Innate Immunity and Infection

The moment a pathogen, which has successfully entered the body, is recognized, the body quickly mobilizes its defenses. Interferons are molecules that are counted among the body’s first line of defense. They prevent proliferation and the spread of viruses in the body and serve to alert the immune system. Read here about the different ways we use to try and decode this system, all in an effort to find new approaches to infectious disease prevention and therapy.


Selected Publications

  • Authors: Kugel,D.; Pulverer,J.E.; Koster,M.; Hauser,Hansjörg*; Staeheli,P.; ( Year: 2011). Title: Novel Nonviral Bioassays for Mouse Type I and Type III Interferon. Journal: Journal of Interferone and Cytokine Research Volume: 31 Issue: 4, S-Page: 345- E-Page: 349 DOI: 10.1089/jir.2010.0079 HZI repository PubMed
  • Authors: Kirschning,C.J.; Dreher,S.; Maass,B.; Fichte,S.; Schade,J.; Koster,M.; Noack,A.; Lindenmaier,Werner*; Wagner,H.; Boldicke,T.; ( Year: 2010). Title: Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation. Journal: BMC Biotechnology Volume: 10, S-Page: 31 DOI: 10.1186/1472-6750-10-31 HZI repository PubMed
  • Authors: Stirnweiss,A.; Ksienzyk,A.; Klages,K.; Rand,U.; Grashoff,M.; Hauser,Hansjörg*; Kroger,A.; ( Year: 2010). Title: IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. Journal: Journal of Immunology Volume: 184 Issue: 9, S-Page: 5179- E-Page: 5185 PubMed
  • Authors: Dietrich,N.; Rohde,Manfred*; Geffers,Robert*; Kroger,A.; Hauser,Hansjörg*; Weiss,Siegfried*; Gekara,N.O.; ( Year: 2010). Title: Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria. Journal: Proceeding of the National Academy of Sciences of the United States of America Volume: 107 Issue: 19, S-Page: 8748- E-Page: 8753 PubMed
  • Authors: Pulverer,J.E.; Rand,U.; Lienenklaus,S.; Kugel,D.; Zietara,N.; Kochs,G.; Naumann,R.; Weiss,Siegfried*; Staeheli,P.; Hauser,Hansjörg*; Koster,M.; ( Year: 2010). Title: Temporal and spatial resolution of type I and III interferon responses in vivo. Journal: Journal of Virology Volume: 84 Issue: 17, S-Page: 8626- E-Page: 8638 PubMed
  • Authors: Probst-Kepper,M.; Geffers,Robert*; Kroger,A.; Viegas,N.; Erck,C.; Hecht,Hans-Jürgen*; Lünsdorf,Heinrich*; Roubin,R.; Moharregh-Khiabani,D.; Wagner,K.; Ocklenburg,F.; Jeron,Andreas*; Garritsen,H.; Arstila,T.P.; Kekalainen,E.; Balling,Rudi*; Hauser,Hansjörg*; Buer,J.; Weiss,Siegfried*; ( Year: 2009). Title: GARP: a key receptor controlling FOXP3 in human regulatory T cells. Journal: Journal of Cellular and Molecular Medicine Volume: 13 Issue: 9, S-Page: 3343- E-Page: 3357 PubMed
  • Authors: Stegemann,S.; Dahlberg,S.; Kroger,A.; Gereke,M.; Bruder,Dunja*; Henriques-Normark,B.; Gunzer,Matthias*; ( Year: 2009). Title: Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia. Journal: PLoS ONE Volume: 4 Issue: 3, S-Page: e4840 DOI: 10.1371/journal.pone.0004840 HZI repository PubMed
  • Authors: Probst-Kepper,Michael*; Kröger,Andrea*; Garritsen,H.S.P.; Buer,J.; ( Year: 2009). Title: Perspectives on regulatory T cell therapies. Journal: Transfusion Medicine and Hemotherapy Volume: 36 Issue: 5, S-Page: 302- E-Page: 308
  • Authors: Kroger,A.; Stirnweiss,A.; Pulverer,J.E.; Klages,K.; Grashoff,M.; Reimann,J.; Hauser,Hansjörg*; ( Year: 2007). Title: Tumor suppression by IFN regulatory factor-1 is mediated by transcriptional down-regulation of cyclin D1. Journal: Cancer Research Volume: 67 Issue: 7, S-Page: 2972- E-Page: 2981 PubMed
  • Authors: Yu,Z.; Beer,C.; Köster,Mario*; Wirth,Manfred*; ( Year: 2006). Title: Caveolin-1 interacts with the Gag precursor of murine leukaemia virus and modulates virus production. Journal: Virology Journal Volume: 3, S-Page: 73 DOI: 10.1186/1743-422X-3-73 HZI repository PubMed
  • Authors: Frahm,T.; Hauser,Hansjörg*; Köster,Mario*; ( Year: 2006). Title: IFN-type-I-mediated signalling is regulated by modulation of STAT2 nuclear export. Journal: Journal of Cell Science Volume: 119, S-Page: 1092- E-Page: 1104 DOI: 10.1242/jcs.02822 HZI repository PubMed
  • Authors: Froese,N.; Schwarzer,M.; Niedick,Inge*; Frischmann,Ursula*; Köster,Mario*; Kröger,Andrea*; Müller,Peter Paul*; Nourbakhsh,Mahtab*; Pasche,Bastian*; Reimann,J.; Staeheli,P.; Hauser,Hansjörg*; ( Year: 2006). Title: Innate immune responses in NF-kappaB-repressing factor (NRF)-deficient mice. Journal: Molecular and Cellular Biology Volume: 26, S-Page: 293- E-Page: 302
  • Authors: Schirmbeck,R.; Riedel,P.; Kupferschmitt,M.; Wegenka,U.; Hauser,Hansjörg*; Rice,J.; Kröger,Andrea*; ( Year: 2006). Title: Priming protective CD8 T cell immunity by DNA vaccines encoding chimeric, stress protein-capturing tumor-associated antigen. Journal: Journal of Immunology Volume: 177 Issue: 3, S-Page: 1534- E-Page: 1542
  • Authors: May,T.; Müller,P.; Weich,H.; Froese,N.; Deutsch,U.; Wirth,D.; Kröger,A.; Hauser,H.; ( Year: 2005). Title: Establishment of murine cell lines by constitutive and conditional immortalization. Journal: Journal of Biotechnology Volume: 120 Issue: 1, S-Page: 99- E-Page: 110
  • Authors: Köster,M.; Frahm,T.; Hauser,H.; ( Year: 2005). Title: Nucleocytoplasmic shuttling analysis of STAT1 by FRAP and FLIP. Journal: Current Opinion in Biotechnology Volume: 16, S-Page: 28- E-Page: 34
  • Authors: Dikopoulos,N.; Bertoletti,A.; Kröger,A.; Hauser,H.; Schirmbeck,R.; Reimann,J.; ( Year: 2005). Title: Type I interferon negatively regulates CD8+ T cell responses through IL-10-producing CD4+ TR1 cells. Journal: Journal of Immunology Volume: 174, S-Page: 99- E-Page: 109
  • Authors: Jomantaité,I.; Dikopoulos,N.; Kröger,A.; Leithäuser,F.; Hauser,H.; Schrimbeck,R.; Reimann,J.; ( Year: 2004). Title: Hepatic dendritic cell subsets in the mouse. Journal: European Journal of Immunology Volume: 34, S-Page: 355- E-Page: 365
  • Authors: Niedick,I.; Froese,N.; Oumard,A.; Müller,P.P.; Nourbakhsh,M.; Hauser,H.; Köster,M.; ( Year: 2004). Title: Nucleolar localization and mobility analysis of the NF-kB repressing factor NRF. Journal: Journal of Cell Science Volume: 117, S-Page: 3447- E-Page: 3458
  • Authors: Dikopoulos,N.; Wegenka,U.; Kröger,A.; Hauser,H.; Schirmbeck,R.; Reimann,J.; ( Year: 2004). Title: Recently primed CD8+ T cells entering the liver allow hepatocytes to interact with naive CD8+ T cell and downregulate their immune-suppressive effects. Journal: Hepatology Volume: 39, S-Page: 1256- E-Page: 1266
  • Authors: Kwissa,M.; Kröger,A.; Hauser,H.; Reimann,J.; Schirmbeck,R.; ( Year: 2003). Title: Defining conditions for cytokine-facilitated priming of CD8+ T cell responses by DNA vaccination. Journal: Journal of Molecular Medicine Volume: 81, S-Page: 91- E-Page: 101
  • Authors: Kröger,A.; Dallügge,A.; Kirchhoff,S.; Hauser,H.; ( Year: 2003). Title: IRF-1 reverts the transformed phenotype of oncogenically transformed cells in vitro an in vivo. Journal: Oncogene Volume: 22 Issue: 7, S-Page: 1045- E-Page: 1056
  • Authors: Trobonjaca,Z.; Kröger,A.; Stober,D.; Leithauser,F.; Moller,P.; Hauser,H.; Schirmbeck,R.; Reimann,J.; ( Year: 2002). Title: Activating immunity in the liver. II. IFN-beta attenuates NK cell- dependent liver injury triggered by liver NKT cell activation. Journal: Journal of Immunology Volume: 168 Issue: 8, S-Page: 3763- E-Page: 3770 PubMed
  • Authors: Kröger,A.; Köster,M.; Schroeder,K.; Hauser,H.; Müller,P.P.; ( Year: 2002). Title: Activities of IRF-1. Journal: Journal of Interferon and Cytokine Research Volume: 22 Issue: 1, S-Page: 5- E-Page: 14 PubMed
  • Authors: Hennecke,M.; Kwissa,M.; Metzger,K.; Oumard,A.; Kröger,A.; Schirmbeck,R.; Reimann,J.; Hauser,H.; ( Year: 2001). Title: Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs. Journal: Nucleic Acids Research Volume: 29 Issue: 16, S-Page: 3327- E-Page: 3334 HZI repository PubMed
  • Authors: Kröger,A.; Ortmann,D.; Krohne,T.U.; Mohr,L.; Blum,H.E.; Hauser,H.; Geissler,M.; ( Year: 2001). Title: Growth suppression of the hepatocellular carcinoma cell line Hepa1-6 by an activatable interferon regulatory factor-1 in mice. Journal: Cancer Research Volume: 61 Issue: 6, S-Page: 2609- E-Page: 2617 PubMed
  • Authors: Unsinger,J.; Kroger,A.; Hauser,H.; Wirth,D.; ( Year: 2001). Title: Retroviral vectors for the transduction of autoregulated, bidirectional expression cassettes. Journal: Molecular therapy Volume: 4 Issue: 5, S-Page: 484- E-Page: 489 PubMed
  • Authors: Lillemeier,B.F.; Köster,M.; Kerr,I.M.; ( Year: 2001). Title: STAT1 from the cell membrane to the DNA.. Journal: Embo Journal Volume: 20, S-Page: 2508- E-Page: 2517
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