NMR in Structural Biology and Structural Genomics: Applications with Prion Proteins
Joint HZI/TU Seminar
Prof. Wüthrich was awarded numerous awards, including the Nobel Prize in Chemistry (2002) for "his development of nuclear magnetic resonance spectroscopy for determining the three-dimensional structure of biological macromolecules in solution". The techniques developed by Prof. Wüthrich are used on a routine basis by protein NMR groups around the world, including the HZI.
Already during his time as a Ph.D. student Prof. Wüthrich worked on magnetic resonance phenomena. He conducted his postdoctoral research in Berkeley on the then newly developed techniques in nuclear magnetic resonance spectroscopy (NMR) to study the hydration of metal complexes. At that time he also started to investigate the structure and dynamics of proteins by NMR, which he has continued to pursue until today.
Prof. Wüthrich collaborated with the Nobel laureate Richard R. Ernst on developing the first multi-dimensional NMR experiments where he established the nuclear Overhauser effect as the way of measuring distances within proteins, which forms the cornerstone of any proteins structure determination by NMR, even today. Among his most outstanding achievements is the extension of the size-limit for protein NMR to several hundred kDa by the invention of the TROSY-NMR technique. In recent years he has made significant NMR spectroscopic contributions towards the automated and semi-automated protein 3D-structure determination.
Currently, Prof. Wüthrich shares his time between the positions of Visiting Scientist at SCRIPPS and Professor of Biophysics at the Eidgenössische Technische Hochschule Zürich (ETHZ), Switzerland. He is also Deputy Director and a Principal Investigator in the Zürich-based National Center of Competence in Research Structural Biology (NCCR Structural Biology).
Braunschweig, HZI Forum X0.13
Prof. Dr. Kurt Wüthrich (The Scripps Institute, La Jolla, USA)
Prof. Dr. Dirk Heinz, Acting Scientific Director of the HZI