HIPS-Talk: "Lectins from bacteria and fungi: therapeutical Targets and Research tools"
A large number of pathogenic microorganisms display receptors for specific recognition and adhesion to the glycoconjugates present on human tissues. In addition to membrane-bound adhesins, soluble lectins are involved in infections caused by the bacteria Pseudomonas aeruginosa and Burkholderia cepacia and by the fungus Aspergillus fumigatus that are responsible for hospital-acquired diseases. The multivalency of lectins is proposed to play a role in their strong avidity for glycosylated cell surfaces and also in their ability to affect membrane dynamics by clustering glycosphingolipids. The role of lectins in membrane invagination indicates that they could also play a role in internalization of intracellular pathogens.
Accumulated knowledge about the structures of the lectins and the interactions with host glycoconjugates has lead to the design of powerful glyco-derived inhibitors that can serve as antimicrobial therapeutic agents, as a complement to or an alternative to antibiotic therapy. Design of glycosylated chips, liposomes, fullerenes and other nanoglycoparticles have provided information on multivalent interaction between receptors and cell surfaces. This also result in development of nanomaterials that can be used in diagnostic applications.
Gebäude und Raum
Blg E8.1, Conference Room (Ground floor)
Dr. Anne Imberty
Centre de Recherches sur les Macromolécules Végétales
Dr. Alexander Titz