Special Seminar: A Different View on Natural Products - Microbial- and Chemo-Microbial Derivatization Strategies
Natural products are a rich source for bioactive compounds and find widespread applications in current medicine. As a result, the majority of all drugs for the treatment of cancer or infectious diseases are derived from natural products. Of particular importance are polyketides, a natural product family with about 7,000 known members, mostly of microbial origin. Among them are well known compounds such as the antibiotic erythromycin, the immunosuppressive and anticancer drug rapamycin, and the cholesterol lowering agent lovastatin, all of them blockbuster drugs.
However, over the last decades the number of newly discovered natural products has drastically decreased, which has caused a lack of novel drug candidates. This is of high concern, especially for the treatment of bacterial infections. Of particular relevance are strategies for the controlled derivatization of natural products to render them clinically useful.
In this talk, studies on polyketide biosynthetic pathways and the participating enzymes will be discussed. A special focus will be on the development of novel enabling tools for the modification of polyketide synthase enzymes. A further focus will be on the heterologous biosynthesis of terpenes – an increasingly useful way of accessing compounds, which are in scarce supply from natural sources.
Guests are welcome!
Gäste sind herzlich willkommen!
Helmholtz-Zentrum für Infektionsforschung
Gebäude und Raum
HZI, Forum X0.13a
Ruhr Universität Bochum