Dr. Sabrina Mühlen
+ 49 531 6181-5706
+ 49 531 6181-5709
Education and Employment
* 2000 - 2003
Bachelor of Science in Cell Biology at the University of Osnabrück
BSc Thesis "Characterization of the nucleotide-binding domain of KdpB of Escherichia coli using site-directed mutagenesis"
* 2003 - 2004
Studies abroad in Microbiology and Biochemistry at the University of Victoria, Canada
* 2004 - 2005
Master of Science in Cell Biology at the University of Osnabrück
MSc Thesis "Characteristics of the novel Streptomyces reticuli heme-binding protein HbpS"
* 2005 - 2008
PhD at the Ruprecht-Karls University of Heidelberg and at the Helmholtz International Graduate School for Cancer Research
PhD Thesis "Influence of Human Papillomavirus Early Proteins on the expression of tumor-progression promoting genes"
* 2009 - 2011
Postdoc at the Institute for Cell and Molecular Biosciences, Newcastle University, UK
* 2011 - 2014
Postdoc in the Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Australia
* since August 2014
Postdoc at the Helmholtz Centre for Infection Research, Department of Molecular Infection Biology (Prof. Dr. Petra Dersch)
Zhang Y, Mühlen S, Oates CV, Pearson JS, Hartland EL (2016). Identification of a distinct substrate binding domain in the bacterial cysteine methyltransferase effectors NleE and OspZ. J Biol Chem. 2016 Jul 21.
Giogha C, Wong Fok Lung T, Mühlen S, Pearson JS, Hartland EL (2015). Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic Escherichia coli. Cell Microbiol. 2015 Jun 11.
Nachbur U, Stafford CA, Bankovacki A, Zhan Y, Lindqvist LM, Fiil BK, Khakham Y, Ko HJ, Sandow JJ, Falk H, Holien JK, Chau D, Hildebrand J, Vince JE, Sharp PP, Webb Al, Jackman KA, Mühlen S, Kennedy CL, Lowes KN, Murphy JM, Gyrd-Hansen M, Parker MW, Hartland EL, Lew AM, Huang DC, Lessene G, Silke J (2015). A RIPK2 inhibitor delays NOD signaling events yet prevents inflammatory cytokine production. Nat Commun. 2015 Mar 17;6:6442.
Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Wong T, Mansell A, Riedmaier P, Oates CVL, Zaid A, Mühlen S, Crepin VF, Marches O, Ang CS, Williamson NA, O'Reilly LA, Bankovacki A, Nachbur U, Infusini G, Webb A, Silke J, Strasser A, Frankel G, and Hartland EL (2013). A type III effector antagonises death receptor signalling during bacterial gut infection. Nature. 2013 Sep 12:501(7466):247-51.
Ruchaud-Sparagano MH, Mühlen S, and Kenny B (2011). The enteropathogenic E. coli (EPEC) Tir effector protein inhibits NFKB activation by targeting TRAF adaptor proteins. PloS Pathogens. 2011 Dec:7(12):e1002414.
Mühlen S, Ruchaud-Sparagano MH, and Kenny B (2010). Protasome-independent degradation of canonical NFKB complex components by the NleC protein of pathogenic E. coli. J Biol Chem. 2011 Feb 18:286(7):5100-7.