Neuroinflammation and Neurodegeneration

What kind of role play infections and the associated inflammatory reactions for the progression or even for the onset of neurodegenerative diseases? Recurrent infections and the involved inflammation may trigger a series of processes in the brain that finally lead to neuronal damage due to the immune response. Thus, better understanding of neurodegenerative processes could improve the therapeutic approach in neurodegenerative disease.

Leader

Selected Publications

2016

  1. Alves S, Churlaud G, Audrain M, Michaelsen-Preusse K, Fol R, Souchet B, Braudeau J, Korte M, Klatzmann D, Cartier N. Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice. Brain. 2016 Dec 20. pii: aww330. doi: 10.1093/brain/aww330. [Epub ahead of print]
  2. Jaitner, C., Reddy, C., Abentung, A., Whittle, N., Rieder, D., Delekate, A., Korte, M., Jain, G., Fischer, A., Sananbenesi, F., Cera, I., Singewald, N., Dechant, G. & Apostolova, G. (2016) Satb2 determines miRNA expression and long-term memory in the adult central nervous system. eLife, 5.
  3. Zagrebelsky, M., Lonnemann, N., Fricke, S., Kellner, Y., Preuss, E., Michaelsen-Preusse, K. & Korte, M. (2016) Nogo-A regulates spatial learning as well as memory formation and modulates structural plasticity in the adult mouse hippocampus. Neurobiol Learn Mem.
  4. Iobbi C, Korte M, Zagrebelsky M (2016) Nogo-66 Restricts Synaptic Strengthening via Lingo1 and the ROCK2-Cofilin Pathway to Control Actin Dynamics. Cereb Cortex. May 10. pii: bhw122
  5. Korte M, Schmitz D (2016) Cellular and system biology of memory: Timing, molecules and beyond. Physiological reviews. DOI: 10.1152/physrev.00010.2015
  6. Michaelsen-Preusse K, Zessin S, Grigoryan G, Scharkowski F, Feuge J, Remus A, Korte M (2016) Neuronal Profilins in Health and Disease: Relevance for Spine Plasticity and Fragile X Syndrome.PNAS doi: 10.1073/pnas.1516697113
  7. Kellner Y, Fricke S, Kramer S, Iobbi C, Wierenga CJ, Schwab ME, Korte M, Zagrebelsky M (2016). Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics. Hippocampus. 2016 Jan 7. doi: 10.1002/hipo.22565.
  8. Fol R Braudeau J, Ludewig S, Abel T, Weyer SW, Roederer JP, Brod F, Audrain M, Bemelmans AP, Buchholz CJ, Korte M, Cartier N, Müller UC (2016).Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model. Acta Neuropathol.
  9. Hafi, N., Grunwald, M., van den Heuvel, L.S., Aspelmeier, T., Steinem, C., Korte, M., Munk, A. & Walla, P.J. (2016) Reply to "Polarization modulation adds little additional information to super-resolution fluorescence microscopy". Nature methods, 13, 8-9.
  10. Li, Q., Korte, M. & Sajikumar, S. (2016) Ubiquitin-Proteasome System Inhibition Promotes Long-Term Depression and Synaptic Tagging/Capture. Cereb Cortex, 26, 2541-2548.
  11. Strecker, P., Ludewig, S., Rust, M., Mundinger, T.A., Gorlich, A., Krachan, E.G., Mehrfeld, C., Herz, J., Korte, M., Guenette, S.Y. & Kins, S. (2016) FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation. Sci Rep, 6, 25652.

2015

  1. Klevanski M, Herrmann U, Weyer SW, Fol R, Cartier N, Wolfer DP, Caldwell JH, Korte M, Müller UC (2015). The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior. J Neurosci. 2015 Dec 9;35(49):16018-33. doi: 10.1523/JNEUROSCI.2009-15.2015.
  2. Burlot MA, Braudeau J, Michaelsen-Preusse K, Potier B, Ayciriex S, Varin J, Gautier B, Djelti F, Audrain M, Dauphinot L, Fernandez-Gomez FJ, Caillierez R, Laprévote O, Bièche I, Auzeil N, Potier MC, Dutar P, Korte M, Buée L, Blum D, Cartier N (2015). Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology. Hum Mol Genet. pii: ddv268.
  3. Chen JH, Kellner Y, Zagrebelsky M, Grunwald M, Korte M, Walla PJ (2015). Two-Photon Correlation Spectroscopy in Single Dendritic Spines Reveals Fast Actin Filament Reorganization during Activity-Dependent Growth. PLoS ONE 10(5):e0128241. doi: 10.1371/journal.pone.0128241
  4. Monory K, Polack M, Remus A, Lutz B, Korte M (2015) Cannabinoid CB1 receptor calibrates excitatory synaptic balance in the mouse hippocampus. J Neurosci. 4;35(9):3842-50. doi: 10.1523/JNEUROSCI.3167-14.2015.
  5. Hick M*, Herrmann U*, Weyer SW, Mallm JP, Tschäpe JA, Borgers M, Mercken M, Roth FC, Draguhn A, Slomianka L, Wolfer DP, Korte M*, Müller UC* (2015) Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity. Acta Neuropathol. 129(1):21-37. doi: 10.1007/s00401-014-1368-x. (*equal contribution)
  6. Fol R, Braudeau J, Ludewig S, Abel T, Weyer SW, Roederer JP, Brod F, Audrain M, Bemelmans AP, Buchholz CJ, Korte M, Cartier N, Müller UC. (2015, Nov 4). Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model. Acta Neuropathol. doi:10.​1007/​s00401-015-1498-9 [Epub ahead of print]

More

  1. Hafi, N., Grunwald, M., Van Den Heuvel, L.S., Aspelmeier, T., Chen, J.H., Zagrebelsky, M., Schutte, O.M., Steinem, C., Korte, M., Munk, A., and Walla, P.J. (2014). Fluorescence nanoscopy by polarization modulation and polarization angle narrowing. Nat Methods 11(5):579-84. doi: 10.1038/nmeth.2919.
  2.  Nair, S., Michaelsen-Preusse, K., Finsterbusch, K., Stegemann-Koniszewski, S., Bruder, D., Grashoff, M., Korte, M., Koster, M., Kalinke, U., Hauser, H., and Kroger, A. (2014). Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons. PLoS Pathog 10, e1003999. doi: 10.1371/journal.ppat.1003999.
  3.  Parlog, A., Harsan, L.A., Zagrebelsky, M., Weller, M., Von Elverfeldt, D., Mawrin, C., Korte, M., and Dunay, I.R. (2014). Chronic murine toxoplasmosis is defined by subtle changes in neuronal connectivity. Dis Model Mech 7, 459-469. doi: 10.1242/dmm.014183.
  4. Weyer, S.W., Zagrebelsky, M., Herrmann, U., Hick, M., Ganss, L., Gobbert, J., Gruber, M., Altmann, C., Korte, M., Deller, T., and Muller, U.C. (2014). Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsalpha expression. Acta Neuropathol Commun 2, 36. doi: 10.1186/2051-5960-2-36.
  5. Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Saecker AV, Griep A, Axt D, Remus A, Tzeng T-C, Gelpi E, Halle A, Korte M, Latz E, Golenbock D (2013) Nature ; 493(7434):674-8. doi: 10.1038/nature11729. Epub 2012 Dec 19.
  6. Kummer MP, Hermes M, Delekate, A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape H-C, König S Roeber S, Jessen F, Klockgether T, Korte M,  Heneka MT, (2011) Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron 71(5): 833-844
  7. Delekate A, Zagrebelsky M, Kramer S, Schwab ME, Korte M (2011) NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scale. Proc Natl Acad Sci USA 108:2569-2574.
  8. Korte M (2008) A protoplasmic kiss to remember. Science 319:1627-1628.
  9. Minichiello, L, Calella, AM, Medina, DL, Bonhoeffer, T, Klein, R, Korte, M. (2002) Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation. Neuron 36: 121-137.
PrintSend per emailShare