Model Systems for Infection and Immunity

In infection research experiments on cells and mice have a pivotal role. Frequently such model systems have to be tailored to allow tackling a specific scientific question. To this end, genetic modification of cell lines and mice is being pursued. 

Leader

Selected Publications

Cebula, M., Riehn, M., Hillebrand, U., Kratzer, Ramona, Kreppel, F., Koutsoumpli, G., Daemen, T., Hauser, H., Wirth, D. (2017) TLR9 mediated conditioning of the liver environment is essential for successful intrahepatic immunotherapy and effective memory recall. Molecular Therapy 25 (10): 2289-2298. DOI:10.1016/j.ymthe.2017.06.018

Riehn, M., Cebula, M., Hauser, H., Wirth, D. (2017) CpG-ODN facilitates effective intratracheal immunization and recall of memory against neoantigen expressing alveolar cells. Frontiers in Immunology 8: 1201. DOI:10.3389/fimmu.2017.01201

Ochel, A., Cebula, M., Riehn, M., Hillebrand, U., Lipps, C., Schirmbeck, R., Hauser, H., Wirth, D. (2016) Effective intrahepatic CD81 T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes. Cell & Mol Immunol 13: 805-815. DOI:10.1038/cmi.2015.80

Gödecke, N., Zha, L., Spencer, S., Behme, S., Riemer, P., Rehli, M., Hauser, H., Wirth, D. (2017) Controlled re-activation of epigenetically silenced Tet promoter-driven transgene expression by targeted demethylation. Nucl Acids Res, doi: 10.1093/nar/gkx601; DOI:10.1093/nar/gkx601 

Lipps, C., Badar, M., Butueva, M., Dubich, T., Singh, V.V., Rau, S., Weber, A., Kracht, M., Köster, M., May, T., Schulz, T.F., Hauser, H., Wirth, D. (2017) Proliferation status defines functional properties of endothelial cells. Cell Mol Life Sci. 74:1319-1333. DOI:10.1007/s00018-016-2417-5

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