Transgenic Mice

Genetically modified mice can provide information about the function of particular genes or individual genetic elements. Further, they can be specifically designed to mimic certain physiologic or pathologic conditions. The Service Unit "Transgenic Mice" (TGSM) creates such genetically modified mice for researchers of the center.


Prof Dr Dagmar Wirth

„Targeted genetic modification of mice represents a unique method in infection research. With this technology, experimental mouse models can be developed that allow the investigation of many aspects of infection and host response.“

Prof Dr Dagmar Wirth

Dagmar Wirth studied chemistry in Braunschweig. She began focusing on gene regulation in mammalian cells as part of her doctoral work at GBF – today’s HZI – with a special focus on chromosomal elements that affect gene expression. As a post-doc, she conducted research on recombination in mammalian cells and viruses and developed recombinant viruses for application in biotechnology and gene therapy.

Following her work as a scientist in the Department of Clinical Immunology at the Medical University in Hannover, she returned in 2004 to assume her current role as principal investigator for the project ‘Immune evasion in chronic infections’ and as head of the research group ‘Model Systems for Infection and Immunity’ (MSYS).

One underlying activity of her research in MSYS is the generation of genetically modified mice with predictable expression properties. To provide this expertise to all research groups of the center, in 2012, the Service Unit "Transgenic Mice" (TGSM) was initiated which is also headed by Dagmar Wirth.


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