Sven Brandau "Granulocytes and granulocytic myeloid-derived suppressor cells in cancer patients"
High numbers of tumor-infiltrating neutrophils and increased frequencies of peripheral blood neutrophils are associated with poor outcome in a number of different solid cancers. In this presentation I will discuss how the bi-directional interaction of neutrophils and tumor cells may result in disease progression and metastasis.
Local tumor growth (but also inflammatory and infectious diseases) triggers systemic changes in the myeloid compartment of the host. One of these changes is the induction of so-called myeloid-derived suppressor cells (MDSCs). While MDSCs are fairly well characterized in mice, their identity and function in humans is still poorly described. I will discuss data on the immunophenotyping and functional characterization of human granulocytic MDSC and will highlight some current challenges in the field.
Helmholtz-Zentrum für Infektionsforschung Braunschweig
Gebäude und Raum
University Hospital of Essen, Dept. of Otorhinolaryngology
Dr. Jadwiga Jablonska-Koch
- Molekulare Immunologie - Dr. Siegfried Weiß