Model Systems for Infection and Immunity

In infection research experiments on cells and mice have a pivotal role. Frequently such model systems have to be tailored to allow tackling a specific scientific question. To this end, genetic modification of cell lines and mice is being pursued. 


Prof Dr Dagmar Wirth

We develop models for studying questions of infection and immunity – using cutting-edge molecular biology strategies and cellular systems for in-vitro studies as well as transgenic mouse systems for in-vivo studies.

Dagmar Wirth

Dagmar Wirth studied chemistry in Braunschweig. She began focusing on gene regulation in mammalian cells as part of her doctoral work at GBF – today’s HZI – with a special focus on chromosomal elements that affect gene expression. As a post-doc, she conducted research on recombination in mammalian cells and viruses and developed recombinant viruses for application in biotechnology and gene therapy.

Following her work as a scientist in the Department of Clinical Immunology at the Medical University in Hannover, she returned in 2004 to assume her current role as principal investigator for the project ‘Immune evasion in chronic infections’ and as head of the research group ‘Model Systems for Infection and Immunity’ (MSYS).

One underlying activity of her research in MSYS is the generation of genetically modified mice with predictable expression properties. To provide this expertise to all research groups of the center, in 2012, the Service Unit "Transgenic Mice (TGSM)" was initiated which is also headed by Dagmar Wirth.

PrintSend per emailShare