Systems-oriented immunology and inflammation research

The idea that death can save lives is indeed a truism, but for complex organisms there is a significant protective mechanism in the background. Apoptosis is the name for the “suicide programme”, with which injured, old, mutated or dangerous cells can be deactivated in human tissue. But this suicide program can be misused by pathogens – or it can get out of control. You can read here how scientists are seeking to understand and make use of programmed cellular death in a cooperative research group within the Institute for Molecular and Clinical Immunology at the Otto-von-Guericke University Magdeburg and the HZI.

Publications

  • Smith AJ, Dai H, Correia C, Takahashi R, Lee SH, Schmitz I, Kaufmann SH.; (2011). Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells.. J Biol Chem: 286(20), 17682-17692 PubMed
  • Brandt,S.; Ellwanger,K.; Beuter-Gunia,C.; Schuster,M.; Hausser,A.; Schmitz,Ingo*; Beer-Hammer,S.; (2010). SLy2 targets the nuclear SAP30/HDAC1 complex. International Journal of Biochemistry and Cell Biology: 42 9, 1472-1481 PubMed
  • Emadi,Baygi M.; Soheili,Z.S.; Schmitz,Ingo*; Sameie,S.; Schulz,W.A.; (2010). Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines. Cell Biology and Toxicology: 26 6, 553-567 DOI: 10.1007/s10565-010-9163-5 HZI repository PubMed
  • Ueffing N, Singh KK, Christians A, Thorns C, Feller AC, Nagl F, Fend F, Heikaus S, Marx A, Zotz RB, Brade J, Schulz WA, Schulze-Osthoff K, Schmitz I*, Schwerk C; (2009). A SNP in the cellular FLICE-inhibitory protein (c-FLIP) gene determines protein isoform production and is associated with risk of follicular lymphoma in humans. Blood:
  • Vogler M, Weber K, Dinsdale D, Schmitz I, Schulze-Osthoff K, Dyer MJS, Cohen GM ; (2009). Different forms of cell death induced by putative BCL2 inhibitors. Cell Death Differ: 16(7), 1030-1039 PubMed
  • Mersmann J, Zacharowski PA, Schmitz I, Zacharowski K; (2008). Caspase inhibitors zVAD.fmk and Q-VD-OPh fail to reduce infarct size after myocardial ischaemia and reperfusion in rodents. Resuscitation: 79(3), 468-474 PubMed
  • Hippe D, Lytovchenko O, Schmitz I, Lüder CGK ; (2008). Fas/CD95-mediated apoptosis of type II cells is blocked by Toxoplasma gondii primarily via interference with the mitochondrial amplification loop. Infect Immun: 76(7), 2905-2912 PubMed
  • Feyen O, Telieps T, Schmitz I, Niehues T ; (2008). Impaired CD95-mediated apoptosis in autoimmunity and occurrence of a p22 caspase-8 cleavage product in JIA. Klin. Pädiatrie: 220(6), 358-364 PubMed
  • Ueffing N, Keil E, Freund C, Kühne R, Schulze-Osthoff K, Schmitz I; (2008). Structural and mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment. Cell Death and Differ: 15(4), 773-782 PubMed
  • Knobloch J, Schmitz I, Götz K, Schulze-Osthoff K, Rüther U; (2008). Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression and stimulation of caspase-dependent cell death. Mol Cell Biol: (2), 529-538 PubMed
  • Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I; (2008). Upregulation of c-FLIPshort by NFAT contributes to apoptosis resistance of short-term activated T cells. Blood: 112(3), 690-698 PubMed
  • Samraj AK, Sohn D, Schulze-Osthoff K, Schmitz I; (2007). Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell: 18(1), 84-93 PubMed
  • Vutova P, Wirth M, Hippe D, Gross U, Schulze-Osthoff K, Schmitz I, and Lüder CGK ; (2007). Toxoplasma gondii inhibits Fas/CD95-triggered cell death by inducing aberrant processing and degradation of caspase 8. Cell Microbiol: 9(6), 1556-1570 PubMed
  • Troeger T, Schmitz I, Siepermann M, Glouchkova L, Gerdemann U, Janka-Schaub GE, Schulze-Osthoff K, Dilloo D; (2007). Upregulation of c-FLIPS+R upon CD40-stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL. Blood: 110(1), 384-387 PubMed
  • Schmitz I, Meyer C, Schulze-Osthoff K; (2006). CD95 ligand mediates T-cell receptor-induced apoptosis of a CD4+ CD8+ double positive thymic lymphoma. Oncogene: 25(58), 7587-7596 PubMed
  • Samraj AK, Keil E, Ueffing N, Schulze-Osthoff K, Schmitz I; (2006). Loss of caspase-9 provides genetic evidence for the type I/II concept of CD95-mediated apoptosis. J Biol Chem: 281(40), 29652-29659 PubMed
  • Golks A, Brenner D, Schmitz I, Watzl C, Krueger A, Krammer PH, Lavrik I; (2006). The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation. Cell Death and Diff: 13(3), 489-498 PubMed
  • Siegmund D, Wiscovsky A, Schmitz I, Schulze-Osthoff K, Kreuz S, Leverkus M, Dittrich-Breiholz O, Kracht M, Wajant H; (2005). Death receptor-induced signaling pathways were differentially regulated by Interferon-g upstream of caspase-8 processing. Mol Cell Biol: 25(15), 6363-6379 PubMed
  • Schmitz I, Weyd H, Krueger A, Baumann S, Fas SC, Krammer PH, Kirchhoff S; (2004). Resistance of activated T cells towards CD95-mediated apoptosis is dependent on de novo protein synthesis. J Immunol: 172(4), 2194-2000
  • Schmitz I, Clayton LK, Reinherz EL ; (2003). Gene expression analysis of thymocyte selection in vivo. Int Immunol: 15(10), 1237-1248 PubMed
  • Lavrik I, Krueger A, Schmitz I, Baumann, S, Weyd H, Krammer PH, Kirchhoff S; (2003). Letter to the Editor: Active caspase-8 tetramer is formed at the CD95 DISC. Cell Death and Diff: 10(1), 144-145 PubMed
  • Schmitz I*, Krueger A*, Baumann S, Krammer PH, Kirchhoff S; (2003). Primary Human T cells Switch from CD95-Type II to CD95-Type I cells in an IL-2 Dependent Manner. J Immunol: 171(6), 2930-2936 PubMed
  • Schmitz I, Krueger A, Baumann S, Krammer PH, Kirchhoff S; (2002). Detection of human CD95 by different antibodies. Biochem Biophys Res Commun: 297(3), 459-462 PubMed
  • Hentze H*, Schmitz I*, Latta M, Krueger A, Krammer PH, Wendel A; (2002). Glutathione dependency of caspase-8 activation at the death-inducing signaling complex (DISC). J Biol Chem: 277(7), 5588-5595 PubMed
  • Fiorini E, Schmitz I, Marissen WE, Osborn SL, Touma M, Sasada T, Reche PA, Tibaldi E, Kruisbeek AM, Reinherz EL, Clayton LK ; (2002). Peptide-induced negative selection of thymocytes activates transcription of a novel NF-kB Inhibitor protein. Mol Cell: 9(3), 637-648 PubMed
  • Eckhart,L.; Santos-Beneit,A.M.; Schmitz,I.; Krueger,A.; Fischer,H.; Bach,J.; Ban,J.; Kirchhoff,S.; Krammer,P.H.; Mollinedo,F.; Tschachler,E.; (2001). Alternative splicing of caspase-8 mRNA during differentiation of human leukocytes. Biochemical and Biophysical Research Communications: 289, 777-781
  • Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S; (2001). Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem: 276(23), 20632-20640 PubMed
  • Chatterjee,D.; Schmitz,I.; Yeung,K.; Krueger,A.; Kirchhoff,S.; Krammer,P.H.; Peter,M.E.; Wyche,H.; Pantazis,P.; (2001). Induction of apoptosis in 9-nitrocampthothecin-treated DU145 human prostate carcinoma cells is increased by de novo synthesis of CD95/Cd95L and downregulation of c-FLIPshort. Cancer Research: 61, 7148-7154 Full text HZI repository
  • Sartorius U, Schmitz I, Krammer PH ; (2001). Molecular mechanisms of death receptor-mediated apoptosis. ChemBioChem: 2(1), 20-29 PubMed
  • Holmström TH, Schmitz I, Johnson VL, Krammer PH, Chow SC, Eriksson JE; (2000). Mitogen-activated protein kinase (MAPK) signaling inhibits CD95 (Fas/APO-1)-mediated apoptosis in activated T-cells:impaired cleavage of Bid and caspase-8. EMBO J: 19(20), 5418-5428
  • Schmitz,I.; Kirchhoff,S.; Krammer,P.H.; (2000). Regulation of death receptor-mediated apoptosis pathway. Journal of Biochemistry and Cell Biology: 32, 1123-1136
  • Kirchhoff,S.; Müller,W.W.; Krueger,A.; Schmitz,I.; Krammer,P.H.; (2000). TCR-mediated Up-regulation of c-FLIP short correlates with resistance towards CD95-mediated apoptosis. Journal of Immunology: 165, 6293-6300
  • Schmitz I, Walczak H, Krammer PH, Peter ME ; (2000). The two CD95 apoptosis signaling pathways may be a way of cells to respond to different amounts and/or forms of CD95 ligand produced in different tissues. Cell Death and Differ: 7(8), 756-758
  • Scaffidi C*, Schmitz I*, Zha J, Korsmeyer SJ, Krammer PH, Peter ME ; (1999). Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem: 274(32), 22532-22538 PubMed
  • Keppler OT, Peter ME, Hinderlich S, Moldenhauer G, Stehling P, Schmitz I, Schwartz-Albiez R, Reutter W, Pawlita M; (1999). Differential sialylation of cell surface glycoconjugates in a human B lymphoma cell line regulates susceptibility for CD95 (APO-1/Fas)-mediated apoptosis and for infection by a lymphotropic virus. Glycobiology: 9(6), 557-569 PubMed
  • Schmitz I, Walczak H, Krammer PH, Peter ME ; (1999). Letter to the Editor: Differences between CD95 type I and type II cells detected with the CD95 ligand. Cell Death and Diff: 6(9), 821-822 PubMed
  • Scaffidi C*, Schmitz I*, Krammer PH, Peter ME; (1999). The role of c-FLIP in modulation of CD95-induced apoptosis. J Biol Chem.: 274(3), 1541-1548 PubMed

Leader

News

Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!

Audio Podcast

  • Gas und Bremse für Immunantworten
    Unser Immunsystem ist geprägt durch ein kompliziertes Wechselspiel unterschiedlicher Immunzellen, das Wissenschaftler stückchenweise verstehen lernen. Um das Immunsystem daran zu hindern, dass es sich gegen uns selbst richtet oder um ihm auch mal einen Schubs geben zu können, müssen sie die molekularen Stellknöpfe finden – und beeinflussen. Einen dieser Stellknöpfe haben Ingo Schmitz und Marc Schuster entdeckt. Folgen Sie den beiden ins Labor...