Systems Immunology

To see the immune system with the eyes of mathematics – that is the goal of the department Systems Immunology. Mathematical models help to faster and better understand diseases that are associated with immune functions. Read here how scientists use mathematics to investigate chronic inflammatory diseases, the regulation of adaptive immune responses, diabetes, cancer irradiation and aging.

Leader

Team

Dr Jaber Dehghany

Scientist

Curriculum Vitae

I am a physicist by education: holding BSc from Zanjan University,
and MSc from Institute for Advanced Studies in Basic Sciences (IASBS),
Zanjan, Iran. I started my PhD in the Systems Immunology group,
at Frankfurt Institute for Advanced Studies (FIAS) on that time,
in May 2008. After my PhD I continue as post-doctoral researcher
at the Systems Immunology (SIMM) department, in HZI now.

Research

My research focuses on the development of agent-based models,
based on the experimental data, representing complex biological
systems. I am currently working on two main topics:
1- Insulin Granule Dynamics in Pancreatic Beta-cells
2- Mechanisms of Microbial Biofilm Development

Moreover, I have developed a robust in-silico model for 3D reconstruction of
(beta-) cell morphology from semi-2D electron micro-graphs.

 

 

Publication

Ghanbari, A.; Rahimi, M.; Dehghany, J.; (2013)
Influence of Surface Grafted Polymers on the Polymer Dynamics in a Silica-Polystyrene Nanocomposite: A Coarse-Grained Molecular Dynamics Investigation.
The Journal of Physical Chemistry C, in press.

Fava E, Dehghany J, Ouwendijk J, Müller A, Niederlein A, Verkade P, Meyer-Hermann M, Solimena M.; (2012). Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.
Diabetologia. 2012 ;55(4):1013-23.

Project leader

News

Audio Podcast

  • BRICS – Rechnen für die InfektionsforschungDie Mischung macht es – im richtigen Leben ebenso wie in der Infektionsforschung. Systembiologen am HZI und an der Technischen Universität Braunschweig mischen Laborerkenntnisse mit Computermodellen. Begleiten Sie Michael Meyer-Hermann virtuell an das BRICS und hören Sie weshalb es so sinnvoll ist, Biologie mit System zu betreiben.
  • Rechnen für die Gesundheit – Systembiologie bringt System in die Arthritis-Therapie Infektionsforscher arbeiten mit Zellkulturen, Krankheitserregern, nehmen Proben, messen und werten die Messergebnisse aus. Allerdings reicht das in der modernen Wissenschaft häufig nicht mehr aus – gerade wenn es um so komplexe Systeme wie uns Menschen geht. Hier kommen Computer ins Spiel: die Systembiologie. Hören Sie Michael Meyer-Hermann zu, wie er am Rechner die Jahrzehnte alte Therapie gegen Rheumatoide Arthritis auf den Kopf stellt...
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