Innate Immunity and Infection

The moment a pathogen, which has successfully entered the body, is recognized, the body quickly mobilizes its defenses. Interferons are molecules that are counted among the body’s first line of defense. They prevent proliferation and the spread of viruses in the body and serve to alert the immune system. Read here about the different ways we use to try and decode this system, all in an effort to find new approaches to infectious disease prevention and therapy.

Selected Publications

  • Kugel,D.; Pulverer,J.E.; Koster,M.; Hauser,Hansjörg*; Staeheli,P.; (2011). Novel Nonviral Bioassays for Mouse Type I and Type III Interferon. Journal of Interferone and Cytokine Research: 31 4, 345-349 DOI: 10.1089/jir.2010.0079 HZI repository PubMed
  • Kirschning,C.J.; Dreher,S.; Maass,B.; Fichte,S.; Schade,J.; Koster,M.; Noack,A.; Lindenmaier,Werner*; Wagner,H.; Boldicke,T.; (2010). Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation. BMC Biotechnology: 10, 31 DOI: 10.1186/1472-6750-10-31 HZI repository PubMed
  • Stirnweiss,A.; Ksienzyk,A.; Klages,K.; Rand,U.; Grashoff,M.; Hauser,Hansjörg*; Kroger,A.; (2010). IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. Journal of Immunology: 184 9, 5179-5185 PubMed
  • Dietrich,N.; Rohde,Manfred*; Geffers,Robert*; Kroger,A.; Hauser,Hansjörg*; Weiss,Siegfried*; Gekara,N.O.; (2010). Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria. Proceeding of the National Academy of Sciences of the United States of America: 107 19, 8748-8753 PubMed
  • Pulverer,J.E.; Rand,U.; Lienenklaus,S.; Kugel,D.; Zietara,N.; Kochs,G.; Naumann,R.; Weiss,Siegfried*; Staeheli,P.; Hauser,Hansjörg*; Koster,M.; (2010). Temporal and spatial resolution of type I and III interferon responses in vivo. Journal of Virology: 84 17, 8626-8638 PubMed
  • Probst-Kepper,M.; Geffers,Robert*; Kroger,A.; Viegas,N.; Erck,C.; Hecht,Hans-Jürgen*; Lünsdorf,Heinrich*; Roubin,R.; Moharregh-Khiabani,D.; Wagner,K.; Ocklenburg,F.; Jeron,Andreas*; Garritsen,H.; Arstila,T.P.; Kekalainen,E.; Balling,Rudi*; Hauser,Hansjörg*; Buer,J.; Weiss,Siegfried*; (2009). GARP: a key receptor controlling FOXP3 in human regulatory T cells. Journal of Cellular and Molecular Medicine: 13 9, 3343-3357 PubMed
  • Stegemann,S.; Dahlberg,S.; Kroger,A.; Gereke,M.; Bruder,Dunja*; Henriques-Normark,B.; Gunzer,Matthias*; (2009). Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia. PLoS ONE: 4 3, e4840 DOI: 10.1371/journal.pone.0004840 HZI repository PubMed
  • Probst-Kepper,Michael*; Kröger,Andrea*; Garritsen,H.S.P.; Buer,J.; (2009). Perspectives on regulatory T cell therapies. Transfusion Medicine and Hemotherapy: 36 5, 302-308
  • Kroger,A.; Stirnweiss,A.; Pulverer,J.E.; Klages,K.; Grashoff,M.; Reimann,J.; Hauser,Hansjörg*; (2007). Tumor suppression by IFN regulatory factor-1 is mediated by transcriptional down-regulation of cyclin D1. Cancer Research: 67 7, 2972-2981 PubMed
  • Yu,Z.; Beer,C.; Köster,Mario*; Wirth,Manfred*; (2006). Caveolin-1 interacts with the Gag precursor of murine leukaemia virus and modulates virus production. Virology Journal: 3, 73 DOI: 10.1186/1743-422X-3-73 HZI repository PubMed
  • Frahm,T.; Hauser,Hansjörg*; Köster,Mario*; (2006). IFN-type-I-mediated signalling is regulated by modulation of STAT2 nuclear export. Journal of Cell Science: 119, 1092-1104 DOI: 10.1242/jcs.02822 HZI repository PubMed
  • Froese,N.; Schwarzer,M.; Niedick,Inge*; Frischmann,Ursula*; Köster,Mario*; Kröger,Andrea*; Müller,Peter Paul*; Nourbakhsh,Mahtab*; Pasche,Bastian*; Reimann,J.; Staeheli,P.; Hauser,Hansjörg*; (2006). Innate immune responses in NF-kappaB-repressing factor (NRF)-deficient mice. Molecular and Cellular Biology: 26, 293-302
  • Schirmbeck,R.; Riedel,P.; Kupferschmitt,M.; Wegenka,U.; Hauser,Hansjörg*; Rice,J.; Kröger,Andrea*; (2006). Priming protective CD8 T cell immunity by DNA vaccines encoding chimeric, stress protein-capturing tumor-associated antigen. Journal of Immunology: 177 3, 1534-1542
  • May,T.; Müller,P.; Weich,H.; Froese,N.; Deutsch,U.; Wirth,D.; Kröger,A.; Hauser,H.; (2005). Establishment of murine cell lines by constitutive and conditional immortalization. Journal of Biotechnology: 120 1, 99-110
  • Köster,M.; Frahm,T.; Hauser,H.; (2005). Nucleocytoplasmic shuttling analysis of STAT1 by FRAP and FLIP. Current Opinion in Biotechnology: 16, 28-34
  • Dikopoulos,N.; Bertoletti,A.; Kröger,A.; Hauser,H.; Schirmbeck,R.; Reimann,J.; (2005). Type I interferon negatively regulates CD8+ T cell responses through IL-10-producing CD4+ TR1 cells. Journal of Immunology: 174, 99-109
  • Jomantaité,I.; Dikopoulos,N.; Kröger,A.; Leithäuser,F.; Hauser,H.; Schrimbeck,R.; Reimann,J.; (2004). Hepatic dendritic cell subsets in the mouse. European Journal of Immunology: 34, 355-365
  • Niedick,I.; Froese,N.; Oumard,A.; Müller,P.P.; Nourbakhsh,M.; Hauser,H.; Köster,M.; (2004). Nucleolar localization and mobility analysis of the NF-kB repressing factor NRF. Journal of Cell Science: 117, 3447-3458
  • Dikopoulos,N.; Wegenka,U.; Kröger,A.; Hauser,H.; Schirmbeck,R.; Reimann,J.; (2004). Recently primed CD8+ T cells entering the liver allow hepatocytes to interact with naive CD8+ T cell and downregulate their immune-suppressive effects. Hepatology: 39, 1256-1266
  • Kwissa,M.; Kröger,A.; Hauser,H.; Reimann,J.; Schirmbeck,R.; (2003). Defining conditions for cytokine-facilitated priming of CD8+ T cell responses by DNA vaccination. Journal of Molecular Medicine: 81, 91-101
  • Kröger,A.; Dallügge,A.; Kirchhoff,S.; Hauser,H.; (2003). IRF-1 reverts the transformed phenotype of oncogenically transformed cells in vitro an in vivo. Oncogene: 22 7, 1045-1056
  • Trobonjaca,Z.; Kröger,A.; Stober,D.; Leithauser,F.; Moller,P.; Hauser,H.; Schirmbeck,R.; Reimann,J.; (2002). Activating immunity in the liver. II. IFN-beta attenuates NK cell- dependent liver injury triggered by liver NKT cell activation. Journal of Immunology: 168 8, 3763-37700022-1767 PubMed
  • Kröger,A.; Köster,M.; Schroeder,K.; Hauser,H.; Müller,P.P.; (2002). Activities of IRF-1. Journal of Interferon and Cytokine Research: 22 1, 5-141079-9907 PubMed
  • Hennecke,M.; Kwissa,M.; Metzger,K.; Oumard,A.; Kröger,A.; Schirmbeck,R.; Reimann,J.; Hauser,H.; (2001). Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs. Nucleic Acids Research: 29 16, 3327-33341362-4962 HZI repository PubMed
  • Kröger,A.; Ortmann,D.; Krohne,T.U.; Mohr,L.; Blum,H.E.; Hauser,H.; Geissler,M.; (2001). Growth suppression of the hepatocellular carcinoma cell line Hepa1-6 by an activatable interferon regulatory factor-1 in mice. Cancer Research: 61 6, 2609-26170008-5472 PubMed
  • Unsinger,J.; Kroger,A.; Hauser,H.; Wirth,D.; (2001). Retroviral vectors for the transduction of autoregulated, bidirectional expression cassettes. Molecular therapy: 4 5, 484-4891525-0016 PubMed
  • Lillemeier,B.F.; Köster,M.; Kerr,I.M.; (2001). STAT1 from the cell membrane to the DNA.. Embo Journal: 20, 2508-2517