Friendship between streptococci and extracellular matrix: a gold mine to find targets for new anti-infectives
Streptococcus pyogenes (group A streptococci) are capable of causing a wide spectrum of diseases in human beings, ranging from self-limiting manifestations such as pharyngitis to life-threatening diseases such as necrotizing fasciitis. With more than 800 million cases worldwide per year, streptococcal infections represent a serious health hazard. In addition, the autoimmune sequelae, such as acute rheumatic fever and chronic rheumatic heart diseases are causes of high degrees of mortality and morbidity. There is no vaccine available, and antibiotics alone have not contributed to reduce the disease burden. There is an urgent need to develop novel combat strategies. Prerequisite for this is the understanding of infection mechanisms used by streptococci. Streptococci have a unique ability to interact with human extracellular matrix components and exploit them for establishing infections, for persistence and dissemination. This talk will focus on the mechanisms of interaction of streptococci with extracellular matrix and how this interaction can be used as a target for new antiinfectives.
Saarland university, Campus, Bldg. B2.1
Singh Chhatwal, HZI, Braunschweig
Rolf Müller (HIPS-MINS)