Genome Analytics

As a research center with ongoing research and development, the Helmholtz Centre for Infection Research possesses broad expertise in gene expression analysis. Scientists at the center can use this service, but it is also available to external clients.
To find out which genes are involved in a particular infection process, the technology platform "Gene Expression Analysis" is an essential tool for scientists at the Helmholtz Centre for Infection Research. Tailor-made gene chips are configured here for researchers at the center or for outside partners. Gene chips make it possible to test which genes are active during certain metabolic processes. Support and advice are also available when using standardized chips from external, commercial providers.

Leader

Publications

  • Authors: Kueneman,J.G.; Bletz,M.C.; McKenzie,V.J.; Becker,C.G.; Joseph,M.B.; Abarca,J.G.; Archer,H.; Arellano,A.L.; Bataille,A.; Becker,M.; Belden,L.K.; Crottini,A.; Geffers,R.; Haddad,C.F.B.; Harris,R.N.; Holden,W.M.; Hughey,M.; Jarek,M.; Kearns,P.J.; Kerby,J.L.; Kielgast,J.; Kurabayashi,A.; Longo,A.V.; Loudon,A.; Medina,D.; Nunez,J.J.; Perl,R.G.B.; Pinto-Tom a s,A.; Rabemananjara,F.C.E.; Rebollar,E.A.; RodrÆguez , A.; Rollins-Smith,L.; Stevenson,R.; Tebbe,C.C.; Vargas Asensio,G.; Waldman,B.; Walke,J.B.; Whitfield,S.M.; Zamudio,K.R.; Z·±iga Chaves,I.; Woodhams,D.C.; Vences,M.; ( Year: 2019). Title: Community richness of amphibian skin bacteria correlates with bioclimate at the global scale.Journal: Nat.Ecol.Evol. Volume: 3 Issue: 3, S-Page: 381- E-Page: 389 DOI: 10.1038/s41559-019-0798-1HZI repositoryPubMed
  • Authors: Will,S.E.; Henke,P.; Boedeker,C.; Huang,S.; Brinkmann,H.; Rohde,M.; Jarek,M.; Friedl,T.; Seufert,S.; Schumacher,M.; Overmann,J.; Neumann-Schaal,M.; Petersen,J.; ( Year: 2019). Title: Day and night: Metabolic profiles and evolutionary relationships of six axenic non-marine cyanobacteria.Journal: Genome Biol.Evol. Volume: 11 Issue: 1, S-Page: 270- E-Page: 294 DOI: 10.1093/gbe/evy275HZI repositoryPubMed
  • Authors: Scharf,G.M.; Kilian,K.; Cordero,J.; Wang,Y.; Grund,A.; Hofmann,M.; Froese,N.; Wang,X.; Kispert,A.; Kist,R.; Conway,S.J.; Geffers,R.; Wollert,K.C.; Dobreva,G.; Bauersachs,J.; Heineke,J.; ( Year: 2019). Title: Inactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation.Journal: JCI Insight Volume: 4 Issue: 15, S-Page: Article number e126721 DOI: 10.1172/jci.insight.126721HZI repositoryPubMed
  • Authors: Koppenhöfer,S.; Wang,H.; Scharfe,M.; Kaever,V.; Wagner-Döbler,I.; Tomasch,J.; ( Year: 2019). Title: Integrated Transcriptional Regulatory Network of Quorum Sensing, Replication Control, and SOS Response in Dinoroseobacter shibae.Journal: Front Microbiol Volume: 10, S-Page: 803 DOI: 10.3389/fmicb.2019.00803HZI repositoryPubMed
  • Authors: Becker,C.G.; Bletz,M.C.; Greenspan,S.E.; Rodriguez,D.; Lambertini,C.; Jenkinson,T.S.; Guimaraes,P.R.,Jr.; Assis,A.P.A.; Geffers,R.; Jarek,M.; Toledo,L.F.; Vences,M.; Haddad,C.F.B.; ( Year: 2019). Title: Low-load pathogen spillover predicts shifts in skin microbiome and survival of a terrestrial-breeding amphibian.Journal: Proc.Biol.Sci. Volume: 286 Issue: 1908, S-Page: 20191114 DOI: 10.1098/rspb.2019.1114PubMed
  • Authors: Waindok,P.; Janecek-Erfurth,E.; Lindenwald,D.; Wilk,E.; Schughart,K.; Geffers,R.; Balas,L.; Durand,T.; Rund,K.M.; Schebb,N.H.; Strube,C.; ( Year: 2019). Title: Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis.Journal: PLoS Negl.Trop.Dis. Volume: 13 Issue: 9, S-Page: e0007706 DOI: 10.1371/journal.pntd.0007706HZI repositoryPubMed
  • Authors: Tang,B.M.; Shojaei,M.; Teoh,S.; Meyers,A.; Ho,J.; Ball,T.B.; Keynan,Y.; Pisipati,A.; Kumar,A.; Eisen,D.P.; Lai,K.; Gillett,M.; Santram,R.; Geffers,R.; Schreiber,J.; Mozhui,K.; Huang,S.; Parnell,G.P.; Nalos,M.; Holubova,M.; Chew,T.; Booth,D.; Kumar,A.; McLean,A.; Schughart,K.; ( Year: 2019). Title: Neutrophils-related host factors associated with severe disease and fatality in patients with influenza infection.Journal: Nature Communications Volume: 10 Issue: 1, S-Page: 3422 DOI: 10.1038/s41467-019-11249-yHZI repositoryPubMed
  • Authors: Samir,M.; Vidal,R.O.; Abdallah,F.; Capece,V.; Seehusen,F.; Geffers,R.; Hussein,A.; Ali,A.A.H.; Bonn,S.; Pessler,F.; ( Year: 2019). Title: Organ-specific small non-coding RNA responses in domestic (Sudani) ducks experimentally infected with highly pathogenic avian influenza virus (H5N1).Journal: RNA.Biol., S-Page: 1- E-Page: 13 DOI: 10.1080/15476286.2019.1669879PubMed
  • Authors: Olsen,R.S.; Dimberg,J.; Geffers,R.; Wagsäter,D.; ( Year: 2019). Title: Possible Role and Therapeutic Target of PDGF-D Signalling in Colorectal Cancer.Journal: Cancer Invest. Volume: 37 Issue: 2, S-Page: 99- E-Page: 112 DOI: 10.1080/07357907.2019.1576191PubMed
  • Authors: Sogkas,G.; Dubrowinskaja,N.; Bergmann,A.K.; Lentes,J.; Ripperger,T.; Fedchenko,M.; Ernst,D.; Jablonka,A.; Geffers,R.; Baumann,U.; Schmidt,R.E.; Atschekzei,F.; ( Year: 2019). Title: Progressive Immunodeficiency with Gradual Depletion of B and CD4(+) T Cells in Immunodeficiency, Centromeric Instability and Facial Anomalies Syndrome 2 (ICF2).Journal: Diseases. Volume: 7 Issue: 2, S-Page: E34 DOI: 10.3390/diseases7020034HZI repositoryPubMed
  • Authors: Guo,L.; Huang,J.; Chen,M.; Piotrowski,E.; Song,N.; Zahner,G.; Paust,H.J.; Alawi,M.; Geffers,R.; Thaiss,F.; ( Year: 2019). Title: T-lymphocyte-specific knockout of IKK-2 or NEMO induces Th17 cells in an experimental nephrotoxic nephritis mouse model.Journal: FASEB J. Volume: 33 Issue: 2, S-Page: 2359- E-Page: 2371 DOI: 10.1096/fj.201800485RRPubMed
  • Authors: Sonnenschein,K.; Fiedler,J.; Pfanne,A.; Just,A.; Mitzka,S.; Geffers,R.R.; Pich,A.; Bauersachs,J.; Thum,T.; ( Year: 2019). Title: Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury.Journal: Cardiovasc.Res. Volume: 115 Issue: 12, S-Page: 1804- E-Page: 1810 DOI: 10.1093/cvr/cvz063HZI repositoryPubMed
  • Authors: Guo,Y.; Cichocki,N.; Schattenberg,F.; Geffers,R.; Harms,H.; Müller,S.; ( Year: 2018). Title: AgNPs Change Microbial Community Structures of Wastewater.Journal: Front Microbiol. Volume: 9, S-Page: 3211 DOI: 10.3389/fmicb.2018.03211HZI repositoryPubMed
  • Authors: Froese,N.; Wang,H.; Zwadlo,C.; Wang,Y.; Grund,A.; Gigina,A.; Hofmann,M.; Kilian,K.; Scharf,G.; Korf-Klingebiel,M.; Melchert,A.; Signorini,M.E.R.; Halloin,C.; Zweigerdt,R.; Martin,U.; Gruh,I.; Wollert,K.C.; Geffers,R.; Bauersachs,J.; Heineke,J.; ( Year: 2018). Title: Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice.Journal: J.Mol.Cell.Cardiol. Volume: 122 Issue: Sept, S-Page: 114- E-Page: 124 DOI: 10.1016/j.yjmcc.2018.08.011PubMed
  • Authors: Wang,J.; Bogdanova,N.; Schürmann,P.; Park-Simon,T.W.; Geffers,R.; Dörk,T.; ( Year: 2018). Title: Assessment of a FBXW8 frameshift mutation, c.1312_1313delGT, in breast cancer patients and controls from Central Europe.Journal: Cancer Genet. Volume: 220 Issue: January, S-Page: 38- E-Page: 43 DOI: 10.1016/j.cancergen.2017.11.006PubMed
  • Authors: Nergadze,S.G.; Piras,F.M.; Gamba,R.; Corbo,M.; Cerutti,F.; McCarter,J.G.W.; Cappelletti,E.; Gozzo,F.; Harman,R.M.; Antczak,D.F.; Miller,D.; Scharfe,M.; Pavesi,G.; Raimondi,E.; Sullivan,K.F.; Giulotto,E.; ( Year: 2018). Title: Birth, evolution, and transmission of satellite-free mammalian centromeric domains.Journal: Genome Res. Volume: 28 Issue: 6, S-Page: 789- E-Page: 799 DOI: 10.1101/gr.231159.117HZI repositoryPubMed
  • Authors: Froese,N.; Wang,H.; Zwadlo,C.; Wang,Y.; Grund,A.; Gigina,A.; Hofmann,M.; Kilian,K.; Scharf,G.; Korf-Klingebiel,M.; Melchert,A.; Signorini,M.E.R.; Halloin,C.; Zweigerdt,R.; Martin,U.; Gruh,I.; Wollert,K.C.; Geffers,R.; Bauersachs,J.; Heineke,J.; ( Year: 2018). Title: Corrigendum to "Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice" [Journal of Molecular and Cellular Cardiology 122 (2018) 114-12.Journal: J.Mol.Cell Cardiol. Volume: 125 Issue: December, S-Page: 205 DOI: 10.1016/j.yjmcc.2018.11.003PubMed
  • Authors: Glaesener,S.; Jaenke,C.; Habener,A.; Geffers,R.; Hagendorff,P.; Witzlau,K.; Imelmann,E.; Krueger,A.; Meyer-Bahlburg,A.; ( Year: 2018). Title: Decreased production of class-switched antibodies in neonatal B cells is associated with increased expression of miR-181b.Journal: PLoS.ONE. Volume: 13 Issue: 2, S-Page: e0192230 DOI: 10.1371/journal.pone.0192230HZI repositoryPubMed
  • Authors: Ludewig-Klingner,A.K.; Michael,V.; Jarek,M.; Brinkmann,H.; Petersen,J.; ( Year: 2018). Title: Distribution and Evolution of Peroxisomes in Alveolates (Apicomplexa, Dinoflagellates, Ciliates).Journal: Genome Biol.Evol. Volume: 10 Issue: 1, S-Page: 3531- E-Page: 3543 DOI: 10.1093/gbe/evx250HZI repositoryPubMed
  • Authors: Riahi,A.; Radmanesh,H.; Schürmann,P.; Bogdanova,N.; Geffers,R.; Meddeb,R.; Kharrat,M.; Dörk,T.; ( Year: 2018). Title: Exome sequencing and case-control analyses identify RCC1 as a candidate breast cancer susceptibility gene.Journal: Int.J.Cancer Volume: 142 Issue: 12, S-Page: 2512- E-Page: 2517 DOI: 10.1002/ijc.31273HZI repositoryPubMed
  • Authors: Koestner,W.; Spanier,J.; Klause,T.; Tegtmeyer,P.K.; Becker,J.; Herder,V.; Borst,K.; Todt,D.; Lienenklaus,S.; Gerhauser,I.; Detje,C.N.; Geffers,R.; Langereis,M.A.; Vondran,F.W.R.; Yuan,Q.; van Kuppeveld,F.J.M.; Ott,M.; Staeheli,P.; Steinmann,E.; Baumgärtner,W.; Wacker,F.; Kalinke,U.; ( Year: 2018). Title: Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice.Journal: PLoS.Pathog. Volume: 14 Issue: 8, S-Page: e1007235 DOI: 10.1371/journal.ppat.1007235FulltextHZI repositoryPubMed
  • Authors: Hosseini,S.; Wilk,E.; Michaelsen-Preusse,K.; Gerhauser,I.; Baumgärtner,W.; Geffers,R.; Schughart,K.; Korte,M.; ( Year: 2018). Title: Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function.Journal: J.Neurosci. Volume: 38 Issue: 12, S-Page: 3060- E-Page: 3080 DOI: 10.1523/JNEUROSCI.1740-17.2018PubMed
  • Authors: Kollmus,H.; Pilzner,C.; Leist,S.R.; Heise,M.; Geffers,R.; Schughart,K.; ( Year: 2018). Title: Of mice and men: the host response to influenza virus infection.Journal: Mamm.Genome Volume: 29 Issue: 7-8, S-Page: 446- E-Page: 470 DOI: 10.1007/s00335-018-9750-yFulltextPubMed
  • Authors: Tomasch,J.; Wang,H.; Hall,A.T.K.; Patzelt,D.; Preusse,M.; Petersen,J.; Brinkmann,H.; Bunk,B.; Bhuju,S.; Jarek,M.; Geffers,R.; Lang,A.S.; Wagner-Döbler,I.; ( Year: 2018). Title: Packaging of Dinoroseobacter shibae DNA into Gene Transfer Agent Particles Is Not Random.Journal: Genome Biol.Evol. Volume: 10 Issue: 1, S-Page: 359- E-Page: 369 DOI: 10.1093/gbe/evy005HZI repositoryPubMed
  • Authors: Walter,C.; Pozzorini,C.; Reinhardt,K.; Geffers,R.; Xu,Z.; Reinhardt,D.; von Neuhoff,N.; Hanenberg,H.; ( Year: 2018). Title: Single-cell whole exome and targeted sequencing in NPM1/FLT3 positive pediatric acute myeloid leukemia.Journal: Pediatr.Blood Cancer Volume: 65 Issue: 2 DOI: 10.1002/pbc.26848PubMed
  • Authors: Deng,Z.L.; Sztajer,H.; Jarek,M.; Bhuju,S.; Wagner-Döbler,I.; ( Year: 2018). Title: Worlds apart - Transcriptome profiles of key oral microbes in the periodontal pocket compared to single laboratory culture reflect synergistic interactions.Journal: Front.Microbiol. Volume: 9 Issue: FEB, S-Page: 124 DOI: 10.3389/fmicb.2018.00124FulltextPubMed
  • Authors: Chen,S.; Nagel,S.; Schneider,B.; Dai,H.; Geffers,R.; Kaufmann,M.; Meyer,C.; Pommerenke,C.; Thress,K.S.; Li,J.; Quentmeier,H.; Drexler,H.G.; MacLeod,R.A.F.; ( Year: 2017). Title: A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report.Journal: Cell Oncol.(Dordr.), S-Page: 2211- E-Page: 3436 DOI: 10.1007/s13402-017-0356-2 HZI repository PubMed
  • Authors: Tang,B.M.; Shojaei,M.; Parnell,G.P.; Huang,S.; Nalos,M.; Teoh,S.; O'Connor,K.; Schibeci,S.; Phu,A.L.; Kumar,A.; Ho,J.; Meyers,A.F.A.; Keynan,Y.; Ball,T.; Pisipati,A.; Kumar,A.; Moore,E.; Eisen,D.; Lai,K.; Gillett,M.; Geffers,R.; Luo,H.; Gul,F.; Schreiber,J.; Riedel,S.; Booth,D.; McLean,A.; Schughart,K.; ( Year: 2017). Title: A novel immune biomarker IFI27 discriminates between influenza and bacteria in patients with suspected respiratory infection.Journal: Eur.Respir.J. Volume: 49 Issue: 6 DOI: 10.1183/13993003.02098-2016PubMed
  • Authors: Nikolouli,E.; Hardtke-Wolenski,M.; Hapke,M.; Beckstette,M.; Geffers,R.; Floess,S.; Jaeckel,E.; Huehn,J.; ( Year: 2017). Title: Alloantigen-induced regulatory t cells generated in presence of vitamin c display enhanced stability of foxp3 expression and promote skin allograft acceptance.Journal: Frontiers in Immunology Volume: 8 Issue: 748 DOI: 10.3389/fimmu.2017.00748HZI repositoryPubMed
  • Authors: Bletz,M.C.; Perl,R.G.; Bobowski,B.T.; Japke,L.M.; Tebbe,C.C.; Dohrmann,A.B.; Bhuju,S.; Geffers,R.; Jarek,M.; Vences,M.; ( Year: 2017). Title: Amphibian skin microbiota exhibits temporal variation in community structure but stability of predicted Bd-inhibitory function.Journal: ISME.J. Volume: 11 Issue: 7, S-Page: 1521- E-Page: 1534 DOI: 10.1038/ismej.2017.41Fulltext HZI repository PubMed
  • Authors: Radmanesh,H.; Spethmann,T.; Enssen,J.; Schurmann,P.; Bhuju,S.; Geffers,R.; Antonenkova,N.; Khusnutdinova,E.; Sadr-Nabavi,A.; Shandiz,F.H.; Park-Simon,T.W.; Hillemanns,P.; Christiansen,H.; Bogdanova,N.; Dork,T.; ( Year: 2017). Title: Assessment of an APOBEC3B truncating mutation, c.783delG, in patients with breast cancer.Journal: Breast Cancer Res Treat. Volume: 162 Issue: 1, S-Page: 31- E-Page: 37 DOI: 10.1007/s10549-016-4100-9HZI repositoryPubMed
  • Authors: Pietrucha,B.; Heropolitanska-Pliszka,E.; Geffers,R.; Enßen,J.; Wieland,B.; Bogdanova,N.V.; Dörk,T.; ( Year: 2017). Title: Clinical and biological manifestation of RNF168 deficiency in two polish siblings.Journal: Frontiers in Immunology Volume: 8 Issue: DEC, S-Page: 1683 DOI: 10.3389/fimmu.2017.01683HZI repositoryPubMed
  • Authors: Möbius,P.; Nordsiek,G.; Holzer,M.; Jarek,M.; Marz,M.; Köhler,H.; ( Year: 2017). Title: Complete Genome Sequence of JII-1961, a Bovine Mycobacterium avium subsp. paratuberculosis Field Isolate from Germany.Journal: Genome Announc. Volume: 5 Issue: 34 DOI: 10.1128/genomeA.00870-17HZI repositoryPubMed
  • Authors: Donner,J.; Bunk,B.; Schober,I.; Spröer,C.; Bergmann,S.; Jarek,M.; Overmann,J.; Wagner-Döbler,I.; ( Year: 2017). Title: Complete genome sequences of three multidrug-resistant clinical isolates of Streptococcus pneumoniae serotype 19A with different susceptibilities to the myxobacterial metabolite carolacton.Journal: Genome Announcement Volume: 5 Issue: 7, S-Page: e01641-16 DOI: 10.1128/genomeA.01641-16HZI repositoryPubMed
  • Authors: Swierzy,I.J.; Handel,U.; Kaever,A.; Jarek,M.; Scharfe,M.; Schlüter,D.; Luder,C.G.K.; ( Year: 2017). Title: Divergent co-transcriptomes of different host cells infected with Toxoplasma gondii reveal cell type-specific host-parasite interactions.Journal: Sci.Rep. Volume: 7 Issue: 1, S-Page: 7229 DOI: 10.1038/s41598-017-07838-wHZI repositoryPubMed
  • Authors: Eichhorn,I.; van der,Linden M.; Jarek,M.; Fulde,M.; ( Year: 2017). Title: Draft Genome Sequence of Zoonotic Streptococcus canis Isolate G361.Journal: Genome Announc. Volume: 5 Issue: 38, S-Page: e00967-17 DOI: 10.1128/genomeA.00967-17HZI repositoryPubMed
  • Authors: Deng,Z.L.; Szafranski,S.P.; Jarek,M.; Bhuju,S.; Wagner-Döbler,I.; ( Year: 2017). Title: Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host.Journal: Sci.Rep. Volume: 7 Issue: 1, S-Page: 3703 DOI: 10.1038/s41598-017-03804-8HZI repositoryPubMed
  • Authors: Ravens,S.; Schultze-Florey,C.; Raha,S.; Sandrock,I.; Drenker,M.; Oberd÷rfer,L.; Reinhardt,A.; Ravens,I.; Beck,M.; Geffers,R.; Von Kaisenberg,C.; Heuser,M.; Thol,F.; Ganser,A.; Förster,R.; Koenecke,C.; Prinz,I.; ( Year: 2017). Title: Erratum to: Human gammadelta T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection (Nature Immunology, (2017), 18, 4, (393-401), 10.1038/ni.3686).Journal: Nat.Immunol. Volume: 19 Issue: 9, S-Page: 1037 DOI: 10.1038/s41590-018-0054-xPubMed
  • Authors: Kar,S.; Bali,K.K.; Baisantry,A.; Geffers,R.; Samii,A.; Bertalanffy,H.; ( Year: 2017). Title: Genome-Wide Sequencing Reveals MicroRNAs Downregulated in Cerebral Cavernous Malformations.Journal: J Mol.Neurosci. Volume: 61 Issue: 2, S-Page: 178- E-Page: 188 DOI: 10.1007/s12031-017-0880-6HZI repositoryPubMed
  • Authors: Singh,A.K.; Rooge,S.B.; Varshney,A.; Vasudevan,M.; Bhardwaj,A.; Venugopal,S.K.; TrehanPati,N.; Kumar,M.; Geffers,R.; Kumar,V.; Sarin,S.K.; ( Year: 2017). Title: Global micro RNA expression profiling in the liver biopsies of Hepatitis B Virus infected patients suggests specific miRNA signatures for viral persistence and hepatocellular injury.Journal: Hepatology Volume: 67 Issue: 5, S-Page: 1695- E-Page: 1709 DOI: 10.1002/hep.29690HZI repositoryPubMed
  • Authors: Ravens,S.; Schultze-Florey,C.; Raha,S.; Sandrock,I.; Drenker,M.; Oberdorfer,L.; Reinhardt,A.; Ravens,I.; Beck,M.; Geffers,R.; von,Kaisenberg C.; Heuser,M.; Thol,F.; Ganser,A.; Forster,R.; Koenecke,C.; Prinz,I.; ( Year: 2017). Title: Human gammadelta T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection.Journal: Nat.Immunol. Volume: 18 Issue: 4, S-Page: 393- E-Page: 401 DOI: 10.1038/ni.3686PubMed
  • Authors: Lang,M.; Berry,D.; Passecker,K.; Mesteri,I.; Bhuju,S.; Ebner,F.; Sedlyarov,V.; Evstatiev,R.; Dammann,K.; Loy,A.; Kuzyk,O.; Kovarik,P.; Khare,V.; Beibel,M.; Roma,G.; Meisner-Kober,N.; Gasche,C.; ( Year: 2017). Title: HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.Journal: Cancer Research Volume: 77 Issue: 9, S-Page: 2424- E-Page: 2438 DOI: 10.1158/0008-5472.CAN-15-1726HZI repositoryPubMed
  • Authors: Westendorf,A.M.; Skibbe,K.; Adamczyk,A.; Buer,J.; Geffers,R.; Hansen,W.; Pastille,E.; Jendrossek,V.; ( Year: 2017). Title: Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity.Journal: Cell Physiol Biochem. Volume: 41 Issue: 4, S-Page: 1271- E-Page: 1284 DOI: 10.1159/000464429HZI repositoryPubMed
  • Authors: Heuser,M.; Gabdoulline,R.; Loffeld,P.; Dobbernack,V.; Kreimeyer,H.; Pankratz,M.; Flintrop,M.; Liebich,A.; Klesse,S.; Panagiota,V.; Stadler,M.; Wichmann,M.; Shahswar,R.; Platzbecker,U.; Thiede,C.; Schroeder,T.; Kobbe,G.; Geffers,R.; Schlegelberger,B.; Gohring,G.; Kreipe,H.H.; Germing,U.; Ganser,A.; Kroger,N.; Koenecke,C.; Thol,F.; ( Year: 2017). Title: Individual outcome prediction for myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia from MDS after allogeneic hematopoietic cell transplantation.Journal: Ann.Hematol. Volume: 96 Issue: 8, S-Page: 1361- E-Page: 1372 DOI: 10.1007/s00277-017-3027-5PubMed
  • Authors: Bernhardt,A.; Fehr,A.; Brandt,S.; Jerchel,S.; Ballhause,T.M.; Philipsen,L.; Stolze,S.; Geffers,R.; Weng,H.; Fischer,K.D.; Isermann,B.; Brunner-Weinzierl,M.C.; Batra,A.; Siegmund,B.; Zhu,C.; Lindquist,J.A.; Mertens,P.R.; ( Year: 2017). Title: Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1.Journal: Kidney Int. Volume: 92 Issue: 5, S-Page: 1157- E-Page: 1177 DOI: 10.1016/j.kint.2017.03.035PubMed
  • Authors: Atschekzei,F.; Dörk,T.; Schürmann,P.; Geffers,R.; Witte,T.; Schmidt,R.E.; ( Year: 2017). Title: Limited role of interferon-kappa (IFNK) truncating mutations in common variable immunodeficiency.Journal: Cytokine Volume: 96 Issue: Aug, S-Page: 71- E-Page: 74 DOI: 10.1016/j.cyto.2017.03.005PubMed
  • Authors: Chaturvedi,A.; Herbst,L.; Pusch,S.; Klett,L.; Goparaju,R.; Stichel,D.; Kaulfuss,S.; Panknin,O.; Zimmermann,K.; Toschi,L.; Neuhaus,R.; Haegebarth,A.; Rehwinkel,H.; Hess-Stumpp,H.; Bauser,M.; Bochtler,T.; Struys,E.A.; Sharma,A.; Bakkali,A.; Geffers,R.; raujo-Cruz,M.M.; Thol,F.; Gabdoulline,R.; Ganser,A.; Ho,A.D.; von,Deimling A.; Rippe,K.; Heuser,M.; Kramer,A.; ( Year: 2017). Title: Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo.Journal: Leukemia Volume: 31 Issue: 10, S-Page: 2020- E-Page: 2028 DOI: 10.1038/leu.2017.46PubMed
  • Authors: Ehrentraut,S.; Nagel,S.; Pommerenke,C.; Dirks,W.G.; Quentmeier,H.; Kaufmann,M.; Meyer,C.; Zaborski,M.; Geffers,R.; Fujiwara,H.; Drexler,H.G.; MacLeod,R.A.F.; ( Year: 2017). Title: Peripheral T-cell lymphoma cell line T8ML-1 highlights conspicuous targeting of PVRL2 by t(14;19)(q11.2;q13.3).Journal: Haematologica Volume: 102 Issue: 9, S-Page: 356- E-Page: 359 DOI: 10.3324/haematol.2017.168203FulltextHZI repositoryPubMed
  • Authors: Irisarri,I.; Baurain,D.; Brinkmann,H.; Delsuc,F.; Sire,J.Y.; Kupfer,A.; Petersen,J.; Jarek,M.; Meyer,A.; Vences,M.; Philippe,H.; ( Year: 2017). Title: Phylotranscriptomic consolidation of the jawed vertebrate timetree.Journal: Nat.Ecol.Evol. Volume: 1 Issue: 9, S-Page: 1370- E-Page: 1378 DOI: 10.1038/s41559-017-0240-5HZI repositoryPubMed
  • Authors: Szafranski,S.P.; Deng,Z.L.; Tomasch,J.; Jarek,M.; Bhuju,S.; Rohde,M.; Sztajer,H.; Wagner-Döbler,I.; ( Year: 2017). Title: Quorum sensing of Streptococcus mutans is activated by Aggregatibacter actinomycetemcomitans and by the periodontal microbiome.Journal: BMC GENOMICS Volume: 18 Issue: 1, S-Page: 238 DOI: 10.1186/s12864-017-3618-5HZI repositoryPubMed
  • Authors: Sabino-Pinto,J.; Galan,P.; Rodriguez,S.; Bletz,M.C.; Bhuju,S.; Geffers,R.; Jarek,M.; Vences,M.; ( Year: 2017). Title: Temporal changes in cutaneous bacterial communities of terrestrial- and aquatic- phase newts (Amphibia).Journal: Environmental Microbiology Volume: 19 Issue: 8, S-Page: 3025- E-Page: 3038 DOI: 10.1111/1462-2920.13762 HZI repository PubMed
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  • Authors: Jurida,L.; Soelch,J.; Bartkuhn,M.; Handschick,K.; Muller,H.; Newel,D.; Weber,A.; Dittrich-Breiholz,O.; Schneider,H.; Bhuju,S.; Saul,V.V.; Schmitz,M.L.; Kracht,M.; ( Year: 2015). Title: The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-kappaB p65.Journal: Cell Reports Volume: 10 Issue: 5, S-Page: 726- E-Page: 739 DOI: 10.1016/j.celrep.2015.01.001HZI repositoryPubMed
  • Authors: Orlik,J.; Schungel,S.; Buitrago-Molina,L.E.; Geffers,R.; Endig,J.; Marhenke,S.; Lobschat,K.; Rossler,S.; Goeppert,B.; Manns,M.P.; Gross,A.; Vogel,A.; ( Year: 2015). Title: The BH3-only protein BID impairs the p38-mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice.Journal: Hepatology Volume: 62, S-Page: 816- E-Page: 828 DOI: 10.1002/hep.27888HZI repositoryPubMed
  • Authors: Roessler,J.; Ammerpohl,O.; Gutwein,J.; Steinemann,D.; Schlegelberger,B.; Weyer,V.; Sariyar,M.; Geffers,R.; Arnold,N.; Schmutzler,R.; Bartram,C.R.; Heinrich,T.; Abbas,M.; Antonopoulos,W.; Schipper,E.; Hasemeier,B.; Kreipe,H.; Lehmann,U.; ( Year: 2015). Title: The CpG island methylator phenotype in breast cancer is associated with the lobular subtype.Journal: Epigenomics Volume: 7 Issue: 2, S-Page: 187- E-Page: 199 WEBURLS
  • Authors: Lauber,C.; Vieyres,G.; Terczynska-Dyla,E.; Anggakusuma; Dijkman,R.; Gad,H.H.; Akhtar,H.; Geffers,R.; Vondran,F.W.; Thiel,V.; Kaderali,L.; Pietschmann,T.; Hartmann,R.; ( Year: 2015). Title: Transcriptome analysis reveals a classical interferon signature induced by IFNlambda4 in human primary cells.Journal: Genes Immun. Volume: 16 Issue: 6, S-Page: 414- E-Page: 421 PubMed
  • Authors: Nuss,A.M.; Heroven,A.K.; Waldmann,B.; Reinkensmeier,J.; Jarek,M.; Beckstette,M.; Dersch,P.; ( Year: 2015). Title: Transcriptomic Profiling of Yersinia pseudotuberculosis Reveals Reprogramming of the Crp Regulon by Temperature and Uncovers Crp as a Master Regulator of Small RNAs.Journal: PLoS Genetics Volume: 11 Issue: 3 DOI: 10.1371/journal.pgen.1005087HZI repositoryPubMed
  • Authors: Woller,N.; Gurlevik,E.; Fleischmann-Mundt,B.; Schumacher,A.; Knocke,S.; Kloos,A.M.; Saborowski,M.; Geffers,R.; Manns,M.P.; Wirth,T.C.; Kubicka,S.; Kuhnel,F.; ( Year: 2015). Title: Viral infection of tumors overcomes resistance to PD-1-immunotherapy by broadening neoantigenome-directed T-cell responses.Journal: Mol.Ther. Volume: 23 Issue: 10, S-Page: 1630- E-Page: 1640 PubMed
  • Authors: Wang,H.; Tomasch,J.; Jarek,M.; Wagner-Döbler,I.; ( Year: 2014). Title: A dual-species co-cultivation system to study the interactions between Roseobacters and dinoflagellates.Journal: Frontiers in Microbiology Volume: 5, S-Page: 311 DOI: 10.3389/fmicb.2014.00311HZI repositoryPubMed
  • Authors: Bohla,D.; Herold,M.; Panzer,I.; Buxa,M.K.; Ali,T.; Demmers,J.; Kruger,M.; Scharfe,Maren; Jarek,Michael; Bartkuhn,M.; Renkawitz,R.; ( Year: 2014). Title: A Functional Insulator Screen Identifies NURF and dREAM Components to Be Required for Enhancer-Blocking.Journal: PLoS ONE Volume: 9 Issue: 9, S-Page: e107765 DOI: 10.1371/journal.pone.0107765HZI repositoryPubMed
  • Authors: Habig,C.; Geffers,Robert; Distl,O.; ( Year: 2014). Title: A replication study for genome-wide gene expression levels in two layer lines elucidates differentially expressed genes of pathways involved in bone remodeling and immune responsiveness.Journal: PLoS ONE Volume: 9 Issue: 6, S-Page: e98350 DOI: 10.1371/journal.pone.0098350HZI repositoryPubMed
  • Authors: Petersen,J.; Ludewig,A.K.; Michael,V.; Bunk,B.; Jarek,Michael; Baurain,D.; Brinkmann,H.; ( Year: 2014). Title: Chromera velia, endosymbioses and the rhodoplex hypothesis - Plastid evolution in cryptophytes, alveolates, stramenopiles, and haptophytes (CASH lineages).Journal: Genome Biology and Evolution Volume: 6 Issue: 3, S-Page: 666- E-Page: 684 DOI: 10.1093/gbe/evu043HZI repositoryPubMed
  • Authors: Courties,A.; Riedel,T.; Jarek,M.; Papadatou,M.; Intertaglia,L.; Lebaron,P.; Suzuki,M.T.; ( Year: 2014). Title: Draft genome sequence of the gammaproteobacterial strain MOLA455, a representative of a ubiquitous proteorhodopsin-producing group in the ocean.Journal: Genome Announce. Volume: 2 Issue: 1, S-Page: e01203-13 DOI: 10.1128/genomeA.e01203-13HZI repositoryPubMed
  • Authors: Jauregui,Ruy; Rodelas,B.; Geffers,Robert; Boon,N.; Pieper,Dietmar H.; Vilchez-Vargas,Ramiro; ( Year: 2014). Title: Draft Genome Sequence of the Naphthalene Degrader Herbaspirillum sp. Strain RV1423.Journal: Genome Announcement Volume: 2 Issue: 2 PubMed
  • Authors: He,F.Q.; Wang,W.; Zheng,P.; Sudhakar,P.; Sun,Jibin; Zeng,A.P.; ( Year: 2014). Title: Essential O-responsive genes of Pseudomonas aeruginosa and their network revealed by integrating dynamic data from inverted conditions.Journal: Integrative Biology Volume: 6 Issue: 2, S-Page: 215- E-Page: 223 PubMed
  • Authors: Vazquez,C.L.; Lerner,T.R.; Kasmapour,B.; Pei,G.; Gronow,Achim; Bianco,M.V.; Blanco,F.C.; Bleck,C.K.; Geffers,Robert; Bigi,F.; Abraham,Wolf-Rainer; Gutierrez,Maximiliano G.; ( Year: 2014). Title: Experimental selection of long-term intracellular mycobacteria.Journal: Cell Microbiology Volume: 16, S-Page: 1425- E-Page: 1440 DOI: 10.1111/cmi.12303HZI repositoryPubMed
  • Authors: Petzold,C.; Steinbronn,N.; Gereke,M.; Strasser,R.H.; Sparwasser,T.; Bruder,D.; Geffers,R.; Schallenberg,S.; Kretschmer,K.; ( Year: 2014). Title: Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin.Journal: European Journal of Immunology Volume: 44 Issue: 12, S-Page: 3632- E-Page: 3645 DOI: ArticleWEBURLS
  • Authors: Weiterer,S.; Uhle,F.; Bhuju,Sabin; Jarek,Michael; Weigand,M.A.; Bartkuhn,M.; ( Year: 2014). Title: From Human Monocytes to Genome-Wide Binding Sites - A Protocol for Small Amounts of Blood: Monocyte Isolation/ChIP-Protocol/Library Amplification/Genome Wide Computational Data Analysis.Journal: PLoS ONE Volume: 9 Issue: 4, S-Page: e94164 DOI: 10.1371/journal.pone.0094164HZI repositoryPubMed
  • Authors: Sergeev,G.; Roy,S.; Jarek,M.; Zapolskii,V.; Kaufmann,D.E.; Nandy,R.K.; Tegge,W.; ( Year: 2014). Title: High-throughput screening and whole genome sequencing identifies an antimicrobially active inhibitor of Vibrio cholerae.Journal: BMC Microbiology Volume: 14 Issue: 1, S-Page: 49 DOI: 10.1186/1471-2180-14-49HZI repositoryPubMed
  • Authors: Eckelt,E.; Jarek,M.; Frömke,C.; Meens,J.; Goethe,R.; ( Year: 2014). Title: Identification of a lineage specific zinc responsive genomic island in Mycobacterium avium ssp. paratuberculosis.Journal: BMC GENOMICS Volume: 15 Issue: 1, S-Page: 1076 DOI: 10.1186/1471-2164-15-1076HZI repositoryPubMed
  • Authors: Kehrmann,J.; Tatura,R.; Zeschnigk,M.; Probst-Kepper,Michael; Geffers,Robert; Steinmann,J.; Buer,J.; ( Year: 2014). Title: Impact of 5-aza-2'-deoxycytidine and epigallocatechin-3-gallate for induction of human regulatory T cells.Journal: Immunology Volume: 142 Issue: 3, S-Page: 384- E-Page: 395 DOI: 10.1111/imm.12261HZI repositoryPubMed
  • Authors: Yun,H.; Damm,F.; Yap,D.; Schwarzer,A.; Chaturvedi,A.; Jyotsana,N.; Lubbert,M.; Bullinger,L.; Dohner,K.; Geffers,Robert; Aparicio,S.; Humphries,R.K.; Ganser,A.; Heuser,M.; ( Year: 2014). Title: Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.Journal: Haematologica Volume: 99 Issue: 9, S-Page: 1456- E-Page: 1464 DOI: 10.3324/haematol.2013.101386HZI repositoryPubMed
  • Authors: Rudalska,R.; Dauch,D.; Longerich,T.; McJunkin,K.; Wuestefeld,T.; Kang,T.W.; Hohmeyer,A.; Pesic,M.; Leibold,J.; von,Thun A.; Schirmacher,P.; Zuber,J.; Weiss,K.H.; Powers,S.; Malek,N.P.; Eilers,M.; Sipos,B.; Lowe,S.W.; Geffers,Robert; Laufer,S.; Zender,L.; ( Year: 2014). Title: In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.Journal: Nature medicine PubMed
  • Authors: Lim,C.H.; Voedisch,S.; Wahl,B.; Rouf,S.F.; Geffers,Robert; Rhen,M.; Pabst,O.; ( Year: 2014). Title: Independent Bottlenecks Characterize Colonization of Systemic Compartments and Gut Lymphoid Tissue by Salmonella.Journal: PLoS Pathogens Volume: 10 Issue: 7, S-Page: e1004270 WEBURLS
  • Authors: Auer,F.; Ruschendorf,F.; Gombert,M.; Husemann,Peter; Ginzel,S.; Izraeli,S.; Harit,M.; Weintraub,M.; Weinstein,O.Y.; Lerer,I.; Stepensky,P.; Borkhardt,A.; Hauer,J.; ( Year: 2014). Title: Inherited susceptibility to pre B-ALL caused by germline transmission of PAX5 c.547G>A.Journal: Leukemia Volume: 28 Issue: 5, S-Page: 1136- E-Page: 1138 PubMed
  • Authors: Gutschner,T.; Hammerle,M.; Pazaitis,N.; Bley,N.; Fiskin,E.; Uckelmann,H.; Heim,A.; Grobeta,M.; Hofmann,N.; Geffers,Robert; Skawran,B.; Longerich,T.; Breuhahn,K.; Schirmacher,P.; Muhleck,B.; Huttelmaier,S.; Diederichs,S.; ( Year: 2014). Title: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma.Journal: Hepatology Volume: 59 Issue: 5, S-Page: 1900- E-Page: 1911 PubMed
  • Authors: Marhenke,S.; Buitrago-Molina,L.E.; Endig,J.; Orlik,J.; Schweitzer,N.; Klett,S.; Longerich,T.; Geffers,Robert; Munoz,A.S.; Dorrell,C.; Katz,S.F.; Lechel,A.; Weng,H.; Krech,T.; Lehmann,U.; Dooley,S.; Rudolph,K.L.; Manns,M.P.; Vogel,A.; ( Year: 2014). Title: P21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury.Journal: GUT Volume: 63 Issue: 9, S-Page: 1501- E-Page: 1512 WEBURLS
  • Authors: Winkler,J.; Ori,A.; Holzer,K.; Sticht,C.; Dauch,D.; Eiteneuer,E.M.; Pinna,F.; Geffers,Robert; Ehemann,V.; Andres-Pons,A.; Breuhahn,K.; Longerich,T.; Bermejo,J.L.; Gretz,N.; Zender,L.; Schirmacher,P.; Beck,M.; Singer,S.; ( Year: 2014). Title: Prosurvival function of the cellular apoptosis susceptibility/importin-?1 transport cycle is repressed by p53 in liver cancer.Journal: Hepatology Volume: 60 Issue: 3, S-Page: 884- E-Page: 895 WEBURLS
  • Authors: Elgohary,N.; Pellegrino,R.; Neumann,O.; Elzawahry,H.M.; Saber,M.M.; Zeeneldin,A.A.; Geffers,Robert; Ehemann,V.; Schemmer,P.; Schirmacher,P.; Longerich,T.; ( Year: 2014). Title: Protumorigenic role of Timeless in hepatocellular carcinoma.Journal: International Journal of Oncology Volume: 46 Issue: 2, S-Page: 597- E-Page: 606 DOI: 10.3892/ijo.2014.2751HZI repositoryPubMed
  • Authors: Dag,Franziska; Dolken,L.; Holzki,Julia; Drabig,Anja; Weingartner,A.; Schwerk,Johannes; Lienenklaus,Stefan; Conte,I.; Geffers,Robert; Davenport,C.; Rand,Ulfert; Köster,Mario; Weiss,Siegfried; Adler,B.; Wirth,Dagmar; Messerle,M.; Hauser,Hansjörg; Cicin-Sain,Luka; ( Year: 2014). Title: Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency.Journal: PLoS Pathogens Volume: 10 Issue: 2, S-Page: e1003962 DOI: 10.1371/journal.ppat.1003962HZI repositoryPubMed
  • Authors: Stielow,C.; Stielow,B.; Finkernagel,F.; Scharfe,Maren; Jarek,Michael; Suske,G.; ( Year: 2014). Title: SUMOylation of the polycomb group protein L3MBTL2 facilitates repression of its target genes.Journal: Nucleic Acids Res Volume: 42 Issue: 5, S-Page: 3044- E-Page: 3058 DOI: 10.1093/nar/gkt1317HZI repositoryPubMed
  • Authors: Willenborg,J.; de,Greeff A.; Jarek,Michael; Valentin-Weigand,P.; Goethe,R.; ( Year: 2014). Title: The CcpA regulon of Streptococcus suis reveals novel insights into the regulation of the streptococcal central carbon metabolism by binding of CcpA to two distinct binding motifs.Journal: Molecular Microbiology Volume: 92 Issue: 1, S-Page: 61- E-Page: 83 PubMed
  • Authors: Strehmel,J.; Neidig,A.; Nusser,M.; Geffers,Robert; Brenner-Weiss,G.; Overhage,J.; ( Year: 2014). Title: The sensor kinase PA4398 modulates swarming motility and biofilm formation in Pseudomonas aeruginosa PA14.Journal: Applied in Environmental Microbiology Volume: 81 Issue: 4, S-Page: 1274- E-Page: 1284 PubMed
  • Authors: Zender,S.; Nickeleit,I.; Wuestefeld,T.; Sörensen,I.; Dauch,D.; Bozko,P.; El-Khatib,M.; Geffers,Robert; Bektas,H.; Manns,M.; Gossler,A.; Wilkens,L.; Plentz,R.; Zender,L.; Malek,N.; ( Year: 2013). Title: A critical role for notch signaling in the formation of cholangiocellular carcinomas.Journal: Cancer Cell Volume: 23 Issue: 6, S-Page: 784- E-Page: 795 WEBURLS
  • Authors: Wuestefeld,T.; Pesic,M.; Rudalska,R.; Dauch,D.; Longerich,T.; Kang,T.W.; Yevsa,T.; Heinzmann,F.; Hoenicke,L.; Hohmeyer,A.; Potapova,A.; Rittelmeier,I.; Jarek,Michael; Geffers,Robert; Scharfe,Maren; Klawonn,Frank; Schirmacher,P.; Malek,N.P.; Ott,M.; Nordheim,A.; Vogel,A.; Manns,M.P.; Zender,L.; ( Year: 2013). Title: A direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration.Journal: Cell Volume: 153 Issue: 2, S-Page: 389- E-Page: 401 WEBURLS
  • Authors: Toker,A.; Engelbert,D.; Garg,G.; Polansky,J.K.; Floess,S.; Miyao,T.; Baron,U.; Düber,S.; Geffers,R.; Giehr,P.; Schallenberg,S.; Kretschmer,K.; Olek,S.; Walter,J.; Weiss,S.; Hori,S.; Hamann,A.; Hühn,J.; ( Year: 2013). Title: Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus.Journal: Journal of Immunology Volume: 190 Issue: 7, S-Page: 3180- E-Page: 3188 WEBURLS
  • Authors: Shepelkova,G.; Pommerenke,C.; Alberts,R.; Geffers,Robert; Evstifeev,V.; Apt,A.; Schughart,Klaus; Wilk,E.; ( Year: 2013). Title: Analysis of the lung transcriptome in Mycobacterium tuberculosis-infected mice reveals major differences in immune response pathways between TB-susceptible and resistant hosts.Journal: Tuberculosis (Edinb.) Volume: 93 Issue: 2, S-Page: 263- E-Page: 269 PubMed
  • Authors: Vilchez-Vargas,Ramiro; Geffers,Robert; Suarez-Diez,Maria; Conte,Ianina; Waliczek,Agnes; Kaser,Vanessa S.; Kralova,M.; Junca,H.; Pieper,Dietmar H.; ( Year: 2013). Title: Analysis of the microbial gene landscape and transcriptome for aromatic pollutants and alkane degradation using a novel internally calibrated microarray system.Journal: Environmental Microbiology Volume: 15 Issue: 4, S-Page: 1016- E-Page: 1039 DOI: 10.1126/scitranslmed.3009925HZI repositoryPubMed
  • Authors: Hasemeier,B.; Geffers,Robert; Bartels,S.; Schlegelberger,B.; Kreipe,H.; Lehmann,U.; ( Year: 2013). Title: Archival bone marrow trephines are suitable for high-throughput mutation analysis using next generation sequencing technology.Journal: Haematologica Volume: 98 Issue: 9, S-Page: e115- E-Page: e116 DOI: 10.3324/haematol.2013.091652HZI repositoryPubMed
  • Authors: Schlereth,K.; Heyl,C.; Krampitz,A.M.; Mernberger,M.; Finkernagel,F.; Scharfe,Maren; Jarek,Michael; Leich,E.; Rosenwald,A.; Stiewe,T.; ( Year: 2013). Title: Characterization of the p53 Cistrome - DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions.Journal: PLoS Genetics Volume: 9 Issue: 8, S-Page: e1003726 DOI: 10.1371/journal.pgen.1003726HZI repositoryPubMed
  • Authors: Handschick,K.; Beuerlein,K.; Jurida,L.; Bartkuhn,M.; Muller,H.; Soelch,J.; Weber,A.; Dittrich-Breiholz,O.; Schneider,H.; Scharfe,Maren; Jarek,Michael; Stellzig,J.; Schmitz,M.L.; Kracht,M.; ( Year: 2013). Title: Cyclin-Dependent Kinase 6 Is a Chromatin-Bound Cofactor for NF-kappaB-Dependent Gene Expression.Journal: Molecular Cell Volume: 53 Issue: 2, S-Page: 193- E-Page: 208 DOI: 10.1016/j.molcel.2013.12.002HZI repositoryPubMed
  • Authors: Günther,K.; Rust,M.; Leers,J.; Boettger,T.; Scharfe,Maren; Jarek,Michael; Bartkuhn,M.; Renkawitz,R.; ( Year: 2013). Title: Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences.Journal: Nucleic Acids Research Volume: 41 Issue: 5, S-Page: 3010- E-Page: 3021 DOI: 10.1093/nar/gkt035HZI repositoryPubMed
  • Authors: de Lima-Morales,D.; Chaves-Moreno,D.; Jarek,M.; Vilchez-Vargas,R.; Jauregui,R.; Pieper,D.H.; ( Year: 2013). Title: Draft Genome Sequence of Pseudomonas veronii Strain 1YdBTEX2.Journal: Genome Announcement Volume: 1 Issue: 3 DOI: 10.1128/genomeA.00258-13HZI repositoryPubMed
  • Authors: Kindler,E.; Jonsdottir,H.R.; Muth,D.; Hamming,O.J.; Hartmann,R.; Rodriguez,R.; Geffers,Robert.; Fouchier,R.A.; Drosten,C.; Muller,M.A.; Dijkman,R.; Thiel,V.; ( Year: 2013). Title: Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential.Journal: MBio Volume: 4 Issue: 1, S-Page: e00611- E-Page: e00612 DOI: 10.1128/mBio.00611-12HZI repositoryPubMed
  • Authors: Courties,A.; Riedel,T.; Jarek,M.; Intertaglia,L.; Lebaron,P.; Suzuki,M.T.; ( Year: 2013). Title: Genome sequence of strain MOLA814, a proteorhodopsin-containing representative of the Betaproteobacteria common in the ocean.Journal: Genome Announce. Volume: 1 Issue: 6, S-Page: e01062-13 DOI: 10.1128/genomeA.01062-13HZI repositoryPubMed
  • Authors: Riedel,Thomas; Gomez-Consarnau,L.; Tomasch,Jürgen; Martin,M.; Jarek,Michael; Gonzalez,J.M.; Spring,S.; Rohlfs,M.; Brinkhoff,T.; Cypionka,H.; Goker,M.; Fiebig,A.; Klein,J.; Goesmann,A.; Fuhrman,J.A.; Wagner-Döbler,Irene; ( Year: 2013). Title: Genomics and physiology of a marine flavobacterium encoding a proteorhodopsin and a xanthorhodopsin-like protein.Journal: PLoS ONE Volume: 8 Issue: 3, S-Page: e57487 DOI: 10.1371/journal.pone.0057487HZI repositoryPubMed
  • Authors: Strempel,N.; Neidig,A.; Nusser,M.; Geffers,Robert; Vieillard,J.; Lesouhaitier,O.; Brenner-Weiss,G.; Overhage,J.; ( Year: 2013). Title: Human host defense peptide LL-37 Stimulates virulence factor production and adaptive resistance in Pseudomonas aeruginosa.Journal: PLoS ONE Volume: 8 Issue: 12, S-Page: e82240 DOI: 10.1371/journal.pone.0082240HZI repositoryPubMed
  • Authors: Adhikary,T.; Brandt,D.T.; Kaddatz,K.; Stockert,J.; Naruhn,S.; Meissner,W.; Finkernagel,F.; Obert,J.; Lieber,S.; Scharfe,M.; Jarek,Michael; Toth,P.M.; Scheer,F.; Diederich,W.E.; Reinartz,S.; Grosse,R.; Muller-Brusselbach,S.; Müller,Rolf; ( Year: 2013). Title: Inverse PPARbeta/delta agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion.Journal: Oncogene Volume: 32 Issue: 44, S-Page: 5241- E-Page: 5252 DOI: 10.1038/onc.2012.549HZI repositoryPubMed
  • Authors: Sundarasetty,B.S.; Singh,V.K.; Salguero,G.; Geffers,Robert; Rickmann,M.; Macke,L.; Borchers,S.; Figueiredo,C.; Schambach,A.; Gullberg,U.; Provasi,E.; Bonini,C.; Ganser,A.; Woelfel,T.; Stripecke,R.; ( Year: 2013). Title: Lentivirus-induced dendritic cells for immunization against high-risk WT1(+) acute myeloid leukemia.Journal: Human gene therapy Volume: 24 Issue: 2, S-Page: 220- E-Page: 237 DOI: 10.1089/hum.2012.128HZI repositoryPubMed
  • Authors: Volkmann,I.; Kumarswamy,R.; Pfaff,N.; Fiedler,J.; Dangwal,S.; Holzmann,A.; Batkai,S.; Geffers,Robert; Lother,A.; Hein,L.; Thum,T.; ( Year: 2013). Title: MicroRNA-Mediated Epigenetic Silencing of Sirtuin1 Contributes to Impaired Angiogenic Responses1.Journal: Circulation Research Volume: 113 Issue: 8, S-Page: 997- E-Page: 1003 PubMed
  • Authors: Bhuju,Sabin; Fonseca,L.D.; Marsico,A.G.; de,Oliveira,V; Sobral,L.F.; Stehr,M.; Singh,Mahavir; Saad,M.H.; ( Year: 2013). Title: Mycobacterium tuberculosis isolates from Rio de Janeiro reveal unusually low correlation between pyrazinamide resistance and mutations in the pncA gene.Journal: Infection, Genetics and Evolution Volume: 19, S-Page: 1- E-Page: 6 DOI: 10.1016/j.meegid.2013.06.008HZI repositoryPubMed
  • Authors: Hämmerle,M.; Gutschner,T.; Uckelmann,H.; Ozgur,S.; Fiskin,E.; Gross,M.; Skawran,B.; Geffers,Robert; Longerich,T.; Breuhahn,K.; Schirmacher,P.; Stoecklin,G.; Diederichs,S.; ( Year: 2013). Title: Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1).Journal: Hepatology Volume: 58 Issue: 5, S-Page: 1703- E-Page: 1712 DOI: 10.1002/hep.26537HZI repositoryPubMed
  • Authors: Ehrentraut,S.; Nagel,S.; Scherr,M.E.; Schneider,B.; Quentmeier,H.; Geffers,Robert; Kaufmann,M.; Meyer,C.; Prochorec-Sobieszek,M.; Ketterling,R.P.; Knudson,R.A.; Feldman,A.L.; Kadin,M.E.; Drexler,H.G.; MacLeod,R.A.; ( Year: 2013). Title: t(8;9)(p22;p24)/PCM1-JAK2 Activates SOCS2 and SOCS3 via STAT5.Journal: PLoS ONE Volume: 8 Issue: 1, S-Page: e53767 DOI: 10.1371/journal.pone.0053767HZI repositoryPubMed
  • Authors: Buitrago-Molina,L.E.; Marhenke,S.; Longerich,T.; Sharma,A.D.; Boukouris,A.E.; Geffers,Robert; Guigas,Bruno; Manns,M.P.; Vogel,A.; ( Year: 2013). Title: The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice.Journal: Hepatology Volume: 58 Issue: 3, S-Page: 1143- E-Page: 1152 DOI: 10.1002/hep.26412HZI repositoryPubMed
  • Authors: Quentmeier,H.; Amini,R.M.; Berglund,M.; Dirks,W.G.; Ehrentraut,S.; Geffers,Robert; MacLeod,R.A.; Nagel,S.; Romani,J.; Scherr,M.; Zaborski,M.; Drexler,H.G.; ( Year: 2013). Title: U-2932: two clones in one cell line, a tool for the study of clonal evolution.Journal: Leukemia Volume: 27 Issue: 5, S-Page: 1155- E-Page: 1164 WEBURLS
  • Authors: Bendrat,K.; Stang,A.; Georgiev,G.; Geffers,Robert; Haase,B.; Schutze,K.; Mogilarov,D.; Branscheid,D.; Niendorf,A.; ( Year: 2012). Title: A compartment-specific transcriptome analysis reveals survival-relevant marker genes in the stroma fraction of squamous non-small cell lung cancer.Journal: Journal of Biophotonics Volume: 5 Issue: 4, S-Page: 367- E-Page: 377 PubMed
  • Authors: Krech,T.; Scheuerer,E.; Geffers,Robert; Kreipe,H.; Lehmann,U.; Christgen,M.; ( Year: 2012). Title: ABCB1/MDR1 contributes to the anticancer drug-resistant phenotype of IPH-926 human lobular breast cancer cells.Journal: Cancer Letters Volume: 315 Issue: 2, S-Page: 153- E-Page: 160 PubMed
  • Authors: Ukena,S.N.; Geffers,Robert; Buchholz,S.; Stadler,M.; Franzke,A.; ( Year: 2012). Title: Biomarkers for acute and chronic graft-versus-host disease in regulatory T cells.Journal: Transplant Immunology Volume: 27 Issue: 4, S-Page: 179- E-Page: 183 DOI: 10.1016/j.trim.2012.07.003PubMed
  • Authors: Boppana,S.; Scheglov,A.; Geffers,Robert; Tarabykin,V.; ( Year: 2012). Title: Cellular retinaldehyde-binding protein (CRALBP) is a direct downstream target of transcription factor Pax6.Journal: Biochimica et biophysica acta Volume: 1820 Issue: 2, S-Page: 151- E-Page: 156 DOI: 10.1016/j.bbagen.2011.09.015HZI repositoryPubMed
  • Authors: Jeron,A.; Hansen,W.; Ewert,F.; Buer,J.; Geffers,R.; Bruder,D.; ( Year: 2012). Title: ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells.Journal: BMC GENOMICS Volume: 13 Issue: 1, S-Page: 705 DOI: 10.1186/1471-2164-13-705HZI repositoryPubMed
  • Authors: Habig,C.; Geffers,Robert; Distl,O.; ( Year: 2012). Title: Differential gene expression from genome-wide microarray analyses distinguishes lohmann selected leghorn and lohmann brown layers.Journal: PLoS ONE Volume: 7 Issue: 10, S-Page: e46787 DOI: 10.1371/journal.pone.0046787HZI repositoryPubMed
  • Authors: Seifert,O.; Matussek,A.; Sjögren,F.; Geffers,R.; Anderson,C.D.; ( Year: 2012). Title: Gene expression profiling of macrophages: Implications for an immunosuppressive effect of dissolucytotic gold ions.Journal: Journal of Inflammation Volume: 9, S-Page: 43 DOI: 10.1186/1476-9255-9-43HZI repositoryPubMed
  • Authors: Terrados,G.; Finkernagel,F.; Stielow,B.; Sadic,D.; Neubert,J.; Herdt,O.; Krause,M.; Scharfe,Maren; Jarek,Michael; Suske,G.; ( Year: 2012). Title: Genome-wide localization and expression profiling establish Sp2 as a sequence-specific transcription factor regulating vitally important genes.Journal: Nucleic Acids Research Volume: 40 Issue: 16, S-Page: 7844- E-Page: 7857 DOI: 10.1093/nar/gks544PubMed
  • Authors: Pommerenke,C.; Wilk,E.; Srivastava,B.; Schulze,A.; Novoselova,N.; Geffers,Robert; Schughart,Klaus; ( Year: 2012). Title: Global transcriptome analysis in influenza-infected mouse lungs reveals the kinetics of innate and adaptive host immune responses.Journal: PLoS ONE Volume: 7 Issue: 7, S-Page: e41169 DOI: 10.1371/journal.pone.0041169HZI repositoryPubMed
  • Authors: Hamisch,D.; Randewig,D.; Schliesky,S.; Brautigam,A.; Weber,A.P.; Geffers,Robert; Herschbach,C.; Rennenberg,H.; Mendel,R.R.; Hansch,R.; ( Year: 2012). Title: Impact of SO(2) on Arabidopsis thaliana transcriptome in wildtype and sulfite oxidase knockout plants analyzed by RNA deep sequencing.Journal: New Phytologist Volume: 196 Issue: 4, S-Page: 1074- E-Page: 1085 DOI: 10.1111/j.1469-8137.2012.04331.xHZI repositoryPubMed
  • Authors: Christgen,M.; Noskowicz,M.; Heil,C.; Schipper,E.; Christgen,H.; Geffers,Robert; Kreipe,H.; Lehmann,U.; ( Year: 2012). Title: IPH-926 lobular breast cancer cells harbor a p53 mutant with temperature-sensitive functional activity and allow for profiling of p53-responsive genes.Journal: Laboratory Investigation Volume: 92 Issue: 11, S-Page: 1635- E-Page: 1647 PubMed
  • Authors: Meier,K.; Mathieu,E.L.; Finkernagel,F.; Reuter,L.M.; Scharfe,M.; Doehlemann,G.; Jarek,Michael; Brehm,A.; ( Year: 2012). Title: LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes.Journal: PLoS Genetics Volume: 8 Issue: 5, S-Page: e1002676 DOI: 10.1371/journal.pgen.1002676HZI repositoryPubMed
  • Authors: Neumann,O.; Kesselmeier,M.; Geffers,Robert; Pellegrino,R.; Radlwimmer,B.; Hoffmann,K.; Ehemann,V.; Schemmer,P.; Schirmacher,P.; Lorenzo,Bermejo J.; Longerich,T.; ( Year: 2012). Title: Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors.Journal: Hepatology Volume: 56 Issue: 5, S-Page: 1817- E-Page: 1827 DOI: 10.1002/hep.25870HZI repositoryPubMed
  • Authors: Schneider,B.; Nagel,S.; Ehrentraut,S.; Kaufmann,M.; Meyer,C.; Geffers,Robert; Drexler,H.G.; MacLeod,R.A.; ( Year: 2012). Title: Neoplastic MiR-17 approximately 92 deregulation at a dna fragility motif (SIDD).Journal: Genes, Chromosomes and Cancer Volume: 51 Issue: 3, S-Page: 219- E-Page: 228 DOI: 10.1002/gcc.20946HZI repositoryPubMed
  • Authors: He,F.; Chen,H.; Probst-Kepper,Michael; Geffers,Robert; Eifes,S.; Del,Sol A.; Schughart,Klaus; Zeng,A.P.; Balling,R.; ( Year: 2012). Title: PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells.Journal: Molecular Systems Biology Volume: 8, S-Page: 624 DOI: 10.1038/msb.2012.56HZI repositoryPubMed
  • Authors: Mathieu,E.L.; Finkernagel,F.; Murawska,M.; Scharfe,M.; Jarek,Michael; Brehm,A.; ( Year: 2012). Title: Recruitment of the ATP-dependent chromatin remodeler dMi-2 to the transcribed region of active heat shock genes.Journal: Nucleic Acids Res Volume: 40 Issue: 11, S-Page: 4879- E-Page: 4891 DOI: 10.1093/nar/gks178HZI repositoryPubMed
  • Authors: Dötsch,A.; Eckweiler,D.; Schniederjans,M.; Zimmermann,A.; Jensen,V.; Scharfe,M.; Geffers,Robert; Häußler,Susanne; ( Year: 2012). Title: The Pseudomonas aeruginosa Transcriptome in Planktonic Cultures and Static Biofilms Using RNA Sequencing.Journal: PLoS ONE Volume: 7 Issue: 2, S-Page: e31092 DOI: 10.1371/journal.pone.0031092HZI repositoryPubMed
  • Authors: Nagel,S.; Ehrentraut,S.; Tomasch,J.; Lienenklaus,S.; Schneider,B.; Geffers,Robert; Meyer,C.; Kaufmann,M.; Drexler,H.G.; MacLeod,R.A.; ( Year: 2012). Title: Transcriptional Activation of Prostate Specific Homeobox Gene NKX3-1 in Subsets of T-Cell Lymphoblastic Leukemia (T-ALL).Journal: PLoS ONE Volume: 7 Issue: 7, S-Page: e40747 DOI: 10.1371/journal.pone.0040747HZI repositoryPubMed
  • Authors: Alberts,R.; Chen,H.; Pommerenke,C.; Smit,A.B.; Spijker,S.; Williams,R.W.; Geffers,Robert*; Bruder,Dunja*; Schughart,Klaus*; ( Year: 2011). Title: Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease1.Journal: BMC GENOMICS Volume: 12, S-Page: 610 DOI: 10.1186/1471-2164-12-610HZI repositoryPubMed
  • Authors: Fleissner,D.; Frede,A.; Knott,M.; Knuschke,T.; Geffers,Robert*; Hansen,W.; Dobos,G.; Langhorst,J.; Buer,J.; Westendorf,A.M.; ( Year: 2011). Title: Generation and function of immunosuppressive human and murine CD8(+) T cells by transforming growth factor-beta and retinoic acid.Journal: Immunology Volume: 134 Issue: 1, S-Page: 82- E-Page: 92 PubMed
  • Authors: Su,F.; Yu,B.; Sun,J.; Ou,H.Y.; Zhao,B.; Wang,L.; Qin,J.; Tang,H.; Tao,F.; Jarek,Michael*; Scharfe,M.; Ma,C.; Ma,Y.; Xu,P.; ( Year: 2011). Title: Genome sequence of the thermophilic strain Bacillus coagulans 2-6, an efficient producer of high-optical-purity L-lactic acid.Journal: Journal of Bacteriology Volume: 193 Issue: 17, S-Page: 4563- E-Page: 4564 DOI: 10.1128/JB.05378-11HZI repositoryPubMed
  • Authors: Ukena,S.N.; Velaga,S.; Geffers,Robert*; Grosse,J.; Baron,U.; Buchholz,S.; Stadler,M.; Bruder,Dunja*; Ganser,A.; Franzke,A.; ( Year: 2011). Title: Human regulatory T cells in allogeneic stem cell transplantation.Journal: Blood Volume: 118 Issue: 13, S-Page: e82- E-Page: e92 PubMed
  • Authors: Svensson,J.; Jenmalm,M.C.; Matussek,A.; Geffers,Robert*; Berg,G.; Ernerudh,J.; ( Year: 2011). Title: Macrophages at the fetal-maternal interface express markers of alternative activation and are induced by M-CSF and IL-10.Journal: Journal of Immunology Volume: 187 Issue: 7, S-Page: 3671- E-Page: 3682 PubMed
  • Authors: Frank,S.; Klockgether,J.; Hagendorf,P.; Geffers,Robert*; Schock,U.; Pohl,T.; Davenport,C.F.; Tummler,B.; ( Year: 2011). Title: Pseudomonas putida KT2440 genome update by cDNA sequencing and microarray transcriptomics.Journal: Environmental Microbiology Volume: 13 Issue: 5, S-Page: 1309- E-Page: 1326 PubMed
  • Authors: Hartmann,D.; Srivastava,U.; Thaler,M.; Kleinhans,K.N.; N'kontchou,G.; Scheffold,A.; Bauer,K.; Kratzer,R.F.; Kloos,N.; Katz,S.F.; Song,Z.; Begus-Nahrmann,Y.; Kleger,A.; von,Figura G.; Strnad,P.; Lechel,A.; Gunes,C.; Potthoff,A.; Deterding,K.; Wedemeyer,H.; Ju,Z.; Song,G.; Xiao,F.; Gillen,S.; Schrezenmeier,H.; Mertens,T.; Ziol,M.; Friess,H.; Jarek,Michael*; Manns,M.P.; Beaugrand,M.; Rudolph,K.L.; ( Year: 2011). Title: Telomerase gene mutations are associated with cirrhosis formation.Journal: Hepatology Volume: 53 Issue: 5, S-Page: 1608- E-Page: 1617 PubMed
  • Authors: Ziegler,C.; Goldmann,O.; Hobeika,E.; Geffers,Robert*; Peters,G.; Medina,Eva*; ( Year: 2011). Title: The dynamics of T cells during persistent Staphylococcus aureus infection: from antigen-reactivity to in vivo anergy.Journal: EMBO Molecular Medicine Volume: 3 Issue: 11, S-Page: 652- E-Page: 666 PubMed
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