Systems-oriented immunology and inflammation research

The idea that death can save lives is indeed a truism, but for complex organisms there is a significant protective mechanism in the background. Apoptosis is the name for the “suicide programme”, with which injured, old, mutated or dangerous cells can be deactivated in human tissue. But this suicide program can be misused by pathogens – or it can get out of control. You can read here how scientists are seeking to understand and make use of programmed cellular death in a cooperative research group within the Institute for Molecular and Clinical Immunology at the Otto-von-Guericke University Magdeburg and the HZI.

Team

    Prof Dr Ingo Schmitz

    Ingo Schmitz

    Research Group Leader

    +49 531 6181-3500

    Contact


    Curriculum Vitae

    Education and Employment

    * 1990 - 1996

    University of Hannover, University of Veterinary Medicine Hannover and Hannover Medical School, Germany; Subject: Biochemistry

    * 1995 - 1996

    Diploma thesis at the Center for Molecular Biology, University of Heidelberg, Germany, Laboratory of Dr. Thomas Wirth, Thema: "Transcriptional regulation of Oct transcription factors by Bob.1/OBF.1"

    * 1996 - 1996

    Research Assistant at the Center for Molecular Biology, University of Heidelberg, Germany, Laboratory of Dr. Hermann Bujard, Thema: "Genomic analysis of a Tet-transactivator transgenic mouse model"

    * 1996 - 1997

    Civil service

    * 1998 - 2000

    Research Assistant at the German Cancer Research Center, Heidelberg, Germany, Laboratory of Dr. Peter Krammer, Thema: "Regulation of apoptosis signaling in the CD95 death receptor system"

    * June 2000

    Ph.D. Thesis: “The Two-Pathway-Model of the CD95 death receptor: implications for the T cell immune response”, University of Hannover, Germany

    * 2000

    Research Assistant and Postdoctoral fellow: Dept. of Immunogenetics, German Cancer Research Center Heidelberg, Germany, Thema: "Regulation of apoptosis signaling in the CD95 death receptor system"

    * 2001 - 2003

    Research Assistant and Postdoctoral fellow: Laboratory of Immunobiology (head: Dr. Ellis L. Reinherz), Dana-Farber Cancer Research Center, Harvard Medical School, Boston, USA, Thema: "Negative selection of murine thymocytes"

    * 2003 - 2008

    Group leader at the Institute of Molecular Medicine (head: Dr. Klaus Schulze-Osthoff), Heinrich-Heine-University Düsseldorf

    * March 2006

    Habilitation in Molecular Medicine at the Medical Faculty of the Heinrich-Heine-University of Düsseldorf.

    * June 2006

    W1-Professorship for Cellular Immunology at the Georg-August-University Göttingen; call turned down

    * 2007 - 2009

    Group leader at the Institute of Medical Microbiology and Hospital Hygiene (head: Dr. Klaus Pfeffer), Heinrich-Heine-University Düsseldorf

    * June 2009

    Start as W2 professor at the Institute of Immunology of the Medical Faculty of the Otto-von-Guericke-University of Magdeburg and as leader of the research group “Systems-oriented immunology and inflammation research” at the Helmholtz Center for Infection Research, Braunschweig, Germany

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    Other professional academic activities

    Grant reviewer for DFG, Wilhelm-Sander-Stiftung (both Germany)

    Ad hoc reviewer for international journals (The EMBO Journal, EMBO Reports, Genes and Development, Blood, Cancer Research, Cell Death & Differentiation, The FASEB Journal, Oncogene, Molecular Therapeutics, BBA – Molecular Cell Research, European Journal of Immunology, Apoptosis, International Journal of Cancer, Cancer Letters, Archives of Biochemistry and Biophysics, Critical Reviews in Oncology/Hematology).

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    Professional societies

    Deutsche Gesellschaft für Biochemie und Molekularbiologie (GBM)
    Deutsche Gesellschaft für Immunologie (DGfI)
    Signal transduction society (STS)

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Bachelor & Master
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Audio Podcast

  • Gas und Bremse für Immunantworten
    Unser Immunsystem ist geprägt durch ein kompliziertes Wechselspiel unterschiedlicher Immunzellen, das Wissenschaftler stückchenweise verstehen lernen. Um das Immunsystem daran zu hindern, dass es sich gegen uns selbst richtet oder um ihm auch mal einen Schubs geben zu können, müssen sie die molekularen Stellknöpfe finden – und beeinflussen. Einen dieser Stellknöpfe haben Ingo Schmitz und Marc Schuster entdeckt. Folgen Sie den beiden ins Labor...