Systems Medicine of Infectious Diseases

Systems Medicine aims at gaining a holistic understanding of health and diseases that leads to personalized medicine. The research of this group aims at understanding the underlying mechanisms between the immune system and diseases. Other objectives are tailoring effective immune interventions and treatments in susceptible groups of the society like seniors and immunocompromised patients and developing new mathematical and computational methods to overcome the challenges for the translation of Systems Medicine into the clinic. All this is achieved by integrating clinical data into phenomenological models and by using computer simulations.



Dr Esteban A. Hernandez-Vargas

Junior Research Group Leader

Curriculum Vitae

He is originally from Guadalajara, Mexico. After obtaining his BSc in Chemical Engineering and MSc in Control Engineering, he moved to Ireland to start a PhD in the Systems Biology group at the Hamilton Institute, NUI Maynooth. In 2011, he completed his doctoral studies (supervised by Prof. Richard H. Middleton). Since July 2011 he belongs to the Department of Systems Immunology in HZI and since July 2014 he leads the junior research group "Systems Medicine of Infection Research". 


His research lies at the interface between control theory, mathematics and  biology. He focus mainly on:
* Viral dynamics: Influenza and HIV
* Ageing: Immunosenescence
* Nonlinear Systems: optimal control and observer design

Research Projects

* GERONTOSHIELD project investigates why our immune defense is getting weaker when we become old. The strategic objective of the project is to draw on a Systems Biology-driven approach to understand the molecular processes affected during immunosenescence to derive strategies to overcome them in order to establish effective immune interventions tailored for the elderly.



Hernandez-Vargas, E. A; Wilk, E.; Canini, L.; Toapanta, F.; Binder, S.; Uvarovskii, A.;  Ross, T.;  Guzman, C. A.;  Perelson,  A. S.; Meyer-Hermann M.; (2014). 
The effects of aging on influenza virus infection dynamics. 
Journal of Virology, in press

Hernandez-Vargas, E.A; Colaneri, P.; Middleton, R.; (2013).
Optimal therapy scheduling for a simplified HIV infection model.

Hernandez-Vargas, E.A; Colaneri, P.; Middleton, R.; (2013).
Optimal therapy scheduling for a simplified HIV infection model.
IEEE Transactions on Control Systems Technology, in press

Hernandez-Vargas, E.A.; Middleton, R.; (2013).  Modelling the three stages in HIV infection. Journal of Theoretical Biology: 320, 33-40

Schmeitz, C.; Hernandez-Vargas, E; Fliegert, R.; Guse, A. H.; Meyer-Hermann, M.; (2013). A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties. Frontiers in immunology: 4

Hernandez-Gonzalez, M.; Alanis, A.; Hernandez-Vargas, E.A .; (2012).  Decentralized Discrete-Time Neural Control for a Quanser 2-DOF Helicopter. Applied Soft Computing: 12

Hernandez-Vargas, E.A; Colaneri, P.; Middleton, R.; Blanchini, F.; (2011). Discrete-time control for switched positive systems with application to mitigating viral escape. International Journal of Robust and Nonlinear Control: 21 (10), 1093–1111

Ferreira, J.; Hernandez-Vargas, E.A.; Middleton, R.; (2011). Computer Simulation of Structured Treatment Interruption for HIV infection. Computers Methods and Programs in Biomedicine: 104 (2), 50-61

Alanis, A.; Sanchez, E. N. ; Loukianov, A.; Hernandez-Vargas, E.A.; (2010).  Discrete-time recurrent high order neural networks for nonlinear identification. Journal of the Franklin Institute: 347  (7), 1253-1265

Hernandez-Vargas, E.A.; Sanchez, E. N.; Cadet, C.; Beteau, J. F.; (2009). Neural observer based hybrid intelligent scheme for activated sludge wastewater treatment. Chemical and Biochemical Engineering Quarterly Journal:  23 (4)

Hernandez-Vargas, E.A.; Alanis, A.; Sanchez, E. N.; Hernandez-Gonzalez, M.;(2009). Supervisor difuso funcional aplicado a una planta urbana de tratamiento de aguas residuales basado en un observador neuronal. Ingenieria Quimica: 36

Segovia-Hernandez, J.G.;  Hernandez–Vargas,E.A.; Marquez–Muñoz, J.A.; (2007). Control Properties of Thermally Coupled Distillation Sequences for Different Operating Conditions. Computers and Chemical Engineering Journal: 31, 867-874

Segovia-Hernandez, J.G. ; Hernandez–Vargas, E.A. ; Marquez–Muñoz, J.A.; Hernandez  S. ; Jimenez, A. ; ( 2005). Control properties and thermodynamic analysis of two alternatives to thermally coupled distillation systems with side columns. Chemical and Biochemical Engineering Quarterly Journal:19 (4), 325-332

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