Neuroinflammation and Neurodegeneration

What kind of role play infections and the associated inflammatory reactions for the progression or even for the onset of neurodegenerative diseases? Recurrent infections and the involved inflammation may trigger a series of processes in the brain that finally lead to neuronal damage due to the immune response. Thus, better understanding of neurodegenerative processes could improve the therapeutic approach in neurodegenerative disease.

Selected Publications

  1. Fol R, Braudeau J, Ludewig S, Abel T, Weyer SW, Roederer JP, Brod F, Audrain M, Bemelmans AP, Buchholz CJ, Korte M, Cartier N, Müller UC. (2015, Nov 4). Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model. Acta Neuropathol. doi:10.​1007/​s00401-015-1498-9 [Epub ahead of print]
  2. Hafi, N., Grunwald, M., Van Den Heuvel, L.S., Aspelmeier, T., Chen, J.H., Zagrebelsky, M., Schutte, O.M., Steinem, C., Korte, M., Munk, A., and Walla, P.J. (2014). Fluorescence nanoscopy by polarization modulation and polarization angle narrowing. Nat Methods 11(5):579-84. doi: 10.1038/nmeth.2919.

  3. Nair, S., Michaelsen-Preusse, K., Finsterbusch, K., Stegemann-Koniszewski, S., Bruder, D., Grashoff, M., Korte, M., Koster, M., Kalinke, U., Hauser, H., and Kroger, A. (2014). Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons. PLoS Pathog 10, e1003999. doi: 10.1371/journal.ppat.1003999.

  4.  Parlog, A., Harsan, L.A., Zagrebelsky, M., Weller, M., Von Elverfeldt, D., Mawrin, C., Korte, M., and Dunay, I.R. (2014). Chronic murine toxoplasmosis is defined by subtle changes in neuronal connectivity. Dis Model Mech 7, 459-469. doi: 10.1242/dmm.014183.

  5. Weyer, S.W., Zagrebelsky, M., Herrmann, U., Hick, M., Ganss, L., Gobbert, J., Gruber, M., Altmann, C., Korte, M., Deller, T., and Muller, U.C. (2014). Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsalpha expression. Acta Neuropathol Commun 2, 36. doi: 10.1186/2051-5960-2-36.

  6. Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Saecker AV, Griep A, Axt D, Remus A, Tzeng T-C, Gelpi E, Halle A, Korte M, Latz E, Golenbock D (2013) Nature ; 493(7434):674-8. doi: 10.1038/nature11729. Epub 2012 Dec 19.

  7. Kummer MP, Hermes M, Delekate, A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape H-C, König S Roeber S, Jessen F, Klockgether T, Korte M,  Heneka MT, (2011) Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron 71(5): 833-844

  8. Delekate A, Zagrebelsky M, Kramer S, Schwab ME, Korte M (2011) NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale. Proc Natl Acad Sci USA 108:2569-2574.

  9. Korte M (2008) A protoplasmic kiss to remember. Science 319:1627-1628.

  10. Minichiello, L, Calella, AM, Medina, DL, Bonhoeffer, T, Klein, R, Korte, M. (2002) Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation. Neuron 36: 121-137.

Leader

  • Prof Dr Martin Korte

    Martin Korte

    Head of Research Group Neuroinflammation and Neurodegeneration

    +49 531 391-3220

    Contact