Intravital Microscopy in Infection and Immunity

Whether or not an infected organism is successful in defending itself against a pathogen depends primarily upon the interaction of the cells within the immune system – both among one another and with the pathogen. The “language” of these interactions, soluble and membrane-linked signal molecules, has been thoroughly examined in recent years. The manner in which these signals are exchanged within the living organism is still unclear. With the aid of specialized microscopy technologies, the interplay between host and pathogen can be tracked nowadays in living tissues.

Prof Dr Andreas Müller

“We are trying to find out how a pathogen reacts to stress that it is exposed to during the immune response.”

Andreas Müller received his doctorate at the ETH Zurich, where he studied the early stages of Salmonella infection at the Institute for Microbiology in the working group of Wolf-Dietrich Hardt. 

He then continued with research residences at the Institut Pasteur in Paris in the working group for Immune Dynamics of Philippe Bousso with studies on the signal range of active T-cells in tissue, and at the University of Lausanne in the Laboratory for Pathology of Leishmania Infections of Fabienne Tacchini-Cottier, where he analyzed the influence of granulocytes in the immune response against Leishmania. Andreas Müller has been appointed Director of the research group “Intra-vital microscopy of infection and immunity” in December of 2013. The group has its base at the Institute for Molecular and Clinical Immunology of the Otto-von-Guericke University of Magdeburg, which is jointly financed by the HZI and the University of Magdeburg.