Neuroinflammation and Neurodegeneration
What kind of role play infections and the associated inflammatory reactions for the progression or even for the onset of neurodegenerative diseases? Recurrent infections and the involved inflammation may trigger a series of processes in the brain that finally lead to neuronal damage due to the immune response. Thus, better understanding of neurodegenerative processes could improve the therapeutic approach in neurodegenerative disease.
Prof Dr Martin Korte
„Our focus is the investigation of processes in learning, memory and forgetting. In particular, we are interested in the long-term consequences of infection and activation of the immune system to the brain and how this influences neuroinflammatory and aging processes of the brain - up to the development of Alzheimer's disease."
Martin Korte has already focused on synaptic plasticity during his PhD projects "Signaling Systems at hippocampal synapses" at the Max Planck Institute (MPI) for Neurobiology in Martinsried. Afterwards he became a research group leader at the MPI of Neurobiology. 2004 Martin Korte got the professorship at the Technische Universität Braunschweig. Since 2007 he is the professor of cellular neurobiology and the director of the zoological institute at the TU Braunschweig. In 2012 he established the research group neuroinflammation and neurodegeneration at the Helmholtz Centre for Infection Research and thereby connect with his experience in the fields of cellular neurobiology and neurophysiology the areas of infection and neurodegenerative diseases.