Prof. Dr. Ursula Bilitewski

Prof. Dr. Ursula Bilitewski
Forschungsgruppenleiterin

Prof. Dr. Ursula Bilitewski

Ursula Bilitewski studierte Chemie an der Universität Münster und promovierte am Institut für Physikalische Chemie. Im Anschluss, nach einem Jahr als Postdoc im selben Institut, wechselte Ursula Bilitewski nach Braunschweig und trat 1988 ins HZI – damals noch GBF – ein. Sie habilitierte 1994 in Biochemie an der Technischen Universität Braunschweig und ist dort seit 2002 außerplanmäßige Professorin für Biochemie.

Zunächst war ihre Forschung auf die Etablierung bioanalytischer Systeme im Mikromaßstab ausgerichtet, ehe sie 2002 in den Bereich der Wirkstoffforschung wechselte, um dort an der Aufklärung von molekularen Wirkmechanismen und der Identifizierung von Angriffspunkten von Wirkstoffen mit zu arbeiten.

Seit 2016 ist sie Leiterin der Arbeitsgruppe „Compound Profiling und Screening (COPS)“.

Publikationen
Haid S., Matthaei A., Winkler M., Sake S.M., Gunesch A.P., Milke V., Köhler N.M., Rückert J., Vieyres G., Kühl D., Nguyen T.-T., Göhl M., Lasswitz L., Zapatero-Belinchon F.J., Brogden G., Gerold G., Wiegmann B., Bilitewski U., Brown R.J.P., Brönstrup M., ... , Schulz T.F., Pietschmann T. (2024)
Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets
Antimicrob.Agents Chemother.

Magar H.S., Abdelghany H., Abbas M.N., Bilitewski U., Hassan R.Y.A. (2023)
Fast analysis of Staphylococcus aureus in food products using disposable label-free nano-electrochemical immunosensor chips
Microchem.J., 193 (October 2023)

Lettl C., Schindele F., Mehdipour A.R., Steiner T., Ring D., Brack-Werner R., Stecher B., Eisenreich W., Bilitewski U., Hummer G., Witschel M., ... , Fischer W., Haas R. (2023)
Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors
Cell Chem.Biol.

Gillsch F., Mbui F., Bilitewski U., Schobert R. (2023)
Syntheses and Antibacterial Evaluation of New Penicillium Metabolites Gregatins G and Thiocarboxylics C
Chem.Biodiversity

Gillsch F., Mbui F., Bilitewski U., Schobert R. (2022)
Synthesis and Bioactivity of Thiocarboxylic A and Derivatives
J Nat.Prod.

Holzwarth M., Ludwig J., Bernz A., Claasen B., Majoul A., Reuter J., Zens A., Pawletta B., Bilitewski U., ... , Weiss I.M., Laschat S. (2022)
Modulating chitin synthesis in marine algae with iminosugars obtained by SmI2 and FeCl3-mediated diastereoselective carbonyl ene reaction
Org.Biomol.Chem.

Wendler J., Vallejo L.F., Rinas U., Bilitewski U. (2022)
Publisher Correction to: Application of an SPR-based receptor assay for the determination of biologically active recombinant bone morphogenetic protein-2 (Analytical and Bioanalytical Chemistry, (2005), 381, 5, (1056-1064), 10.1007/s00216-004-3016-0)
Anal.Bioanal.Chem., 414 (22)

Suerbaum S., Coombs N., Patel L., Pscheniza D., Rox K., Falk C., Gruber A.D., Kershaw O., Chhatwal P., Brönstrup M., ... , Bilitewski U., Josenhans C. (2022)
Correction for Suerbaum et al., "Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model"
MBio.

Arshad H., Siokis A., Franke R., Habib A., Alfonso J.C.L., Poliakova Y., Lücke E., Michaelis K., Brönstrup M., Meyer-Hermann M., Bilitewski U., Vila J., Abel L., Illig T., ... , Schreiber J., Pessler F. (2022)
Reprogramming of Amino Acid Metabolism Differs between Community-Acquired Pneumonia and Infection-Associated Exacerbation of Chronic Obstructive Pulmonary Disease
Cells, 11 (15)

Zapol'skii V.A., Berneburg I., Bilitewski U., Dillenberger M., Becker K., Jungwirth S., Shekhar A., ... , Krueger B., Kaufmann D.E. (2022)
Chemistry of polyhalogenated nitrobutadienes, 17: Efficient synthesis of persubstituted chloroquinolinyl-1H-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities
Beilstein J.Org.Chem., 18

Suerbaum S., Coombs N., Patel L., Pscheniza D., Rox K., Falk C., Gruber A.D., Kershaw O., Chhatwal P., Brönstrup M., ... , Bilitewski U., Josenhans C. (2022)
Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model
MBio., 13 (2)

Hotop S.K., Reimering S., Shekhar A., Asgari E., Beutling U., Dahlke C., Fathi A., Khan F., Lütgehetmann M., Ballmann R., Gerstner A., Tegge W., Cicin-Sain L., Bilitewski U., ... , McHardy A.C., Brönstrup M. (2022)
Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2
Emerg.Microbes Infect, 11 (1)

Mühlen S., Zapol'skii V.A., Bilitewski U., Dersch P. (2021)
Identification of translocation inhibitors targeting the type III secretion system of enteropathogenic Escherichia coli
Antimicrob.Agents Chemother.

Treiber L., Pezolt C., Zeng H., Schrey H., Jungwirth S., Shekhar A., Stadler M., Bilitewski U., ... , Erb-Brinkmann M., Schobert R. (2021)
Dual Agents: Fungal Macrocidins and Synthetic Analogues with Herbicidal and Antibiofilm Activities
Antibiotics.(Basel), 10 (8)

Lettl C., Schindele F., Testolin G., Bär A., Rehm T., Brönstrup M., Schobert R., Bilitewski U., ... , Haas R., Fischer W. (2020)
Inhibition of Type IV Secretion Activity and Growth of Helicobacter pylori by Cisplatin and Other Platinum Complexes
Front Cell Infect.Microbiol., 10 (December 2020)

Icik E., Jolly A., Löffler P., Agelidis N., Bugdayci B., Altevogt L., Bilitewski U., ... , Baro A., Laschat S. (2020)
Synthesis and Biological Evaluation of a Library of AGE-Related Amino Acid Triazole Crosslinkers
Eur.J.Org.Chem., 2020 (33)

Seubert P., Freund M., Rudolf R., Lin Y., Altevogt L., Bilitewski U., ... , Baro A., Laschat S. (2020)
Buchwald-Hartwig versus Microwave-Assisted Amination of Chloroquinolines: En Route to the Pyoverdin Chromophore
Synlett, 31 (12)

Zapol'skii V.A., Bilitewski U., Kupiec S.R., Ramming I., Kaufmann D.E. (2020)
Polyhalonitrobutadienes as Versatile Building Blocks for the Biotargeted Synthesis of Substituted N-Heterocyclic Compounds
Molecules., 25 (12)

Cui S., Li M., Hassan R.Y.A., Heintz-Buschart A., Wang J., Bilitewski U. (2020)
Inhibition of Respiration of Candida albicans by Small Molecules Increases Phagocytosis Efficacy by Macrophages
mSphere, 5 (2)

Westerhausen S., Nowak M., Torres-Vargas C.E., Bilitewski U., Bohn E., ... , Grin I., Wagner S. (2020)
A NanoLuc luciferase-based assay enabling the real-time analysis of protein secretion and injection by bacterial type III secretion systems
Mol.Microbiol., 113 (6)

Hammad S.G., El-Gazzar M.G., Abutaleb N.S., Li D., Ramming I., Shekhar A., bdel-Halim M., Elrazaz E.Z., Seleem M.N., Bilitewski U., ... , Abouzid K.A.M., El-Hossary E.M. (2020)
Synthesis and antimicrobial evaluation of new halogenated 1,3-Thiazolidin-4-ones
Bioorg.Chem., 95 (January)

Arshad H., Alfonso J.C.L., Franke R., Michaelis K., Araujo L., Habib A., Zboromyrska Y., Lucke E., Strungaru E., Akmatov M.K., Hatzikirou H., Meyer-Hermann M., Petersmann A., Nauck M., Brönstrup M., Bilitewski U., Abel L., Sievers J., Vila J., Illig T., ... , Schreiber J., Pessler F. (2019)
Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia
J.Transl.Med., 17 (1)

Brennecke P., Rasina D., Aubi O., Herzog K., Landskron J., Cautain B., Vicente F., Quintana J., Mestres J., Stechmann B., Ellinger B., Brea J., Kolanowski J.L., Pilarski R., Orzaez M., Pineda-Lucena A., Laraia L., Nami F., Zielenkiewicz P., Paruch K., Hansen E., von Kries J.P., Neuenschwander M., Specker E., Bartunek P., Simova S., Lesnikowski Z., Krauss S., Lehtio L., Bilitewski U., Brönstrup M., Tasken K., Jirgensons A., Lickert H., Clausen M.H., Andersen J.H., Vicent M.J., Genilloud O., Martinez A., Nazare M., ... , Fecke W., Gribbon P. (2019)
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
SLAS.Discov., 24 (3)

Götz T., Schädel N., Petri N., Kirchhof M., Bilitewski U., Tovar G.E.M., ... , Laschat S., Southan A. (2018)
Triazole-based cross-linkers in radical polymerization processes: tuning mechanical properties of poly(acrylamide) and poly(N,N-dimethylacrylamide) hydrogels
RSC Adv., 8 (60)

Bilitewski U., Blodgett J.A.V., Duhme-Klair A.K., Dallavalle S., Laschat S., ... , Routledge A., Schobert R. (2017)
Chemical and Biological Aspects of Nutritional Immunity-Perspectives for New Anti-Infectives that Target Iron Uptake Systems
Angew.Chem.Int.Ed., 56 (46)

Neidhardt M.M., Schmitt K., Baro A., Schneider C., Bilitewski U., Laschat S. (2018)
Self-assembly and biological activities of ionic liquid crystals derived from aromatic amino acids
Phys.Chem.Chem.Phys., 20 (31)

Kempf K., Kempf O., Orozco M., Bilitewski U., Schobert R. (2017)
Synthesis and Structural Revision of the Fungal Tetramic Acid Metabolite Spiroscytalin
J.Org.Chem., 82 (15)

Gilardi A., Bhamidimarri S.P., Brönstrup M., Bilitewski U., Marreddy R.K.R., Pos K.M., Benier L., Gribbon P., ... , Winterhalter M., Windshugel B. (2017)
Biophysical characterization of E. coli TolC interaction with the known blocker hexaamminecobalt
Biochim.Biophys.Acta

Gündemir-Durmaz T., Schmid F., El Baz Y., Häusser A., Schneider C., Bilitewski U., Rauhut G., Garnier D., ... , Baro A., Laschat S. (2016)
Truncated borrelidin analogues: synthesis by sequential cross metathesis/olefination for the southern fragment and biological evaluation
Org.Biomol.Chem., 14 (35)

Cui S., Hassan R.Y., Heintz-Buschart A., Bilitewski U. (2016)
Regulation of Candida albicans Interaction with Macrophages through the Activation of HOG Pathway by Genistein
Molecules., 21 (2)

Bruckner S., Bilitewski U., Schobert R. (2016)
Synthesis and Antibacterial Activity of Four Stereoisomers of the Spider-Pathogenic Fungus Metabolite Torrubiellone D
Org.Lett., 18 (5)

Kaba H.E.J., Pölderl A., Bilitewski U. (2015)
Short Peptides Allowing Preferential Detection of Candida albicans Hyphae
Anal.Chem., 87 (17)

Khodari M., Bilitewski U., Basry A.A.H. (2015)
Screen-Printed Electrodes for Amperometric Determination of Iodide
Electroanalysis, 27 (2)

Kempf K., Schmitt F., Bilitewski U., Schobert R. (2015)
Synthesis, stereochemical assignment, and bioactivity of the Penicillium metabolites penicillenols B<inf>1</inf> and B<inf>2</inf>
Tetrahedron, 71 (31)

Kaba Hani E.J., Maier N., Schliebe-Ohler N., Mayer Y., Müller Peter P., van den Heuvel Joop, Schuchhardt J., ... , Hanack K., Bilitewski Ursula (2015)
Identification of whole pathogenic cells by monoclonal antibodies generated against a specific peptide from an immunogenic cell wall protein
Journal of Microbiological Methods, 108

Cui S., Bilitewski Ursula (2014)
[Effect of genistein on the TLR and MAPK transduction cascades in lipopolysaccharide -stimulated macrophages]
Xi.Bao.Yu Fen.Zi.Mian.Yi.Xue Za Zhi., 30 (3)

Cui S., Wienhoefer N., Bilitewski Ursula (2013)
Genistein induces morphology change and G2/M cell cycle arrest by inducing p38 MAPK activation in macrophages
International Immunopharmacology, 18 (1)

Buschart A., Gremmer K., El-Mowafy M., van den Heuvel Joop, Müller Peter P., Bilitewski Ursula (2012)
A novel functional assay for fungal histidine kinases group III reveals the role of HAMP domains for fungicide sensitivity
Journal of Biotechnology, 157 (1)

Kaba H.E., Nimtz Manfred, Müller Peter P., Bilitewski Ursula (2013)
Involvement of the mitogen activated protein kinase Hog1p in the response of Candida albicans to iron availability
BMC Microbiology, 13

El-Mowafy Mohammed, Bahgat M.M., Bilitewski Ursula (2013)
Deletion of the HAMP domains from the histidine kinase CaNik1p of Candida albicans or treatment with fungicides activates the MAP kinase Hog1p in S. cerevisiae transformants
BMC Microbiology, 13 (1)

Hassan R.Y.A., Bilitewski Ursula (2013)
Direct electrochemical determination of Candida albicans
Biosensors and Bioelectronics, 49

Heintz-Buschart A., Eickhoff H., Hohn E., Bilitewski Ursula (2013)
Identification of inhibitors of yeast-to-hyphae transition in Candida albicans
Journal of Biotechnology, 164 (1)

Buschart A., Burakowska A., Bilitewski Ursula (2012)
The fungicide fludioxonil antagonizes fluconazole activity in the human fungal pathogen Candida albicans
Journal of Medical Microbiology, 61 (Pt 12)

Hassan R.Y., Bilitewski Ursula* (2011)
A viability assay for Candida albicans
Analytical biochemistry, 419 (1)

Klippel N., Cui S., Groebe L., Bilitewski U. (2010)
Deletion of the Candida albicans histidine kinase gene CHK1 improves recognition by phagocytes through an increased exposure of cell wall beta-1,3-glucans
Microbiology, 156 (Pt 11)

Wesolowski J, Hassan R.Y.A., Reinhardt K., Hodde S., Bilitewski Ursula* (2010)
Antifungal compounds redirect metabolic pathways in yeasts: Metabolites as indicators of modes of action
Journal of Applied Microbiology, 108 (2)

Bilitewski Ursula* (2009)
DNA microarrays: an introduction to the technology

Bilitewski Ursula* (2008)
Determination of immunomodulatory effects: focus on functional analysis of phagocytes as representatives of the innate immune system
Analytical and Bioanalytical Chemistry, 391 (5)

Wesolowski J., Hassan R.Y., Hodde S., Bardroff C., Bilitewski Ursula* (2008)
Sensing of oxygen in microtiter plates: a novel tool for screening drugs against pathogenic yeasts
Analytical and Bioanalytical Chemistry, 391 (5)

Bilitewski Ursula* (2007)
Biochemische Methoden in der Wasseranalytik - Stand der Technik und Perspektiven. Teil III: Signalprofile und effektbasierte Analytik
Vom Wasser - Das Journal, 105 (4)

Frank Ronald*, Gerth Klaus*, Kalesse Markus*, Menche Dirk*, Bilitewski Ursula* (2007)
The chemical pipeline - a research program and infrastructure for the discovery and evaluation of new anti-infectives

Klippel N., Bilitewski Ursula* (2007)
Phagocytosis assay based on living Candida albicans
Analytical Letters, 40 (7)

Behnsen J., Narang P., Hasenberg M., Gunzer F., Bilitewski Ursula*, Klippel N., Rohde Manfred*, Brock M., ... , Brakhage A.A., Gunzer Matthias* (2007)
Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus
PLoS Pathogens, 3 (2)

Bilitewski U. (2006)
Biochemische Methoden in der Wasseranalytik - Stand der Technik und Perspektiven - Teil II: Organismische Tests
Vom Wasser - Das Journal, 104 (3)

Bilitewski U. (2006)
Biochemische Methoden in der Wasseranalytik - Stand der Technik und Perspektiven - Teil. I: Molekulare Tests
Vom Wasser - Das Journal, 104 (1)

Bilitewski U. (2006)
Protein sensing assay formats and devices
Annals in Chimica Acta, 568

Wendler J., Hoffmann A., Gross G., Weich H.A., Bilitewski U. (2005)
Development of an enzyme-linked receptor assay (ELIRA) for quantification of biological activity of recombinant bone morphogenic protein-2
Journal of Biotechnology, 119 (4)

Mersal G.A.M., Bilitewski U. (2005)
Development of monolithic enzymatic reactors in glass microchips for the quantitative determination of enzyme substrates using the example of glucose determination via immobilized glucose oxidase
Electrophoresis, 26 (12)

Mersal G.A.M., Bilitewski U. (2005)
Manipulation of the electroosmotic flow in glass and PMMA microchips with respect to specific enzymatic glucose determinations
Microchimica Acta, 151

Kadow S., Betiku E., Rinas U., Bilitewski U. (2005)
Development of a rapid, quantitative glucosyltransferase assay based on a screen-printed fructose enzyme electrode and application to optimization studies on gtfD expression in recombinant Escherichia coli
Biotechnology and Bioengineering, 91 (2)

Wendler J., Vallejo L.F., Rinas U., Bilitewski U. (2005)
Application of an SPR-based receptor assay for the determination of biologically active recombinant bone morphogenetic protein-2
Analytical and Bioanalytical Chemistry, 381 (5)

Michalzik M., Wendler J., Rabe J., Büttgenbach S., Bilitewski U. (2005)
Development and application of a miniaturised quartz crystal microbalance (QCM) resonator as immunosensor for bone morphogenic protein-2
Sensors and Actuators B: Chemical, 105 (2)

Mersal G.A.M., Khodari M., Bilitewski U. (2004)
Optimisation of the composition of the enzyme layer with respect to an improved selectivity and stability of glucose electrodes
Biosensors & Bioelectronics, 20

Kuhlmeier D., Rodda E., Kolarik L.O., Furlong D.N., Bilitewski U. (2003)
Application of atomic force microscopy and grating coupler for the characterization of biosensor surfaces
Biosensors & Bioelectronics, 18

Bilitewski U., Genrich M., Mersal G., Kadow S. (2003)
Biochemical analysis in microfluidic systems
Analytical and Bioanalytical Chemistry, 377 (3)

Tiedemann v. B., Bilitewski U. (2002)
Characterization of the vascular endothelial growth factor - receptor interaction and determination of the recombinant protein by an optical receptor sensor
Biosensors & Bioelectronics, 17

Stiene M., Bilitewski U. (2002)
Electrochemical characterization of screen-printed carbonaceous electrodes for the determination of peroxidase activity in novel screen- printed flow-through modules
Analytical and Bioanalytical Chemistry, 372 (2)

Schmidt A., Schumacher J.T., Reichelt J., Hecht H.J., Bilitewski U. (2002)
Mechanistic and molecular investigations on stabilization of horseradish peroxidase C
Analytical Chemistry, 74 (13)

Ruzgas T., Lindgren A., Gorton L., Hecht H.-J., Reichelt J., Bilitewski U. (2002)
Electrochemistry of peroxidases

Richter T., Shultz-Lockyear L.L., Oleschuk R.D., Bilitewski U., Harrison D.J. (2002)
Bi-enzymatic and capillary electrophoretic analysis of non- fluorescent compounds in microfluidic devices - determination of xanthine
Sensors and Actuators B: Chemical, 81 (2-3)

Henze B., Bilitewski U., van den Heuvel J. (2002)
Biosensorsysteme zur Genexpressionsanalytik

Henze B., Bebber C., van den Heuvel J., Bilitewski U. (2002)
Detection of mRNA using the BIAcore

Calmano W., Bilitewski U., Flemming H.C., Hofmann T., Peiffer S., ... , Ternes T., Wilken R.D. (2002)
The German Water Chemical Society: Actual trends and fields of research in the principle committee "Basic Research"
Acta Hydrochimica Et Hydrobiologica, 29 (6-7)

Akkoyun A., Bilitewski U. (2002)
Optimisation of glass surfaces for optical immunosensors
Biosensors & Bioelectronics, 17 (8)

Schumacher J.T., Hecht H.J., Dengler U., Reichelt J., Bilitewski U. (2001)
Direct electron transfer observed for peroxidase to screen-printed graphite electrodes.
Electroanalysis, 13

Schmidt A., Bilitewski U. (2001)
Biosensors for process monitoring and quality assurance in the food industry
, 2

Bilitewski U. (2001)
Proteomics - a tool for bioresponse-linked analysis

Gauglitz G., Piehler J., Bilitewski U. (2000)
Affinity sensor systems (Pesticide analysis)

Bilitewski U., Turner A.P.F. (2000)
Flow injection analysis

Bilitewski U., Denecke M. (2000)
Biologische Messverfahren in der Entsorgungswirtschaft - Grundlagen, Beispiele und Perspektiven

Bilitewski U., Brenner-Weiss G., Hansen P.D., Hock B., Meulenberg E., Muller G., Obst U., Sauerwein H., Scheller F.W., Schmid R., ... , Schnabl G., Spener F. (2000)
Bioresponse-linked instrumental analysis
Trends in Analytical Chemistry, 19 (7)

Akkoyun A., Bilitewski U. (2000)
Detection of sulphamethazine with an optical biosensor and anti-idiotypic antibodies
Sensors and Actuators B: Chemical, 70 (1-3)

Shumyantseva V.V., Bulko T.V., Bachmann T.T., Bilitewski U., Schmid R.D., Archakov A.I. (2000)
Electrochemical reduction of flavocytochromes 2B4 and 1A2 and their catalytic activity
Archives of Biochemistry and Biophysics, 377 (1)

Wicke C., Huners M., Wray V., Nimtz M., Bilitewski U., Lang S. (2000)
Production and structure elucidation of glycoglycerolipids from a marine sponge-associated microbacterium species
Journal of Natural Products, 63 (5)

Wissing J., Heim S., Flohé L., Bilitewski U., Frank R. (2000)
Enrichment of hydrophobic proteins via Triton X-114 phase partitioning and hydroxyapatite column chromatography for mass spectrometry
Electrophoresis, 21 (13)

Schuderer J., Akkoyun A., Brandenburg A., Bilitewski U., Wagner E. (2000)
Development of a multichannel fluorescence affinity sensor system
Analytical Chemistry, 72 (16)

Bilitewski U. (2000)
Can affinity sensors be used to detect food contaminants?
Analytical Chemistry, 72 (21)