., Medema M.H., ... , Surup F., Jogler C. (2020)
Author Correction: The planctomycete Stieleria maiorica Mal15T employs stieleriacines to alter the species composition in marine biofilms (Communications biology (2020) 3 1 (303))
Commun Biol, 3 (1)
DOI: 10.1038/s42003-020-01228-1 HZI-Repositorium PubMed
Surup F., Wiegand S., Boedeker C., Heuer A., Peeters S.H., Jogler M., Jetten M.S.M., Rohde M., ... , Jogler C., Kallscheuer N. (2020)
Stieleria varia sp. nov., isolated from wood particles in the Baltic Sea, constitutes a novel species in the family Pirellulaceae within the phylum Planctomycetes
Antonie Van Leeuwenhoek Int.J.Gen.Mol.Microbiol., 113 (12)
DOI: 10.1007/s10482-020-01456-9 HZI-Repositorium PubMed
Becker K., Pfütze S., Kuhnert E., Cox R., Stadler M., Surup F. (2020)
Hybridorubrins A-D, novel azaphilone heterodimers from stromata of Hypoxylon fragiforme and insights into the biosynthetic machinery for azaphilone diversification
Chemistry.
DOI: 10.1002/chem.202003215 HZI-Repositorium PubMed
Sandargo B., Jeske O., Boedeker C., Wiegand S., Wennrich J.P., Kallscheuer N., Jogler M., Rohde M., ... , Jogler C., Surup F. (2020)
Stieleriacines, N-Acyl Dehydrotyrosines From the Marine Planctomycete Stieleria neptunia sp. nov
Front.Microbiol., 11
DOI: 10.3389/fmicb.2020.01408 HZI-Repositorium PubMed
Surup F., Minh Thi Tran T., Pfütze S., Budde J., Moussa-Ayoub T.E., ... , Rohn S., Jerz G. (2021)
Opuntisines, 14-membered cyclopeptide alkaloids from fruits of Opuntia stricta var. dillenii isolated by high-performance countercurrent chromatography
Food Chem., 334 (January)
DOI: 10.1016/j.foodchem.2020.127552 HZI-Repositorium PubMed
Khodamoradi S., Stadler M., Wink J., Surup F. (2020)
Litoralimycins A and B, New Cytotoxic Thiopeptides from Streptomonospora sp. M2
Mar.Drugs, 18 (6)
DOI: 10.3390/md18060280 HZI-Repositorium PubMed
Kallscheuer N., Jeske O., Sandargo B., Boedeker C., Wiegand S., Bartling P., Jogler M., Rohde M., Petersen J., Medema M.H., ... , Surup F., Jogler C. (2020)
The planctomycete Stieleria maiorica Mal15(T) employs stieleriacines to alter the species composition in marine biofilms
Commun.Biol., 3 (1)
DOI: 10.1038/s42003-020-0993-2 HZI-Repositorium PubMed
Pourmoghaddam M.J., Lambert C., Surup F., Khodaparast S.A., Krisai-Greilhuber I., ... , Voglmayr H., Stadler M. (2020)
Discovery of a new species of the Hypoxylon rubiginosum complex from Iran and antagonistic activities of Hypoxylon spp. against the Ash Dieback pathogen, Hymenoscyphus fraxineus, in dual culture
MycoKeys., 66
DOI: 10.3897/mycokeys.66.50946 HZI-Repositorium PubMed
Halecker S., Wennrich J.P., Rodrigo S., Andrée N., Rabsch L., Baschien C., Steinert M., Stadler M., ... , Surup F., Schulz B. (2020)
Fungal endophytes for biocontrol of ash dieback: The antagonistic potential of Hypoxylon rubiginosum
Fungal Ecol., 45 (June 2020)
DOI: 10.1016/j.funeco.2020.100918
Lopez-Fernández S., Campisano A., Schulz B.J., Steinert M., Stadler M., Surup F. (2020)
Viriditins from Byssochlamys spectabilis, their stereochemistry and biosynthesis
Tetrahedron Lett., 61 (5)
DOI: 10.1016/j.tetlet.2019.151446 HZI-Repositorium
Sandargo B., Michehl M., Stadler M., Surup F. (2020)
Antifungal Sesquiterpenoids, Rhodocoranes, from Submerged Cultures of the Wrinkled Peach Mushroom, Rhodotus palmatus
J.Nat.Prod., 83 (3)
DOI: 10.1021/acs.jnatprod.9b00871 HZI-Repositorium PubMed
Buatong J., Rukachaisirikul V., Sangkanu S., Surup F., Phongpaichit S. (2019)
Antifungal metabolites from marine-derived Streptomyces sp. AMA49 against Pyricularia oryzae
J.Pure Appl.Microbiol., 13 (2)
DOI: 10.22207/JPAM.13.2.02 HZI-Repositorium
Surup F., Hennicke F., Sella N., Stroot M., Bernecker S., Pfütze S., ... , Stadler M., Rühl M. (2019)
New terpenoids from the fermentation broth of the edible mushroom Cyclocybe aegerita
Beilstein J.Org.Chem., 15
DOI: 10.3762/bjoc.15.98 HZI-Repositorium PubMed
Sandargo B., Michehl M., Praditya D., Steinmann E., Stadler M., Surup F. (2019)
Antiviral Meroterpenoid Rhodatin and Sesquiterpenoids Rhodocoranes A-E from the Wrinkled Peach Mushroom, Rhodotus palmatus
Org.Lett., 21 (9)
DOI: 10.1021/acs.orglett.9b01017 HZI-Repositorium PubMed
Adam S., Klein A., Surup F., Koehnke J. (2019)
The structure of CgnJ, a domain of unknown function protein from the crocagin gene cluster
Acta Crystallogr.Sect.F Struct.Biol.Commun., 75 (3)
DOI: 10.1107/S2053230X19000712 PubMed
Kretz R., Wendt L., Wongkanoun S., Luangsa-ard J.J., Surup F., Helaly S.E., Noumeur S.R., ... , Stadler M., Stradal T.E.B. (2019)
The Effect of Cytochalasans on the Actin Cytoskeleton of Eukaryotic Cells and Preliminary Structure(-)Activity Relationships
Biomolecules., 9 (2)
DOI: 10.3390/biom9020073 HZI-Repositorium PubMed
Narmani A., Teponno R.B., Arzanlou M., Surup F., Helaly S.E., Wittstein K., Praditya D.F., Babai-Ahari A., ... , Steinmann E., Stadler M. (2019)
Cytotoxic, antimicrobial and antiviral secondary metabolites produced by the plant pathogenic fungus Cytospora sp. CCTU A309
Fitoterapia, 134
DOI: 10.1016/j.fitote.2019.02.015 HZI-Repositorium PubMed
Narmani A., Pichai S., Palani P., Arzanlou M., Surup F., Stadler M. (2019)
Daldinia sacchari (Hypoxylaceae) from India produces the new cytochalasins Saccalasins A and B and belongs to the D. eschscholtzii species complex
Mycol.Prog., 18 (1-2)
DOI: 10.1007/s11557-018-1413-6 PubMed
Mountessou B.Y.G., Tchamgoue J., Paul Dzoyem J., Tchuenguem R.T., Surup F., Choudhary M.I., ... , Green I.R., Kouam S.F. (2018)
Two xanthones and two rotameric (3->8) biflavonoids from the Cameroonian medicinal plant Allanblackia floribunda Oliv. (Guttiferae)
Tetrahedron Lett., 59 (52)
DOI: 10.1016/j.tetlet.2018.11.035 HZI-Repositorium
Surup F., Chauhan D., Niggemann J., Bartok E., Herrmann J., Keck M., Zander W., Stadler M., ... , Hornung V., Müller R. (2018)
Activation of the NLRP3 Inflammasome by Hyaboron, a New Asymmetric Boron-Containing Macrodiolide from the Myxobacterium Hyalangium minutum
ACS Chem.Biol., 13 (10)
DOI: 10.1021/acschembio.8b00659 PubMed
Yuyama K.T., Wendt L., Surup F., Kretz R., Chepkirui C., Wittstein K., Boonlarppradab C., Wongkanoun S., Luangsa-ard J., ... , Stadler M., Abraham W.R. (2018)
Cytochalasans Act as Inhibitors of Biofilm Formation of Staphylococcus Aureus
Biomolecules, 8 (4)
DOI: 10.3390/biom8040129 HZI-Repositorium PubMed
Sandargo B., Thongbai B., Praditya D., Steinmann E., Stadler M., Surup F. (2018)
Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete Hohenbuehelia grisea
Molecules., 23 (10)
DOI: 10.3390/molecules23102697 HZI-Repositorium
Surup F., Narmani A., Wendt L., Pfütze S., Kretz R., Becker K., Membrivès C., Giosa A., Elliott M., Petit C., ... , Rohde M., Stadler M. (2018)
Identification of fungal fossils and novel azaphilone pigments in ancient carbonised specimens of Hypoxylon fragiforme from forest soils of Chatillon-sur-Seine (Burgundy)
Fungal Diversity, 92 (1)
DOI: 10.1007/s13225-018-0412-x
Surup F., Halecker S., Nimtz M., Rodrigo S., Schulz B., ... , Steinert M., Stadler M. (2018)
Hyfraxins A and B, cytotoxic ergostane-type steroid and lanostane triterpenoid glycosides from the invasive ash dieback ascomycete Hymenoscyphus fraxineus
Steroids, 135 (July)
DOI: 10.1016/j.steroids.2018.03.007 PubMed
Surup F., Pommerehne K., Schroers H.J., Stadler M. (2018)
Elsinopirins A-D, Decalin Polyketides from the Ascomycete Elsinoë pyri
Biomolecules., 8 (1)
DOI: 10.3390/biom8010008 HZI-Repositorium PubMed
Sandargo B., Thongbai B., Stadler M., Surup F. (2018)
Cysteine-Derived Pleurotin Congeners from the Nematode-Trapping Basidiomycete Hohenbuehelia grisea
J.Nat.Prod., 81 (2)
DOI: 10.1021/acs.jnatprod.7b00713
Abouzeid S., Beutling U., Surup F., Abdel Bar F.M., Amer M.M., Badria F.A., Yahyazadeh M., ... , Brönstrup M., Selmar D. (2017)
Treatment of Vinca minor Leaves with Methyl Jasmonate Extensively Alters the Pattern and Composition of Indole Alkaloids
J.Nat.Prod., 80 (11)
DOI: 10.1021/acs.jnatprod.7b00424 PubMed
Surup F., Viehrig K., Rachid S., Plaza A., Maurer C.K., ... , Hartmann R.W., Müller R. (2017)
Crocadepsins-Depsipeptides from the Myxobacterium Chondromyces crocatus Found by a Genome Mining Approach
ACS Chem.Biol., 13 (1)
DOI: 10.1021/acschembio.7b00900 PubMed
Surup F., Kuhnert E., Bohm A., Wiebach V., Solga D., Engler H., Pendzialek T., Berkessel A., ... , Stadler M., Kalesse M. (2017)
The rickiols, 20-, 22-, and 24-membered macrolides from the ascomycete Hypoxylon rickii
Chemistry, 24 (9)
DOI: 10.1002/chem.201704928 PubMed
Bihelovic F., Stichnoth D., Surup F., Müller R., Trauner D. (2017)
Total Synthesis of Crocagin A
Angew.Chem.Int.Ed., 56 (42)
DOI: 10.1002/anie.201612641 PubMed
Mohammadi-Ostad-Kalayeh S., Hrupins V., Helmsen S., Stahl F., Scheper T., Preller M., Surup F., Stadler M., ... , Kirschning A., Zeilinger C. (2017)
Development of a microarray-based assay for efficient testing of new HSP70/DnaK inhibitors
Bioorg.Med.Chem., 25 (24)
DOI: 10.1016/j.bmc.2017.10.003
Halecker S., Surup F., Solheim H., Stadler M. (2017)
Albiducins A and B, salicylaldehyde antibiotics from the ash tree-associated saprotrophic fungus Hymenoscyphus albidus
J.Antibiot.(Tokyo), 71 (2)
DOI: 10.1038/ja.2017.66 PubMed
Viehrig K., Surup F., Volz C., Herrmann J., Abou Fayad A., Adam S., Kohnke J., ... , Trauner D., Müller R. (2017)
Structure and Biosynthesis of Crocagins: Polycyclic Postranslationally Modified Ribosomal Peptides from Chondromyces crocatus
Angew.Chem.Int.Ed Engl., 56 (26)
DOI: 10.1002/anie.201612640 PubMed
Kuhnert E., Surup F., Halecker S., Stadler M. (2017)
Minutellins A - D, azaphilones from the stromata of Annulohypoxylon minutellum (Xylariaceae)
Phytochemistry, 137
DOI: 10.1016/j.phytochem.2017.02.014 HZI-Repositorium PubMed
Wiebach V., Surup F., Kuhnert E., Stadler M. (2016)
Rickicaryophyllane, a caryophyllane from the ascomyceteous fungus Hypoxylon rickii and a 10-norbotryane congener
Natural Product Communications, 11 (7)
DOI: 10.9555/9475/npc/11/7/90 HZI-Repositorium PubMed
Sudarman E., Kuhnert E., Hyde K.D., Sir E.B., Surup F., Stadler M. (2016)
Truncatones A-D, benzo[j]fluoranthenes from Annulohypoxylon species (Xylariaceae, Ascomycota)
Tetrahedron, 72 (41)
DOI: 10.1016/j.tet.2016.08.054
Jeske O., Surup F., Ketteniss M., Rast P., Forster B., Jogler M., ... , Wink J., Jogler C. (2016)
Developing Techniques for the Utilization of Planctomycetes As Producers of Bioactive Molecules
Front Microbiol., 7
DOI: 10.3389/fmicb.2016.01242 HZI-Repositorium PubMed
Surup F., Wiebach V., Kuhnert E., Stadler M. (2016)
Truncaquinones A and B, asterriquinones from Annulohypoxylon truncatum
Tetrahedron Lett., 57 (20)
DOI: 10.1016/j.tetlet.2016.04.014
Kuhnert E., Surup F., Herrmann J., Huch V., Müller R., Stadler M. (2015)
Rickenyls A-E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota)
Phytochemistry, 118
Surup F., Kuhnert E., Liscinskij E., Stadler M. (2015)
Silphiperfolene-Type Terpenoids and Other Metabolites from Cultures of the Tropical Ascomycete Hypoxylon rickii (Xylariaceae)
Nat.Prod.Bioprospect., 5 (3)
DOI: 10.1007/s13659-015-0065-3 HZI-Repositorium PubMed
Kuhnert E., Surup F., Wiebach V., Bernecker S., Stadler M. (2015)
Botryane, noreudesmane and abietane terpenoids from the ascomycete Hypoxylon rickii
Phytochemistry, 117
DOI: 10.1016/j.phytochem.2015.06.002 HZI-Repositorium PubMed
Surup F., Medjedovic A., Schroers H.J., Stadler M. (2015)
Production of Obionin A and Derivatives by the Sooty Blotch Fungus Microcyclospora malicola
Planta Med.
DOI: 10.1055/s-0035-1545908 HZI-Repositorium PubMed
Surup F., Thongbai B., Kuhnert E., Sudarman E., Hyde K.D., Stadler M. (2015)
Deconins A-E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471
J Nat.Prod., 78 (4)
Kuhnert E., Surup F., Sir E.B., Lambert C., Hyde K.D., Hladki A.I., ... , Romero A.I., Stadler M. (2015)
Lenormandins AùG, new azaphilones from Hypoxylon lenormandii and Hypoxylon jaklitschii sp. nov., recognised by chemotaxonomic data
Fungal Diversity, 71 (1)
Sir E.B., Kuhnert E., Surup F., Hyde K.D., Stadler M. (2015)
Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales)
Mycol.Prog., 14 (5)
Surup F., Viehrig K., Mohr K.I., Herrmann J., Jansen R., Müller R. (2014)
Disciformycins A and B: 12-Membered Macrolide Glycoside Antibiotics from the Myxobacterium Pyxidicoccus fallax Active against Multiresistant Staphylococci
Angewandte Chemie International Edition, 53 (49)
Surup F., Kuhnert E., Lehmann E., Heitkämper S., Hyde K.D., ... , Fournier J., Stadler M. (2014)
Sporothriolide derivatives as chemotaxonomic markers for Hypoxylon monticulosum
Mycologia, 5 (3)
Müller S., Rachid S., Hoffmann T., Surup F., Volz C., ... , Zaburannyi N., Müller Rolf (2014)
Biosynthesis of Crocacin Involves an Unusual Hydrolytic Release Domain Showing Similarity to Condensation Domains
Chemistry and Biology, 21 (7)
DOI: 10.1016/j.chembiol.2014.05.012 HZI-Repositorium PubMed
Surup F., Medjedovic A., Szczygielski M., Schroers H.J., Stadler M. (2014)
Production of Trichothecenes by the Apple Sooty Blotch Fungus Microcyclospora tardicrescens
Journal of Agricultural and Food Chemistry, 62 (16)
Halecker S., Surup F., Kuhnert E., Mohr K.I., Brock N.L., Dickschat J.S., Junker C., ... , Schulz B., Stadler M. (2014)
Hymenosetin, a 3-decalinoyltetramic acid antibiotic from cultures of the ash dieback pathogen, Hymenoscyphus pseudoalbidus
Phytochemistry, 100
DOI: 10.1016/j.phytochem.2014.01.018 HZI-Repositorium PubMed
Kuhnert E., Heitkämper S., Fournier J., Surup F., Stadler Marc (2014)
Hypoxyvermelhotins A-C, new pigments from Hypoxylon lechatii sp. nov
Fungal Biology, 118 (2)
DOI: 10.1016/j.funbio.2013.12.003 HZI-Repositorium PubMed
Surup F., Mohr K.I., Jansen R., Stadler M. (2013)
Cohaerins G-K, azaphilone pigments from Annulohypoxylon cohaerens and absolute stereochemistry of cohaerins C-K
Phytochemistry, 95
Thongbai B., Surup F., Mohr K., Kuhnert E., Hyde K.D., Stadler M. (2013)
Gymnopalynes A and B, Chloropropynyl-isocoumarin Antibiotics from Cultures of the Basidiomycete Gymnopus sp
Journal of Natural Products, 76 (11)
Viehrig K., Surup F., Harmrolfs K., Jansen Rolf, Kunze Brigitte, Müller Rolf (2013)
Concerted Action of P450 Plus Helper Protein To Form the Amino-hydroxy-piperidone Moiety of the Potent Protease Inhibitor Crocapeptin
Journal of the American Chemical Society, 135 (45)
Pazoutova S., Follert S., Bitzer J., Keck Matthias, Surup F., Srutka P., ... , Holusa J., Stadler Marc (2013)
A new endophytic insect-associated Daldinia species, recognised from a comparison of secondary metabolite profiles and molecular phylogeny
Fungal Diversity, 60 (1)
Surup F., Shojaei H., von Zezschwitz P., Kunze Brigitte*, Grond S. (2008)
Iromycins from Streptomyces sp. and from synthesis: new inhibitors of the mitochondrial electron transport chain
Bioorganic & Medicinal Chemistry, 16 (4)
DOI: 10.1016/j.bmc.2007.11.023 HZI-Repositorium PubMed

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