Model Systems for Infection and Immunity

In infection research experiments on cells and mice have a pivotal role. Frequently such model systems have to be tailored to allow tackling a specific scientific question. To this end, genetic modification of cell lines and mice is being pursued. 


Selected Publications

Lipps, C., Badar, M., Butueva, M., Dubich, T., Singh, V.V., Rau, S., Weber, A., Kracht, M., Köster, M., May, T., Schulz, T.F., Hauser, H., Wirth, D. (2017) Proliferation status defines functional properties of endothelial cells. Cell Mol Life Sci. 74:1319-1333. DOI 10.1007/s00018-016-2417-5

Ochel, A., Cebula, M., Riehn, M., Hillebrand, U., Lipps, C., Schirmbeck, R., Hauser, H., Wirth, D. (2016) Effective intrahepatic CD81 T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes. Cell & Mol Immunol 13: 805-815. 

Rand, U., Hillebrand, U., Sievers, S., Willenberg, S., Koster, M., Hauser, H., Wirth, D. (2014) Uncoupling of the dynamics of host-pathogen interaction uncovers new mechanisms of viral interferon antagonism at the single-cell level. Nucleic Acids Res 42: e109.

Sandhu, U., Cebula, M., Behme, S., Riemer, P., Wodarczyk, C., Reimann, J., Schirmbeck, R., Hauser, H. and Wirth, D. (2011) Strict control of transgene expression in a mouse model for sensitive biological applications. Nucleic Acids Res. 1;39:e1.

Nehlsen, K., Herrmann, S., Zauers, J., Hauser, H. and Wirth, D. (2010) Toxin-antitoxin based transgene expression in mammalian cells. Nucleic Acids Res, 38, e32.

Full list of publications

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