Vaccination is the most efficient strategy to prevent infectious diseases. The art of the vaccine researcher lies in finding substances that prevent us from falling ill with diseases such as flu, viral hepatitis or HIV/AIDS. But what makes a vaccine successful and ensures effective protection? Our scientists study the reaction of the immune system to answer that question – and to develop better vaccination strategies.

Contact Partner

    Ingeborg Kristen

    Technical Assistant

    +49 (0) 531-6181-4009

    +49 (0) 531-6181-4699



  • Krawczyk-Barsch,E.; Lünsdorf,Heinrich*; Arnold,T.; Brendler,V.; Eisbein,E.; Jenk,U.; Zimmermann,U.; (2011). The influence of biofilms on the migration of uranium in acid mine drainage (AMD) waters. Science of the Total Environment: 409 16, 3059-3065 PubMed
  • Sabirova,J.S.; Becker,A.; Lünsdorf,Heinrich*; Nicaud,J.M.; Timmis,Kenneth N.*; Golyshin,P.N.; (2011). Transcriptional profiling of the marine oil-degrading bacterium Alcanivorax borkumensis during growth on n-alkanes. Fems Microbiology Letters: 319 2, 160-168 DOI: 10.1111/j.1574-6968.2011.02279.x HZI repository PubMed
  • Lünsdorf,Heinrich*; Gurramkonda,C.; Adnan,A.; Khanna,N.; Rinas,Ursula*; (2011). Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the Hepatitis B surface antigen. Microbial Cell Factories: 10, 48 DOI: 10.1186/1475-2859-10-48 HZI repository PubMed
  • Osanjo,G.O.; Muthike,E.W.; Tsuma,L.; Okoth,M.W.; Bulimo,W.D.; Lünsdorf,Heinrich*; Abraham,Wolf-Rainer*; Dion,M.; Timmis,Kenneth N.*; Golyshin,Peter N.*; Mulaa,F.J.; (2009). A salt lake extremophile, Paracoccus bogoriensis sp. nov., efficiently produces xanthophyll carotenoids. African Journal of Microbiology Research: 3 8, 426-433
  • Golyshina,Olga V.*; Yakimov,M.M.; Lünsdorf,Heinrich*; Ferrer,M.; Nimtz,Manfred*; Timmis,Kenneth N.*; Wray,Victor*; Tindall,B.J.; Golyshin,Peter N.*; (2009). Acidiplasma aeolicum gen. nov., sp. nov., a euryarchaeon of the family Ferroplasmaceae isolated from a hydrothermal pool, and transfer of Ferroplasma cupricumulans to Acidiplasma cupricumulans comb. nov. International Journal of Systematic and Evolutionary Microbiology: 59 Pt 11, 2815-2823 DOI: 10.1099/ijs.0.009639-0 HZI repository PubMed
  • Zharkouskay,A.; Lünsdorf,Heinrich*; Feldmann,C.; (2009). Ionic liquid-based synthesis of luminescent YVO4:Eu and YVO4:Eu@YF3 nanocrystals. Journal of Materials Science: 44 15, 39361-39427
  • Gurramkonda,C.; Adnan,A.; Gabel,T.; Lünsdorf,Heinrich*; Ross,Antonius*; Nemani,S.K.; Swaminathan,S.; Khanna,N.; Rinas,Ursula*; (2009). Simple high-cell density fed-batch technique for high-level recombinant protein production with Pichia pastoris: Application to intracellular production of Hepatitis B surface antigen. Microbial Cell Factories: 8, 13 DOI: 10.1186/1475-2859-8-13 HZI repository PubMed
  • Spring,S.; Lünsdorf,Heinrich*; Fuchs,B.M.; Tindall,B.J.; (2009). The photosynthetic apparatus and its regulation in the aerobic gammaproteobacterium Congregibacter litoralis gen. nov., sp. nov. PLoS ONE: 4 3, e4866 DOI: 10.1371/journal.pone.0004866 HZI repository PubMed
  • Roming, M.; Lünsdorf, H.; Dittmar, K.E.J.; Feldmann, C.; (2009). ZrO(HPO4)1−x(FMN)x: Quick and easy synthesis of a nanoscale luminescent biomarker. Angew. Chem. Int. Ed.: 48, 1-7 PubMed
  • Stackebrandt,E.; Lang,E.; Cousin,S.; Päuker,O.; Brambilla,E.; Kroppenstedt,R.; Lünsdorf,Heinrich*; (2007). Deefgea rivuli gen. nov., sp. nov., a member of the class Betaproteobacteria. International Journal of Systematic and Evolutionary Microbiology: 57 3, 639-645
  • Romero-Tabarez,M.; Jansen,Rolf*; Sylla,Marita*; Lünsdorf,Heinrich*; Häußler,Susanne*; Santosa,D.A.; Timmis,Kenneth N.*; Molinari,Gabriella*; (2006). 7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus , vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. Antimicrobial Agents and Chemotherapy: 50 5, 1701-1709 DOI: 10.1128/AAC.50.5.1701-1709.2006 HZI repository PubMed
  • Lünsdorf,Heinrich*; Kristen,I.; Barth,E.; (2006). Cationic hydrous thorium dioxide colloids - a useful tool for staining negatively charged surface matrices of bacteria for use in energy-filtered transmission electron microscopy. BMC Microbiology: 6, 591471-2180 DOI: 10.1186/1471-2180-6-59 HZI repository PubMed
  • Biebl,H.; Tindall,B.; Pukall,R.; Lünsdorf,H.; Allgaier,M.; Wagner-Döbler,I.; (2006). Hoeflea phototrophica , nov. sp., a new marine aerobic Alphaproteobacterium that forms bacteriochlorophyll a. International Journal of Systematic and Evolutionary Microbiology: 56, 821-826 DOI: 10.1099/ijs.0.63958-0 HZI repository PubMed
  • Wang,X.; Rochon,M.; Lamprokostopoulou,A.; Lünsdorf,Heinrich*; Nimtz,Manfred*; Römling,U.; (2006). Impact of biofilm matrix components on interaction of commensal Escherichia coli with the gastrointestinal cell line HT-29. Cellular and Molecular Life Sciences - CMLS: 63, 2352-2363 DOI: 10.1007/s00018-006-6222-4 HZI repository PubMed
  • Khalil,M.W.; Sasse,Florian*; Lünsdorf,Heinrich*; Elnakady,Y.A.; Reichenbach,Hans*; (2006). Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. ChemBioChem: 7, 678-683
  • Sabirova,Julia S.*; Ferrer,M.; Lünsdorf,Heinrich*; Wray,Victor*; Kalscheuer,R.; Steinbüchel,A.; Timmis,Kenneth N.*; Golyshin,Peter N.*; (2006). Mutation in a ' tes B-like' hydroxyacyl-Coenzyme A-specific thioesterase gene causes hyperproduction of extracellular polyhydroxyalkanoates by Alcanivorax borkumensis SK2. Journal of Bacteriology: 188, 8452-8459 DOI: 10.1128/JB.01321-06 HZI repository PubMed
  • Biebl,H.; Allgaier,M.; Tindall,B.; Koblizek,M.; Lünsdorf,H.; Pukall,R.; Wagner-Döbler,I.; (2005). Dinoroseobacter shibae , gen. nov., sp. nov., a new aerobic phototrophic bacterium isolated from dinoflagellates. International Journal of Systematic and Evolutionary Microbiology: 55, 1089-1096 DOI: 10.1099/ijs.0.63511-0 Full text HZI repository
  • Dinesh,D.; Sriramulu,D.D.; Lünsdorf,H.; Lam,J.S.; Römling,U.; (2005). Microcolony formations: a novel biofilm model of Pseudomonas aeruginosa for the cystic fibrosis lung. Journal of Medical Microbiology: 54, 667-676
  • Biebl,H.; Allgaier,M.; Lünsdorf,H.; Pukall,R.; Tindall,B.J.; Wagner-Döbler,I.; (2005). Roseovarius mucosus , sp. nov., a novel member of the Rosebacter clade with trace amounts of bacteriochlorophyll a.. International Journal of Systematic and Evolutionary Microbiology: 55, 2377-2383 DOI: 10.1099/ijs.0.63832-0 Full text HZI repository
  • Elnakady,Y.A.; Sasse,F.; Lünsdorf,H.; Reichenbach,H.; (2004). Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells. Biochemical Pharmacology: 67, 927-935
  • Hahn,M.W.; Lünsdorf,H.; Janke,L.; (2004). Exopolymer production and microcolony formation by planktonic freshwater bacteria: defence against protistan grazing. Aquatic Microbial Ecology: 35, 297-308
  • Ferrer,M.; Lünsdorf,H.; Chernikova,T.N.; Yakimov,M.M.; Golyshin,P.N.; Timmis,K.N.; (2004). Functional consequences of single:double ring transitions in chaperonins: life in the cold. Molecular Microbiology: 53, 167-182
  • Chávez,F.P.; Lünsdorf,H.; Jerez,C.A.; (2004). Growth of polychlorinated-biphenyl-degrading bacteria in the presence of biphenyl and chlorobiphenyls generates oxidative stress and massive accumulation of inorganic polyphosphate. Applied and Environmental Microbiology: 70 5, 3064-3072 DOI: 10.1128/AEM.70.5.3064-3072.2004 Full text HZI repository
  • Comini,M.A.; Guerrero,S.A.; Haile,S.; Menge,U.; Lünsdorf,H.; Flohé,L.; (2004). Validation of Trypanosoma brucei trypanothione synthetase as drug target. Free Radical Biology and Medicine: 36, 1289-1302 DOI: 10.1016/j.freeradbiomed.2004.02.008 Full text HZI repository
  • Abraham,W.-R.; Strömpl,C.; Vancanneyt,M.; Bennasar,A.; Swings,J.; Smit,J.; Moore,E.R.B.; (2004). Woodsholea maritima gen. nov., sp. nov., a marine bacterium with a low diversity of polar lipids. International Journal of Systematic and Evolutionary Microbiology: 54, 1227-1234
  • Sabra,W.; Lünsdorf,H.; Zeng,A.-P.; (2003). Alterations in the formation of lipopolysaccharide and membrane vesicle on the surface of Pseudomonas aeruginosa PAO1 under oxidative stress conditions. Microbiology <Reading>: 149, 2789-2795
  • Golyshin,P.N.; Martins dos Santos,V.A.P.; Kaiser,O.; Ferrer,M.; Sabirova,Y.S.; Lünsdorf,H.Chernikova T.N.; Golyshina,O.V.; Yakimov,M.M.; Pühler,A.; Timmis,K.N.; (2003). Genome sequence completed of Alcanivorax borkumensis, a hydrocarbon-degrading bacterium that plays a global role in oil removal from marine systems. Journal of Biotechnology: 106, 215-220
  • Hahn,M.W.; Lünsdorf,H.; Wu,Q.; Schauer,M.; Höfle,M.G.; Boenigk,J.; Stadler,P.; (2003). Isolation of novel ultramicrobacteria classified as Actinobacteria from five freshwater habitats in Europe and Asia. Applied and Environmental Microbiology: 69, 1442-1451 DOI: 10.1128/AEM.69.3.1442-1451.2003 HZI repository PubMed
  • Budde,H.; Flohé,L.; Hecht,H.-J.; Hofmann,B.; Stehr,M.; Wissing,J.; Lünsdorf,H.; (2003). Kinetics and redox-sensitive oligomerisation reveal negative subunit cooperativity in tryparedoxin peroxidase of Trypanosoma brucei brucei. Biological Chemistry: 384, 619-633
  • Abraham,W.-R.; Lünsdorf,H.; Strömpl,C.; Nogales,B.; Moore,E.R.B.; Timmis,K.N.; (2003). Microbial communities in composite biofilms participating in the degradation of PCB. Water, Air and Soil Pollution: Focus: 3, 57-64
  • Strömpl,C.; Hold,G.N.; Lündsorf,H.; Graham,J.; Gallacher,S.; Abraham,W.-R.; Moore,E.R.B.; Timmis,K.N.; (2003). Oceanicaulis alexandrii gen. nov., sp. nov., a novel stalked bacterium isolated from a culture of the dinoflagellate Alexandrium tamarense (Lebour) Balech. International Journal of Systematic and Evolutionary Microbiology: 53, 1901-1906
  • Yakimov,M.M.; Giuliano,L.; Gentile,G.; Cristafi,E.; Chernikova,T.N.; Abraham,W.-R.; Lünsdorf,H.; Timmis,K.N.; Golyshin,P.N.; (2003). Oleispira antarctica gen. nov., sp. nov., a new hydrocarbonoclastic marine bacterium, isolated from an antarctic coastal seawater. International Journal of Systematic and Evolutionary Microbiology: 53, 779-785
  • Yakimov,M.M.; Lünsdorf,H.; Golyshin,P.N.; (2003). Thermoleophilum album and Thermoleophilum minutum are culturable representatives of group 2 of the Rubrobacteidae (Actinobacteria). International Journal of Systematic and Evolutionary Microbiology: 53, 377-380
  • Golyshin,P.N.; Chernikova,T.N.; Abraham,W.R.; Lünsdorf,H.; Timmis,K.N.; Yakimov,M.M.; (2002). Oleiphilaceae fam. nov., to include Oleiphilus messinensis gen. nov., sp nov., a novel marine bacterium that obligately utilizes hydrocarbons. International Journal of Systematic and Evolutionary Microbiology: 52, 901-911 ISI
  • Castro,H.; Budde,H.; Flohé,L.; Hofmann,B.; Lünsdorf,H.; Wissing,J.; Tomás,A.M.; (2002). Specificity and kinetics of a mitochondrial peroxiredoxin of Leishmania infantum. Free Radical Biology & Medicine: 33, 1563-1574 DOI: 10.1016/S0891-584901088-2 Full text HZI repository


  • Prof Dr Carlos A. Guzmán

    Carlos Guzman

    Head of the Department Vaccinology and Applied Microbiology

    +49 531 6181-4600

    +49 531 6181-4699


    CV and Publications


Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!


  • Schnupfimpfung
  • KrankheitsErregend - Impfung

Audio Podcast

  • Ein neuer Impfstoff gegen Tuberkulose – die Infektion Nr. 1 in der Welt
    Alle 15 Sekunden stirbt ein Mensch an Tuberkulose. Bislang gibt es keinen ausreichend wirksamen Impfstoff gegen das Mycobacterium tuberkulosis, lediglich einen, der Säuglinge in den ersten zwei Lebensjahren schützt. Jetzt kristallisiert sich in klinischen Studien ein vielversprechender neuer Impfstoff heraus, den die Vakzine Projekt Management GmbH auf ihrem Weg zur Zulassung begleitet. Bernd Eisele und Leander Grode stellen Ihnen den Impfstoff vor und berichten von ihren Hoffnungen und Erwartungen…
  • Turbo für die Impfung – neue Hilfsstoffe ermöglichen neue Impfmethoden
    Sie habe einen schlechten Ruf, aber ohne sie geht nichts: Impfverstärker. Seit es Impfungen gibt, brauchen Impfstoff die Unterstützung kleiner Moleküle. Thomas Ebensen und Rimma Libanova haben einen vielversprechenden Impfturbo entdeckt – der ganz nebenbei die gesamte Impftechnik revolutionieren könnte. Kommen Sie mit...
  • Influenza zwischen Schwein und Mensch - die Experten Klaus Schughart und Carlos Guzman im Gespräch
    Die Influenzawelle rollt, aber die Informationen über Schweinegrippe, saisonale Grippe und die verschiedenen Impfstoffe sind verwirrend - teilweise beängstigend. Soll ich mich impfen lassen? Sind die Impfstoffe sicher? Mein Nachbar kennt aber jemanden... Die Grippe ist doch gar nicht so schlimm... Sind Sie ebenfalls unsicher? Dann lassen Sie sich die wichtigsten Fragen von unseren Experten des Helmholtz-Zentrums für Infektionsforschung für Influenza Klaus Schughart und Carlos Guzman beantworten...
  • Schnupfimpfung
    Impfen ohne Spritze. Darauf warten nicht nur Spritzen-Phobiker. Nasensprays sollen in Zukunft das Impfen revolutionieren. Doch es gibt ein großes Problem: Der Impfstoff muss zuerst durch die wehrhafte Schleimhaut, um zu seinem Ziel zu gelangen.