Vaccinology

Vaccination is the most efficient strategy to prevent infectious diseases. The art of the vaccine researcher lies in finding substances that prevent us from falling ill with diseases such as flu, viral hepatitis or HIV/AIDS. But what makes a vaccine successful and ensures effective protection? Our scientists study the reaction of the immune system to answer that question – and to develop better vaccination strategies.

Leader

Publications

  • Authors: Demoulins,T.; Englezou,P.C.; Milona,P.; Ruggli,N.; Tirelli,N.; Pichon,C.; Sapet,C.; Ebensen,T.; Guzmán,C.A.; McCullough,K.C.; (Year: 2017). Title: Self-Replicating RNA Vaccine Delivery to Dendritic Cells.Journal: Methods in molecular biology (Clifton, N.J.)Volume: 1499, S-Page: 37-E-Page: 75 PubMed
  • Authors: Tomic,A.; Varanasi,P.R.; Golemac,M.; Malic,S.; Riese,P.; Borst,E.M.; Mischak-Weissinger,E.; Guzmán,C.A.; Krmpotic,A.; Jonjic,S.; Messerle,M.; (Year: 2016). Title: Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.Journal: PLoS PathogensVolume: 12Issue: 12, S-Page: e1006015 PubMed
  • Authors: Borger,A.K.; Eicke,D.; Wolf,C.; Gras,C.; Aufderbeck,S.; Schulze,K.; Engels,L.; Eiz-Vesper,B.; Schambach,A.; Guzmán,C.A.; Lachmann,N.; Moritz,T.; Martin,U.; Blasczyk,R.; Figueiredo,C.; (Year: 2016). Title: Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions.Volume: 22, S-Page: 274-E-Page: 285 DOI: 10.2119/molmed.2015.00235 PubMed
  • Authors: Vazquez,C.L.; Rodgers,A.; Herbst,S.; Coade,S.; Gronow,A.; Guzmán,C.A.; Wilson,M.S.; Kanzaki,M.; Nykjaer,A.; Gutierrez,M.G.; (Year: 2016). Title: The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages.Volume: 6, S-Page: 29332 DOI: 10.1038/srep29332 HZI repository PubMed
  • Authors: Riese,P.; Trittel,S.; May,T.; Cicin-Sain,L.; Chambers,B.J.; Guzmán,C.A.; (Year: 2015). Title: Activated NKT cells imprint NK-cell differentiation, functionality and education.Volume: 45Issue: 6, S-Page: 1794-E-Page: 1807 PubMed
  • Authors: Kaufmann,S.H.; Fletcher,H.A.; Guzmán,C.A.; Ottenhoff,T.H.; (Year: 2015). Title: Big Data in Vaccinology: Introduction and section summaries.Journal: VaccineVolume: 33Issue: 40, S-Page: 5237-E-Page: 5240 PubMed
  • Authors: Kramer,R.; Sauer-Heilborn,A.; Welte,T.; Guzman,C.A.; Abraham,W.R.; Höfle,M.G.; (Year: 2015). Title: Cohort study of airway mycobiome in adult cystic fibrosis patients: Differences in community structure between fungi and bacteria reveal predominance of transient fungal elements.Volume: 53Issue: 9, S-Page: 2900-E-Page: 290700951137 WEBURLS
  • Authors: Daenthanasanmak,A.; Salguero,G.; Sundarasetty,B.S.; Waskow,C.; Cosgun,K.N.; Guzmán,C.A.; Riese,P.; Gerasch,L.; Schneider,A.; Ingendoh,A.; Messerle,M.; Gabaev,I.; Woelk,B.; Ruggiero,E.; Schmidt,M.; von,Kalle C.; Figueiredo,C.; Eiz-Vesper,B.; von,Kaisenberg C.; Ganser,A.; Stripecke,R.; (Year: 2015). Title: Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV.Volume: 1, S-Page: 14060 DOI: 10.1038/mtm.2014.60 HZI repository PubMed
  • Authors: Perin,P.M.; Haid,S.; Brown,R.J.; Doerrbecker,J.; Schulze,K.; Zeilinger,C.; von,Schaewen M.; Heller,B.; Vercauteren,K.; Luxenburger,E.; Baktash,Y.M.; Vondran,F.W.; Speerstra,S.; Awadh,A.; Mukhtarov,F.; Schang,L.M.; Kirschning,A.; Müller,R.; Guzmán,C.A.; Kaderali,L.; Randall,G.; Meuleman,P.; Ploss,A.; Pietschmann,T.; (Year: 2015). Title: Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.Journal: HepatologyVolume: 63, S-Page: 49-E-Page: 62 DOI: 10.1002/hep.28111 HZI repository PubMed
  • Authors: Kügler,J.; Wilke,S.; Meier,D.; Tomszak,F.; Frenzel,A.; Schirrmann,T.; Dubel,S.; Garritsen,H.; Hock,B.; Toleikis,L.; Schutte,M.; Hust,M.; (Year: 2015). Title: Generation and analysis of the improved human HAL9/10 antibody phage display libraries.Volume: 15Issue: 1, S-Page: 10 DOI: 10.1186/s12896-015-0125-0 HZI repository PubMed
  • Authors: Kramer,R.; Sauer-Heilborn,A.; Welte,T.; Jauregui,R.; Brettar,I.; Guzmán,C.A.; Höfle,M.G.; (Year: 2015). Title: High individuality of respiratory bacterial communities in a large cohort of adult cystic fibrosis patients under continuous antibiotic treatment.Journal: PLoS ONEVolume: 10Issue: 2, S-Page: e011743619326203 DOI: 10.1371/journal.pone.0117436 HZI repository PubMed
  • Authors: Schulze,K.; Mittal,A.; Hansen,S.; Ebensen,T.; Weißmann,S.; Guzmán,C.A.; Lehr,C.-M.; (Year: 2015). Title: Impfung durch Eincremen: Transkutane Immunisierung mittels Nanopartikel.Journal: GIT - LaborfachzeitschriftVolume: 4, S-Page: 25-E-Page: 27
  • Authors: Stern,C.; Kasnitz,N.; Kocijancic,D.; Trittel,S.; Riese,P.; Guzmán,C.A.; Leschner,S.; Weiss,S.; (Year: 2015). Title: Induction of CD4 and CD8 anti-tumor effector T cell responses by bacteria mediated tumor therapy. PubMed
  • Authors: Major,D.; Chichester,J.A.; Pathirana,R.D.; Guilfoyle,K.; Shoji,Y.; Guzmán,C.A.; Yusibov,V.; Cox,R.J.; (Year: 2015). Title: Intranasal vaccination with a plant-derived H5 HA vaccine protects mice and ferrets against highly pathogenic avian influenza virus challenge.Journal: Human Vaccines and ImmunotherapeuticsVolume: 11Issue: 5, S-Page: 1235-E-Page: 124321645515 WEBURLS
  • Authors: Mittal,A.; Schulze,K.; Ebensen,T.; Weissmann,S.; Hansen,S.; Guzmán,C.A.; Lehr,C.M.; (Year: 2015). Title: Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination.Volume: 206, S-Page: 140-E-Page: 15201683659 WEBURLS
  • Authors: Yang,R.; Lirussi,D.; Thornton,T.M.; Jelley-Gibbs,D.M.; Diehl,S.A.; Case,L.K.; Madesh,M.; Taatjes,D.J.; Teuscher,C.; Haynes,L.; Rincon,M.; (Year: 2015). Title: Mitochondrial Ca and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function.Volume: 4, S-Page: e0637622 DOI: 10.7554/eLife.06376. HZI repository PubMed
  • Authors: Boianelli,A.; Nguyen,V.K.; Ebensen,T.; Schulze,K.; Wilk,E.; Sharma,N.; Stegemann-Koniszewski,S.; Bruder,D.; Toapanta,F.R.; Guzm b n,C.A.; Meyer-Hermann,M.; Hernandez-Vargas,E.A.; (Year: 2015). Title: Modeling influenza virus infection: A roadmap for influenza research.Journal: VirusesVolume: 7Issue: 10, S-Page: 5274-E-Page: 530419994915 DOI: 10.3390/v7102875 HZI repository PubMed
  • Authors: Gordon,S.; Daneshian,M.; Bouwstra,J.; Caloni,F.; Constant,S.; Davies,D.E.; Dandekar,G.; Guzmán,C.A.; Fabian,E.; Haltner,E.; Hartung,T.; Hasiwa,N.; Hayden,P.; Kandarova,H.; Khare,S.; Krug,H.F.; Kneuer,C.; Leist,M.; Lian,G.; Marx,U.; Metzger,M.; Ott,K.; Prieto,P.; Roberts,M.S.; Roggen,E.L.; Tralau,T.; van den,Braak C.; Walles,H.; Lehr,C.M.; (Year: 2015). Title: Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.Volume: 32Issue: 4, S-Page: 327-E-Page: 378 HZI repository PubMed
  • Authors: Demoulins,T.; Milona,P.; Englezou,P.C.; Ebensen,T.; Schulze,K.; Suter,R.; Pichon,C.; Midoux,P.; Guzmán,C.A.; Ruggli,N.; McCullough,K.C.; (Year: 2015). Title: Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines.Volume: 12, S-Page: 711-E-Page: 722 PubMed
  • Authors: Vázquez,N.L.A.; Casalegno,R.; Monroy-Lopez,E.; Velázquez-Moctezuma,J.; (Year: 2015). Title: Rodent models in psychiatric research.Book Title: Rodent Model as Tools in Ethical Biomedical ResearchPublisher: Springer International Publishing, S-Page: 345-E-Page: 360 ISBN: 9783319115788 (ISBN); 9783319115771 (ISBN) DOI: Book WEBURLS
  • Authors: Riese,P.; Trittel,S.; Schulze,K.; Guzmán,C.A.; (Year: 2015). Title: Rodents as pre-clinical models for predicting vaccine performance in humans.Volume: 14Issue: 9, S-Page: 1213-E-Page: 1225 HZI repository PubMed
  • Authors: Geels,M.J.; Thogersen,R.L.; Guzman,C.A.; Ho,M.M.; Verreck,F.; Collin,N.; Robertson,J.S.; McConkey,S.J.; Kaufmann,S.H.; Leroy,O.; (Year: 2015). Title: TRANSVAC research infrastructure - Results and lessons learned from the European network of vaccine research and development.Journal: VaccineVolume: 33Issue: 41, S-Page: 5481-E-Page: 5487 PubMed
  • Authors: Holzki,J.K.; Dag,F.; Dekhtiarenko,I.; Rand,U.; Casalegno-Garduno,R.; Trittel,S.; May,T.; Riese,P.; Cicin-Sain,L.; (Year: 2015). Title: Type I IFN released by Myeloid Dendritic Cells reversibly impairs Cytomegalovirus replication by inhibiting immediate early gene expression.Volume: 89, S-Page: 9886-E-Page: 9895 PubMed
  • Authors: Barcia,R.N.; Santos,J.M.; Filipe,M.; Teixeira,M.; Martins,J.P.; Almeida,J.; Agua-Doce,A.; Varela,A.; Pohl,S.; Dittmar,K.E.; Calado,S.; Simoes,S.I.; Gaspar,M.M.; Cruz,M.E.; Lindenmaier,W.; Graca,L.; Cruz,H.; Cruz,P.E.; (Year: 2015). Title: What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?.Volume: 2015, S-Page: 583984 DOI: 10.1155/2015/583984 HZI repository PubMed
  • Authors: Neuhaus,V.; Chichester,J.A.; Ebensen,Thomas; Schwarz,K.; Hartman,C.E.; Shoji,Y.; Guzmán,Carlos A.; Yusibov,V.; Sewald,K.; Braun,A.; (Year: 2014). Title: A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung.Journal: VaccineVolume: 32Issue: 26, S-Page: 3216-E-Page: 3222 DOI: 10.1016/j.vaccine.2014.04.011 HZI repository PubMed
  • Authors: Kramer,R.; Sauer-Heilborn,A.; Welte,T.; Guzmán,Carlos A.; Höfle,Manfred G.; Abraham,Wolf-Rainer; (Year: 2014). Title: A rapid method for breath analysis in cystic fibrosis patients.Journal: European Journal of Clinical Microbiology and Infectious DiseasesVolume: 34, S-Page: 745-E-Page: 751 DOI: 10.1007/s10096-014-2286-5 HZI repository PubMed
  • Authors: Skrnjug,I.; Guzmán,Carlos A.; Ruecker,C.; (Year: 2014). Title: Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice.Journal: PLoS ONEVolume: 9Issue: 10, S-Page: e110150 DOI: 10.1371/journal.pone.0110150 HZI repository PubMed
  • Authors: Salguero,G.; Daenthanasanmak,A.; Münz,C.; Raykova,A.; Guzmán,Carlos A.; Riese,Peggy; Figueiredo,C.; Länger,F.; Schneider,A.; Macke,L.; Sundarasetty,B.S.; Witte,T.; Ganser,A.; Stripecke,R.; (Year: 2014). Title: Dendritic cell-mediated immune humanization of mice: Implications for allogeneic and xenogeneic stem cell transplantation.Journal: Journal of ImmunologyVolume: 192Issue: 10, S-Page: 4636-E-Page: 464715506606 WEBURLS
  • Authors: Mittal,A.; Schulze,Kai; Ebensen,Thomas; Weissmann,Sebastian; Hansen,Sonja; Lehr,Claus-Michael; Guzmán,Carlos A.; (Year: 2014). Title: Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation.Volume: 11, S-Page: 147-E-Page: 154 DOI: 10.1016/j.nano.2014.08.009 HZI repository PubMed
  • Authors: Akmatov,Manas K.; Kimani-Murage,E.; Pessler,Frank; Guzmán,Carlos A.; Krause,Gerard; Kreienbrock,L.; Mikolajczyk,Rafael T.; (Year: 2014). Title: Evaluation of invalid vaccine doses in 31 countries of the WHO African Region.Journal: VaccineVolume: 33, S-Page: 892-E-Page: 901 PubMed
  • Authors: Flores,A.E.; Chhatwal,G.S.; Hillier,S.L.; Baker,C.J.; Ferrieri,P.; (Year: 2014). Title: Expression of Group B Protective Surface Protein (BPS) by Invasive and Colonizing Isolates of Group B Streptococci.Journal: Current MicrobiologyVolume: 69Issue: 6, S-Page: 894-E-Page: 89803438651 WEBURLS
  • Authors: Caccuri,F.; Rueckert,C.; Giagulli,C.; Schulze,K.; Basta,D.; Zicari,S.; Marsico,S.; Cervi,E.; Fiorentini,S.; Slevin,M.; Guzmán,Carlos A.; Caruso,A.; (Year: 2014). Title: HIV-1 matrix protein p17 promotes lymphangiogenesis and activates the endothelin-1/endothelin B receptor axis.Journal: Arteriosclerosis, Thrombosis, and Vascular BiologyVolume: 34Issue: 4, S-Page: 846-E-Page: 85615244636 WEBURLS
  • Authors: Sanchez,M.V.; Ebensen,Thomas; Schulze,Kai; Cargnelutti,D.; Blazejewska,Paulina*; Scodeller,E.A.; Guzmán,Carlos A.; (Year: 2014). Title: Intranasal Delivery of Influenza rNP Adjuvanted with c-di-AMP Induces Strong Humoral and Cellular Immune Responses and Provides Protection against Virus Challenge.Journal: PLoS ONEVolume: 9Issue: 8, S-Page: e104824 PubMed
  • Authors: Riese,Peggy; Sakthivel,Priya; Trittel,S.; Guzmán,Carlos A.; (Year: 2014). Title: Intranasal formulations: promising strategy to deliver vaccines.Journal: Expert Opinion on Drug DeliveryVolume: 11Issue: 10, S-Page: 1619-E-Page: 1634 PubMed
  • Authors: Cazorla,S.I.; Matos,M.N.; Cerny,N.; Ramirez,C.; Alberti,A.S.; Bivona,A.E.; Morales,C.; Guzmán,Carlos A.; Malchiodi,E.L.; (Year: 2014). Title: Oral Multicomponent DNA Vaccine Delivered by Attenuated Salmonella Elicited Immunoprotection against American Trypanosomiasis.Journal: Journal of Infectious DiseasesVolume: 211, S-Page: 698-E-Page: 707 PubMed
  • Authors: Pandey,S.P.; Chandel,H.S.; Srivastava,S.; Selvaraj,S.; Jha,M.K.; Shukla,D.; Ebensen,Thomas; Guzmán,Carlos A.; Saha,B.; (Year: 2014). Title: Pegylated Bisacycloxypropylcysteine, a Diacylated Lipopeptide Ligand of TLR6, Plays a Host-Protective Role against Experimental Leishmania major Infection.Journal: Journal of ImmunologyVolume: 193Issue: 7, S-Page: 3632-E-Page: 3643 PubMed
  • Authors: Caccuri,F.; Giagulli,C.; Reichelt,J.; Martorelli,D.; Marsico,S.; Bugatti,A.; Barone,I.; Rusnati,M.; Guzmán,C.A.; Dolcetti,R.; Caruso,A.; (Year: 2014). Title: Simian immunodeficiency virus and human immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate b cell growth.Journal: Journal of VirologyVolume: 88Issue: 10, S-Page: 5706-E-Page: 57170022538X DOI: Article WEBURLS
  • Authors: Matos,M.N.; Cazorla,S.I.; Bivona,A.E.; Morales,C.; Guzmán,Carlos A.; Malchiodi,E.L.; (Year: 2014). Title: Tc52 Amino Terminal Domain DNA Carried by Attenuated Salmonella Induce Protection against a Trypanosoma cruzi Lethal Challenge.Journal: Infection and ImmunityVolume: 82Issue: 10, S-Page: 4265-E-Page: 4275 PubMed
  • Authors: Skrnjug,I.; Rueckert,C.; Libanova,R.; Lienenklaus,Stefan; Weiss,Siegfried; Guzmán,Carlos A.; (Year: 2014). Title: The Mucosal Adjuvant Cyclic di-AMP Exerts Immune Stimulatory Effects on Dendritic Cells and Macrophages.Journal: PLoS ONEVolume: 9Issue: 4, S-Page: e95728 DOI: 10.1371/journal.pone.0095728 HZI repository PubMed
  • Authors: Dutruel,C.; Thole,J.; Geels,M.; Mollenkopf,H.J.; Ottenhoff,T.; Guzmán,Carlos A.; Fletcher,H.A.; Leroy,O.; Kaufmann,S.H.; (Year: 2014). Title: TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'How can big data help?'.Journal: VaccineVolume: 32Issue: 35, S-Page: 4365-E-Page: 4368 DOI: 10.1016/j.vaccine.2014.06.014 HZI repository PubMed
  • Authors: Retamal-Diaz,A.; Riquelme-Neira,R.; Saez,D.; Rivera,A.; Fernandez,P.; Cabrera,A.; Guzmán,Carlos A.; Onate,A.; (Year: 2014). Title: Use of S-[2,3-bispalmitoyiloxy-(2R)-propyl]-R-cysteinyl-amido-monomethoxy polyethylene glycol as adjuvant improved protective immunity associated with a DNA vaccine encoding Cu,Zn superoxide dismutase of Brucella abortus in mice.Journal: Clinical and Vaccine ImmunologyVolume: 21Issue: 11, S-Page: 1474-E-Page: 1480 DOI: 10.1128/CVI.00554-14 HZI repository PubMed
  • Authors: Svindland,S.C.; Pedersen,G.K.; Pathirana,R.D.; Bredholt,G.; Nostbakken,J.K.; Jul-Larsen,A.; Guzmán,Carlos A.; Montomoli,E.; Lapini,G.; Piccirella,S.; Jabbal-Gill,I.; Hinchcliffe,M.; Cox,R.J.; (Year: 2013). Title: A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine1.Journal: Influenza and other Respiratory VirusesVolume: 7Issue: 6, S-Page: 1181-E-Page: 1193 DOI: 10.1111/irv.12056 HZI repository PubMed
  • Authors: Roy,Bishnudeo; Agarwal,Shiwani; Brennecke,Anne-Margarete; Krey,Martina; Pabst,O.; Düber,Sandra; Weiss,Siegfried; (Year: 2013). Title: B-1 cell subpopulations contribute differently to gut immunity.Journal: European Journal of ImmunologyVolume: 43Issue: 8, S-Page: 2023-E-Page: 2032 DOI: 10.1002/eji.201243070 HZI repository PubMed
  • Authors: Yevsa,Tatiana; Ebensen,T.; Fuchs,B.; Zygmunt,B.; Libanova,R.; Gross,R.; Schulze,K.; Guzmán,Carlos A.; (Year: 2013). Title: Development and characterization of attenuated metabolic mutants of Bordetella bronchiseptica for applications in vaccinology.Journal: Environmental MicrobiologyVolume: 15Issue: 1, S-Page: 64-E-Page: 76 DOI: 10.1111/j.1462-2920.2012.02779.x HZI repository PubMed
  • Authors: Gismondi,M.I.; Díaz Carrasco,J.M.; Valva,P.; Becker,Pablo D.; Guzmán,Carlos A.; Campos,R.H.; Preciado,M.V.; (Year: 2013). Title: Dynamic changes in viral population structure and compartmentalization during chronic hepatitis C virus infection in children.Journal: VirologyVolume: 447Issue: 1-2, S-Page: 187-E-Page: 19600426822 DOI: 10.1016/j.virol.2013.09.002 HZI repository PubMed
  • Authors: Fiebig,A.; Pradella,S.; Petersen,J.; Päuker,O.; Michael,V.; Lünsdorf,Heinrich; Göker,M.; Klenk,H.P.; Wagner-Döbler,Irene; (Year: 2013). Title: Genome of the R-body producing marine alphaproteobacterium Labrenzia alexandrii type strain (DFL-11T).Journal: Standards in Genomic SciencesVolume: 7Issue: 3, S-Page: 413-E-Page: 42619443277 DOI: 10.4056/sigs.3456959 HZI repository PubMed
  • Authors: Gras,C.; Schulze,Kai; Goudeva,L.; Guzmán,Carlos A.; Blasczyk,R.; Figueiredo,C.; (Year: 2013). Title: HLA-Universal Platelet Transfusions Prevent Platelet Refractoriness in a Mouse Model.Journal: Human gene therapyVolume: 24Issue: 12, S-Page: 1018-E-Page: 1028 PubMed
  • Authors: Mittal,A.; Raber,A.S.; Schaefer,U.F.; Weissmann,S.; Ebensen,Thomas; Schulze,Kai; Guzmán,Carlos A.; Lehr,Claus-Michael; Hansen,S.; (Year: 2013). Title: Non-invasive delivery of nanoparticles to hair follicles: A perspective for transcutaneous immunization.Journal: VaccineVolume: 31Issue: 34, S-Page: 3442-E-Page: 3451 PubMed
  • Authors: Gurramkonda,C.; Zahid,M.; Nemani,S.K.; Adnan,A.; Gudi,S.K.; Khanna,N.; Ebensen,Thomas; Lünsdorf,Heinrich; Guzmán,Carlos A.; Rinas,Ursula; (Year: 2013). Title: Purification of hepatitis B surface antigen virus-like particles from recombinant Pichia pastoris and in vivo analysis of their immunogenic properties.Journal: Journal of Chromatography BVolume: 940C, S-Page: 104-E-Page: 111 DOI: 10.1016/j.jchromb.2013.09.030 HZI repository PubMed
  • Authors: Mittal,A.; Raber,A.S.; Schaefer,U.F.; Weissmann,S.; Ebensen,Thomas; Schulze,Kai; Guzmán,Carlos A.; Hansen,S.; Lehr,Claus-Michael; (Year: 2013). Title: Transfollicular delivery of antigen using nanocarriers for non-invasive transcutaneous immunization.Journal: Controlled Release Society (CRS) LettersVolume: 30, S-Page: 16-E-Page: 17
  • Authors: Riese,Peggy; Schulze,Kai; Ebensen,Thomas; Prochnow,B.; Guzmán,Carlos A.; (Year: 2013). Title: Vaccine Adjuvants: Key Tools For Innovative Vaccine Design.Journal: Current Topics in Medicinal ChemistryVolume: 13Issue: 20, S-Page: 2562-E-Page: 2580 PubMed
  • Authors: Brettar,I.; Christen,R.; Höfle,Manfred G.; (Year: 2012). Title: Analysis of bacterial core communities in the central Baltic by comparative RNA-DNA-based fingerprinting provides links to structure-function relationships.Journal: ISME JournalVolume: 6Issue: 1, S-Page: 195-E-Page: 212 DOI: 10.10038/ismej.2011.80 PubMed
  • Authors: Henne,K.; Kahlisch,L.; Brettar,I.; Höfle,Manfred G.; (Year: 2012). Title: Analysis of structure and composition of bacterial core communities in mature drinking water biofilms and bulk water of a citywide network in Germany.Journal: Applied and Environmental MicrobiologyVolume: 78Issue: 10, S-Page: 3530-E-Page: 3538 DOI: 10.1128/AEM.06373-11 HZI repository PubMed
  • Authors: Ebermann,L.; Ruzsics,Z.; Guzmán,Carlos A.; Van,Rooijen N.; Casalegno-Garduno,R.; Koszinowski,U.; Cicin-Sain,Luka; (Year: 2012). Title: Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient host.Journal: PLoS PathogensVolume: 8Issue: 12, S-Page: e1003062 DOI: 10.1371/journal.ppat.1003062 HZI repository PubMed
  • Authors: Fiege,K.; Lünsdorf,Heinrich; Atarijabarzadeh,S.; Mischnick,P.; (Year: 2012). Title: Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles.Journal: Beilstein Journal of Organic ChemistryVolume: 8, S-Page: 551-E-Page: 566 DOI: 10.3762/bjoc.8.63 HZI repository PubMed
  • Authors: Libanova,R.; Becker,P.D.; Guzmán,Carlos A.; (Year: 2012). Title: Cyclic di-nucleotides: new era for small molecules as adjuvants.Journal: Microbial BiotechnologyVolume: 5Issue: 2, S-Page: 168-E-Page: 176 DOI: 10.1111/j.1751-7915.2011.00306.x HZI repository PubMed
  • Authors: Waern,J.M.; Yuan,Q.; Rudrich,U.; Becker,P.D.; Schulze,K.; Strick-Marchand,H.; Huntington,N.D.; Zacher,B.J.; Wursthorn,K.; DiSanto,J.P.; Guzmán,Carlos A.; Manns,M.P.; Ott,M.; Bock,M.; (Year: 2012). Title: Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice.Journal: HepatologyVolume: 56Issue: 4, S-Page: 1479-E-Page: 1488 DOI: 10.1002/hep.25816 HZI repository PubMed
  • Authors: Caro-Quintero,A.; Auchtung,J.; Deng,J.; Brettar,I.; Höfle,Manfred; Tiedje,J.M.; Konstantinidis,K.T.; (Year: 2012). Title: Genome sequencing of five Shewanella baltica strains recovered from the oxic-anoxic interface of the Baltic Sea.Journal: Journal of BacteriologyVolume: 194Issue: 5, S-Page: 1236 PubMed
  • Authors: Caccuri,F.; Giagulli,C.; Bugatti,A.; Benetti,A.; Alessandri,G.; Ribatti,D.; Marsico,S.; Apostoli,P.; Slevin,M.A.; Rusnati,M.; Guzman,Carlos A.; Fiorentini,S.; Caruso,A.; (Year: 2012). Title: HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2.Journal: Proceedings of the National Academy of Sciences USAVolume: 109Issue: 36, S-Page: 14580-E-Page: 14585 PubMed
  • Authors: Krawczyk-Bärsch,E.; Lünsdorf,Heinrich; Pedersen,K.; Arnold,T.; Bok,F.; Steudtner,R.; Lehtinen,A.; Brendler,V.; (Year: 2012). Title: Immobilization of uranium in biofilm microorganisms exposed to groundwater seeps over granitic rock tunnel walls in Olkiluoto, Finland.Journal: Geochimica et Cosmochimica ActaVolume: 96, S-Page: 94-E-Page: 104
  • Authors: Vezzulli,L.; Brettar,I.; Pezzati,E.; Reid,P.C.; Colwell,R.R.; Höfle,Manfred G.; Pruzzo,C.; (Year: 2012). Title: Long-term effects of ocean warming on the prokaryotic community: evidence from the vibrios.Journal: ISME JournalVolume: 6Issue: 1, S-Page: 21-E-Page: 30 DOI: 10.1038/ismej.2011.89 HZI repository PubMed
  • Authors: Nörder,M.; Gutierrez,M.G.; Zicari,S.; Cervi,E.; Caruso,A.; Guzmán,Carlos A.; (Year: 2012). Title: Lymph node-derived lymphatic endothelial cells express functional costimulatory molecules and impair dendritic cell-induced allogenic T-cell proliferation.Journal: FASEB journalVolume: 26Issue: 7, S-Page: 2835-E-Page: 2846 PubMed
  • Authors: Garcia,K.; Gavilan,R.G.; Höfle,Manfred G.; Martinez-Urtaza,J.; Espejo,R.T.; (Year: 2012). Title: Microevolution of Pandemic Vibrio parahaemolyticus Assessed by the Number of Repeat Units in Short Sequence Tandem Repeat Regions.Journal: PLoS ONEVolume: 7Issue: 1, S-Page: e30823 DOI: 10.1371/journal.pone.0030823 HZI repository PubMed
  • Authors: Zygmunt,B.M.; Weissmann,S.F.; Guzmán,Carlos A.; (Year: 2012). Title: NKT Cell Stimulation with alpha-Galactosylceramide Results in a Block of Th17 Differentiation after Intranasal Immunization in Mice.Journal: PLoS ONEVolume: 7Issue: 1, S-Page: e30382 DOI: 10.1371/journal.pone.0030382 HZI repository PubMed
  • Authors: Mehner,D.; Osadnik,H.; Lünsdorf,Heinrich; Bruser,T.; (Year: 2012). Title: The Tat System for Membrane Translocation of Folded Proteins Recruits the Membrane-stabilizing Psp Machinery in Escherichia coli.Journal: Journal of Biological ChemistryVolume: 287Issue: 33, S-Page: 27834-E-Page: 27842 PubMed
  • Authors: Krishnaswamy,J.K.; Jirmo,A.C.; Baru,A.M.; Ebensen,T.; Guzmán,Carlos A.; Sparwasser,Tim; Behrens,G.M.; (Year: 2012). Title: Toll-like receptor-2 agonist-allergen coupling efficiently redirects th2 cell responses and inhibits allergic airway eosinophilia.Journal: American Journal of Respiratory Cell and Molecular BiologyVolume: 47Issue: 6, S-Page: 852-E-Page: 863 DOI: 10.1165/rcmb.2011-0414OC PubMed
  • Authors: Rueckert,C.; Guzmán,Carlos A.; (Year: 2012). Title: Vaccines: from empirical development to rational design.Journal: PLoS PathogensVolume: 8Issue: 11, S-Page: e1003001 DOI: 10.1371/journal.ppat.1003001 HZI repository PubMed
  • Authors: Danilov,S.M.; Gordon,K.; Nesterovitch,A.B.; Lünsdorf,Heinrich*; Chen,Z.; Castellon,M.; Popova,I.A.; Kalinin,S.; Mendonca,E.; Petukhov,P.A.; Schwartz,D.E.; Minshall,R.D.; Sturrock,E.D.; (Year: 2011). Title: An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding.Journal: PLoS ONEVolume: 6Issue: 10, S-Page: e25952 PubMed
  • Authors: Kahlisch,L.; Henne,K.; Gröbe,Lothar*; Brettar,I.; Höfle,Manfred G.*; (Year: 2011). Title: Assessing the Viability of Bacterial Species in Drinking Water by Combined Cellular and Molecular Analyses3526.Journal: Microbial EcologyVolume: 63Issue: 2, S-Page: 383-E-Page: 397 DOI: 10.1007/s00248-011-9918-4 PubMed
  • Authors: Ebensen,T.; Libanova,R.; Schulze,K.; Yevsa,T.; Morr,M.; Guzmán,Carlos A.*; (Year: 2011). Title: Bis-(3',5')-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant.Journal: VaccineVolume: 29Issue: 32, S-Page: 5210-E-Page: 5220 PubMed
  • Authors: Pedersen,G.K.; Ebensen,T.; Gjeraker,I.H.; Svindland,S.; Bredholt,G.; Guzmán,Carlos A.*; Cox,R.J.; (Year: 2011). Title: Evaluation of the Sublingual Route for Administration of Influenza H5N1 Virosomes in Combination with the Bacterial Second Messenger c-di-GMP.Journal: PLoS ONEVolume: 6Issue: 11, S-Page: e26973 DOI: 10.1371/journal.pone.0026973 HZI repository PubMed
  • Authors: TrehanPati,N.; Sukriti,S.; Geffers,Robert*; Hissar,S.; Riese,P.; Toepfer,T.; Guzmán,Carlos A.*; Sarin,S.K.; (Year: 2011). Title: Gene expression profiles of T cells from hepatitis E virus infected patients in acute and resolving phase.Journal: Journal of Clinical ImmunologyVolume: 31Issue: 3, S-Page: 498-E-Page: 508 DOI: 10.1007/s10875-010-9506-210.1007/s10875-010-9506-2 HZI repository PubMed
  • Authors: Brettar,Ingrid*; Christen,R.; Höfle,Manfred G.*; (Year: 2011). Title: Genus III. Aquiflexum Brettar, Christen and Höfle 2004b, 2339 VP.Book Title: Bergey's Manual of Systematic BacteriologyEditors: Krieg,N.R.et al.; (Ed.)., S-Page: 433-E-Page: 434
  • Authors: Brettar,Ingrid*; Christen,R.; Höfle,Manfred G.*; (Year: 2011). Title: Genus IV. Belliella Brettar, Christen and Höfle 2004a, 69 VP.Book Title: Bergey's Manual of Systematic BacteriologyEditors: Krieg,N.R.et al.; (Ed.)., S-Page: 434-E-Page: 437
  • Authors: Duarte,M.; Ferreira-da-Silva,F.; Lünsdorf,Heinrich*; Junca,H.; Gales,L.; Pieper,Dietmar H.*; Nunes,O.C.; (Year: 2011). Title: Gulosibacter molinativorax ON4T molinate hydrolase, a novel cobalt-dependent amidohydrolase.Journal: Journal of BacteriologyVolume: 193Issue: 20, S-Page: 5810-E-Page: 5816 DOI: 10.1128/JB.05054-11 HZI repository PubMed
  • Authors: Huntington,N.D.; Alves,N.L.; Legrand,N.; Lim,A.; Strick-Marchand,H.; Mention,J.J.; Plet,A.; Weijer,K.; Jacques,Y.; Becker,P.D.; Guzmán,Carlos*; Soussan,P.; Kremsdorf,D.; Spits,H.; Di Santo,J.P.; (Year: 2011). Title: IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo.Journal: Proceeding of the National Academy of Sciences USAVolume: 108Issue: 15, S-Page: 6217-E-Page: 6222 PubMed
  • Authors: Ebensen,T.; Libanova,R.; Guzmán,Carlos A.*; (Year: 2011). Title: Infection prevention: oil- and lipid-containing products in vaccinology.Book Title: Handbook of Hydrocarbon and Lipid MicrobiologyEditors: Timmis,K.N.; (Ed.).City: Berlin, HeidelbergPublisher: Springer-Verlag, S-Page: 3311-E-Page: 3331
  • Authors: Madhun,A.S.; Haaheim,L.R.; Nostbakken,J.K.; Ebensen,T.; Chichester,J.; Yusibov,V.; Guzmán,Carlos A.*; Cox,R.J.; (Year: 2011). Title: Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4(+) cells and strong mucosal and systemic antibody responses in mice.Journal: VaccineVolume: 29Issue: 31, S-Page: 4973-E-Page: 4982 PubMed
  • Authors: Knothe,S.; Mutschler,V.; Rochlitzer,S.; Winkler,C.; Ebensen,T.; Guzmán,Carlos A.*; Hohlfeld,J.; Braun,A.; Muller,M.; (Year: 2011). Title: Local treatment with BPPcysMPEG reduces allergic airway inflammation in sensitized mice.Journal: ImmunobiologyVolume: 216Issue: 1-2, S-Page: 110-E-Page: 117 DOI: 10.1016/j.imbio.2010.05.003 HZI repository PubMed
  • Authors: Leidinger,P.; Popescu,R.; Gerthsen,D.; Lünsdorf,Heinrich*; Feldmann,C.; (Year: 2011). Title: Nanoscale copper sulfide hollow spheres with phase-engineered composition: covellite (CuS), digenite (Cu1.8S), chalcocite (Cu2S).Journal: NanoscaleVolume: 3Issue: 6, S-Page: 2544-E-Page: 2551 PubMed
  • Authors: Zygmunt,B.M.; Gröbe,Lothar*; Guzmán,Carlos A.*; (Year: 2011). Title: Peritoneal cavity is dominated by IFNgamma-secreting CXCR3+ Th1 cells.Journal: PLoS ONEVolume: 6Issue: 7, S-Page: e18032 DOI: 10.1371/journal.pone.0018032 HZI repository PubMed
  • Authors: Hedrich,S.; Lünsdorf,Heinrich*; Kleeberg,R.; Heide,G.; Seifert,J.; Schlomann,M.; (Year: 2011). Title: Schwertmannite Formation Adjacent to Bacterial Cells in a Mine Water Treatment Plant and in Pure Cultures of Ferrovum myxofaciens.Journal: Environmental Science and TechnologyVolume: 45Issue: 18, S-Page: 7685-E-Page: 7692 PubMed
  • Authors: Krawczyk-Barsch,E.; Lünsdorf,Heinrich*; Arnold,T.; Brendler,V.; Eisbein,E.; Jenk,U.; Zimmermann,U.; (Year: 2011). Title: The influence of biofilms on the migration of uranium in acid mine drainage (AMD) waters.Journal: Science of the Total EnvironmentVolume: 409Issue: 16, S-Page: 3059-E-Page: 3065 PubMed
  • Authors: Knothe,S.; Mutschler,V.; Rochlitzer,S.; Winkler,C.; Ebensen,T.; Guzmán,Carlos A.*; Hohlfeld,J.; Braun,A.; Muller,M.; (Year: 2011). Title: The NKT cell ligand alphagalactosylceramide suppresses allergic airway inflammation by induction of a Th1 response.Journal: VaccineVolume: 29Issue: 25, S-Page: 4249-E-Page: 4255 DOI: 10.1016/j.vaccine.2011.03.068 HZI repository PubMed
  • Authors: Sabirova,J.S.; Becker,A.; Lünsdorf,Heinrich*; Nicaud,J.M.; Timmis,Kenneth N.*; Golyshin,P.N.; (Year: 2011). Title: Transcriptional profiling of the marine oil-degrading bacterium Alcanivorax borkumensis during growth on n-alkanes.Journal: Fems Microbiology LettersVolume: 319Issue: 2, S-Page: 160-E-Page: 168 DOI: 10.1111/j.1574-6968.2011.02279.x HZI repository PubMed
  • Authors: Lünsdorf,Heinrich*; Gurramkonda,C.; Adnan,A.; Khanna,N.; Rinas,Ursula*; (Year: 2011). Title: Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the Hepatitis B surface antigen.Journal: Microbial Cell FactoriesVolume: 10, S-Page: 48 DOI: 10.1186/1475-2859-10-48 HZI repository PubMed
  • Authors: Becker,P.D.; Royo,J.L.; Guzmán,Carlos A.*; (Year: 2010). Title: Based on the salicylate-dependent control circuit encompassing nahR/Psal::xylS2 for biotechnological applications.Journal: Bioengineered BugsVolume: 1Issue: 4, S-Page: 244-E-Page: 251
  • Authors: Ebensen,T.; Libanova,R.; Guzman,Carlos A.*; (Year: 2010). Title: Bis-(3',5')-cyclic di-GMP: promising adjuvant for vaccine design.Book Title: The Second Messenger Cyclic di-GMPEditors: Wolf,A.J.; Visick,K.L.I.; (Ed.).City: Washington, D.C., USAPublisher: ASM Press, S-Page: 311-E-Page: 319
  • Authors: Wang,X.; Lünsdorf,Heinrich*; Ehren,I.; Brauner,A.; Romling,U.; (Year: 2010). Title: Characteristics of Biofilms from Urinary Tract Catheters and Presence of Biofilm-Related Components in Escherichia coli.Journal: Current MicrobiologyVolume: 60, S-Page: 446-E-Page: 453 PubMed
  • Authors: Libanova,R.; Ebensen,T.; Schulze,K.; Bruhn,D.; Nörder,M.; Yevsa,T.; Morr,M.; Guzmán,Carlos A.*; (Year: 2010). Title: Corrigendum to "The member of the cyclic di-nucleotide family bis- (3',5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant [Vaccine 28 (2010) 2249-2258].Journal: VaccineVolume: 28Issue: 20, S-Page: 3625
  • Authors: Becker,P.D.; Royo,J.L.; Guzmán,Carlos A.*; (Year: 2010). Title: Exploitation of prokaryotic expression systems based on the salicylate-dependent control circuit encompassing nahRPsal::xylS2 for biotechnological applications.Journal: Bioengineered BugsVolume: 1, S-Page: 246-E-Page: 253
  • Authors: Bjorkstrom,N.K.; Riese,P.; Heuts,F.; Andersson,S.; Fauriat,C.; Ivarsson,M.A.; Bjorklund,A.T.; Flodstrom-Tullberg,M.; Michaelsson,J.; Rottenberg,M.E.; Guzmán,Carlos A.*; Ljunggren,H.G.; Malmberg,K.J.; (Year: 2010). Title: Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education.Journal: BloodVolume: 116Issue: 19, S-Page: 3853-E-Page: 3864 PubMed
  • Authors: Becker,P.D.; Legrand,N.; van Geelen,C.M.; Noerder,M.; Huntington,N.D.; Lim,A.; Yasuda,E.; Diehl,S.A.; Scheeren,F.A.; Ott,M.; Weijer,K.; Wedemeyer,H.; Di Santo,J.P.; Beaumont,T.; Guzmán,Carlos A.*; Spits,H.; (Year: 2010). Title: Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice.Journal: PLoS ONEVolume: 5Issue: 10 DOI: 10.1371/journal.pone.0013137 HZI repository PubMed
  • Authors: Kahlisch,L.; Henne,K.; Draheim,J.; Brettar,I.; Höfle,Manfred G.*; (Year: 2010). Title: High-resolution in situ genotyping of Legionella pneumophila populations in drinking water by multiple-locus variable-number tandem-repeat analysis using environmental DNA.Journal: Applied in Environmental MicrobiologyVolume: 76Issue: 18, S-Page: 6186-E-Page: 6195 DOI: 10.1128/AEM.00416-10 HZI repository PubMed
  • Authors: Stegmann,K.A.; Björkström,N.K.; Liermann,H.; Ciesek,S.; Riese,P.; Wiegand,J.; Hadem,J.; Suneetha,P.V.; Jaroszewicz,J.; Wang,C.; Schlaphoff,V.; Fytili,P.; Cornberg,M.; Manns,M.P.; Geffers,Robert*; Pietschmann,Thomas*; Guzmán,Carlos A.*; Ljunggren,H.-G.; Wedemeyer,H.; (Year: 2010). Title: IFN alpha-induced TRAIL on human NK cells is associated with control of hepatitis C virus infection.Journal: GastroenterologyVolume: 138Issue: 5, S-Page: 1885-E-Page: 1897
  • Authors: Nörder,M.; Becker,P.D.; Drexler,I.; Link,C.; Erfle,V.; Guzmán,Carlos A.*; (Year: 2010). Title: Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model.Journal: PLoS ONEVolume: 5Issue: 6, S-Page: e11400 DOI: 10.1371/journal.pone.0011400 HZI repository PubMed
  • Authors: Kahlisch,L.; Henne,K.; Gröbe,Lothar*; Draheim,J.; Höfle,Manfred G.*; Brettar,I.; (Year: 2010). Title: Molecular analysis of the bacterial drinking water community with respect to live/dead status.Journal: Water Science and TechnologyVolume: 61Issue: 1, S-Page: 9-E-Page: 14 DOI: 10.2166/wst.2010.773 PubMed
  • Authors: Switalla,S.; Lauenstein,L.; Prenzler,F.; Knothe,S.; Forster,C.; Fieguth,H.G.; Pfennig,O.; Schaumann,F.; Martin,C.; Guzmán,Carlos A.*; Ebensen,T.; Muller,M.; Hohlfeld,J.M.; Krug,N.; Braun,A.; Sewald,K.; (Year: 2010). Title: Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices.Journal: Toxicology and Applied PharmacologyVolume: 246Issue: 3, S-Page: 107-E-Page: 115 PubMed
  • Authors: Fritzer,A.; Senn,B.M.; Minh,D.B.; Hanner,M.; Gelbmann,D.; Noiges,B.; Henics,T.; Schulze,K.; Guzmán,Carlos A.*; Goodacre,J.; von,Gabain A.; Nagy,E.; Meinke,A.L.; (Year: 2010). Title: Novel conserved group A streptococcal proteins identified by the antigenome technology as vaccine candidates for a non-M protein-based vaccine.Journal: Infection and ImmunityVolume: 78Issue: 9, S-Page: 4051-E-Page: 4067 PubMed
  • Authors: Hahn,M.W.; Lang,E.; Brandt,U.; Lünsdorf,Heinrich*; Wu,Q.L.; Stackebrandt,E.; (Year: 2010). Title: Polynucleobacter cosmopolitanus sp. nov., free-living planktonic bacteria inhabiting freshwater lakes and rivers.Journal: International Journal of Systematic and Evolutionary MicrobiologyVolume: 60Issue: Pt 1, S-Page: 166-E-Page: 173 PubMed
  • Authors: Chen,H.L.; Lünsdorf,Heinrich*; Hecht,H.J.; Tsai,H.; (Year: 2010). Title: Porcine pulmonary angiotensin I-converting enzyme-Biochemical characterization and spatial arrangement of the N- and C-domains by three-dimensional electron microscopic reconstruction.Journal: MicronVolume: 41Issue: 6, S-Page: 674-E-Page: 685 DOI: 10.1016/j.micron.2010.01.005 HZI repository PubMed
  • Authors: Cazorla,S.I.; Frank,F.M.; Becker,P.D.; Arnaiz,M.; Mirkin,G.A.; Corral,R.S.; Guzmán,Carlos A.*; Malchiodi,E.L.; (Year: 2010). Title: Redirection of the immune response to the functional catalytic domain of the cystein proteinase cruzipain improves protective immunity against Trypanosoma cruzi infection.Journal: Journal of Infectious DiseasesVolume: 202Issue: 1, S-Page: 136-E-Page: 144 DOI: 10.1086/652872 HZI repository PubMed
  • Authors: Guzmán,Carlos .A.*; (Year: 2010). Title: Research needs in vaccinology.Book Title: Handbook of Hydrocarbon and Lipid MicrobiologyEditors: Timmis,K.N.; (Ed.).City: Berlin HeidelbergPublisher: Springer-Verlag, S-Page: 3383-E-Page: 3385
  • Authors: Libanova,R.; Ebensen,T.; Schulze,K.; Bruhn,D.; Norder,M.; Yevsa,T.; Morr,M.; Guzmán,Carlos A.*; (Year: 2010). Title: The member of the cyclic di-nucleotide family bis-(3', 5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant.Journal: VaccineVolume: 28Issue: 10, S-Page: 2249-E-Page: 2258 PubMed
  • Authors: Prajeeth,C.K.; Jirmo,A.C.; Krishnaswamy,J.K.; Ebensen,T.; Guzmán,Carlos A.*; Weiss,Siegfried*; Constabel,H.; Schmidt,R.E.; Behrens,G.M.; (Year: 2010). Title: The synthetic TLR2 agonist BPPcysMPEG leads to efficient cross-priming against co-administered and linked antigens.Journal: European Journal of ImmunologyVolume: 40Issue: 5, S-Page: 1272-E-Page: 1283 PubMed
  • Authors: Caro-Quintero,A.; Deng,J.; Auchtung,J.; Brettar,I.; Höfle,Manfred G.*; Klappenbach,J.; Konstantinidis,K.T.; (Year: 2010). Title: Unprecedented levels of horizontal gene transfer among spatially co-occurring Shewanella bacteria from the Baltic Sea.Journal: ISME JournalVolume: 5Issue: 131, S-Page: 140 PubMed
  • Authors: Roming,M.; Lünsdorf,Heinrich*; Dittmar,Kurt E.*; Feldmann,C.; (Year: 2010). Title: ZrO(HPO(4))(1-x)(FMN)(x): quick and easy synthesis of a nanoscale luminescent biomarker.Journal: Angewandte Chemie International EditionVolume: 49Issue: 3, S-Page: 632-E-Page: 637 PubMed
  • Authors: Osanjo,G.O.; Muthike,E.W.; Tsuma,L.; Okoth,M.W.; Bulimo,W.D.; Lünsdorf,Heinrich*; Abraham,Wolf-Rainer*; Dion,M.; Timmis,Kenneth N.*; Golyshin,Peter N.*; Mulaa,F.J.; (Year: 2009). Title: A salt lake extremophile, Paracoccus bogoriensis sp. nov., efficiently produces xanthophyll carotenoids.Journal: African Journal of Microbiology ResearchVolume: 3Issue: 8, S-Page: 426-E-Page: 433
  • Authors: Fuchs,B.; Knothe,S.; Rochlitzer,S.; Nassimi,M.; Greweling,M.; Lauenstein,H.D.; Nassenstein,C.; Muller,M.; Ebensen,T.; Dittrich,A.M.; Krug,N.; Guzman,Carlos A.*; Braun,A.; (Year: 2009). Title: A Toll-Like Receptor 2/6 Agonist Reduces Allergic Airway Inflammation in Chronic Respiratory Sensitisation to Timothy Grass Pollen Antigens.Journal: International Archives of Allergy and ImmunologyVolume: 152Issue: 2, S-Page: 131-E-Page: 139 PubMed
  • Authors: Golyshina,Olga V.*; Yakimov,M.M.; Lünsdorf,Heinrich*; Ferrer,M.; Nimtz,Manfred*; Timmis,Kenneth N.*; Wray,Victor*; Tindall,B.J.; Golyshin,Peter N.*; (Year: 2009). Title: Acidiplasma aeolicum gen. nov., sp. nov., a euryarchaeon of the family Ferroplasmaceae isolated from a hydrothermal pool, and transfer of Ferroplasma cupricumulans to Acidiplasma cupricumulans comb. nov.Journal: International Journal of Systematic and Evolutionary MicrobiologyVolume: 59Issue: Pt 11, S-Page: 2815-E-Page: 2823 DOI: 10.1099/ijs.0.009639-0 HZI repository PubMed
  • Authors: Gismondi,M.I.; Becker,P.D.; az Carrasco,J.M.; Guzmán,Carlos A.*; Campos,R.H.; Preciado,M.V.; (Year: 2009). Title: Evolution of hepatitis C virus hypervariable region 1 in immunocompetent children born to HCV-infected mothers.Journal: Journal of Viral HepatitisVolume: 16Issue: 5, S-Page: 332-E-Page: 339 DOI: 10.1111/j.1365-2893.2009.01071.x HZI repository PubMed
  • Authors: Probst-Kepper,M.; Geffers,Robert*; Kroger,A.; Viegas,N.; Erck,C.; Hecht,Hans-Jürgen*; Lünsdorf,Heinrich*; Roubin,R.; Moharregh-Khiabani,D.; Wagner,K.; Ocklenburg,F.; Jeron,Andreas*; Garritsen,H.; Arstila,T.P.; Kekalainen,E.; Balling,Rudi*; Hauser,Hansjörg*; Buer,J.; Weiss,Siegfried*; (Year: 2009). Title: GARP: a key receptor controlling FOXP3 in human regulatory T cells.Journal: Journal of Cellular and Molecular MedicineVolume: 13Issue: 9, S-Page: 3343-E-Page: 3357 PubMed
  • Authors: Pati,N.T.; Geffers,Robert*; Sukriti,Hissar S.; Riese,P.; Toepfer,T.; Buer,J.; Guzmán,Carlos A.*; Sarin,S.K.; (Year: 2009). Title: Gene expression signatures of peripheral CD4+ T cells clearly discriminate between patients with acute and chronic hepatitis B viral infection.Journal: HepatologyVolume: 49Issue: 3, S-Page: 781-E-Page: 790
  • Authors: Valva,P.; Becker,P.; Streitemberger,P.; Garcia,Lombardi M.; Rey,G.; Guzmán,Carlos A.*; Preciado,M.V.; (Year: 2009). Title: Germline TP53 mutations and single nucleotide polymorphisms in children.Volume: 69Issue: 1/2, S-Page: 143-E-Page: 147 PubMed
  • Authors: Wurdemann,D.; Tindall,B.J.; Pukall,R.; Lünsdorf,Heinrich*; Strompl,C.; Namuth,T.; Nahrstedt,H.; Wos-Oxley,M.; Ott,S.; Schreiber,S.; Timmis,Kenneth N.*; Oxley,A.P.; (Year: 2009). Title: Gordonibacter pamelaeae gen. nov., sp. nov., a new member of the Coriobacteriaceae isolated from a patient with Crohn's disease, and reclassification of Eggerthella hongkongensis Lau et al. 2006 as Paraeggerthella hongkongensis gen. nov., comb. nov.Journal: International Journal of Systematic and Evolutionary MicrobiologyVolume: 59Issue: Pt 6, S-Page: 1405-E-Page: 1415 PubMed
  • Authors: Bosch,V.; Pfeiffer,T.; Devitt,G.; Allespach,I.; Ebensen,T.; Emerson,V.; Guzmán,C.A.; Keppler,O.T.; (Year: 2009). Title: HIV pseudovirion vaccine exposing Env "fusion intermediates"-Response to immunisation in human CD4/CCR5-transgenic rats.Journal: VaccineVolume: 27Issue: 16, S-Page: 2202-E-Page: 2212
  • Authors: Legrand,N.; Ploss,A.; Balling,Rudi*; Becker,P.D.; Borsotti,C.; Brezillon,N.; Debarry,J.; de,Jong Y.; Deng,H.; Di Santo,J.P.; Eisenbarth,S.; Eynon,E.; Flavell,R.A.; Guzmán,Carlos A.*; Huntington,N.D.; Kremsdorf,D.; Manns,M.P.; Manz,M.G.; Mention,J.J.; Ott,M.; Rathinam,C.; Rice,C.M.; Rongvaux,A.; Stevens,S.; Spits,H.; Strick-Marchand,H.; Takizawa,H.; van Lent,A.U.; Wang,C.; Weijer,K.; Willinger,T.; Ziegler,P.; (Year: 2009). Title: Humanized mice for modeling human infectious disease: challenges, progress, and outlook.Journal: Cell Host and MicrobeVolume: 6Issue: 1, S-Page: 5-E-Page: 9 PubMed
  • Authors: Ebensen,Thomas*; Guzmán,Carlos A.*; (Year: 2009). Title: Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design.Journal: Advances in Experimental Medicine and BiologyVolume: 655, S-Page: 171-E-Page: 188 PubMed
  • Authors: Ebensen,T.; Fuchs,B.; Schulze,K.; Guzmán,Carlos A.*; (Year: 2009). Title: Infection prevention: oil- and lipid-containing products in vaccinology.Book Title: Handbook of Hydrocarbon and Lipid MicrobiologyEditors: Timmis,K.N.; (Ed.).City: Berlin HeidelbergPublisher: Springer-Verlag, S-Page: 3311-E-Page: 3331
  • Authors: Zygmunt,B.M.; Rharbaoui,F.; Gröbe,Lothar*; Guzman,Carlos A.*; (Year: 2009). Title: Intranasal immunization promotes th17 immune responses.Journal: Journal of ImmunologyVolume: 183Issue: 11, S-Page: 6933-E-Page: 6938 PubMed
  • Authors: Zharkouskay,A.; Lünsdorf,Heinrich*; Feldmann,C.; (Year: 2009). Title: Ionic liquid-based synthesis of luminescent YVO4:Eu and YVO4:Eu@YF3 nanocrystals.Journal: Journal of Materials ScienceVolume: 44Issue: 15, S-Page: 39361-E-Page: 39427
  • Authors: Harth-Chu,E.; Espejo,R.T.; Christen,R.; Guzmán,Carlos A.*; Höfle,Manfred G.*; (Year: 2009). Title: Multiple-locus variable-number tandem-repeat analysis for clonal identification of Vibrio parahaemolyticus isolates by using capillary electrophoresis.Journal: Applied in Environmental MicrobiologyVolume: 75Issue: 12, S-Page: 4079-E-Page: 4088 PubMed
  • Authors: Guzmán,Carlos A.*; (Year: 2009). Title: Optimizing rational vaccine design.Journal: Microbial BiotechnologyVolume: 2Issue: 2 spec. iss., S-Page: 136-E-Page: 138
  • Authors: Giagulli,C.; Noerder,M.; Avolio,M.; Becker,P.D.; Fiorentini,S.; Guzmán,Carlos A.*; Caruso,A.; (Year: 2009). Title: Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level.Journal: International ImmunopharmacologyVolume: 9Issue: 12, S-Page: 1366-E-Page: 1373 DOI: 10.1016/j.intimp.2009.08.010 HZI repository PubMed
  • Authors: Haridass,D.; Yuan,Q.; Becker,P.D.; Cantz,T.; Iken,M.; Rothe,M.; Narain,N.; Bock,M.; Norder,M.; Legrand,N.; Wedemeyer,H.; Weijer,K.; Spits,H.; Manns,M.P.; Cai,J.; Deng,H.; Di Santo,J.P.; Guzman,Carlos A.*; Ott,M.; (Year: 2009). Title: Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice.Journal: American Journal of PathologyVolume: 175Issue: 4, S-Page: 1483-E-Page: 1492 PubMed
  • Authors: Gurramkonda,C.; Adnan,A.; Gabel,T.; Lünsdorf,Heinrich*; Ross,Antonius*; Nemani,S.K.; Swaminathan,S.; Khanna,N.; Rinas,Ursula*; (Year: 2009). Title: Simple high-cell density fed-batch technique for high-level recombinant protein production with Pichia pastoris: Application to intracellular production of Hepatitis B surface antigen.Journal: Microbial Cell FactoriesVolume: 8, S-Page: 13 DOI: 10.1186/1475-2859-8-13 HZI repository PubMed
  • Authors: Spring,S.; Lünsdorf,Heinrich*; Fuchs,B.M.; Tindall,B.J.; (Year: 2009). Title: The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov.Journal: PLoS ONEVolume: 4Issue: 3, S-Page: e4866 DOI: 10.1371/journal.pone.0004866 HZI repository PubMed
  • Authors: Palma,C.; Iona,E.; Ebensen,T.; Guzmán,Carlos A.*; Cassone,A.; (Year: 2009). Title: The toll-like receptor 2/6 ligand MALP-2 reduces the viability of Mycobacterium tuberculosis in murine macrophages.Journal: Open Microbiology JournalVolume: 3, S-Page: 47-E-Page: 52
  • Authors: Schulze,K.; Staib,C.; Schatzl,H.M.; Ebensen,Thomas*; Erfle,V.; Guzmán,Carlos A.*; (Year: 2008). Title: A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus.Journal: VaccineVolume: 26Issue: 51, S-Page: 6678-E-Page: 6684 DOI: 10.1016/j.vaccine.2008.09.006 HZI repository PubMed
  • Authors: Vezzulli,L.; Guzmán,Carlos A.*; Colwell,R.R.; Pruzzo,C.; (Year: 2008). Title: Dual role colonization factors connecting Vibrio cholerae's lifestyles in human and aquatic environments open new perspectives for combating infectious diseases.Journal: Current Opinion in BiotechnologyVolume: 19Issue: 3, S-Page: 254-E-Page: 259 PubMed
  • Authors: Jordao,L.; Lengeling,Andreas*; Bordat,Y.; Boudou,F.; Gicquel,B.; Neyrolles,O.; Becker,P.D.; Guzmán,Carlos .A.*; Griffiths,G.; Anes,E.; (Year: 2008). Title: Effects of omega-3 and -6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice.Journal: Microbes and InfectionVolume: 10Issue: 12-13, S-Page: 1379-E-Page: 1386 PubMed
  • Authors: Cataldi,A.; Yevsa,T.; Vilte,D.A.; Schulze,K.; Castro-Parodi,M.; Larzabal,M.; Ibarra,C.; Mercado,E.C.; Guzmán,Carlos A.*; (Year: 2008). Title: Efficient immune responses against Intimin and EspB of enterohaemorragic Escherichia coli after intranasal vaccination using the TLR2/6 agonist MALP-2 as adjuvant.Journal: VaccineVolume: 26Issue: 44, S-Page: 5662-E-Page: 5667 DOI: 10.1016/j.vaccine.2008.07.027 Fulltext HZI repository PubMed
  • Authors: Becker,P.D.; Nörder,Miriam*; Guzmán,Carlos.A.*; (Year: 2008). Title: Genetic immunization: Bacteria as DNA vaccine delivery vehicles.Journal: Human VaccinesVolume: 4Issue: 3, S-Page: 189-E-Page: 202 Fulltext
  • Authors: Marini,E.; Tiberio,L.; Fiorentini,S.; Caracciolo,S.; Tosti,G.; Guzmán,Carlos A.*; Schiaffonati,L.; Fiorentini,S.; Caruso,A.; (Year: 2008). Title: HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: role of the transcriptional factor AP-1.Journal: Cellular MicrobiologyVolume: 10Issue: 3, S-Page: 655-E-Page: 666
  • Authors: Fiorentini,S.; Riboldi,E.; Facchetti,F.; Avolio,M.; Fabbri,M.; Tosti,G.; Becker,P.D.; Guzmán,Carlos A.*; Sozzani,S.; Caruso,A.; (Year: 2008). Title: HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype.Journal: Proceedings of the National Academy of Sciences of the United States of AmericaVolume: 105Issue: 10, S-Page: 3867-E-Page: 3872 PubMed
  • Authors: Ebensen,Thomas*; Guzmán,Carlos.A.*; (Year: 2008). Title: Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design.Journal: Human VaccinesVolume: 4Issue: 1, S-Page: 13-E-Page: 22 HZI repository PubMed
  • Authors: Mastini,C.; Becker,P.D.; Iezzi,M.; Curcio,C.; Musiani,P.; Forni,G.; Cavallo,F.; Guzmán,Carlos A.*; (Year: 2008). Title: Intramammary application of non-methylated-CpG oligodeoxynucleotides (CpG) inhibits both local and systemic mammary carcinogenesis in female BALB/c Her-2/neu transgenic mice.Journal: Current Cancer Drug TargetsVolume: 8Issue: 3, S-Page: 230-E-Page: 242 HZI repository PubMed
  • Authors: Gobert,A.P.; Coste,A.; Guzmán,Carlos A.*; Hindré,T.; Girardeau,P.; Martin,C.; (Year: 2008). Title: Modulation of chemokine gene expression by Shiga-toxin producing Escherichia coli belonging to various origin and serotypes.Journal: Microbes and InfectionVolume: 10Issue: 2, S-Page: 159-E-Page: 165 DOI: 10.1016/j.micinf.2007.10.018 HZI repository PubMed
  • Authors: Brettar,Ingrid*; Höfle,Manfred G.*; (Year: 2008). Title: Molecular assessment of bacterial pathogens-a contribution to drinking water safety.Journal: Current Opinion in BiotechnologyVolume: 19Issue: 3, S-Page: 274-E-Page: 280 PubMed
  • Authors: Höfle,Manfred G.*; Kirchman,D.L.; Christen,R.; Brettar,Ingrid*; (Year: 2008). Title: Molecular diversity of bacterioplankton: Link to a predictive biogeochemistry of pelagic ecosystems.Journal: Aquatic Microbial EcologyVolume: 53Issue: 1, S-Page: 39-E-Page: 58
  • Authors: Gillen,C.M.; Courtney,H.S.; Schulze,K.; Rohde,Manfred*; Wilson,M.R.; Timmer,A.M.; Guzmán,Carlos A.*; Nizet,V.; Chhatwal,Gursharan S.*; Walker,M.J.; (Year: 2008). Title: Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete.Journal: Journal of Biological ChemistryVolume: 283, S-Page: 6359-E-Page: 6366
  • Authors: Cazorla,S.I.; Becker,P.D.; Frank,F.M.; Ebensen,T.; Sartori,M.J.; Corral,R.S.; Malchiodi,E.L.; Guzmán,Carlos A.*; (Year: 2008). Title: Oral vaccination with Salmonella enterica as a cruzipain-DNA delivery system confers protective immunity against Trypanosoma cruzi.Journal: Infection and ImmunityVolume: 76Issue: 1, S-Page: 324-E-Page: 333 DOI: 10.1128/IAI.01163-07 HZI repository PubMed
  • Authors: Hegermann,J.; Lünsdorf,Heinrich*; Overbeck,J.; Schrempf,H.; (Year: 2008). Title: Polyphosphate at the Streptomyces lividans cytoplasmic membrane is enhanced in the presence of the potassium channel KcsA.Journal: Journal of MicroscopyVolume: 229Issue: Pt 1, S-Page: 174-E-Page: 182 PubMed
  • Authors: Henne,K.; Kahlisch,L.; Draheim,J.; Brettar,Ingrid*; Höfle,Manfred*; (Year: 2008). Title: Polyvalent fingerprint based molecular surveillance methods for drinking water supply systems.Journal: Water Science and Technology: Water SupplyVolume: 8Issue: 5, S-Page: 527-E-Page: 532
  • Authors: Cazorla,S.I.; Frank,F.M.; Becker,P.D.; Corral,R.S.; Guzmán,Carlos A.*; Malchiodi,E.L.; (Year: 2008). Title: Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury an experimental Trypanosoma cruzi infection model.Journal: VaccineVolume: 26, S-Page: 1999-E-Page: 2009 DOI: 10.1016/j.vaccine.2008.02.011 HZI repository PubMed
  • Authors: Becker,P.D.; Royo,J.L.; (Year: 2008). Title: Prokaryotic gene regulation: Aspirin as a regulator of the gene expression.Journal: BiospektrumVolume: 14Issue: 5, S-Page: 506-E-Page: 50709470867 DOI: Article WEBURLS
  • Authors: Standar,K.; Mehner,D.; Osadnik,H.; Berthelmann,F.; Hause,G.; Lünsdorf,Heinrich*; Bruser,T.; (Year: 2008). Title: PspA can form large scaffolds in Escherichia coli.Journal: Febs LettersVolume: 582Issue: 25-26, S-Page: 3585-E-Page: 3589 DOI: 10.1016/j.febslet.2008.09.002 HZI repository PubMed
  • Authors: Fiorentini,S.; Marsico,S.; Becker,P.D.; Iaria,M.L.; Bruno,R.; Guzmán,Carlos A.*; Caruso,A.; (Year: 2008). Title: Synthetic peptide AT20 coupled to KLH elicits antibodies against a conserved conformational epitope from a major functional area of the HIV-1 matrix protein p17.Journal: VaccineVolume: 26Issue: 36, S-Page: 4758-E-Page: 4765 PubMed
  • Authors: Schulze,K.; Goldmann,Oliver*; Medina,Eva*; Guzmán,Carlos A.*; (Year: 2008). Title: The FAI protein of group C streptococci acts as a mucosal adjuvant by the specific targeting and activation of B cells.Journal: International Journal of Medical MicrobiologyVolume: 298Issue: 1-2, S-Page: 3-E-Page: 10
  • Authors: Gross,R.; Guzmán,Carlos A.*; Sebaihia,M.; Martins dos Santos,Vitor A.P.M.*; Pieper,Dietmar H.*; Koebnik,R.; Lechner,M.; Bartels,D.; Buhrmester,J.; Choudhuri,J.V.; Ebensen,T.; Gaigalat,L.; Herrmann,S.; Khachane,A.N.; Larisch,C.; Link,S.; Linke,B.; Meyer,F.; Mormann,S.; Nakunst,D.; Ruckert,C.; Schneiker-Bekel,S.; Schulze,K.; Vorholter,F.J.; Yevsa,T.; Engle,J.T.; Goldman,W.E.; Puhler,A.; Gobel,U.B.; Goesmann,A.; Blöcker,Helmut*; Kaiser,O.; Martinez-Arias,R.; (Year: 2008). Title: The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae.Journal: BMC GENOMICSVolume: 9, S-Page: 449 DOI: 10.1186/1471-2164-9-449 HZI repository PubMed
  • Authors: Ebensen,T.; Link,C.; Riese,P.; Schulze,K.; Morr,M.; Guzmán,Carlos A.*; (Year: 2007). Title: A pegylated derivative of alpha-galactosylceramide exhibits improved biological properties.Volume: 179Issue: 4, S-Page: 2065-E-Page: 2073
  • Authors: Brettar,I.; Christen,R.; Bötel,J.; Lünsdorf,Heinrich*; Höfle,Manfred*; (Year: 2007). Title: Anderseniella baltica gen. nov., sp. nov., a novel marine bacterium of the Alphaproteobacteria isolated from sediment in the central Baltic Sea.Journal: International Journal of Systematic and Evolutionary MicrobiologyVolume: 57Issue: 10, S-Page: 2399-E-Page: 2405
  • Authors: Becker,P.D.; Guzmán,Carlos A.*; (Year: 2007). Title: Community-acquired pneumonia : paving the way towards new vaccination concepts.Book Title: Birkhäuser Advances in Infectious Diseases: Community-acquired pneumoniaEditors: Suttorp,N.; Welte,T.; Marre,R.; (Ed.).City: BaselPublisher: Birkhäuser Verlag, S-Page: 201-E-Page: 245
  • Authors: Höfle,Manfred G.*; Brettar,Ingrid*; (Year: 2007). Title: Ein molekularbiologischer Blick in unser Trinkwasser - Mikrobielle Diagnostik für Umweltproben.Journal: BioforumVolume: 3Issue: 2, S-Page: 4
  • Authors: Olive,C.; Schulze,K.; Kuo Sun,H.; Ebensen,Thomas*; Horváth,A.; Toth,I.; Guzmán,Carlos A.*; (Year: 2007). Title: Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/Sfbl lipid core peptide vaccine formulation.Journal: VaccineVolume: 25Issue: 10, S-Page: 1789-E-Page: 1797
  • Authors: Brettar,Ingrid*; Guzmán,Carlos A.*; Höfle,Manfred G.*; (Year: 2007). Title: Human pathogenic micro-organisms in the marine environment - an ecological perspective.Journal: CIESM ReportsVolume: 31
  • Authors: Becker,P.D.; Nörder,Miriam*; Guzmán,Carlos A.*; Grinstein,S.; (Year: 2007). Title: Immune modulator adamantylamide dipeptide stimulates efficient Major Histocompatibility complex class I-restricted responses in mice.Journal: Clinical and Vaccine ImmunologyVolume: 14, S-Page: 538-E-Page: 543 DOI: 10.1128/CVI.00316-06 Fulltext HZI repository
  • Authors: Royo,J.L.; Becker,P.D.; Camacho,E.M.; Cebolla,A.; Link,C.; Santero,E.; Guzmán,Carlos A.*; (Year: 2007). Title: In vivo gene regulation in Salmonella spp. by a salicylate-dependent control circuit.Journal: Nature MethodsVolume: 4Issue: 11, S-Page: 937-E-Page: 942 DOI: 10.1038/nmeth1107 HZI repository PubMed
  • Authors: Becker,P.D.; Bertot,G.M.; Souss,D.; Ebensen,T.; Guzmán,Carlos A.*; Grinstein,S.; (Year: 2007). Title: Intranasal vaccination with recombinant outer membrane protein CD and adamantylamide dipeptide as the mucosal adjuvant enhances pulmonary clearance of Moraxella catarrhalis in an experimental murine model.Journal: Infection and ImmunityVolume: 75Issue: 4, S-Page: 1778-E-Page: 1784 DOI: 10.1128/IAI.01081-06 HZI repository PubMed
  • Authors: Fiorentini,S.; Marconi,P.; Avolio,M.; Marini,E.; Garrafa,E.; Caracciolo,S.; Rossi,D.; Bozac,A.; Becker,P.D.; Gentili,F.; Facchetti,F.; Guzmán,Carlos A.*; Manservigi,R.; Caruso,A.; (Year: 2007). Title: Replication-deficient mutant Herpes Simplex Virus-1 targets professional antigen presenting cells and induces efficient CD4+ T helper responses.Journal: Microbes and InfectionVolume: 9Issue: 8, S-Page: 988-E-Page: 996 DOI: 10.1016/j.micinf.2007.04.001 HZI repository PubMed
  • Authors: Ebensen,Thomas*; Schulze,Kai*; Riese,Peggy*; Morr,Michael*; Guzmán,Carlos A.*; (Year: 2007). Title: The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant.Journal: Clinical and Vaccine ImmunologyVolume: 14Issue: 8, S-Page: 952-E-Page: 958 DOI: 10.1128/CVI.00119-07 HZI repository PubMed
  • Authors: Ebensen,Thomas*; Schulze,Kai*; Riese,Peggy*; Link,Claudia*; Morr,Michael*; Guzmán,Carlos A.*; (Year: 2007). Title: The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties.Journal: VaccineVolume: 25Issue: 8, S-Page: 1464-E-Page: 1469 DOI: 10.1128/CVI.00119-07
  • Authors: Gattinger,A.; Höfle,Manfred G.*; Schloter,M.; Embacher,A.; Böhme,F.; Munch,J.C.; Labrenz,M.; (Year: 2007). Title: Traditional cattle manure application determines abundance, diversity and activity of methanogenic Archaea in an arable European soil.Journal: Environmental MicrobiologyVolume: 9Issue: 3, S-Page: 612-E-Page: 624 DOI: 10.1111/j.1462-2920.2006.01181.x HZI repository PubMed
  • Authors: Link,C.; Ebensen,Thomas*; Ständner,L.; Déjosez,M.; Reinhard,E.; Rharbaoui,F.; Guzmán,Carlos A.*; (Year: 2006). Title: An SopB-mediated immune escape mechanism of Salmonella enterica can be subverted to optimise the performance of live attenuated vaccine carrier strains.Journal: Microbes and InfectionVolume: 8, S-Page: 2262-E-Page: 2269 DOI: 10.1016/j.micinf.2006.04.013 HZI repository PubMed
  • Authors: De Buhr,M.; Mähler,M.; Geffers,Robert*; Hansen,W.; Westendorf,Astrid M.*; Lauber,J.; Buer,Jan*; Akira,S.; Schlegelberger,B.; Hedrich,H.J.; Bleich,A.; (Year: 2006). Title: Cd14, Gbp1, and Pla2g2a: 3 major candidate genes for experimental IBD identified by combining QTL and microarray analyses.Journal: Physiological GenomicsVolume: 25, S-Page: 426-E-Page: 434 DOI: 10.1152/physiolgenomics.00022.2005 Fulltext PubMed
  • Authors: Borsutzky,S.; Ebensen,T.; Link,C.; Becker,P.D.; Fiorelli,V.; Cafaro,A.; Ensoli,B.; Guzmán,C.A.; (Year: 2006). Title: Efficient systemic and mucosal responses against the HIV-1 Tat protein by Prime/Boost vaccination using the lipopeptide MALP-2 as adjuvant.Journal: VaccineVolume: 24, S-Page: 2049-E-Page: 2056 DOI: 10.1016./j.vaccine.2005.11.025
  • Authors: Garbe,A.I.; Vermeer,B.; Gamrekelashivili,J.; von Wasielewski,R.; Greten,F.R.; Westendorf,Astrid M.*; Buer,Jan*; Schmid,R.M.; Manns,M.P.; Korangy,F.; Greten,T.F.; (Year: 2006). Title: Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses.Journal: Cancer ResearchVolume: 66, S-Page: 508-E-Page: 516
  • Authors: Hansen,W.; Loser,K.; Westendorf,Astrid M.*; Bruder,Dunja*; Pförtner,S.; Siewert,C.; Huehn,J.; Beissert,S.; Buer,Jan*; (Year: 2006). Title: GPR83-overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo.Journal: Journal of ImmunologyVolume: 177, S-Page: 209-E-Page: 215
  • Authors: Fiorentini,S.; Becker,P.D.; Marini,E.; Marconi,P.; Avolio,M.; Tosti,G.; Link,C.; Manservigi,R.; Guzmán,Carlos A.*; Caruso,A.; (Year: 2006). Title: HIV-1 matrix protein p17 modulates in vivo preactivated murine T-cell response and enhances the induction of systemic and mucosal immunity against intranasally co-administered antigens.Journal: Viral ImmunologyVolume: 19, S-Page: 177-E-Page: 188
  • Authors: Veldman,C.; Pahl,A.; Beissert,S.; Hansen,W.; Buer,Jan*; Dieckmann,D.; Schuler,G.; Hertl,M.; (Year: 2006). Title: Inhibition of the transcription factor Foxp3 converts desmoglein 3-specific type 1 regulatory T cells into Th 2-like cells.Journal: Journal of ImmunologyVolume: 176, S-Page: 3215-E-Page: 3222
  • Authors: Schulze,K.; Medina,Eva*; Guzmán,Carlos A.*; (Year: 2006). Title: Intranasal immunization with serum opacity factor (SOF) of Streptococcus pyogenes fails to protect mice against lethal mucosal challenge with a heterologous strain.Journal: VaccineVolume: 24, S-Page: 1446-E-Page: 1450 DOI: 10.1016/j.vaccine.2005.06.039
  • Authors: Schulze,K.; Olive,C.; Ebensen,Thomas*; Guzmán,Carlos A.*; (Year: 2006). Title: Intranasal vaccination with Sfbl or M protein-derived peptides conjugated to diphtheria toxoid confers protective immunity against a lethal challenge with S. pyogenes.Journal: VaccineVolume: 24, S-Page: 6088-E-Page: 6095
  • Authors: Gismondi,M.I.; Becker,P.D.; Valva,P.; Guzmán,Carlos A.*; Preciado,M.V.; (Year: 2006). Title: Phylogenetic analysis of previously non-typeable hepatitis C virus isolates from Argentina.Journal: Journal of Clinical MicrobiologyVolume: 44, S-Page: 2229-E-Page: 2232 DOI: 10.1128/JCM.02569-05 HZI repository PubMed
  • Authors: Pfoertner,Susanne*; Jeron,A.; Probst-Kepper,M.; Guzmán,Carlos A.*; Hansen,W.; Westendorf,A.M.; Toepfer,T.; Schrader,A.J.; Franzke,A.; Buer,Jan*; Geffers,Robert*; (Year: 2006). Title: Signatures of human regulatory T cells: an encounter with old friends and new players.Journal: Genome BiologyVolume: 7, S-Page: R54 DOI: 10.1186/gb-2006-7-7-r54 HZI repository PubMed
  • Authors: Becker,P.D.; Fiorentini,S.; Link,C.; Tosti,G.; Ebensen,T.; Caruso,A.; Guzmán,C.A.; (Year: 2006). Title: The HIV-1 matrix protein p17 can be efficiently delivered by intranasal route in mice using the TLR 1/6 agonist MALP-2 as mucosal adjuvant.Journal: VaccineVolume: 24, S-Page: 5269-E-Page: 5276 DOI: 10.1016/j.vaccine.2005.11.008
  • Authors: Ocklenburg,F.; Moharregh-Khiabani,D.; Geffers,Robert*; Janke,V.; Pfoertner,S.; Garritsen,H.; Groebe,L.; Klempnauer,J.; Dittmar,Kurt E.J.*; Weiss,Siegfried*; Buer,Jan*; Probst-Kepper,M.; (Year: 2006). Title: UBD, a down-stream element of Foxp3, leads to the identification of LGALS3, a new marker of human regulatory T cells.Journal: Laboratory InvestigationVolume: 86, S-Page: 724-E-Page: 737
  • Authors: Guzmán,Carlos A.*; Borsutzky,S.; Griot-Wenk,M.; Metcalfe,I.C.; Pearman,J.; Collioud,A.; Favre,D.; Dietrich,G.; (Year: 2006). Title: Vaccines against Typhoid fever.Journal: VaccineVolume: 24, S-Page: 3804-E-Page: 3811 DOI: 10.1016/J.vaccine.2005.07.111 HZI repository PubMed
  • Authors: González-Escalona,N.; Romero,J.; Guzmán,Carlos A.*; Espejo,R.T.; (Year: 2006). Title: Variation in the 16S-23S rRNA intergenic spacer regions in Vibrio parahaemolyticus strains are due to indels nearby their tRNA Glu.Journal: Fems Microbiology LettersVolume: 256, S-Page: 38-E-Page: 43
  • Authors: Rharbaoui,F.; Bruder,D.; Vidakovic,M.; Ebensen,T.; Buer,J.; Guzmán,C.A.; (Year: 2005). Title: Characterization of a B220+ lymphoid cell subpopulation with immune modulatory functions.Journal: Journal of ImmunologyVolume: 174, S-Page: 1317-E-Page: 1324
  • Authors: Ebensen,Thomas; Link,Claudia; Guzmán,Carlos A.; (Year: 2005). Title: Human and veterinary classical vaccines against bacterial diseases.Book Title: Growth factors and oncogenesin gastrointestinal cancers to informatics (Computational biology)Editors: .; (Ed.).City: WeinheimPublisher: Wiley-VCH, S-Page: 297-E-Page: 322 ISBN: 3-527-30548-3
  • Authors: Schulze,K.; Ebensen,T.; Link,C.; Guzmán,C.A.; (Year: 2005). Title: Mukosale versus systemische Vakzinierung: Neue Strategien zur Entwicklung effizienterer Impfstoffe.Journal: Deutsche Industrievereinigung Biotechnologie (DIB)
  • Authors: Rharbaoui,F.; Guzmán,C.A.; (Year: 2005). Title: New generation of immune modulators based on toll-like receptor signaling.Journal: Current Immunology ReviewVolume: 1Issue: 2, S-Page: 107-E-Page: 118
  • Authors: Guzmán,C.A.; Cebolla,A.; Beltrametti,F.; Staendner,L.H.; de Lorenzo,V.; (Year: 2005). Title: Physiological stress of intracellular Shigella flexneri visualized with a metabolic sensor fused to a surface-reporter system.Journal: Febs LettersVolume: 579Issue: 3, S-Page: 813-E-Page: 818
  • Authors: Schulze,K.; Goldmann,O.; Toppel,A.; Medina,E.; Guzmán,C.A.; (Year: 2005). Title: The FAI protein of group C streptococci targets B cells and exhibits adjuvant activity.Journal: VaccineVolume: 23, S-Page: 1408-E-Page: 1413
  • Authors: Borsutzky,S.; Kretschmer,K.; Becker,P.D.; Mühlradt,P.F.; Kirschning,C.J.; Weiss,S.; Guzmán,C.A.; (Year: 2005). Title: The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells.Journal: Journal of ImmunologyVolume: 174Issue: 10, S-Page: 6308-E-Page: 6313
  • Authors: Erfle,V.; Goebel,F.D.; Guzmán,C.A.; Le Grand,R.; (Year: 2005). Title: Vaccines based on Nef and on Nef/delta V2 Env.Journal: Microbes and InfectionVolume: 7, S-Page: 1400-E-Page: 1404
  • Authors: Ebensen,Thomas; Paukner,S.; Link,C.; Kudela,P.; de Domenico,C.; Lubitz,W.; Guzmán,C.A.; (Year: 2004). Title: Bacterial ghosts are an efficient delivery system for DNA vaccines.Journal: Journal of ImmunologyVolume: 172, S-Page: 6858-E-Page: 6865
  • Authors: Fey,A.; Eichler,S.; Flavier,S.; Christen,R.; Höfle,M.G.; Guzmán,C.A.; (Year: 2004). Title: Establishment of a real-time PCR-based approach for accurate quantification of bacterial RNA targets in water, using Salmonella as a model organism.Journal: Applied and Environmental MicrobiologyVolume: 70Issue: 6, S-Page: 3618-E-Page: 3623 DOI: 10.1128/AEM.70.6.3618-3623.2004 HZI repository PubMed
  • Authors: Gismondi,M.I.; Staendner,L.H.; Grinstein,S.; Guzmán,C.A.; Preciado,M.V.; (Year: 2004). Title: Hepatitis C virus isolates from Argentina disclose a novel genotype 1-associated restriction pattern.Journal: Journal of Clinical MicrobiologyVolume: 42Issue: 3, S-Page: 1298-E-Page: 1301 DOI: 10.1128/JCM.42.3.1298-1301.2004 HZI repository PubMed
  • Authors: McArthur,J.; Schulze,K.; Chin,J.; Currie,B.J.; Sriprakash,K.S.; Talay,S.R.; Chhatwal,G.S.; ,Guzmán C.A.; (Year: 2004). Title: Immune responses of a liposome/ISCOM vaccine adjuvant against streptococcal fibronectin binding protein 1 (Sfb1) in mice.Journal: Indian Journal of Medical ResearchVolume: 119Issue: Suppl., S-Page: 113-E-Page: 118
  • Authors: Bertot,G.M.; Becker,P.D.; Guzmán,C.A.; Grinstein,S.; (Year: 2004). Title: Intranasal vaccination with recombinant P6 protein and adamantylamide dipeptide as mucosal adjuvant confers efficient protection against Otitis media and lung infection by nontypeable Haemophilus influenzae.Journal: Journal of Infectious DiseasesVolume: 189Issue: 7, S-Page: 1304-E-Page: 1312 DOI: 10.1086/382508 Fulltext HZI repository
  • Authors: Guzmán,C.A.; Feuerstein,G.; (Year: 2004). Title: Pharmaceutical Biotechnology - Editorial Overview.Journal: Current Opinion in BiotechnologyVolume: 15, S-Page: 503-E-Page: 505
  • Authors: Becker,P.D.; Guzmán,C.A.; (Year: 2004). Title: Rational design of vaccination strategies to promote antigen entry into the MHC class I-restricted presentation pathway.Journal: Transfusion Medicine and HemotherapyVolume: 31, S-Page: 398-E-Page: 411 DOI: 10.1159/000082484) Fulltext PubMed
  • Authors: Ebensen,Thomas; Guzmán,C.A.; Schulze,K.; (Year: 2004). Title: Salmonellen - Feind, aber auch Freund.Journal: Labor PraxisVolume: Oktober, S-Page: 30.33
  • Authors: Borsutzky,S.; Cazac,B.B.; Roes,J.; Guzmán,C.A.; (Year: 2004). Title: TGF-ß receptor signaling is critical for mucosal IgA responses.Journal: Journal of ImmunologyVolume: 173, S-Page: 3305-E-Page: 3309
  • Authors: Rharbaoui,F.; Westendorf,A.; Link,C.; Felk,S.; Buer,J.; Gunzer,M.; Guzmán,C.A.; (Year: 2004). Title: The mycoplasma-derived lipopeptide MALP-2 triggers a global immune activation on nasal associated lymphoid tissues.Journal: Infection and ImmunityVolume: 72, S-Page: 6978-E-Page: 6986
  • Authors: Link,C.; Gavioli,R.; Ebensen,T.; Canella,A.; Reinhard,E.; Guzmán,C.A.; (Year: 2004). Title: The toll-like receptor ligand MALP-2 stimulates dendritic cell maturation and modulates proteasome composition and activity.Journal: European Journal of ImmunologyVolume: 34Issue: 3, S-Page: 899-E-Page: 907
  • Authors: Guzmán,C.A.; Borsutzky,S.; Favre,D.; Dietrich,G.; (Year: 2004). Title: Vaccines against infections caused by Salmonella, Shigella, and pathogenic Escherichia coli.Volume: 1Issue: 123246200 DOI: Article WEBURLS
  • Authors: Mcarthur,J.D.; West,N.P.; Cole,J.N.; Jungnitz,H.; Guzmán,C.A.; Chin,J.; Lehrbach,P.R.; Djordjevic,S.P.; Walker,M.J.; (Year: 2003). Title: An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection.Journal: Fems Microbiology LettersVolume: 221, S-Page: 7-E-Page: 16
  • Authors: Ebensen,Thomas; Link,Claudia; Guzmán,Carlos A.; (Year: 2003). Title: Classical bacterial vaccines.Book Title: Novel Vaccination StrategiesEditors: Kaufmann,Stefan H.E.; (Ed.).City: WeinheimPublisher: Wiley-VCH, S-Page: 221-E-Page: 2423-527-3052-8
  • Authors: Dietrich,G.; Spreng,S.; Favre,D.; Viret,J.-F.; Guzmán,C.A.; (Year: 2003). Title: Delivery of cancer DNA vaccines by live attenuated bacteria..Journal: Enhancer-immunotherapy of cancerVolume: 1, S-Page: 16-E-Page: 18
  • Authors: Noguera-Obenza,M.; Ochoa,T.J.; Gomez,H.F.; Guerrero,M.L.; Herrera-Insua,I.; Morrow,A.L.; Ruiz-Palacios,G.; Pickering,L.K.; Guzmán,C.A.; Cleary,T.G.; (Year: 2003). Title: Human milk secretory antibodies against attching and effacing Escherchia coli antigens..Journal: Emerging Infectious DiseasesVolume: 9, S-Page: 545-E-Page: 551
  • Authors: Schulze,K.; Medina,E.; Chhatwal,G.S.; Guzmán,C.A.; (Year: 2003). Title: Identification of B- and T-cell epitopes within the fibronectin-binding domain of the SfbI protein of Streptococcus pyogenes.Journal: Infection and ImmunityVolume: 71Issue: 12, S-Page: 7197-E-Page: 7201
  • Authors: Schulze,K.; Guzmán,C.A.; (Year: 2003). Title: Identification of the domains of the fibronectin-binding protein I of Streptococcus pyogenes responsible for adjuvanticity.Journal: Fems Immunology and Medical MicrobiologyVolume: 37, S-Page: 173-E-Page: 177
  • Authors: Ochoa,T.J.; Noguera-Obenza,M.; Ebel,F.; Guzmán,C.A.; Gomez,H.F.; Cleary,T.G.; (Year: 2003). Title: Lactoferrin impairs Type III secretory system function in enteropathogenic Escherichia coli.Journal: Infection and ImmunityVolume: 71, S-Page: 5149-E-Page: 5155
  • Authors: Dietrich,G.; Spreng,S.; Favre,D.; Viret,J.-F.; Guzmán,C.A.; (Year: 2003). Title: Live attenuated bacteria as vectors to deliver plasmid DNA vaccines.Journal: Current opinion in molecular therapeuticsVolume: 5, S-Page: 10-E-Page: 19
  • Authors: Buttó,S.; Fiorelli,V.; Tripiciano,A.; Ruiz-Alverez,M.J.; Scoglio,A.; Ensoli,F.; Ciccozzi,M.; Collacchi,B.; Sabbatucci,M.; Cafaro,A.; Guzmán,C.A.; Borsetti,A.; Caputo,A.; Vardas,E.; Colvin,M.; Lukwija,M.; Rezza,G.; Ensoli,B.; and the Tat Multicentric Study Group; (Year: 2003). Title: Sequence conservation and antibody cross-recognition of the Clade B HIV-1 Tat protein vaccine candidate in HIV-1-infected Italian, Ugandan and South African individuals..Journal: Journal of Infectious Diseases.Volume: 188, S-Page: 1171-E-Page: 1180
  • Authors: Schulze,K.; Medina,E.; Chhatwal,G.S.; Guzmán,C.A.; (Year: 2003). Title: Stimulation of long-lasting protection against Streptococcus pyogenes after intranasal vaccination with non adjuvanted fibronectin-binding domain of the SfbI protein..Journal: VaccineVolume: 21Issue: 17-18, S-Page: 1958-E-Page: 1964
  • Authors: Viret,J.-F.; Moser,C.; Rharbaoui,F.; Metcalfe,I.C.; Guzmán,C.A.; (Year: 2003). Title: Virosomal technology and mucosal adjuvants..Book Title: Novel Vaccination StrategiesEditors: Kaufmann,Stefan H.E.; (Ed.).City: WeinheimPublisher: Wiley-VCH, S-Page: 197-E-Page: 217

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  • Schnupfimpfung

    Impfen ohne Spritze. Darauf warten nicht nur Spritzen-Phobiker. Nasensprays sollen in Zukunft das Impfen revolutionieren. Doch es gibt ein großes Problem: Der Impfstoff muss zuerst durch die wehrhafte Schleimhaut, um zu seinem Ziel zu gelangen. Der Lösung dieses Problems hat sich ein Forscherteam des Helmholtz-Zentrums für Infektionsforschung mit großem Erfolg verschrieben. Länge: 05:59

  • KrankheitsErregend - Impfung

    Noch vor wenigen Jahrzehnten waren die Pocken eine weit verbreitete, oft tödliche Seuche. Heute gelten sie weltweit als ausgerottet. Diese Erfolgsgeschichte geht auf eine der wirksamsten vorbeugenden Maßnahmen der Medizin zurück: die Impfung. Diese befähigen das Immunsystem, Krankheitserreger zu eliminieren, noch bevor es zu einem Krankheitsausbruch kommt. Im ersten Teil der Vortragsreihe „KrankheitsErregend – Meilensteine der Medizin“ beleuchteten Marion Hulverscheidt, Carlos Guzmán und Hans Georg Koch das Thema aus verschiedenen Blickwinkeln.

Audio Podcast

  • Ein neuer Impfstoff gegen Tuberkulose – die Infektion Nr. 1 in der WeltAlle 15 Sekunden stirbt ein Mensch an Tuberkulose. Bislang gibt es keinen ausreichend wirksamen Impfstoff gegen das Mycobacterium tuberkulosis, lediglich einen, der Säuglinge in den ersten zwei Lebensjahren schützt. Jetzt kristallisiert sich in klinischen Studien ein vielversprechender neuer Impfstoff heraus, den die Vakzine Projekt Management GmbH auf ihrem Weg zur Zulassung begleitet. Bernd Eisele und Leander Grode stellen Ihnen den Impfstoff vor und berichten von ihren Hoffnungen und Erwartungen…
  • Turbo für die Impfung – neue Hilfsstoffe ermöglichen neue Impfmethoden Sie habe einen schlechten Ruf, aber ohne sie geht nichts: Impfverstärker. Seit es Impfungen gibt, brauchen Impfstoff die Unterstützung kleiner Moleküle. Thomas Ebensen und Rimma Libanova haben einen vielversprechenden Impfturbo entdeckt – der ganz nebenbei die gesamte Impftechnik revolutionieren könnte. Kommen Sie mit...
  • Influenza zwischen Schwein und Mensch - die Experten Klaus Schughart und Carlos Guzman im Gespräch Die Influenzawelle rollt, aber die Informationen über Schweinegrippe, saisonale Grippe und die verschiedenen Impfstoffe sind verwirrend - teilweise beängstigend. Soll ich mich impfen lassen? Sind die Impfstoffe sicher? Mein Nachbar kennt aber jemanden... Die Grippe ist doch gar nicht so schlimm... Sind Sie ebenfalls unsicher? Dann lassen Sie sich die wichtigsten Fragen von unseren Experten des Helmholtz-Zentrums für Infektionsforschung für Influenza Klaus Schughart und Carlos Guzman beantworten...
  • SchnupfimpfungImpfen ohne Spritze. Darauf warten nicht nur Spritzen-Phobiker. Nasensprays sollen in Zukunft das Impfen revolutionieren. Doch es gibt ein großes Problem: Der Impfstoff muss zuerst durch die wehrhafte Schleimhaut, um zu seinem Ziel zu gelangen.
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