Recombinant Protein Expression

Proteins play an important role in infectious diseases. They not only take over central functions in the invasion and replication of pathogens, but also in the defensive reaction of our body or as a drug. For a detailed investigation of proteins, scientists often require them in large amounts and extremely pure state. Read more about how proteins are artificially produced and purified.

Leader

Publications

  • Authors: Schütz,A.; Bernhard,F.; Berrow,N.; Buyel,J.F.; Ferreira-da-Silva,F.; Haustraete,J.; van den Heuvel,J.; Hoffmann,J.E.; de Marco,A.; Peleg,Y.; Suppmann,S.; Unger,T.; Vanhoucke,M.; Witt,S.; Remans,K.; ( Year: 2023). Title: A concise guide to choosing suitable gene expression systems for recombinant protein production.Journal: STAR.Protoc. Volume: 4 Issue: 4 DOI: 10.1016/j.xpro.2023.102572HZI repositoryPubMed
  • Authors: Sun,S.; Fushimi,M.; Rossetti,T.; Kaur,N.; Ferreira,J.; Miller,M.; Quast,J.; van den Heuvel,J.; Steegborn,C.; Levin,L.R.; Buck,J.; Myers,R.W.; Kargman,S.; Liverton,N.; Meinke,P.T.; Huggins,D.J.; ( Year: 2023). Title: Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.Journal: J.Chem.Inf.Model. Volume: 63 Issue: 9 DOI: 10.1021/acs.jcim.2c0157PubMed
  • Authors: Kaipa,J.M.; Krasnoselska,G.; Owens,R.J.; van den Heuvel,J.; ( Year: 2023). Title: Screening of Membrane Protein Production by Comparison of Transient Expression in Insect and Mammalian Cells.Journal: Biomolecules. Volume: 13 Issue: 5 DOI: 10.3390/biom13050817HZI repositoryPubMed
  • Authors: Katzmarzyk,M.; Clesle,D.C.; van den Heuvel,J.; Hoffmann,M.; Garritsen,H.; Pöhlmann,S.; Jacobsen,H.; Cicin-Sain,L.; ( Year: 2023). Title: Systematical assessment of the impact of single spike mutations of SARS-CoV-2 Omicron sub-variants on the neutralization capacity of post-vaccination sera.Journal: Frontiers in Immunology Volume: 14 DOI: 10.3389/fimmu.2023.1288794HZI repositoryPubMed
  • Authors: Sevenich,M.; van den Heuvel,J.; Gering,I.; Mohrlüder,J.; Willbold,D.; ( Year: 2022). Title: A So-Far Overlooked Secondary Conformation State in the Binding Mode of SARS-CoV-2 Spike Protein to Human ACE2 and Its Conversion Rate Are Crucial for Estimating Infectivity Efficacy of the Underlying Virus Variant.Journal: Journal of Virology, S-Page: e0068522 DOI: 10.1128/jvi.00685-22HZI repositoryPubMed
  • Authors: Jaron,M.; Lehky,M.; Zarà,M.; Zaydowicz,C.N.; Lak,A.; Ballmann,R.; Heine,P.A.; Wenzel,E.V.; Schneider,K.T.; Bertoglio,F.; Kempter,S.; Köster,R.W.; Barbieri,S.S.; van den Heuvel,J.; Hust,M.; Dübel,S.; Schubert,M.; ( Year: 2022). Title: Baculovirus-Free SARS-CoV-2 Virus-like Particle Production in Insect Cells for Rapid Neutralization Assessment.Journal: Viruses Volume: 14 Issue: 10 DOI: 10.3390/v14102087HZI repositoryPubMed
  • Authors: Miller,M.; Rossetti,T.; Ferreira,J.; Ghanem,L.; Balbach,M.; Kaur,N.; Levin,L.R.; Buck,J.; Kehr,M.; Coquille,S.; van den Heuvel,J.; Steegborn,C.; Fushimi,M.; Finkin-Groner,E.; Myers,R.W.; Kargman,S.; Liverton,N.J.; Huggins,D.J.; Meinke,P.T.; ( Year: 2022). Title: Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.Journal: J.Med.Chem. DOI: 10.1021/acs.jmedchem.2c01133HZI repositoryPubMed
  • Authors: Peukert,C.; Popat Gholap,S.; Green,O.; Pinkert,L.; van den Heuvel,J.; Van Ham,M.; Shabat,D.; Brönstrup,M.; ( Year: 2022). Title: Enzyme-Activated, Chemiluminescent Siderophore-Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial Pathogens.Journal: Angew.Chem.Int.Ed Engl., S-Page: e202201423 DOI: 10.1002/anie.202201423HZI repositoryPubMed
  • Authors: Li,Z.; Nees,M.; Bettenbrock,K.; Rinas,U.; ( Year: 2022). Title: Is energy excess the initial trigger of carbon overflow metabolism? Transcriptional network response of carbon-limited Escherichia coli to transient carbon excess.Journal: Microbial Cell Factories Volume: 21 Issue: 1, S-Page: 67 DOI: 10.1186/s12934-022-01787-4HZI repositoryPubMed
  • Authors: Reboll,M.R.; Klede,S.; Taft,M.H.; Cai,C.-L.; Field,L.J.; Lavine,K.J.; Koenig,A.L.; Fleischauer,J.; Meyer,J.; Schambach,A.; Niessen,H.W.; Kosanke,M.; van den Heuvel,J.; Pich,A.; Bauersachs,J.; Wu,X.; Zheng,L.; Wang,Y.; Korf-Klingebiel,M.; Polten,F.; Wollert,K.C.; ( Year: 2022). Title: Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.Journal: Science Volume: 376 Issue: 6599, S-Page: 1343-- E-Page: 1347 DOI: 10.1126/science.abn3027HZI repositoryPubMed
  • Authors: Sevenich,M.; Thul,E.; Lakomek,N.A.; Klünemann,T.; Schubert,M.; Bertoglio,F.; van den Heuvel,J.; Petzsch,P.; Mohrlüder,J.; Willbold,D.; ( Year: 2022). Title: Phage Display-Derived Compounds Displace hACE2 from Its Complex with SARS-CoV-2 Spike Protein.Journal: Biomedicines Volume: 10 Issue: 2, S-Page: Article number 441 DOI: 10.3390/biomedicines10020441HZI repositoryPubMed
  • Authors: Fushimi,M.; Buck,H.; Balbach,M.; Gorovyy,A.; Ferreira,J.; Rossetti,T.; Kaur,N.; Levin,L.R.; Buck,J.; Quast,J.; van den Heuvel,J.; Steegborn,C.; Finkin-Groner,E.; Kargman,S.; Michino,M.; Foley,M.A.; Miller,M.; Liverton,N.J.; Huggins,D.J.; Meinke,P.T.; ( Year: 2021). Title: Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).Journal: ACS Med.Chem.Lett. DOI: 10.1021/acsmedchemlett.1c00273HZI repositoryPubMed
  • Authors: Korf-Klingebiel,M.; Reboll,M.R.; Polten,F.; Weber,N.; Jäckle,F.; Wu,X.; Kallikourdis,M.; Kunderfranco,P.; Condorelli,G.; Giannitsis,E.; Kustikova,O.S..; Schambach,A.; Pich,A.; Widder,J.D.; Bauersachs,J.; van den Heuvel,J.; Kraft,T.; Wang,Y.; Wollert,K.C.; ( Year: 2021). Title: Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca(2+)-ATPase Expression in Cardiomyocytes.Journal: Circulation DOI: 10.1161/CIRCULATIONAHA.120.053365HZI repositoryPubMed
  • Authors: Taubert,R.; Engel,B.; Diestelhorst,J.; Hupa-Breier,K.L.; Behrendt,P.; Baerlecken,N.T.; Sühs,K.W.; Janik,M.K.; Zachou,K.; Sebode,M.; Schramm,C.; Londono,M.C.; Habes,S.; Oo,Y.H.; Lalanne,C.; Pape,S.; Schubert,M.; Hust,M.; Dübel,S.; Thevis,M.; Jonigk,D.; Beimdiek,J.; Buettner,F.F.R.; Drenth,J.P.; Muratori,L.; Adams,D.H.; Dyson,J.K.; Renand,A.; Graupera,I.; Lohse,A.W.; Dalekos,G.N.; Milkiewicz,P.; Stangel,M.; Maasoumy,B.; Witte,T.; Wedemeyer,H.; Manns,M.P.; Jaeckel,E.; ( Year: 2021). Title: Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis.Journal: Hepatology DOI: 10.1002/hep.32134HZI repositoryPubMed
  • Authors: Weber,J.; Li,Z.; Rinas,U.; ( Year: 2021). Title: Recombinant protein production provoked accumulation of ATP, fructose-1,6-bisphosphate and pyruvate in E. coli K12 strain TG1.Journal: Microbial Cell Factories Volume: 20 Issue: 1, S-Page: Art. no 169 DOI: 10.1186/s12934-021-01661-9HZI repositoryPubMed
  • Authors: Li,Z.; Rinas,U.; ( Year: 2021). Title: Recombinant protein production-associated metabolic burden reflects anabolic constraints and reveals similarities to a carbon overfeeding response.Journal: Biotechnol.Bioeng. Volume: 118 Issue: 1, S-Page: 94- E-Page: 105 DOI: 10.1002/bit.27553HZI repositoryPubMed
  • Authors: Li,Z.; Geffers,R.; Jain,G.; Klawonn,F.; Kökpinar,Ö.; Nimtz,M.; Schmidt-Heck,W.; Rinas,U.; ( Year: 2021). Title: Transcriptional network analysis identifies key elements governing the recombinant protein production provoked reprogramming of carbon and energy metabolism in Escherichia coli BL21 (DE3).Journal: Engineering Reports Volume: 3 Issue: 9 DOI: 10.1002/eng2.12393HZI repositoryWEBURLS
  • Authors: König,J.; Hust,M.; van den Heuvel,J.; ( Year: 2021). Title: Validation of the Production of Antibodies in Different Formats in the HEK 293 Transient Gene Expression System.Book Title: Multiprotein Complexes City: Clifton Publisher: Springer, S-Page: 59- E-Page: 76 DOI: 10.1007/978-1-0716-1126-5_4PubMed
  • Authors: Böldicke,T.; ( Year: 2021). Title: Varianten von SARS-CoV-2: Wie viel Schutz noch bleibt.Journal: Dtsch Arztebl International Volume: 118 Issue: 38, S-Page: A1701- E-Page: A1706+A5 DOI: -HZI repositoryWEBURLS
  • Authors: Korn,J.; Schäckermann,D.; Kirmann,T.; Bertoglio,F.; Steinke,S.; Heisig,J.; Ruschig,M.; Rojas,G.; Langreder,N.; Wenzel,E.V.; Roth,K.D.R.; Becker,M.; Meier,D.; van den Heuvel,J.; Hust,M.; Dübel,S.; Schubert,M.; ( Year: 2020). Title: Baculovirus-free insect cell expression system for high yield antibody and antigen production.Journal: Sci.Rep. Volume: 10 Issue: 1, S-Page: Article number 21393 DOI: 10.1038/s41598-020-78425-9HZI repositoryPubMed
  • Authors: Bolten,S.N.; Knoll,A.S.; Li,Z.; Gellermann,P.; Pepelanova,I.; Rinas,U.; Scheper,T.; ( Year: 2020). Title: Purification of the human fibroblast growth factor 2 using novel animal-component free materials.Journal: J.Chromatogr.A Volume: 1626, S-Page: Article number 461367 DOI: 10.1016/j.chroma.2020.461367HZI repositoryWEBURLS
  • Authors: Li,Z.; Rinas,U.; ( Year: 2020). Title: Recombinant protein production associated growth inhibition results mainly from transcription and not from translation.Journal: Microbial Cell Factories Volume: 19 Issue: 1, S-Page: 83 DOI: 10.1186/s12934-020-01343-yHZI repositoryPubMed
  • Authors: Testolin,G.; Cirnski,K.; Rox,K.; Prochnow,H.; Fetz,V.; Grandclaudon,C.; Mollner,T.; Baiyoumy,A.; Ritter,A.; Leitner,C.; Krull,J.; van den Heuvel,J.; Vassort,A.; Sordello,S.; Hamed,M.M.; Elgaher,W.A.M.; Herrmann,J.; Hartmann,R.W.; Müller,R.; Brönstrup,M.; ( Year: 2020). Title: Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high: In vivo efficacy.Journal: Chemical Science Volume: 11 Issue: 5, S-Page: 1316- E-Page: 1334 DOI: 10.1039/c9sc04769gHZI repositoryWEBURLS
  • Authors: de Marco,A.; Ferrer-Miralles,N.; Garcia-Fruitós,E.; Mitraki,A.; Peternel,S.; Rinas,U.; Trujillo-Roldán,M.A.; Valdez-Cruz,N.A.; Vázquez,E.; Villaverde,A.; ( Year: 2019). Title: Bacterial inclusion bodies are industrially exploitable amyloids.Journal: FEMS Microbiol.Rev. Volume: 43 Issue: 1, S-Page: 53- E-Page: 72 DOI: 10.1093/femsre/fuy038PubMed
  • Authors: Chen,F.; Lukat,P.; Iqbal,A.A.; Saile,K.; Kaever,V.; van den,Heuvel J.; Blankenfeldt,W.; Büssow,K.; Pessler,F.; ( Year: 2019). Title: Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis.Journal: Proc.Natl.Acad.Sci.U.S.A Volume: 116 Issue: 41, S-Page: 20644- E-Page: 20654 DOI: 10.1073/pnas.1908770116HZI repositoryPubMed
  • Authors: Büssow,K.; Themann,P.; Luu,S.; Pentrowski,P.; Harting,C.; Majewski,M.; Vollmer,V.; Köster,M.; Grashoff,M.; Zawatzky,R.; van den Heuvel,J.; Kröger,A.; Böldicke,T.; ( Year: 2019). Title: ER intrabody-mediated inhibition of interferon a secretion by mouse macrophages and dendritic cells.Journal: PLoS ONE Volume: 14 Issue: 4 DOI: 10.1371/journal.pone.0215062HZI repositoryPubMed
  • Authors: Zahid,M.; Rinas,U.; ( Year: 2019). Title: Guidelines for Small-Scale Production and Purification of Hepatitis B Surface Antigen Virus-Like Particles from Recombinant Pichia pastoris.Book Title: Recombinant Protein Production in Yeast Publisher: Springer, S-Page: 309- E-Page: 322 DOI: 10.1007/978-1-4939-9024-5_14HZI repositoryPubMed
  • Authors: Bleckmann,M.; Schürig,M.; Endres,M.; Samuels,A.; Gebauer,D.; Konisch,N.; van den Heuvel,J.; ( Year: 2019). Title: Identifying parameters to improve the reproducibility of transient gene expression in High Five cells.Journal: PLoS ONE Volume: 14 Issue: 6 DOI: 10.1371/journal.pone.0217878HZI repositoryPubMed
  • Authors: de Groot,C.; Müsken,M.; Bleckmann,M.; Ebensen,T.; Guzmán,C.A.; Müller-Goymann,C.C.; ( Year: 2019). Title: Novel colloidal associations of soyasaponins and lipid components (DPPC, cholesterol) as potential adjuvants for vaccines.Journal: Vaccine Volume: 37 Issue: 35, S-Page: 4975- E-Page: 4986 DOI: 10.1016/j.vaccine.2019.07.020PubMed
  • Authors: Quaas,B.; Burmeister,L.; Li,Z.; Satalov,A.; Behrens,P.; Hoffmann,A.; Rinas,U.; ( Year: 2019). Title: Stability and Biological Activity of E. coli Derived Soluble and Precipitated Bone Morphogenetic Protein-2.Journal: Pharm.Res. Volume: 36 Issue: 12, S-Page: 184 DOI: 10.1007/s11095-019-2705-5HZI repositoryPubMed
  • Authors: Pesarrodona,M.; Jauset,T.; Díaz-Riascos,Z.V.; Sánchez-Chardi,A.; Beaulieu,M.E.; Seras-Franzoso,J.; Sánchez-García,L.; Baltà-Foix,R.; Mancilla,S.; Fernández,Y.; Rinas,U.; Schwartz,S.,Jr.; Soucek,L.; Villaverde,A.; Abasolo,I.; Vázquez,E.; ( Year: 2019). Title: Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies.Journal: Advanced Science Volume: 6 Issue: 18, S-Page: Article number 1900849 DOI: 10.1002/advs.201900849HZI repositoryWEBURLS
  • Authors: Stolt-Bergner,P.; Benda,C.; Bergbrede,T.; Besir,H.; Celie,P.H.N.; Chang,C.; Drechsel,D.; Fischer,A.; Geerlof,A.; Giabbai,B.; van den Heuvel,J.; Huber,G.; Knecht,W.; Lehner,A.; Lemaitre,R.; Nord; q; n,K.; Pardee,G.; Racke,I.; Remans,K.; Sander,A.; Scholz,J.; Stadnik,M.; Storici,P.; Weinbruch,D.; Zaror,I.; Lua,L.H.L.; ; Suppmann,S.; ( Year: 2018). Title: Baculovirus-driven protein expression in insect cells: A benchmarking study.Journal: J.Struct.Biol. Volume: 203 Issue: 2, S-Page: 71- E-Page: 80 DOI: 10.1016/j.jsb.2018.03.004HZI repositoryPubMed
  • Authors: Bolten,S.N.; Rinas,U.; Scheper,T.; ( Year: 2018). Title: Heparin: role in protein purification and substitution with animal-component free material.Journal: Applied Microbiology and Biotechnology Volume: 102 Issue: 20, S-Page: 8647- E-Page: 8660 DOI: 10.1007/s00253-018-9263-3HZI repositoryPubMed
  • Authors: Muthukumar,Y.; Münkemer,J.; Mathieu,D.; Richter,C.; Schwalbe,H.; Steinmetz,H.; Kessler,W.; Reichelt,J.; Beutling,U.; Frank,R.; Bussow,K.; van den,Heuvel J.; Brönstrup,M.; Taylor,R.E.; Laschat,S.; Sasse,F.; ( Year: 2018). Title: Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria.Journal: PLoS One. Volume: 13 Issue: 7, S-Page: e0201605 DOI: 10.1371/journal.pone.0201605HZI repositoryPubMed
  • Authors: Rinas,U.; Garcia-Fruitos,E.; Corchero,J.L.; V; b; zquez,E.; Seras-Franzoso,J.; ; Villaverde,A.; ( Year: 2017). Title: Bacterial Inclusion Bodies: Discovering Their Better Half.Journal: Trends Biochem.Sci. Volume: 42 Issue: 9, S-Page: 726- E-Page: 737 DOI: 10.1016/j.tibs.2017.01.005HZI repositoryPubMed
  • Authors: DiCara,D.M.; Chirgadze,D.Y.; Pope,A.R.; Karatt-Vellatt,A.; Winter,A.; Slavny,P.; van den,Heuvel J.; Parthiban,K.; Holland,J.; Packman,L.C.; Mavria,G.; Hoffmann,J.; Birchmeier,W.; Gherardi,E.; McCafferty,J.; ( Year: 2017). Title: Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.Journal: Sci.Rep. Volume: 7 Issue: 1, S-Page: 9000 DOI: 10.1038/s41598-017-09460-2HZI repositoryPubMed
  • Authors: Marschall,A.L.; Zhang,C.; Dubel,S.; ( Year: 2017). Title: Evaluating the Delivery of Proteins to the Cytosol of Mammalian Cells.Book Title: Cancer Gene Networks Publisher: Springer, S-Page: 201- E-Page: 208 DOI: 10.1007/978-1-4939-6539-7_14 HZI repository PubMed
  • Authors: Li,Z.; Nimtz,M.; Rinas,U.; ( Year: 2017). Title: Global proteome response of Escherichia coli BL21 to production of human basic fribroblast growth factor in complex and defined medium.Journal: Engineering in Life Sciences Volume: 17 Issue: 8, S-Page: 881- E-Page: 891 DOI: 10.1002/elsc.201700036HZI repositoryWEBURLS
  • Authors: Karste,K.; Bleckmann,M.; van den,Heuvel J.; ( Year: 2017). Title: Not Limited to E. coli: Versatile Expression Vectors for Mammalian Protein Expression.Book Title: Heterologous Gene Expression in E.coli Publisher: Springer, S-Page: 313- E-Page: 324 DOI: 10.1007/978-1-4939-6887-9_20PubMed
  • Authors: Böldicke,T.; ( Year: 2017). Title: Single domain antibodies for the knockdown of cytosolic and nuclear proteins.Journal: Protein Sci. Volume: 26 Issue: 5, S-Page: 925- E-Page: 945 DOI: 10.1002/pro.3154HZI repositoryPubMed
  • Authors: Baser,B.; Spehr,J.; Bussow,K.; van den,Heuvel J.; ( Year: 2016). Title: A method for specifically targeting two independent genomic integration sites for co-expression of genes in CHO cells.Journal: Methods Volume: 95, S-Page: 3- E-Page: 12 DOI: 10.1016/j.ymeth.2015.11.022PubMed
  • Authors: Marschall,A.L.; Dübel,S.; ( Year: 2016). Title: Antibodies inside of a cell can change its outside: Can intrabodies provide a new therapeutic paradigm?.Journal: Comput.Struct.Biotechnol.J Volume: 14, S-Page: 304- E-Page: 308 DOI: 10.1016/j.csbj.2016.07.003HZI repositoryPubMed
  • Authors: Baser,B.; van den,Heuvel J.; ( Year: 2016). Title: Assembling Multi-subunit Complexes Using Mammalian Expression.Journal: Adv.Exp.Med.Biol. Volume: 896, S-Page: 225- E-Page: 238 DOI: 10.1007/978-3-319-27216-0_15PubMed
  • Authors: Kleinboelting,S.; Ramos-Espiritu,L.; Buck,H.; Colis,L.; van den,Heuvel J.; Glickman,J.F.; Levin,L.R.; Buck,J.; Steegborn,C.; ( Year: 2016). Title: Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.Journal: J Biol.Chem. Volume: 291 Issue: 18, S-Page: 9776- E-Page: 9784 DOI: 10.1074/jbc.M115.708255HZI repositoryPubMed
  • Authors: Pesarrodona,M.; Fernandez,Y.; Foradada,L.; Sanchez-Chardi,A.; Conchillo-Sole,O.; Unzueta,U.; Xu,Z.; Roldan,M.; Villegas,S.; Ferrer-Miralles,N.; Schwartz S Jr; Rinas,U.; Daura,X.; Abasolo,I.; Vazquez,E.; Villaverde,A.; ( Year: 2016). Title: Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria.Journal: Biofabrication. Volume: 8 Issue: 2, S-Page: 025001 PubMed
  • Authors: Ramos-Espiritu,L.; Kleinboelting,S.; Navarrete,F.A.; Alvau,A.; Visconti,P.E.; Valsecchi,F.; Starkov,A.; Manfredi,G.; Buck,H.; Adura,C.; Zippin,J.H.; van den,Heuvel J.; Glickman,J.F.; Steegborn,C.; Levin,L.R.; Buck,J.; ( Year: 2016). Title: Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.Journal: Nat.Chem.Biol. Volume: 12 Issue: 10, S-Page: 838- E-Page: 844 DOI: 10.1038/nchembio.2151HZI repositoryPubMed
  • Authors: Bleckmann,M.; Schmelz,S.; Schinkowski,C.; Scrima,A.; van den,Heuvel J.; ( Year: 2016). Title: Fast plasmid based protein expression analysis in insect cells using an automated SplitGFP screen.Journal: Biotechnol.Bioeng. Volume: 113 Issue: 9, S-Page: 1975- E-Page: 1983 DOI: 10.1002/bit.25956HZI repositoryPubMed
  • Authors: Bleckmann,M.; Schurig,M.; Chen,F.F.; Yen,Z.Z.; Lindemann,N.; Meyer,S.; Spehr,J.; van den,Heuvel J.; ( Year: 2016). Title: Identification of Essential Genetic Baculoviral Elements for Recombinant Protein Expression by Transactivation in Sf21 Insect Cells.Journal: PLoS ONE Volume: 11 Issue: 3, S-Page: e0149424 DOI: 10.1371/journal.pone.0149424HZI repositoryPubMed
  • Authors: Dübel,S.; Marschall,A.L.J.; ( Year: 2016). Title: Neue Impulse für den Protein-Knock-down mit intrabodies.Journal: Biospektrum Volume: 22 Issue: 1, S-Page: 33- E-Page: 36 DOI: 10.1007/s12268-016-0654-7WEBURLS
  • Authors: Böldicke,T.; ( Year: 2016). Title: Preface.Publisher: Springer International Publishing, S-Page: v- E-Page: vi ISBN: 9783319224732 (ISBN)9783319224725 (ISBN)DOI: 10.1007/978-3-319-22473-2WEBURLS
  • Authors: Marschall,A.L.J.; Dübel,S.; Böldicke,T.; ( Year: 2016). Title: Recent advances with ER targeted intrabodies.Book Title: Protein Targeting Compounds: Prediction, Selection and Activity of Specific Inhibitors Publisher: Springer International Publishing, S-Page: 77- E-Page: 93 ISBN: 9783319224732 (ISBN)9783319224725 (ISBN)DOI: 10.1007/978-3-319-22473-2_5WEBURLS
  • Authors: Rueda,F.; C; q; spedes,M.V.; Sanchez-Chardi,A.; Seras-Franzoso,J.; Pesarrodona,M.; Ferrer-Miralles,N.; Vazquez,E.; Rinas,U.; Unzueta,U.; Mamat,U.; Mangues,R.; GarcÆa-Fruit£s,E; .; ; ; Villav; e; rde,A.; ( Year: 2016). Title: Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.Journal: Microbial Cell Factories Volume: 15 Issue: 1 DOI: 10.1186/s12934-016-0457-zHZI repositoryPubMed
  • Authors: Zahid,M.; Lünsdorf,H.; Rinas,U.; ( Year: 2015). Title: Assessing stability and assembly of the hepatitis B surface antigen into virus-like particles during down-stream processing.Journal: Vaccine DOI: 10.1016/j.vaccine.2015.05.066HZI repositoryPubMed
  • Authors: Quade,N.; Boehringer,D.; Leibundgut,M.; van den,Heuvel J.; Ban,N.; ( Year: 2015). Title: Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-A resolution.Journal: Nature Communications Volume: 6, S-Page: 7646 DOI: 10.1038/ncomms8646HZI repositoryPubMed
  • Authors: Bleckmann,M.; Fritz,M.H.; Bhuju,S.; Jarek,M.; Schurig,M.; Geffers,R.; Benes,V.; Besir,H.; van den,Heuvel J.; ( Year: 2015). Title: Genomic Analysis and Isolation of RNA Polymerase II Dependent Promoters from Spodoptera frugiperda.Journal: PLoS ONE Volume: 10 Issue: 8, S-Page: e0132898 PubMed
  • Authors: Marschall,A.L.J.; Dübel,S.; Böldicke,T.; ( Year: 2015). Title: Specific in vivo knockdown of protein function by intrabodies.Journal: MAbs Volume: 7 Issue: 6, S-Page: 1010- E-Page: 1035 DOI: 10.1080/19420862.2015.1076601HZI repositoryPubMed
  • Authors: Büssow,K.; ( Year: 2015). Title: Stable mammalian producer cell lines for structural biology.Journal: Curr.Opin.Struct.Biol. Volume: 32, S-Page: 81- E-Page: 90 DOI: 10.1016/j.sbi.2015.03.002HZI repositoryPubMed
  • Authors: Kleinboelting,S.; Diaz,A.; Moniot,S.; van den Heuvel,Joop; Weyand,M.; Levin,L.R.; Buck,J.; Steegborn,C.; ( Year: 2014). Title: Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 111 Issue: 10, S-Page: 3727- E-Page: 3732 WEBURLS
  • Authors: Kleinboelting,S.; van den,Heuvel Joop; Kambach,C.; Weyand,M.; Leipelt,M.; Steegborn,C.; ( Year: 2014). Title: Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mammalian type 10 adenylyl cyclase.Journal: Acta Crystallographica Section F: Structural Biology and Crystallization Communications Volume: 70 Issue: Pt 4, S-Page: 467- E-Page: 469 DOI: 10.1107/S2053230X14004014HZI repositoryPubMed
  • Authors: Marschall,A.L.J.; Single,F.N.; Schlarmann,K.; Bosio,A.; Strebe,N.; van den Heuvel,J.; Frenzel,A.; Dübel,S.; ( Year: 2014). Title: Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies.Journal: MAbs Volume: 6 Issue: 6, S-Page: 1394- E-Page: 1401 WEBURLS
  • Authors: Seras-Franzoso,J.; Peebo,K.; Garcia-Fruitos,E.; Vazquez,E.; Rinas,U.; Villaverde,A.; ( Year: 2014). Title: Improving protein delivery of fibroblast growth factor-2 from bacterial inclusion bodies used as cell culture substrates.Journal: Acta Biomaterialia Volume: 10 Issue: 3, S-Page: 1354- E-Page: 1359 WEBURLS
  • Authors: Li,Z.; Carstensen,B.; Rinas,U.; ( Year: 2014). Title: Smart sustainable bottle (SSB) system for E. coli based recombinant protein production.Journal: Microbial Cell Factories Volume: 13, S-Page: 153 DOI: 10.1186/s12934-014-0153-9HZI repositoryPubMed
  • Authors: Kleinboelting,S.; van den Heuvel,Joop; Steegborn,C.; ( Year: 2014). Title: Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes - Implications for cyclase catalysis and evolution.Journal: FEBS Journal Volume: 281 Issue: 18, S-Page: 4151- E-Page: 4164 WEBURLS
  • Authors: Li,Z.; Nimtz,M.; Rinas,U.; ( Year: 2014). Title: The metabolic potential of Escherichia coli BL21 in defined and rich medium.Journal: Microbial Cell Factories Volume: 13 Issue: 1, S-Page: 45 DOI: 10.1186/1475-2859-13-45HZI repositoryPubMed
  • Authors: Hofmeyer,T.; Schmelz,S.; Degiacomi,M.T.; Dal Peraro,M.; Daneschdar,M.; Scrima,Andrea; van den Heuvel,Joop; Heinz,Dirk W.; Kolmar,H.; ( Year: 2013). Title: Arranged sevenfold: Structural insights into the C-terminal oligomerization domain of human C4b-binding protein.Journal: Journal of Molecular Biology Volume: 425 Issue: 8, S-Page: 1302- E-Page: 1317 DOI: 10.1016/j.jmb.2012.12.017HZI repositoryPubMed
  • Authors: Ringel,P.; Krausze,Joern; van den Heuvel,Joop; Curth,U.; Pierik,A.J.; Herzog,S.; Mendel,R.R.; Kruse,T.; ( Year: 2013). Title: Biochemical characterization of molybdenum cofactor-free nitrate reductase from Neurospora crassa.Journal: Journal of Biological Chemistry Volume: 288 Issue: 20, S-Page: 14657- E-Page: 14671 WEBURLS
  • Authors: Khetarpal,N.; Poddar,A.; Nemani,S.K.; Dhar,N.; Patil,A.; Negi,P.; Perween,A.; Viswanathan,R.; Lünsdorf,H.; Tyagi,P.; Raut,R.; Arora,U.; Jain,S.K.; Rinas,U.; Swaminathan,S.; Khanna,N.; ( Year: 2013). Title: Dengue-specific subviral nanoparticles: Design, creation and characterization.Journal: Journal of Nanobiotechnology Volume: 11 Issue: 1, S-Page: 15 DOI: 10.1186/1477-3155-11-15HZI repositoryPubMed
  • Authors: Bice,I.; Celik,H.; Wolff,C.; Beutel,S.; Zahid,M.; Hitzmann,B.; Rinas,U.; Kasper,C.; Gerardy-Schahn,R.; Scheper,T.; ( Year: 2013). Title: Downstream processing of high chain length polysialic acid using membrane adsorbers and clay minerals for application in tissue engineering.Journal: Engineering in Life Sciences Volume: 13 Issue: 2, S-Page: 140- E-Page: 148 WEBURLS
  • Authors: Vallejo,L.F.; Rinas,U.; ( Year: 2013). Title: Folding and dimerization kinetics of bone morphogenetic protein-2, a member of the transforming growth factor-beta family.Journal: FEBS Journal Volume: 280 Issue: 1, S-Page: 83- E-Page: 92 DOI: 10.1111/febs.12051HZI repositoryPubMed
  • Authors: Jäger,Volker; Büssow,Konrad; Wagner,A.; Weber,S.; Hust,M.; Frenzel,A.; Schirrmann,T.; ( Year: 2013). Title: High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells.Journal: BMC Biotechnology Volume: 13 Issue: 1, S-Page: 52 DOI: 10.1186/1472-6750-13-52HZI repositoryPubMed
  • Authors: Kaleta,C.; Schäuble,S.; Rinas,U.; Schuster,S.; ( Year: 2013). Title: Metabolic costs of amino acid and protein production in Escherichia coli.Journal: Biotechnology Journal Volume: 8 Issue: 9, S-Page: 1105- E-Page: 1114 PubMed
  • Authors: Meyer,S.; Lorenz,C.; Baser,B.; Wordehoff,M.; Jäger,Volker; van den Heuvel,Joop; ( Year: 2013). Title: Multi-host expression system for recombinant production of challenging proteins.Journal: PLoS ONE Volume: 8 Issue: 7, S-Page: e68674 DOI: 10.1371/journal.pone.0068674HZI repositoryPubMed
  • Authors: Böldicke,T.; ( Year: 2013). Title: Polyclonal antibodies for detection of witches' broom disease of lime.Journal: Iranian Journal of Biotechnology Volume: 11 Issue: 3, S-Page: 144 WEBURLS
  • Authors: Gurramkonda,C.; Zahid,M.; Nemani,S.K.; Adnan,A.; Gudi,S.K.; Khanna,N.; Ebensen,T.; Lünsdorf,H.; Guzmán,C.A.; Rinas,U.; ( Year: 2013). Title: Purification of hepatitis B surface antigen virus-like particles from recombinant Pichia pastoris and in vivo analysis of their immunogenic properties.Journal: Journal of Chromatography B Volume: 940C, S-Page: 104- E-Page: 111 DOI: 10.1016/j.jchromb.2013.09.030HZI repositoryPubMed
  • Authors: Cano-Garrido,O.; Rodriguez-Carmona,E.; Diez-Gil,C.; Vazquez,E.; Elizondo,E.; Cubarsi,R.; Seras-Franzoso,J.; Corchero,J.L.; Rinas,U.; Ratera,I.; Ventosa,N.; Veciana,J.; Villaverde,A.; Garcia-Fruitos,E.; ( Year: 2013). Title: Supramolecular organization of protein-releasing functional amyloids solved in bacterial inclusion bodies.Journal: Acta Biomaterialia Volume: 9 Issue: 4, S-Page: 6134- E-Page: 6142 DOI: 10.1016/j.actbio.2012.11.033.WEBURLS
  • Authors: Buschart,A.; Gremmer,K.; El-Mowafy,M.; van den Heuvel,Joop; Müller,Peter P.; Bilitewski,Ursula; ( Year: 2012). Title: A novel functional assay for fungal histidine kinases group III reveals the role of HAMP domains for fungicide sensitivity.Journal: Journal of Biotechnology Volume: 157 Issue: 1, S-Page: 268- E-Page: 277 PubMed
  • Authors: Chen,R.; John,J.; Lavrentieva,A.; Müller,S.; Tomala,M.; Zhao,Y.; Zweigerdt,R.; Beutel,S.; Hitzmann,B.; Kasper,C.; Martin,U.; Rinas,U.; Stahl,F.; Scheper,T.; ( Year: 2012). Title: Cytokine production using membrane adsorbers: Human basic fibroblast growth factor produced by.Journal: Engineering in Live Sciences Volume: 12 Issue: 1, S-Page: 29- E-Page: 38
  • Authors: Endres,S.; Hiebl,B.; Hägele,J.; Beltzer,C.; Fuhrmann,R.; Jäger,Volker; Almeida,M.; Costa,E.; Santos,C.; Traupe,H.; Jung,E.M.; Prantl,L.; Jung,F.; Wilkea,A.; Franke,R.-P.; ( Year: 2012). Title: Erratum: Angiogenesis and healing with non-shrinking, fast degradeable PLGA/CaP scaffolds in critical-sized defects in the rabbit femur with or without osteogenically induced mesenchymal stem cells (Clinical Hemorheology and Microcirculation (2011) 48:1 (.Journal: Clinical Hemorheology and Microcirculation Volume: 49 Issue: 1-4, S-Page: 551
  • Authors: Vazquez,E.; Corchero,J.L.; Burgueno,J.F.; Seras-Franzoso,J.; Kosoy,A.; Bosser,R.; Mendoza,R.; Martinez-Lainez,J.M.; Rinas,U.; Fernandez,E.; Ruiz-Avila,L.; Garcia-Fruitos,E.; Villaverde,A.; ( Year: 2012). Title: Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies.Journal: Advanced Materials Volume: 24 Issue: 13, S-Page: 1742- E-Page: 1747 PubMed
  • Authors: Kugler,J.; Schmelz,S.; Gentzsch,J.; Haid,S.; Pollmann,E.; van den Heuvel,Joop; Franke,R.; Pietschmann,Thomas; Heinz,Dirk W.; Collins,J.; ( Year: 2012). Title: High Affinity Peptide Inhibitors of the Hepatitis C Virus NS3-4A Protease Refractory to Common Resistant Mutants.Journal: Journal of Biological Chemistry Volume: 287 Issue: 46, S-Page: 39224- E-Page: 39232 DOI: 10.1074/jbc.M112.393843HZI repositoryPubMed
  • Authors: Sans,C.; Garcia-Fruitos,E.; Ferraz,R.M.; Gonzalez-Montalban,N.; Rinas,U.; Lopez-Santin,J.; Villaverde,A.; Alvaro,G.; ( Year: 2012). Title: Inclusion bodies of fuculose-1-phosphate aldolase as stable and reusable biocatalysts.Journal: Biotechnology progress Volume: 28 Issue: 2, S-Page: 421- E-Page: 427 DOI: 10.1002/btpr.1518HZI repositoryPubMed
  • Authors: Villaverde,A.; García-Fruitós,E.; Rinas,U.; Seras-Franzoso,J.; Kosoy,A.; Corchero,J.L.; Vazquez,E.; ( Year: 2012). Title: Packaging protein drugs as bacterial inclusion bodies for therapeutic applications.Journal: Microbial Cell Factories Volume: 11 Issue: 1, S-Page: 76 DOI: 10.1186/1475-2859-11-76HZI repositoryPubMed
  • Authors: Vanz,A.L.; Lünsdorf,H.; Adnan,A.; Nimtz,M.; Gurramkonda,C.; Khanna,N.; Rinas,U.; ( Year: 2012). Title: Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes.Journal: Microbial Cell Factories Volume: 11, S-Page: 103 DOI: 10.1186/1475-2859-11-103HZI repositoryPubMed
  • Authors: Iphofer,A.; Kummer,A.; Nimtz,Manfred; Ritter,A.; Arnold,T.; Frank,R.; van den Heuvel,Joop; Kessler,B.M.; Jänsch,Lothar; Franke,R.; ( Year: 2012). Title: Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.Journal: ChemBioChem Volume: 13 Issue: 10, S-Page: 1416- E-Page: 1420 PubMed
  • Authors: Schmidt,G.; Krings,U.; Nimtz,Manfred*; Berger,R.G.; ( Year: 2011). Title: A surfactant tolerant laccase of.Journal: World Journal of Microbiology and Biotechnology Volume: 28 Issue: 4, S-Page: 1623- E-Page: 1632
  • Authors: Endres,S.; Hiebl,B.; Hagele,J.; Beltzer,C.; Fuhrmann,R.; Jäger,Volker*; Almeida,M.; Costa,E.; Santos,C.; Traupe,H.; Jung,E.M.; Prantl,L.; Jung,F.; Wilke,A.; Franke,R.P.; ( Year: 2011). Title: Angiogenesis and healing with non-shrinking, fast degradeable PLGA/CaP scaffolds in critical-sized defects in the rabbit femur with or without osteogenically induced mesenchymal stem cells.Journal: Clinical Hemorheology and Microcirculation Volume: 48 Issue: 1, S-Page: 29- E-Page: 40 PubMed
  • Authors: Bals,C.; Schambach,A.; Meyer,J.; Scheper,T.; Rinas,U.; ( Year: 2011). Title: Expression and purification of bioactive soluble murine stem cell factor from recombinant Escherichia coli using thioredoxin as fusion partner.Journal: Journal of Biotechnology Volume: 152 Issue: 1-2, S-Page: 1- E-Page: 8 DOI: 10.1016/j.jbiotec.2011.01.012HZI repositoryPubMed
  • Authors: Busso,D.; Peleg,Y.; Heidebrecht,T.; Romier,C.; Jacobovitch,Y.; Dantes,A.; Salim,L.; Troesch,E.; Schuetz,A.; Heinemann,U.; Folkers,G.E.; Geerlof,A.; Wilmanns,M.; Polewacz,A.; Quedenau,C.; Bussow,Konrad*; Adamson,R.; Blagova,E.; Walton,J.; Cartwright,J.L.; Bird,L.E.; Owens,R.J.; Berrow,N.S.; Wilson,K.S.; Sussman,J.L.; Perrakis,A.; Celie,P.H.; ( Year: 2011). Title: Expression of protein complexes using multiple Escherichia coli protein co-expression systems: A benchmarking study.Journal: Journal of Structural Biology Volume: 175 Issue: 2, S-Page: 159- E-Page: 170 DOI: 10.1016/j.jsb.2011.03.004HZI repositoryPubMed
  • Authors: Ergin,A.; Syrbe,U.; Scheer,R.; Thiel,A.; Adam,T.; Büssow,Konrad*; Duchmann,R.; Zeitz,M.; Sieper,J.; ( Year: 2011). Title: Impaired Peripheral Th1 CD4+ T Cell Response to Escherichia coli Proteins in Patients with Crohn's Disease and Ankylosing Spondylitis3529.Journal: Journal of Clinial Immunology Volume: 31 Issue: 6, S-Page: 998- E-Page: 1009 PubMed
  • Authors: Gohler,A.K.; Kokpinar,O.; Schmidt-Heck,W.; Geffers,R.; Guthke,R.; Rinas,U.; Schuster,S.; Jahreis,K.; Kaleta,C.; ( Year: 2011). Title: More than just a metabolic regulator - elucidation and validation of new targets of PdhR in Escherichia coli1.Journal: BMC Systems Biology Volume: 5, S-Page: 197 DOI: 10.1186/1752-0509-5-197HZI repositoryPubMed
  • Authors: Jain,G.; Jayaraman,G.; Kökpinar,O.; Rinas,U.; Hitzmann,B.; ( Year: 2011). Title: On-line monitoring of recombinant bacterial cultures using multi-wavelength fluorescence spectroscopy.Journal: Biochemical Engineering Journal Volume: 58-59 Issue: 1, S-Page: 133- E-Page: 139
  • Authors: Li,Z.; Nimtz,M.; Rinas,U.; ( Year: 2011). Title: Optimized procedure to generate heavy isotope and selenomethionine-labeled proteins for structure determination using Escherichia coli-based expression systems.Journal: Applied Microbiology and Biotechnology Volume: 92 Issue: 4, S-Page: 823- E-Page: 833 DOI: 10.1007/s00253-011-3603-xHZI repositoryPubMed
  • Authors: Gueorguieva,L.; Palani,S.; Rinas,U.; Jayaraman,G.; Seidel-Morgenstern,A.; ( Year: 2011). Title: Recombinant protein purification using gradient assisted simulated moving bed hydrophobic interaction chromatography. Part II: Process design and experimental validation.Journal: Journal of Chromatography A Volume: 1218 Issue: 37, S-Page: 6402- E-Page: 6411 PubMed
  • Authors: Palani,S.; Gueorguieva,L.; Rinas,U.; Seidel-Morgenstern,A.; Jayaraman,G.; ( Year: 2011). Title: Recombinant protein purification using gradient-assisted simulated moving bed hydrophobic interaction chromatography. Part I: Selection of chromatographic system and estimation of adsorption isotherms.Journal: Journal of Chromatography A Volume: 1218 Issue: 37, S-Page: 6396- E-Page: 6401 PubMed
  • Authors: Li,Z.; Kessler,W.; van den,Heuvel J.; Rinas,U.; ( Year: 2011). Title: Simple defined autoinduction medium for high-level recombinant protein production using T7-based Escherichia coli expression systems.Journal: Applied Microbiology and Biotechnology Volume: 91 Issue: 4, S-Page: 1203- E-Page: 1213 DOI: 10.1007/s00253-011-3407-zHZI repositoryPubMed
  • Authors: Wilke,S.; Gröbe,Lothar*; Maffenbeier,V.; Jäger,Volker*; Gossen,M.; Josewski,J.; Duda,A.; Polle,L.; Owens,R.J.; Wirth,Dagmar*; Heinz,Dirk* W.; van den,Heuvel Joop*; Büssow,Konrad*; ( Year: 2011). Title: Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development.Journal: PLoS ONE Volume: 6 Issue: 12, S-Page: e27829 DOI: 10.1371/journal.pone.0027829HZI repositoryPubMed
  • Authors: de Groot,J.C.; Schluter,K.; Carius,Y.; Quedenau,C.; Vingadassalom,D.; Faix,J.; Weiss,S.M.; Reichelt,J.; Standfuss-Gabisch,C.; Lesser,C.F.; Leong,J.M.; Heinz,Dirk W.*; Büssow,Konrad*; Stradal,Theresia E.*; ( Year: 2011). Title: Structural Basis for Complex Formation between Human IRSp53 and the Translocated Intimin Receptor Tir of Enterohemorrhagic E. coli.Journal: Structure Volume: 19 Issue: 9, S-Page: 1294- E-Page: 1306 DOI: 10.1016/j.str.2011.06.015HZI repositoryPubMed
  • Authors: Lünsdorf,H.; Gurramkonda,C.; Adnan,A.; Khanna,N.; Rinas,U.; ( Year: 2011). Title: Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the Hepatitis B surface antigen.Journal: Microbial Cell Factories Volume: 10, S-Page: 48 DOI: 10.1186/1475-2859-10-48HZI repositoryPubMed
  • Authors: Gurramkonda,C.; Polez,S.; Skoko.N.; Adnan,A.; Gäbel,T.; Chugh,D.; Swaminathan,S.; Khanna,N.; Tisminetzky,S.; Rinas,U.; ( Year: 2010). Title: Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin..Journal: Microbial Cell Factories Volume: 12 Issue: 9, S-Page: 31 DOI: 10.1186/1475-2859-9-31HZI repositoryPubMed
  • Authors: Wilke,S.; Krausze,J.; Gossen,M.; Gröbe,Lothar*; Jager,V.; Gherardi,E.; van den,Heuvel J.; Bussow,Konrad*; ( Year: 2010). Title: Glycoprotein production for structure analysis with stable, glycosylation mutant CHO cell lines established by fluorescence-activated cell sorting.Journal: Protein Science Volume: 19 Issue: 6, S-Page: 1264- E-Page: 1271 PubMed
  • Authors: Martinez-Alonso,M.; Garcia-Fruitos,E.; Ferrer-Miralles,N.; Rinas,U.; Villaverde,A.; ( Year: 2010). Title: Side effects of chaperone gene co-expression in recombinant protein production.Journal: Microbial Cell Factories Volume: 9, S-Page: 64 DOI: 10.1186/1475-2859-9-64HZI repositoryPubMed
  • Authors: Lu,X.; Sun,J.; Nimtz,M.; Wissing,J.; Zeng,A.-P.; Rinas,U.; ( Year: 2010). Title: The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate.Journal: Microbial Cell Factories Volume: 9 Issue: 23, S-Page: 1- E-Page: 13 DOI: 10.1186/1475-2859-9-23HZI repositoryPubMed
  • Authors: Schliephake,H.; Zghoul,N.; Jäger,Volker*; van,Griensven M.; Zeichen,J.; Gelinsky,M.; Szubtarsky,N.; ( Year: 2009). Title: Bone formation in trabecular bone cell seeded scaffolds used for reconstruction of the rat mandible.Journal: International Journal of Oral and Maxillofacial Surgery Surgery Volume: 38 Issue: 2, S-Page: 166- E-Page: 172 PubMed
  • Authors: Schliephake,H.; Zghoul,N.; Jäger,V.; van Griensven,M.; Zeichen,J.; Gelinsky,M.; Wulfing,T.; ( Year: 2009). Title: Effect of seeding technique and scaffold material on bone formation in tissue-engineered constructs.Journal: Journal of Biomedical Materials Research - A Volume: 90 Issue: 2, S-Page: 429- E-Page: 437 DOI: 10.1002/jbm.a.32104PubMed
  • Authors: Shiloach,J.; Rinas,U.; ( Year: 2009). Title: Glucose and acetate metbolism in.Book Title: Systems Biology and Biotechnology of Editors: Lee,S.-Y.; (Ed.). City: Berlin, Heidelberg, New York Publisher: Springer Netherlands, S-Page: 377- E-Page: 400 ISBN: 978-1-4020-9393-7,978-1-4020-9394-4 (ISBN)DOI: 10.1007/978-1-4020-9394-4_18PubMed
  • Authors: Wiesand,U.; Sorg,I.; Amstutz,M.; Wagner,S.; van den Heuvel,Joop*; Lührs,Thorsten*; Cornelis,G.R.; Heinz,Dirk W.*; ( Year: 2009). Title: Structure of the type III secretion recognition protein YscU from.Journal: Journal of Molecular Biology Volume: 385 Issue: 3, S-Page: 854- E-Page: 866 DOI: 10.1016/j.jmb.2008.10.034HZI repositoryPubMed
  • Authors: Visser,R.; Arrabal,P.M.; Becerra,J.; Rinas,U.; Cifuentes,M.; ( Year: 2009). Title: The effect of an rhBMP-2 absorbable collagen sponge-targeted system on bone formation in vivo.Journal: Biomaterials Volume: 30 Issue: 11, S-Page: 2032- E-Page: 2037 PubMed
  • Authors: Wollert,T.; Pasche,Bastian*; Rochon,Maike*; Deppenmeier,S.; van den Heuvel,Joop*; Gruber,A.D.; Heinz,Dirk W.*; Lengeling,Andreas*; Schubert,Wolf-Dieter*; ( Year: 2007). Title: Extending the host range of.Journal: Cell Volume: 129 Issue: 5, S-Page: 891- E-Page: 902
  • Authors: Zieseniss,A.; Schroeder,U.; Buchmeier,S.; Schoenberger,C.; van den Heuvel,Joop*; Jockusch,B.; Illenberger,S.; ( Year: 2007). Title: Raver1 is an integral component of muscle contractile elements.Journal: Cell and Tissue Research Volume: 327 Issue: 3, S-Page: 583- E-Page: 594 DOI: 10.1007/s00441-006-0322-1HZI repositoryPubMed
  • Authors: Niemann,H.N.; Jäger,Volker*; Butler,P.J.G.; van den Heuvel,Joop*; Schmidt,S.; Ferraris,D.; Gherardi,E.; Heinz,Dirk W.*; ( Year: 2007). Title: Structure of the human receptor tyrosine kinase met in complex with the.Journal: Cell Volume: 130 Issue: 2, S-Page: 235- E-Page: 246 DOI: 10.1016/j.cell.2007.05.037HZI repositoryPubMed
  • Authors: Zheng,P; Sun,Jibin*; van den Heuvel,Joop*; Zeng,An-Ping*; ( Year: 2006). Title: Discovery and investigation of a new, second triose phosphate isomerase in.Journal: Journal of Biotechnology Volume: 125 Issue: 4, S-Page: 462- E-Page: 473
  • Authors: Zheng,P.; Wereath,K.; Sun,Jibin*; van den Heuvel,Joop*; Zeng,An-Ping*; ( Year: 2006). Title: Overexpression of genes of the dha regulon and its effects on cell growth, glycerol fermentation to 1,3-propanediol and plasmid stability in.Journal: Process Biochemistry Volume: 41 Issue: 10, S-Page: 2160- E-Page: 2169
  • Authors: Dresler,K.; van den Heuvel,Joop*; Müller,Rolf-Joachim*; Deckwer,Wolf-Dieter*; ( Year: 2006). Title: Production of a recombinant polyester-cleaving hydrolase from.Journal: Bioprocess and Biosystems Engineering Volume: 29, S-Page: 169- E-Page: 183 WEBURLS
  • Authors: Kleeberg,I.; Welzel,K.; van den Heuvel,J.; Müller,R.-J.; Deckwer,W.-D.; ( Year: 2005). Title: Characterization of a new extracellular hydrolase from Thermobifida fusca degrading aliphatic-aromatic copolyesters.Journal: Biomacromolecules Volume: 6, S-Page: 262- E-Page: 270
  • Authors: Astner,I.; Schulze,J.O.; van den Heuvel,J.; Jahn,D.; Schubert,W.-D.; Heinz,D.W.; ( Year: 2005). Title: Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans.Journal: Embo Journal Volume: 24, S-Page: 3166- E-Page: 3177 DOI: 10.1038/sj.emboj.7600792HZI repository
  • Authors: Bollati-Fogolin,M.; Irani,N.; Beccaria,A.J.; Schulz,C.; van den Heuvel,J.; Elias,C.B.; Carpentier,E.; Durocher,Y.; Bisson,L.; Etcheverrigaray,M.; Kratje,R.B.; Wirth,M.; Kamen,A.; Wagner,R.; ( Year: 2005). Title: Impact of yeast pyruvate carboxylase on the productivity of animal host cell lines.Book Title: Animal Cell Technology Meets Genomics Editors: Godia,F.; Fussenegger,M.; (Ed.). City: Dordrecht Publisher: Kluwer Academic Publishers, S-Page: 87- E-Page: 89
  • Authors: Hoffmann,F.; van den Heuvel,J.; Zidek,N.; Rinas,U.; ( Year: 2004). Title: Minimizing inclusion body formation during recombiant protein production in Escherichia coli at bench and pilot plant scale..Journal: Enzyme and Microbial Technology Volume: 34, S-Page: 235- E-Page: 241
  • Authors: Ross,A.; Kessler,W.; Krumme,D.; Menge,U.; Wissing,J.; van den Heuvel,J.; Flohé,L.; ( Year: 2004). Title: Optimised fermentation strategy for 13C/15N recombinant protein labelling in Escherichia coli for NMR-structure analysis.Journal: Journal of Biotechnology Volume: 108, S-Page: 31- E-Page: 39

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