Dr Hansjörg Hauser


    Director Friends of the HZI

    +49 531 6181-5000


    Curriculum Vitae

    Date of Birth:            

    January 2, 1949


    Education and Employment

    * 1967                 

    Abitur, Albert-Schweitzer.Gymnasium, Leonberg

    * 1968-1974       

    Studies in Food Technology and Nutrition Sciences, University of Hohenheim

    * 1974-1977       

    Studies in Biologiy;  University of Konstanz 

    * 1977                

    Dr. rer nat., University of Konstanz

    * 1978-1980       

    Postgraduate studies: Max-Planck-Institute for Molecular Genetics, Berlin 

    and German Cancer Research Centre, Heidelberg

    * 1982                

    EMBO Fellowship MRC in Mill Hill, London 

    * 1986                

    Director and Professor; BFA Tübingen (not accepted)            

    * 1986                

    Head of Group "Genetics of  Eukaryotes", GBF, Braunschweig 

    * 1993               

    C3 Professorship, University of Bielefeld. (not accepted)

    * since 1994      

    Head of Department "Gene Regulation and Differentiation", GBF, Braunschweig 

    * since 1995       

    Head of Division Molecular Biotechnology; GBF, Braunschweig  

    * 1996                

    C4 Professorship, University of Stuttgart-Hohenheim (not accepted)

     * since 2004      

    Permanent guest professor at the University of Lisbon


    Other Professional Activities: 

    * 1989-2001       

    Scientific advisor for the German-Israeli-Foundation DISNAT.

    * 1992-1997       

    Scientific advisor, HKFG (Hamburger Kommission für Gentechnologie). 

    * since 1995      

    Advisor; Bundesinstitut für Arzneimittelzulassung 

    * since 1992      

    Member, Executive Committee of ESACT (European Society of Animal Cell Technology) 

    * since 1994      

    Chair  “Medical Biotechnology” DECHEMA 

    * since 1996      

    Scientific advisor; Promega/Madison and Symphogen/Copenhavn


    Reviewer for Scientific Journals and Research Foundations from Germany, Europe, USA and Israel


    Coordinator and partner in more than 20 EU projects 


    Professional Societies:

     ISICR: International Society for Interferon and Cytokine Research

     ASM: American Society for Microbiology

     ESACT: European Society for Cell Culture Technology


     Deutsche Gesellschaft für Zellbiologie

     Gesellschaft für Biologische Chemie

     ACTIP: Animal Cell Technology Industrial Platform



    * since 1983      

    Universities of Oldenburg, Bielefeld und the Medical University, Hannover.  Invited speaker for theoretical and practical courses. 

    * 1991               

    Guest professorship at the Hebrew University of Jerusalem/Israel   

    * since 1982      

    Advisor for Diploma and Doctoral Thesises. 


    Major Research Interests

    1.      Biotechnology of mammalian cells

    2.      Interferons in infection and disease

    3.      Gene and cell theraphy


    Publications (since 2000)


    Ben-Asouli, Y., Banai, Y., Hauser, H. and Kaempfer, R.: Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2. Nucleic Acids Res., 18, 1011-1018 (2000) pubmed


    Carvalhal, A.V., Moreira, J.L., Cruz, H., Mueller, P.P., Hauser, H. and Carrondo, M.J.T.: Manipulation of culture conditions for BHK cell growth inhibition by IRF-1 activation. Cytotechnology 32, 135-145 (2000) pubmed


    Oumard, A., Hennecke, M., Hauser, H., and Nourbakhsh, M.: Translation of NRF mRNA is mediated by a highly efficient internal ribosome entry site. Mol. Cell. Biol., 20, 2755-2759 (2000) pubmed


    Geserick, C., Bonarius, H.P.J., Kongerslev, L., Hauser, H. and Müller, P.P.: Enhanced productivity during controlled proliferation of BHK cells in continuously perfused bioreactors. Biotech. Bioeng., 69, 266-274 (2000) pubmed


    Hauser, H., Spitzer, D., Verhoeyen, E., and Wirth, D.: New approaches towards ex vivo and in vivo gene therapy. Cells Tissues Organs, 167, 75-80 (2000) pubmed


    Kollmus, H., and Hauser, H.: A frameshifting assay to characterize RNA-protein interactions in eukaryotic cells, Methods in Enzymology, 318, 363-374 (2000) pubmed


    Hauser, H.: Perspektiven in der modernen Medizin, in  Jahrbuch 1999 der Braunschweigischen Wissenschaftlichen Gesellschaft (Cramer Verlag, Braunschweig) 103-114 (2000)


    Köster, M., and Hauser, H.: Einsatz von GFP in der zellbiologischen Forschung, Bioforum, 9, 574-576 (2000)


    Mielke, C., Tümmler, M, Schübeler, D., von Hoegen, I. and Hauser, H,: Stabilized, long-term expression of heteromeric proteins from tricistronic mRNA. Gene, 254, 1-8 (2000) pubmed


    Kirchhoff, S., Oumard, A., Nourbakhsh, M., Levi, B.-Z. and Hauser, H.: Interplay between repressing and activating domains defines the transcriptional activity of IRF-1. Eur. J. Biochem., 267, 6753-6761 (2000) pubmed


    Nourbakhsh, M., Oumard, A., Schwarzer, M. and Hauser, H.: NRF, a nuclear inhibitor of NF-kB proteins silences the IFN-ß promoter. Europ. Cytokine Network,  11, 500-501 (2000) pubmed


    Kwissa, M., Unsinger,  J., Schirmbeck, R., Hauser, H. and Reimann, J.: Polyvalent DNA vaccines with bidirectional promoters. J. Mol. Med., 78, 495-506 (2000) pubmed



    Nourbakhsh, M., Kälble, S., Hauser, H., Resch, K. and Kracht, M.: The NF-kappaB repressor factor NRF is involved in basal repression and interleukin (IL)-1-induced activation of IL-8 transcription by binding to a conserved NF-kappaB-flanking sequence element. J. Biol. Chem., 276,  4501-4508 (2001) pubmed


    Müller, P., Oumard, A., Wirth, D., Kröger, A., and Hauser, H.: Polyvalent vectors for coexpression of multiple genes, in Plasmids for Therapy and Vaccination (ed. Schleef, M.) Wiley-VCH, Weinheim, 119-136 (2001)


    Kröger, A., Ortmann, D., Krohne, T.U., Blum, H., Hauser, H., and Geissler, M.: Growth Suppression of the Hepatocellular Carcinoma Cell Line Hepa1-6 by an Activatable Interferon Regulatory Factor-1 in Mice. Cancer Res., 61, 2609-2617 (2001) pubmed


    Hennecke, M., van Kampen, J., Metzger, K., Schirmbeck, R., Reimann, J., and Hauser, H.: The strength of IRES-driven translation of bicistronic expression vectors depends on the composition of the mRNA. Nucleic Acids Res. 29, 3327-3334 (2001) pubmed


    Verhoeyen, E., Hauser, H., and Wirth, D.: Evaluation of retroviral vector design in defined chromosomal loci by Flp-mediated cassette replacement. Human Gene Ther., 12, 933-944 (2001) pubmed


    Hauser, H. and Zylstra, G.J.: Mammals, plants, bacteria, and soil: common problems ans solutions in gene expression ans analysis. Current Opinion in  Biotechnology, 12, 437-438 (2001) 


    Niemann, H., Verhoeyen, E., Wonigeit, K., Schwinzer, R., Hauser, H., Kues, W., Halter, R., Lemme, E., Herrmann, D., Wirth, D. and Paul, D.: The CMV early  promoter directs strong expression of hCD59 to porcine organs relevant for xenotransplantation. Transplantation, 72, 1898-1906 (2001)


    Unsinger, J., Kröger, A., Hauser, H., and Wirth, D.: Retroviral vectors for transduction of an autoregulated bidirectional expression cassette. Molecular Therapy, 4, 484-489 (2001) pubmed


    Schroeder, K., Koschmieder, S., Ottmann, O.G., Hoelzer, D., Hauser, H., and Mueller, P.P.: Establishment of a genetic system to coordinate feeder cell growth in cocultures with primary cells. In Animal Cell Technology: From Target to Market (eds. Lindner-Olsson, E. et al.) Kluwer Academic Publishers, The Netherlands, 565-567 (2001) 


    Kröger, A., Köster, M., Schroeder, K., Hauser, H. and Mueller, P.P..: Activities of IRF_1. J. Interferon and Cytokine Res., 22, 5-14 (2002) pubmed


    Carvalhal, A.V., Coroadinha, A.S., Alves, P.M., Moreira, J.L., Hauser, H., and Carrondo, M.J.T: Metabolic changes during cell growth inhibition by the IRF-1 system. Enzyme and Microbial Technology 30, 95-109 (2002)


    Hirschmann, F., Verhoeyen, E., Wirth, D., Bauwens, S., Hauser, H. and Rudert, M.: Vital marking of articular chondrocytes by retronviral infection using enhanced green fluorescence protein. Osteoarthritis and Cartilage, 10, 100-108 (2002) pubmed


    Schroeder, K., Koschmieder, S., Ottmann, O.G., Hoelzer, D., Hauser, H., and Mueller, P.P.: Coordination of cell growth in cocultures by a genetic proliferation control system.  Biotech. Bioeng., 78, 346-352 (2002) pubmed


    Trobonjaca, Z., Kröger, A., Stober, D., Leithauser, F., Hauser H., Schirmbeck, R. and Reimann, J.: Activating immunity in the liver. II. Interferon-ß attenuates NK cell-mediated liver injury triggered by liver NKT cell activation. J. Immunol. 168, 3763-3770  (2002) pubmed


    Meraro, D., Gleit-Kielmanowicz, M., Hauser, H. and Levi, B.-Z.: ISG15 is synergistically activated through interactions between the myelocyte/lymphocyte-specific transcription factors, PU.1, IRF-8/ICSBP and IRF-4: Characterization of a new subtype of ISREs. J. Immunology, 168, 6224-6231 (2002)


    Feng, X., Guo, Z., Nourbakhsh, M., Hauser, H., Ganster, R., Shao, L., and Geller, D.A.: Identification of a negative response element in the human inducible nitric oxide synthase (hiNOS) promoter:  the role of NF-kB repressing factor (NRF) in basal repression of the hiNOS gene. Proc. Natl. Acad. Sci., U.S.A., 99, 14212-14217 (2002) pubmed


    Mueller, P.P., Wirth, D., Unsinger, U. and Hauser, H.: Genetic approaches to recombinant protein production in mammalian cells in Handbook of Industrial Cell Culture: Mammalian, Microbial and Plant Cells (ed. V. A. Vinci, S.R. Parekh) Humana Press, 21-50 (2003) 


    Kröger, A., Dallügge, A., Kirchhoff, S. and Hauser, H.: IRF_1 reverts the transformed phenotype of oncogenically transformed cells in vitro and in vivo, Oncogene, 22, 1045-1056 (2003) pubmed


    Köster, M., Lykke-Andersen, S., Elnakady, Y.A., Gerth, K., Washausen, P., Höfle, G., Sasse, F., Kjems, J., and Hauser, H.: Ratjadones inhibit nuclear export by blocking CRM1/exportin 1. Exp. Cell Res., 286, 321-331 (2003) pubmed


    Spitzer, D., Dittmar, K.E.J., Rohde, M.,  Hauser, H., and Wirth, D.: A GFP tagged retroviral envelope protein for analysis of virus/cell interactions. J. Virol, 77, 6070-6075 (2003)


    Kwissa, M., Kröger, A., Hauser, H., Reimann, J. and Schirmbeck, R.: Defining conditions for cytokine-facilitated priming of CD8+ T cell responses by DNA vaccination. J. Mol. Med., 81, 91-101 (2003)


    Alter-Koltunoff, M., Ehrlich, S., Dror, N., Azriel, A., Eilers, M., Hauser, H., Bowen, H., Barton, C.-H., Tamura, T., Ozato, K., and Levi, B.-Z.: Nramp 1 mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1 and Miz-1. J. Biol. Chem., 278, 44025-44032 (2003) pubmed


    Wirth, D. and Hauser, H.: Flp-mediated integration of expression cassettes into FRT-tagged chromosomal loci in mammalian cells. Methods in Molecular Biology, 267, 467-476 (2004) pubmed


    Jomantaité, I., Dikopoulos, N., Kröger, A., Leithäuser, F., Hauser, H., Schirmbeck, R., and Reimann, J.: Hepatic dendritic cell subsets in the mouse. Eur. J. Immunol., 34, 355-365 (2004) pubmed


    Niedick, I., Froese, N., Oumard, A., Mueller, P.P., Nourbakhsh, M., Hauser. H.and Köster, M.: Nucleolar localization and mobility analysis of the NF-B repressing factor NRF. J.Cell Science, 117, 3447-3458 (2004) pubmed


    Dikopoulos, N., Wegenka, U., Kröger, A., Hauser, H., Schirmbeck, R. and Reimann, J.: Recently primed CD8+ T cells entering the liver allow hepatocytes to interact with naive CD8+ T cells and downregulate their immune-suppressive effects. Hepatology, 39, 1256-1266 (2004) pubmed


    Unsinger, J., Lindenmaier, W., May, T., Hauser, H., and Wirth, D.: LTR-flanked autoregulated expression cassettes for homogenous and strictly controlled expression in adenoviral vectors. BBRC, 319, 879-887 (2004) pubmed


    May, T., Hauser, H., Wirth, D.:.Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization,  Nucleic Acids Res.,  32, 5529-5538 (2004) pubmed


    Dikopoulos, N., Bertoletti, A., Kröger, A., Hauser, H., Schirmbeck, R., and Reimann, J.: Type I interferon negatively regulates CD8+ T cell responses through IL-10-producing CD4+ TR1 cells  J. Immunol.,  174, 99-109 (2005) pubmed


    Köster, M., Frahm, T.,  Hauser, H.: Nucleocytoplasmic shuttling analysis of STAT1 by FRAP and FLIP, Current Opinion in Biotech., 16, 28-34 (2005) pubmed


    May, T., Mueller, P.P., Weich, H., Froese, N., Deutsch, U., Wirth, D., Kröger, A. and Hauser, H.: Establishment of murine cell lines by constitutive and conditional immortalization. J. Biotech. 120, 99-110 (2005) pubmed


    Samuelsson, C.V., Linienklaus, S., Müller, P.P., Zawatzky, R., Hauser, H., and Weiss, S..: Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection, BBRC, 335, 584-589 (2005) pubmed


    Froese, N., Schwarzer, M., Niedick, I., Frischmann, U., Köster, M., Kröger, A., Mueller, P.P., Nourbakhsh, M., Pasche, B., Reimann, J., Staeheli, P., and Hauser, H.: Innate immune responses in NF-kappaB-repressing factor-deficient mice. Mol. Cell. Biol. 26, 293-302 (2006) pubmed


    Frahm, T., Hauser, H., and Köster, M.: IFN-type-I-mediated signalling is regulated by modulation of STAT2 nuclear export. J. Cell Science. 119, 1092-1104 (2006) pubmed


    Coroadinha, A.S., Schucht, R., Norton, L., Wirth, D.,  Hauser, H., and Carrondo, M.J.T.: The use of recombinase cassette exchange in retroviral vector producer cell lines: predictability and efficiency in transgene exchange. J. Biotech. 124, 457-468 (2006) pubmed


    Schucht, R., Coroadinha, A.S., Verhoeyen, E., Zanta-Boussif, M.A., Carrondo, M.J.T., Hauser, H.., and Wirth, D.: A new generation of retroviral producer cells: Predictable and stable virus production by Flp mediated site-specific integration of retroviral vectors. Mol.Ther. 14, 285-292 (2006) pubmed


    Müller, P.P., May, T., Perz, A., Hauser, H., Peuster, M.: Control of smooth muscle cell proliferation by ferrous iron.  Biomaterials 27, 2193-2200 (2006) pubmed


    Kues, W.A., Schwinzer, R., Wirth, D., Verhoeyen, E., Lemme, E., Herrmann, D., Barg-Kues, B., Hauser, H., Wonigeit, K, and Niemann, H.: Epigenetic silencing and tissue independent expression of a novel tetracycline inducible system in double transgenic pigs. FASEB Journal 20, 1200-1202 (2006) pubmed


    Peuster, M., Beerbaum, P., Hauser. H. and Bach, F-W.: Resorbable implants. Is it out there? A review, Cardiol Young., 16, 107-116 (2006) pubmed


    Schirmbeck, R., Riedl, P., Kupferschmitt, M., Wegenka, U., Hauser, H., Rice, J., Kroeger, A., and Reimann, J.: Priming protective CD8 T cell immunity by DNA vaccines encoding chimeric, stress protein-capturing tumor-associated antigen. J. Immunol. 177, 1534-1542 (2006) pubmed


    Dror, N., Alter-Koltunoff, M., Azriel, A., Amariglio, N., Jacob-Hirsch, J., Zeligson, S., Morgenstern, A., Tamura, T., Hauser, H., Rechavi, G.,  Ozato, K., and Levi, B.-Z.: Identification of IRF-8 and IRF-1 target genes in activated macrophages. Mol. Immunol. 44; 338-346 (2006) pubmed


    May, T., Hauser, H. and Wirth, D.: Current Status of transcriptional regulation systems. Cytotechnology, in press (2006) pubmed


    Kröger, A., Wiese, A., Pulverer, J.E., Klages, K., Grasshoff, M., Reimann, J., and Hauser, H.: Tumor Suppression by IRF-1 relies on down-regulation of Cyclin D1.  Cancer Res. in revision pubmed