Sandra Halecker

    Sandra Halecker

    PhD Student

    +49 531 6181-4244


    Curriculum Vitae

    Since 09/2013 
    PhD student in the group of Prof. Marc Stadler, Helmholtz Centre for Infection Research, Braunschweig, Germany

    10/2012 - 06/2013            
    Diploma thesis in the department of Prof. Dr. Marc Stadler,  Helmholtz Centre for Infection Research, Braunschweig, Germany Title: “Charakterisierung der Sekundärmetabolitbildung des pathogenen Ascomyceten Hymenoscyphus pseudoalbidus und der endophytischen Mycobiota seines Wirtsbaumes Fraxinus excelsior”  

    2003 - 2013                     
    study of biotechnology at the Technical University of Braunschweig (focus on bioprocess engineering)

    The ascomycete Hymenoscyphus pseudoalbidus was proven to be the causal agent of ash dieback in extended parts of Europe, however, virulence factors responsible for the pathogenicity of this fungus are hitherto unknown. My project will focus on the novel antimicrobially active natural product from H. pseudoalbidus that was recently isolated by me and my colleagues in preliminary work and furthermore on the exploitation of new secondary metabolites of the pathogen by using antagonistic assays as well as chemical-epigenetic methods to induce changes in fungal secondary metabolism. The cultures (from fermentations in solid and liquid media) of several strains of H. pseudoalbidus and of promising antagonists will be screened by HPLC/DAD-MS profiling and antimicrobial assays and the most promising biologically active compounds will be isolated using bioassay-guided isolation procedures using preparative chromatography and identified by NMR and MS.