Dr Hansjörg Hauser

    Hauser_Portrait

    Director Friends of the HZI

    +49 531 6181-5000

    Contact


    Curriculum Vitae

    Date of Birth:            

    January 2, 1949

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    Education and Employment

    * 1967                 

    Abitur, Albert-Schweitzer.Gymnasium, Leonberg

    * 1968-1974       

    Studies in Food Technology and Nutrition Sciences, University of Hohenheim

    * 1974-1977       

    Studies in Biologiy;  University of Konstanz 

    * 1977                

    Dr. rer nat., University of Konstanz

    * 1978-1980       

    Postgraduate studies: Max-Planck-Institute for Molecular Genetics, Berlin 

    and German Cancer Research Centre, Heidelberg

    * 1982                

    EMBO Fellowship MRC in Mill Hill, London 

    * 1986                

    Director and Professor; BFA Tübingen (not accepted)            

    * 1986                

    Head of Group "Genetics of  Eukaryotes", GBF, Braunschweig 

    * 1993               

    C3 Professorship, University of Bielefeld. (not accepted)

    * since 1994      

    Head of Department "Gene Regulation and Differentiation", GBF, Braunschweig 

    * since 1995       

    Head of Division Molecular Biotechnology; GBF, Braunschweig  

    * 1996                

    C4 Professorship, University of Stuttgart-Hohenheim (not accepted)

     * since 2004      

    Permanent guest professor at the University of Lisbon

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    Other Professional Activities: 

    * 1989-2001       

    Scientific advisor for the German-Israeli-Foundation DISNAT.

    * 1992-1997       

    Scientific advisor, HKFG (Hamburger Kommission für Gentechnologie). 

    * since 1995      

    Advisor; Bundesinstitut für Arzneimittelzulassung 

    * since 1992      

    Member, Executive Committee of ESACT (European Society of Animal Cell Technology) 

    * since 1994      

    Chair  “Medical Biotechnology” DECHEMA 

    * since 1996      

    Scientific advisor; Promega/Madison and Symphogen/Copenhavn

    *

    Reviewer for Scientific Journals and Research Foundations from Germany, Europe, USA and Israel

    *

    Coordinator and partner in more than 20 EU projects 

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    Professional Societies:

     ISICR: International Society for Interferon and Cytokine Research

     ASM: American Society for Microbiology

     ESACT: European Society for Cell Culture Technology

     DECHEMA 

     Deutsche Gesellschaft für Zellbiologie

     Gesellschaft für Biologische Chemie

     ACTIP: Animal Cell Technology Industrial Platform

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    Teaching

    * since 1983      

    Universities of Oldenburg, Bielefeld und the Medical University, Hannover.  Invited speaker for theoretical and practical courses. 

    * 1991               

    Guest professorship at the Hebrew University of Jerusalem/Israel   

    * since 1982      

    Advisor for Diploma and Doctoral Thesises. 

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    Major Research Interests

    1.      Biotechnology of mammalian cells

    2.      Interferons in infection and disease

    3.      Gene and cell theraphy

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    Publications (since 2000)

    2000

    Ben-Asouli, Y., Banai, Y., Hauser, H. and Kaempfer, R.: Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2. Nucleic Acids Res., 18, 1011-1018 (2000) pubmed

     

    Carvalhal, A.V., Moreira, J.L., Cruz, H., Mueller, P.P., Hauser, H. and Carrondo, M.J.T.: Manipulation of culture conditions for BHK cell growth inhibition by IRF-1 activation. Cytotechnology 32, 135-145 (2000) pubmed

     

    Oumard, A., Hennecke, M., Hauser, H., and Nourbakhsh, M.: Translation of NRF mRNA is mediated by a highly efficient internal ribosome entry site. Mol. Cell. Biol., 20, 2755-2759 (2000) pubmed

     

    Geserick, C., Bonarius, H.P.J., Kongerslev, L., Hauser, H. and Müller, P.P.: Enhanced productivity during controlled proliferation of BHK cells in continuously perfused bioreactors. Biotech. Bioeng., 69, 266-274 (2000) pubmed

     

    Hauser, H., Spitzer, D., Verhoeyen, E., and Wirth, D.: New approaches towards ex vivo and in vivo gene therapy. Cells Tissues Organs, 167, 75-80 (2000) pubmed

     

    Kollmus, H., and Hauser, H.: A frameshifting assay to characterize RNA-protein interactions in eukaryotic cells, Methods in Enzymology, 318, 363-374 (2000) pubmed

     

    Hauser, H.: Perspektiven in der modernen Medizin, in  Jahrbuch 1999 der Braunschweigischen Wissenschaftlichen Gesellschaft (Cramer Verlag, Braunschweig) 103-114 (2000)

     

    Köster, M., and Hauser, H.: Einsatz von GFP in der zellbiologischen Forschung, Bioforum, 9, 574-576 (2000)

     

    Mielke, C., Tümmler, M, Schübeler, D., von Hoegen, I. and Hauser, H,: Stabilized, long-term expression of heteromeric proteins from tricistronic mRNA. Gene, 254, 1-8 (2000) pubmed

     

    Kirchhoff, S., Oumard, A., Nourbakhsh, M., Levi, B.-Z. and Hauser, H.: Interplay between repressing and activating domains defines the transcriptional activity of IRF-1. Eur. J. Biochem., 267, 6753-6761 (2000) pubmed

     

    Nourbakhsh, M., Oumard, A., Schwarzer, M. and Hauser, H.: NRF, a nuclear inhibitor of NF-kB proteins silences the IFN-ß promoter. Europ. Cytokine Network,  11, 500-501 (2000) pubmed

     

    Kwissa, M., Unsinger,  J., Schirmbeck, R., Hauser, H. and Reimann, J.: Polyvalent DNA vaccines with bidirectional promoters. J. Mol. Med., 78, 495-506 (2000) pubmed

     

    2001 

    Nourbakhsh, M., Kälble, S., Hauser, H., Resch, K. and Kracht, M.: The NF-kappaB repressor factor NRF is involved in basal repression and interleukin (IL)-1-induced activation of IL-8 transcription by binding to a conserved NF-kappaB-flanking sequence element. J. Biol. Chem., 276,  4501-4508 (2001) pubmed

     

    Müller, P., Oumard, A., Wirth, D., Kröger, A., and Hauser, H.: Polyvalent vectors for coexpression of multiple genes, in Plasmids for Therapy and Vaccination (ed. Schleef, M.) Wiley-VCH, Weinheim, 119-136 (2001)

     

    Kröger, A., Ortmann, D., Krohne, T.U., Blum, H., Hauser, H., and Geissler, M.: Growth Suppression of the Hepatocellular Carcinoma Cell Line Hepa1-6 by an Activatable Interferon Regulatory Factor-1 in Mice. Cancer Res., 61, 2609-2617 (2001) pubmed

     

    Hennecke, M., van Kampen, J., Metzger, K., Schirmbeck, R., Reimann, J., and Hauser, H.: The strength of IRES-driven translation of bicistronic expression vectors depends on the composition of the mRNA. Nucleic Acids Res. 29, 3327-3334 (2001) pubmed

     

    Verhoeyen, E., Hauser, H., and Wirth, D.: Evaluation of retroviral vector design in defined chromosomal loci by Flp-mediated cassette replacement. Human Gene Ther., 12, 933-944 (2001) pubmed

     

    Hauser, H. and Zylstra, G.J.: Mammals, plants, bacteria, and soil: common problems ans solutions in gene expression ans analysis. Current Opinion in  Biotechnology, 12, 437-438 (2001) 

     

    Niemann, H., Verhoeyen, E., Wonigeit, K., Schwinzer, R., Hauser, H., Kues, W., Halter, R., Lemme, E., Herrmann, D., Wirth, D. and Paul, D.: The CMV early  promoter directs strong expression of hCD59 to porcine organs relevant for xenotransplantation. Transplantation, 72, 1898-1906 (2001)

     

    Unsinger, J., Kröger, A., Hauser, H., and Wirth, D.: Retroviral vectors for transduction of an autoregulated bidirectional expression cassette. Molecular Therapy, 4, 484-489 (2001) pubmed

     

    Schroeder, K., Koschmieder, S., Ottmann, O.G., Hoelzer, D., Hauser, H., and Mueller, P.P.: Establishment of a genetic system to coordinate feeder cell growth in cocultures with primary cells. In Animal Cell Technology: From Target to Market (eds. Lindner-Olsson, E. et al.) Kluwer Academic Publishers, The Netherlands, 565-567 (2001) 

    2002 

    Kröger, A., Köster, M., Schroeder, K., Hauser, H. and Mueller, P.P..: Activities of IRF_1. J. Interferon and Cytokine Res., 22, 5-14 (2002) pubmed

     

    Carvalhal, A.V., Coroadinha, A.S., Alves, P.M., Moreira, J.L., Hauser, H., and Carrondo, M.J.T: Metabolic changes during cell growth inhibition by the IRF-1 system. Enzyme and Microbial Technology 30, 95-109 (2002)

     

    Hirschmann, F., Verhoeyen, E., Wirth, D., Bauwens, S., Hauser, H. and Rudert, M.: Vital marking of articular chondrocytes by retronviral infection using enhanced green fluorescence protein. Osteoarthritis and Cartilage, 10, 100-108 (2002) pubmed

     

    Schroeder, K., Koschmieder, S., Ottmann, O.G., Hoelzer, D., Hauser, H., and Mueller, P.P.: Coordination of cell growth in cocultures by a genetic proliferation control system.  Biotech. Bioeng., 78, 346-352 (2002) pubmed

     

    Trobonjaca, Z., Kröger, A., Stober, D., Leithauser, F., Hauser H., Schirmbeck, R. and Reimann, J.: Activating immunity in the liver. II. Interferon-ß attenuates NK cell-mediated liver injury triggered by liver NKT cell activation. J. Immunol. 168, 3763-3770  (2002) pubmed

     

    Meraro, D., Gleit-Kielmanowicz, M., Hauser, H. and Levi, B.-Z.: ISG15 is synergistically activated through interactions between the myelocyte/lymphocyte-specific transcription factors, PU.1, IRF-8/ICSBP and IRF-4: Characterization of a new subtype of ISREs. J. Immunology, 168, 6224-6231 (2002)

                

    Feng, X., Guo, Z., Nourbakhsh, M., Hauser, H., Ganster, R., Shao, L., and Geller, D.A.: Identification of a negative response element in the human inducible nitric oxide synthase (hiNOS) promoter:  the role of NF-kB repressing factor (NRF) in basal repression of the hiNOS gene. Proc. Natl. Acad. Sci., U.S.A., 99, 14212-14217 (2002) pubmed

    2003

    Mueller, P.P., Wirth, D., Unsinger, U. and Hauser, H.: Genetic approaches to recombinant protein production in mammalian cells in Handbook of Industrial Cell Culture: Mammalian, Microbial and Plant Cells (ed. V. A. Vinci, S.R. Parekh) Humana Press, 21-50 (2003) 

     

    Kröger, A., Dallügge, A., Kirchhoff, S. and Hauser, H.: IRF_1 reverts the transformed phenotype of oncogenically transformed cells in vitro and in vivo, Oncogene, 22, 1045-1056 (2003) pubmed

     

    Köster, M., Lykke-Andersen, S., Elnakady, Y.A., Gerth, K., Washausen, P., Höfle, G., Sasse, F., Kjems, J., and Hauser, H.: Ratjadones inhibit nuclear export by blocking CRM1/exportin 1. Exp. Cell Res., 286, 321-331 (2003) pubmed

     

    Spitzer, D., Dittmar, K.E.J., Rohde, M.,  Hauser, H., and Wirth, D.: A GFP tagged retroviral envelope protein for analysis of virus/cell interactions. J. Virol, 77, 6070-6075 (2003)

     

    Kwissa, M., Kröger, A., Hauser, H., Reimann, J. and Schirmbeck, R.: Defining conditions for cytokine-facilitated priming of CD8+ T cell responses by DNA vaccination. J. Mol. Med., 81, 91-101 (2003)

     

    Alter-Koltunoff, M., Ehrlich, S., Dror, N., Azriel, A., Eilers, M., Hauser, H., Bowen, H., Barton, C.-H., Tamura, T., Ozato, K., and Levi, B.-Z.: Nramp 1 mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1 and Miz-1. J. Biol. Chem., 278, 44025-44032 (2003) pubmed

    2004 

    Wirth, D. and Hauser, H.: Flp-mediated integration of expression cassettes into FRT-tagged chromosomal loci in mammalian cells. Methods in Molecular Biology, 267, 467-476 (2004) pubmed

     

    Jomantaité, I., Dikopoulos, N., Kröger, A., Leithäuser, F., Hauser, H., Schirmbeck, R., and Reimann, J.: Hepatic dendritic cell subsets in the mouse. Eur. J. Immunol., 34, 355-365 (2004) pubmed

     

    Niedick, I., Froese, N., Oumard, A., Mueller, P.P., Nourbakhsh, M., Hauser. H.and Köster, M.: Nucleolar localization and mobility analysis of the NF-B repressing factor NRF. J.Cell Science, 117, 3447-3458 (2004) pubmed

     

    Dikopoulos, N., Wegenka, U., Kröger, A., Hauser, H., Schirmbeck, R. and Reimann, J.: Recently primed CD8+ T cells entering the liver allow hepatocytes to interact with naive CD8+ T cells and downregulate their immune-suppressive effects. Hepatology, 39, 1256-1266 (2004) pubmed

     

    Unsinger, J., Lindenmaier, W., May, T., Hauser, H., and Wirth, D.: LTR-flanked autoregulated expression cassettes for homogenous and strictly controlled expression in adenoviral vectors. BBRC, 319, 879-887 (2004) pubmed

     

    May, T., Hauser, H., Wirth, D.:.Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization,  Nucleic Acids Res.,  32, 5529-5538 (2004) pubmed

    2005 

    Dikopoulos, N., Bertoletti, A., Kröger, A., Hauser, H., Schirmbeck, R., and Reimann, J.: Type I interferon negatively regulates CD8+ T cell responses through IL-10-producing CD4+ TR1 cells  J. Immunol.,  174, 99-109 (2005) pubmed

     

    Köster, M., Frahm, T.,  Hauser, H.: Nucleocytoplasmic shuttling analysis of STAT1 by FRAP and FLIP, Current Opinion in Biotech., 16, 28-34 (2005) pubmed

     

    May, T., Mueller, P.P., Weich, H., Froese, N., Deutsch, U., Wirth, D., Kröger, A. and Hauser, H.: Establishment of murine cell lines by constitutive and conditional immortalization. J. Biotech. 120, 99-110 (2005) pubmed

     

    Samuelsson, C.V., Linienklaus, S., Müller, P.P., Zawatzky, R., Hauser, H., and Weiss, S..: Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection, BBRC, 335, 584-589 (2005) pubmed

    2006

    Froese, N., Schwarzer, M., Niedick, I., Frischmann, U., Köster, M., Kröger, A., Mueller, P.P., Nourbakhsh, M., Pasche, B., Reimann, J., Staeheli, P., and Hauser, H.: Innate immune responses in NF-kappaB-repressing factor-deficient mice. Mol. Cell. Biol. 26, 293-302 (2006) pubmed

     

    Frahm, T., Hauser, H., and Köster, M.: IFN-type-I-mediated signalling is regulated by modulation of STAT2 nuclear export. J. Cell Science. 119, 1092-1104 (2006) pubmed

     

    Coroadinha, A.S., Schucht, R., Norton, L., Wirth, D.,  Hauser, H., and Carrondo, M.J.T.: The use of recombinase cassette exchange in retroviral vector producer cell lines: predictability and efficiency in transgene exchange. J. Biotech. 124, 457-468 (2006) pubmed

     

    Schucht, R., Coroadinha, A.S., Verhoeyen, E., Zanta-Boussif, M.A., Carrondo, M.J.T., Hauser, H.., and Wirth, D.: A new generation of retroviral producer cells: Predictable and stable virus production by Flp mediated site-specific integration of retroviral vectors. Mol.Ther. 14, 285-292 (2006) pubmed

     

    Müller, P.P., May, T., Perz, A., Hauser, H., Peuster, M.: Control of smooth muscle cell proliferation by ferrous iron.  Biomaterials 27, 2193-2200 (2006) pubmed

     

    Kues, W.A., Schwinzer, R., Wirth, D., Verhoeyen, E., Lemme, E., Herrmann, D., Barg-Kues, B., Hauser, H., Wonigeit, K, and Niemann, H.: Epigenetic silencing and tissue independent expression of a novel tetracycline inducible system in double transgenic pigs. FASEB Journal 20, 1200-1202 (2006) pubmed

     

    Peuster, M., Beerbaum, P., Hauser. H. and Bach, F-W.: Resorbable implants. Is it out there? A review, Cardiol Young., 16, 107-116 (2006) pubmed

     

    Schirmbeck, R., Riedl, P., Kupferschmitt, M., Wegenka, U., Hauser, H., Rice, J., Kroeger, A., and Reimann, J.: Priming protective CD8 T cell immunity by DNA vaccines encoding chimeric, stress protein-capturing tumor-associated antigen. J. Immunol. 177, 1534-1542 (2006) pubmed

     

    Dror, N., Alter-Koltunoff, M., Azriel, A., Amariglio, N., Jacob-Hirsch, J., Zeligson, S., Morgenstern, A., Tamura, T., Hauser, H., Rechavi, G.,  Ozato, K., and Levi, B.-Z.: Identification of IRF-8 and IRF-1 target genes in activated macrophages. Mol. Immunol. 44; 338-346 (2006) pubmed

     

    May, T., Hauser, H. and Wirth, D.: Current Status of transcriptional regulation systems. Cytotechnology, in press (2006) pubmed

     

    Kröger, A., Wiese, A., Pulverer, J.E., Klages, K., Grasshoff, M., Reimann, J., and Hauser, H.: Tumor Suppression by IRF-1 relies on down-regulation of Cyclin D1.  Cancer Res. in revision pubmed