Mouse Pathology

Histology is the science of tissues and pathology. In a sense, it is also the science of diseases and their pathogenesis. The major concern of histologists working in our service unit is helping other HZI researchers make this connection and work out the details of the relationship between histological changes at the tissue level and the infectious diseases they are studying.


  1. Loof, T. G., Goldmann, O., Naudin, C., Morgelin, M., Neumann, Y., Pils, M. C., Foster, S. J., Medina, E. and Herwald, H., Staphylococcus aureus-induced clotting of plasma is an immune evasion mechanism for persistence within the fibrin network. Microbiology 2015. 161: 621-627.
  2. Pawar, V., Komor, U., Kasnitz, N., Bielecki, P., Pils, M. C., Gocht, B., Moter, A., Rohde, M., Weiss, S. and Haussler, S., In Vivo Efficacy of Antimicrobials against Biofilm-Producing Pseudomonas aeruginosa. Antimicrob Agents Chemother 2015. 59: 4974-4981.
  3. Perner, F., Schnoder, T. M., Ranjan, S., Wolleschak, D., Ebert, C., Pils, M. C., Frey, S., Polanetzki, A., Fahldieck, C., Schonborn, U., Schraven, B., Isermann, B., Fischer, T. and Heidel, F. H., Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function. Leukemia 2015.
  4. Marschall, A. L., Single, F. N., Schlarmann, K., Bosio, A., Strebe, N., van den Heuvel, J., Frenzel, A. and Dubel, S., Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies. MAbs 2014. 6: 1394-1401.
  5. Suwandi A, Bargen I, Roy B, et al. Experimental colitis is exacerbated by concomitant infection with Mycobacterium avium ssp. paratuberculosis. Inflammatory bowel diseases. 2014;20:1962-1971
  6. Loof T, Goldmann O, Naudin C, et al. Staphylococcus aureus induced clotting of plasma is an immune evasion mechanism to persist within the fibrin network. Microbiology. 2014
  7. Grundstrom J, Saarne T, Kemi C, et al. Development of a Mouse Model for Chronic Cat Allergen-Induced Asthma. International archives of allergy and immunology. 2014;165:195-205
  8. Wolleschak D, Mack TS, Perner F, et al. Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function. Haematologica. 2014;99:e90-93
  9. Ewald F, Annemann M, Pils MC, et al. Constitutive expression of murine c-FLIPR causes autoimmunity in aged mice. Cell death & disease. 2014;5:e1168
  10. Schweer J, Kulkarni D, Kochut A, et al. The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases. PLoS pathogens. 2013;9:e1003746
  11. Cebula M, Ochel A, Hillebrand U, et al. An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells. PloS one. 2013;8:e68720
  12. Avalos AM, Kirak O, Oelkers JM, et al. Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice. Journal of immunology. 2013;190:695-702
  13. Wos-Oxley M, Bleich A, Oxley AP, et al. Comparative evaluation of establishing a human gut microbial community within rodent models. Gut microbes. 2012;3:234-249
  14. Pils MC, Bleich A, Prinz I, et al. Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-10. Inflammatory bowel diseases. 2011;17:2038-2046
  15. Chaudhry A, Samstein RM, Treuting P, et al. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity. 2011;34:566-578
  16. Pils MC, Pisano F, Fasnacht N, et al. Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model. European journal of immunology. 2010;40:443-448
  17. Fuchs B, Knothe S, Rochlitzer S, et al. A Toll-like receptor 2/6 agonist reduces allergic airway inflammation in chronic respiratory sensitisation to Timothy grass pollen antigens. International archives of allergy and immunology. 2010;152:131-139
  18. Stehr M, Greweling MC, Tischer S, et al. Charles River altered Schaedler flora (CRASF) remained stable for four years in a mouse colony housed in individually ventilated cages. Laboratory animals. 2009;43:362-370
  19. Madan R, Demircik F, Surianarayanan S, et al. Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. Journal of immunology. 2009;183:2312-2320
  20. Fasnacht N, Greweling MC, Bollati-Fogolin M, et al. T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection. European journal of immunology. 2009;39:2173-2183