HIPS-Talk “Chemical Space Discovery of Bioactive Small Molecules and Peptides “
Chemical space describes the ensemble of all molecules that are possible by assembling atoms through covalent bonds. This concept is particularly relevant in drug discovery, where new molecular entities are constantly needed to develop new drugs addressing unmet medical needs. In our research we design cheminformatics methods for enumerating, mapping and virtual screening the chemical space of small organic molecules and peptides. We then implement these methods to choose, synthesize and test molecules in the laboratory. I will describe applications targeting ion channels, transporters and enzymes, as well as new peptide based antibiotics against multi-drug resistant bacteria.
Gebäude und Raum
Blg E8.1, Seminar Room (Ground Floor)
Prof. Dr. Jean-Louis Reymond
Jean-Louis Reymond is Professor of chemistry and chemical biology at the University of Bern, Switzerland. He studied at the ETH Zürich, the University of Lausanne, and the Scripps Research Institute. His research focuses on exploring chemical space for drug discovery by computational enumeration, virtual screening and synthesis in the areas of small molecule drug-like compounds and of topologically diverse peptides such as peptide dendrimers and polycyclic peptides. He has published over 200 scientific publications and holds several patents. For more details visit the Reymond group website at www.gdb.unibe.ch.
Dr. Alexander Titz