Biosafety Level 3 Laboratory
Biological agents of risk group 3 (RG3) pose a constant global as well as national challenge because they cause severe illnesses in humans against which there are usually no effective preventive or treatment measures. Since these pathogens can only be handled in special biosafety level 3 (BSL3) laboratories, the modern BSL3 laboratories at the HZI provide a technology platform that is indispensable in today's infection research - only in this way can our scientists develop new therapies, prevention measures or diagnostic procedures against these pathogens.
Leader
Publications from the BSL3
Department CBIO (Prof. Dr. Mark Brönstrup):
The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway. Fleta-Soriano E, Martinez JP, Hinkelmann B, Gerth K, Washausen P, Diez J, Frank R, Sasse F, Meyerhans A. Microb Cell Fact. 2014 Jan 29;13:17. doi: 10.1186/1475-2859-13-17.
Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assay.Martinez JP, Hinkelmann B, Fleta-Soriano E, Steinmetz H, Jansen R, Diez J, Frank R, Sasse F, Meyerhans A. Microb Cell Fact. 2013 Sep 24;12:85. doi: 10.1186/1475-2859-12-85.
The Myxobacterial Metabolite Soraphen A Inhibits HIV-1 by Reducing Virus Production and Altering Virion Composition. Fleta-Soriano E, Smutná K, Martínez JP, Lorca Oró C, Sadiq SK, Mirambeau G, Lopez-Iglesias C, Bosch M, Pol A, Brönstrup M, Diez J, Meyerhans A. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00739-17. doi: 10.1128/AAC.00739-17. Print 2017 Aug
Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity. Koutsoudakis G, Romero-Brey I, Berger C, Pérez-Vilaró G, Monteiro Perin P, Vondran FW, Kalesse M, Harmrolfs K, Müller R, Martinez JP, Pietschmann T, Bartenschlager R, Brönstrup M, Meyerhans A, Díez J. J Hepatol. 2015 Oct;63(4):813-21. doi: 10.1016/j.jhep.2015.06.002. Epub 2015 Jun 10
Patente:
Brönstrup M., Prochnow H., Birudukota N. V. S., Schulz T., Messerle M., Pietschmann T., Haid S., Blockus S., Laqmani-Goffinet C., Franz S., Banda D., (2017) Labyrinthopeptins As Anti-Viral Agents Pa-tent No. WO/2017/085257, International Patent No. PCT/EP2016/078143
Department INFG, Prof.Dr. Klaus Schughart:
Kanrai P, Mostafa A, Madhugiri R, Lechner M, Wilk E, Schughart K, Ylösmäki L, Saksela K, Ziebuhr J, Pleschka S. Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems. J Gen Virol. 2016 Sep;97(9):2135-48.
Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function. Shirin Hosseini, Esther Wilk, Kristin Michaelsen-Preusse, Ingo Gerhauser, Wolfgang Baumgärtner, Robert Geffers, Klaus Schughart, Martin Korte. Journal of Neuroscience; in press.
Hatesuer B, Bertram S, Mehnert N, Bahgat MM, Nelson PS, Pöhlmann S, Schughart K. Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice. PLoS Pathog. 2013;9(12):e1003774.
Kühn N, Bergmann S, Kösterke N, Lambertz RL, Keppner A, van den Brand JM, Pöhlmann S, Weiß S, Hummler E, Hatesuer B, Schughart K. The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases. J Virol. 2016 Apr 14;90(9):4298-307.
Research Group IMMI, Prof. Dr. Andrea Kröger:
Asghar N, Lee YP, Nilsson E, Lindqvist R, Melik W, Kröger A, Overby AK, Johansson M (2016) The role of the poly(A) tract in the replication and virulence of tick-borne encephalitis virus. Scientific reports 6: 39265
Kurhade C, Zegenhagen L, Weber E, Nair S, Michaelsen-Preusse K, Spanier J, Gekara NO, Kröger A*, Overby AK* (2016) Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1. Journal of neuroinflammation 13: 22
Lindqvist R, Mundt F, Gilthorpe JD, Wolfel S, Gekara NO, Kröger A, Overby AK (2016) Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects. Journal of neuroinflammation 13: 277
Weber E, Finsterbusch K, Lindquist R, Nair S, Lienenklaus S, Gekara NO, Janik D, Weiss S, Kalinke U, Overby AK*, Kröger A* (2014) Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses. Journal of virology 88: 12202-12212