Systems Immunology

To see the immune system with the eyes of mathematics – that is the goal of the department Systems Immunology. Mathematical models help to faster and better understand diseases that are associated with immune functions. Read here how scientists use mathematics to investigate chronic inflammatory diseases, the regulation of adaptive immune responses, diabetes, cancer irradiation and aging.

Publikationen von Prof. Dr. Michael Meyer-Hermann

  • Grise, G., Meyer-Hermann, M. ; (2011). Surface reconstruction using Delauny triangulation for applications in life sciences. Comput. Phys. Commun.: 182, 967-977
  • Jain, H., Meyer-Hermann, M.; (2011). The molecular basis of synergism between carboplatin and ABT-737 therapy targeting ovarian carcinomas. Cancer Research: 71 3, 705-715 PubMed
  • Meyer-Hermann, M., Benninger, R.K.P. ; (2010). A mathematical model of betacells in an islet of Langerhans sensing a glucose gradient. HFSP: 4, 61-71 PubMed
  • Victora, G.D., Schwickert, T.A., Fooksman, D.R., Meyer-Hermann, M., Dustin, M.L., Nussenzweig, M.C.; (2010). Germinal center selection mechanism revealed by multiphoton microscopy using a photoactivatable fluorescent reporter. Cell: 143, 592-605 PubMed
  • Fatehi, H., Meyer-Hermann, M., Figge, M.T; (2010). Modeling cellular aggregation induced by chemotaxis and phototaxis. Math. Med. Biol.: 4 27, 373-384 PubMed
  • Kempf, H., Bleicher, M., Meyer-Hermann, M; (2010). Spatio-temporal cell dynamics in tumour spheroid irradiation. Eur. Phys. J.: D 60, 177-193
  • Garin*, A., Meyer-Hermann*, M., Contie, M., Figge, M.T., Buatois, V., Gunzer, M., Toellner, K.-M., Elson, G., Kosco-Vilbois, M.H. *: shared first author; (2010). Toll-Like Receptor 4 signaling by Follicular Dendritic Cells is pivotal for germinal center onset and affinity maturation. Immunity: 33, 84-95 PubMed
  • Grise, G., Meyer-Hermann, M.; (2010). Towards sub-cellular modeling with Delaunay triangulation. Math. Model. Nat. Phenom.: 1 5, 224-238
  • Meyer-Hermann, M., Figge, M.T., Toellner, K.M.; (2009). Germinal centres seen through the mathematical eye: B cell models on the catwalk. Trends Immunol.: 30, 157-164 PubMed
  • Meyer-Hermann, M., Figge, M.T., Straub, R. ; (2009). Mathematical modeling of the circadian rhythm of key neuroendocrine immune players in rheumatoid arthritis: A systems biology approach. Arthritis & Rheumatism: 60, 2585-2594 PubMed
  • Figge, M.T., Meyer-Hermann, M. ; (2009). Modeling receptor-ligand binding kinetics in immunological synapse formation. Eur. Phys. J. D: 51, 153-160
  • Savin, C., Triesch, J., Meyer-Hermann, M. ; (2009). Seizure induction by glia-mediated synaptic scaling. J. Roy. Soc. Interface: 6, 655-668
  • Kosco-Vilbois, M., Meyer-Hermann, M. ; (2009). The 16th international conference on lymphatic tissues and germinal centres in immune responses. Eur. J. Immunol.: 39, 2311-2312
  • Beyer, T., Meyer-Hermann, M. ; (2008). Cell transmembrane receptors determine tissue pattern stability. Phys. Rev. Lett.: 101 PubMed
  • Meyer-Hermann, M. ; (2008). Delaunay-Object-Dynamics: Cell mechanics with a 3D kinetic and dynamic weighted Delaunay-triangulation. Curr. Top. Dev. Biol.: 81, 373-399 PubMed
  • Figge, M.T., Garin, A., Gunzer, M., Kosco-Vilbois, M., Toellner, K.-M., Meyer-Hermann, M. ; (2008). Deriving a germinal center lymphocyte migration model from two-photon data. J. Exp. Med.: 205, 3019-3029 PubMed
  • Beyer, T., Meyer-Hermann, M. ; (2008). Mechanisms of organogenesis of primary lymphoid follicles. Int. Immunol.: 20, 615-623 PubMed
  • Meyer-Hermann, M.; (2007). Are T cells at the origin of B cell lymphomas?. Theor. Biol.: 244, 656-669 PubMed
  • Meyer-Hermann, M. ; (2007). B cell selection mechanisms revisited: A concerted action. Adv. Compl. Sys.: 10, 557-580
  • Schaller, G., Meyer-Hermann, M. ; (2007). Epidermal homeostasis control in an off-lattice agent-based model. J. Theor. Biol.: 247, 554-573 PubMed
  • Caliceti, E., Meyer-Hermann, M., Ribeca, P., Surzhykov, A., Jentschura, U.D.; (2007). From useful algorithms for slowly convergent series to physical predictions based on divergent perturbative expansions. Phys. Rep.: 446, 1-96
  • Beyer, T., Meyer-Hermann, M.; (2007). Modeling emergent tissue organization involving high-speed migrating cells in a flow equilibrium. Phys. Rev. E: 76, 1-13 PubMed
  • Meyer-Hermann, M. ; (2007). The electrophysiology of the beta-cell based on single transmembrane protein characteristics. Biophys. J.: 93, 2952-2968 PubMed
  • Meyer-Hermann, M., Maini, P.K., Iber, D.; (2006). An analysis of B cell selection mechanisms in germinal centers. Math. Med. Biol.: 23, 255-277 PubMed
  • Schaller, G., Meyer-Hermann, M. ; (2006). Continuum versus discrete model: a comparison for multicellular tumour spheroids. Philos. Trans. Roy. Soc. A: 364, 1443-1464 PubMed
  • Figge, M.T., Meyer-Hermann, M.; (2006). Geometrically re-patterned immunological synapses uncover formation mechanisms. PLoS Comput. Biol.: 2 e171
  • Graupner, M., Erler, F., Meyer-Hermann, M.; (2005). A theory of Plasma Membrane Calcium Pump stimulation and activity. J. Biol. Phys.: 31, 183-206
  • Meyer-Hermann, M., Maini, P.K.; (2005). Cutting edge: Back to “one-way” germinal centers. J. Immunol.: 174, 2489-2493 PubMed
  • Krafft, C., Salzer, R., Soff, G., Meyer-Hermann, M.; (2005). Identification of B- and T-cells in human spleen samples by infrared microspectroscopic imaging. Cytometry Part A: 64A, 53-61 PubMed
  • Meyer-Hermann, M., Maini, P.K.; (2005). Interpreting two-photon imaging data of lymphocyte motility. Phys. Rev. E: 71 PubMed
  • Schaller, G., Meyer-Hermann, M. ; (2005). Multicellular tumor spheroid in an off-lattice Voronoi/Delaunay cell model. Phys. Rev. E: 71 PubMed
  • Beyer, T., Schaller, G., Deutsch, A., Meyer-Hermann, M.; (2005). Parallel dynamic and kinetic regular triangulation in three dimensions. Comput. Phys. Commun.: 172, 86-108
  • Erler, F., Meyer-Hermann, M., Soff, G.; (2004). A quantitative model for presynaptic free calcium dynamics during different stimulation protocols. Neurocomp.: 61, 169-191
  • Schaller, G., Meyer-Hermann, M.; (2004). Kinetic and dynamic Delaunay tetrahedralizations in three dimensions. Comput. Phys. Commun.: 162, 9-23
  • Meyer-Hermann, M., Beyer, T. ; (2004). The type of seeder cells determines the efficiency of germinal center reactions. Bull. Math. Biol.: 66, 125-141 PubMed
  • Meyer-Hermann, M.; (2002). A mathematical model for the germinal center morphology and affinity maturation. J. Theor. Biol.: 216, 273-300 PubMed
  • Beyer, T., Meyer-Hermann, M., Soff, G.; (2002). A possible role of chemotaxis in germinal center formation. Int. Immunol.: 14, 1369-1381 PubMed
  • Meyer-Hermann, M., Beyer, T.; (2002). Conclusions from two model concepts on germinal center dynamics and morphology. Dev. Immunol.: 9, 203-214 PubMed
  • Meyer-Hermann, M. ; (2002). Does Recycling in Germinal Centers exist?. Immunol. Cell Biol.: 80, 30-35 PubMed
  • Knauf, A., Meyer-Hermann, M., Soff, G. ; (2002). Estimating the small-x exponent of the structure function g1NS from the Bjorken Sum Rule. Phys. Lett. B: 549, 109-114
  • Meyer-Hermann, M., Kuhn, R., Schützhold, R.; (2001). On the anomalous dimension for the transversity distribution. Phys. Rev. D: 63
  • Meyer-Hermann, M., Deutsch, A., Or-Guil, M. ; (2001). Recycling probability and dynamical properties of germinal center reactions. J. Theor. Biol.: 210, 265-285 PubMed
  • Meyer-Hermann, M., Schäfer, A.; (1999). The Mass of a Quark-Squark Bound State from QCD Sum Rules.. Int. J. Mod. Phys. A: 14, 4763-4780
  • Meyer-Hermann, M., Schäfer, A.; (1999). The renormalon contribution to the current product j5 jS. Eur. Phys. J. A: 5, 91-95
  • Meyer-Hermann, M., Maul, M., Mankiewicz, L., Stein, E., Schäfer, A.,; (1996). IR Renormalon Contribution to the Polarized Structure Function g1. Phys. Lett. B 383, 463-469; Phys. Lett. B 393 (E), 487:
  • Stein, E., Meyer-Hermann, M., Mankiewicz, L., Schäfer, A.; (1996). IR-Renormalon Contribution to the Longitudinal Structure Function FL. Phys. Lett. B: 376, 177-185
  • Meyer-Hermann, M., Schäfer, A., Greiner, W.; (1995). QCD sum rules with finite masses. Z. Phys. A: 351, 345-351

Leader

  • Prof Dr Michael Meyer-Hermann

    Michael Meyer-Hermann

    Head of Department

    +49 531 391 55210

    +49 531 391-55211

    Contact

    +49 531 6181-5400

    +49 531 6181-7099

News

Audio Podcast

  • BRICS – Rechnen für die Infektionsforschung
    Die Mischung macht es – im richtigen Leben ebenso wie in der Infektionsforschung. Systembiologen am HZI und an der Technischen Universität Braunschweig mischen Laborerkenntnisse mit Computermodellen. Begleiten Sie Michael Meyer-Hermann virtuell an das BRICS und hören Sie weshalb es so sinnvoll ist, Biologie mit System zu betreiben.
  • Rechnen für die Gesundheit – Systembiologie bringt System in die Arthritis-Therapie
    Infektionsforscher arbeiten mit Zellkulturen, Krankheitserregern, nehmen Proben, messen und werten die Messergebnisse aus. Allerdings reicht das in der modernen Wissenschaft häufig nicht mehr aus – gerade wenn es um so komplexe Systeme wie uns Menschen geht. Hier kommen Computer ins Spiel: die Systembiologie. Hören Sie Michael Meyer-Hermann zu, wie er am Rechner die Jahrzehnte alte Therapie gegen Rheumatoide Arthritis auf den Kopf stellt...